Objectives:To examine the 16-year developmental history,research hotspots,and emerging trends of zinc-based biodegradable metallic materials from the perspective of structural and temporal dynamics.Methods:The literat...Objectives:To examine the 16-year developmental history,research hotspots,and emerging trends of zinc-based biodegradable metallic materials from the perspective of structural and temporal dynamics.Methods:The literature on zinc-based biodegradable metallic materials in WoSCC was searched.Historical characteristics,the evolution of active topics and development trends in the field of zinc-based biodegradable metallic materials were analyzed using the bibliometric tools CiteSpace and HistCite.Results:Over the past 16 years,the field of zinc-based biodegradable metal materials has remained in a hotspot stage,with extensive scientific collaboration.In addition,there are 45 subject categories and 51 keywords in different research periods,and 80 papers experience citation bursts.Keyword clustering anchored 3 emerging research subfields,namely,#1 plastic deformation#4 additive manufacturing#5 surface modification.The keyword alluvial map shows that the longest-lasting research concepts in the field are mechanical property,microstructure,corrosion behavior,etc.,and emerging keywords are additive manufacturing,surface modification,dynamic recrystallization,etc.The most recent research on reference clustering has six subfields.Namely,#0 microstructure,#2 sem,#3 additive manufacturing,#4 laser powder bed fusion,#5 implant,and#7 Zn-1Mg.Conclusion:The results of the bibliometric study provide the current status and trends of research on zinc-based biodegradable metallic materials,which can help researchers identify hot spots and explore new research directions in the field.展开更多
Demand for biliary stents has expanded with the increasing incidence of biliary disease.The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures.However,these st...Demand for biliary stents has expanded with the increasing incidence of biliary disease.The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures.However,these stents are nondegradable and prone to restenosis.Surgical removal or replacement of the nondegradable stents is necessary in cases of disease resolution or restenosis.To overcome these shortcomings,improvements were made to the materials and surfaces used for the stents.First,this paper reviews the advantages and limitations of nondegradable stents.Second,emphasis is placed on biodegradable polymer and biodegradable metal stents,along with functional coatings.This also encompasses tissue engineering&3D-printed stents were highlighted.Finally,the future perspectives of biliary stents,including pro-epithelialization coatings,multifunctional coated stents,biodegradable shape memory stents,and 4D bioprinting,were discussed.展开更多
Endothelial cell(EC)-specific coatings for vascular stents are crucial for enhancing their biocompatibility and preventing complications such as restenosis and thrombosis.This study developed an innovative CD47-VE-cad...Endothelial cell(EC)-specific coatings for vascular stents are crucial for enhancing their biocompatibility and preventing complications such as restenosis and thrombosis.This study developed an innovative CD47-VE-cadherin-Mfp5(CD47-VE-M)fusion protein coating for cardiovascular stents that integrates three distinct functional domains:endothelial adhesion enhancement(VE-cadherin EC1-2),macrophage inhibitory signaling(CD47),and substrate adhesion reinforcement(Mfp5).In vitro,CD47-VE-M coatings significantly promoted EC adhesion(3.4-fold increase vs.bare-metal stent(BMS)(p<0.001)),directional migration(accelerated 62%compared to BMS at 24 h)and proliferation(2.3-fold increase vs.BMS(p<0.01)),with increased VE-cadherin expression and improved tight junction formation(1.5-fold higher than BMS(p<0.001)).Additionally,the CD47-VE-M coating reduced macrophage phagocytosis by 59%(p<0.01).Compared with BMS,synergistic CD47-VE-M fusion protein-coated stents showed accelerated endothelialization and reduced neointimal hyper-plasia and restenosis by 64.4%(p<0.001)in vivo.Besides,the coating also decreased the presence of M1 pro-inflammatory macrophages(64.74%decrease vs.BMS(p<0.01)),which mitigated the inflammatory response.This novel coating strategy overcomes the limitations of current drug-eluting stent(DES)by simultaneously enhancing endothelial regeneration and suppressing pathological inflammation.展开更多
基金supported by grants from the National Natural Science Foundation of China(12032007,31971242,82270535)the Science and Technology Innovation Project of JinFeng Laboratory,Chongqing,China(jfkyjf202203001)。
文摘Objectives:To examine the 16-year developmental history,research hotspots,and emerging trends of zinc-based biodegradable metallic materials from the perspective of structural and temporal dynamics.Methods:The literature on zinc-based biodegradable metallic materials in WoSCC was searched.Historical characteristics,the evolution of active topics and development trends in the field of zinc-based biodegradable metallic materials were analyzed using the bibliometric tools CiteSpace and HistCite.Results:Over the past 16 years,the field of zinc-based biodegradable metal materials has remained in a hotspot stage,with extensive scientific collaboration.In addition,there are 45 subject categories and 51 keywords in different research periods,and 80 papers experience citation bursts.Keyword clustering anchored 3 emerging research subfields,namely,#1 plastic deformation#4 additive manufacturing#5 surface modification.The keyword alluvial map shows that the longest-lasting research concepts in the field are mechanical property,microstructure,corrosion behavior,etc.,and emerging keywords are additive manufacturing,surface modification,dynamic recrystallization,etc.The most recent research on reference clustering has six subfields.Namely,#0 microstructure,#2 sem,#3 additive manufacturing,#4 laser powder bed fusion,#5 implant,and#7 Zn-1Mg.Conclusion:The results of the bibliometric study provide the current status and trends of research on zinc-based biodegradable metallic materials,which can help researchers identify hot spots and explore new research directions in the field.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2024CDJCGJ-016)National Natural Science Foundation of China(No.82270535)+1 种基金the Science and Technology Innovation Project of Jinfeng Laboratory,Chongqing,China(jfkyjf202203001)China Postdoctoral Science Foundation(2023MD734198).
文摘Demand for biliary stents has expanded with the increasing incidence of biliary disease.The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures.However,these stents are nondegradable and prone to restenosis.Surgical removal or replacement of the nondegradable stents is necessary in cases of disease resolution or restenosis.To overcome these shortcomings,improvements were made to the materials and surfaces used for the stents.First,this paper reviews the advantages and limitations of nondegradable stents.Second,emphasis is placed on biodegradable polymer and biodegradable metal stents,along with functional coatings.This also encompasses tissue engineering&3D-printed stents were highlighted.Finally,the future perspectives of biliary stents,including pro-epithelialization coatings,multifunctional coated stents,biodegradable shape memory stents,and 4D bioprinting,were discussed.
基金supported by grants from the National Natural Science Foundation of China(12032007,32471366)the Science and Technology Innovation Project of JinFeng Laboratory,Chongqing,China(jfkyjf202203001)+2 种基金the China Postdoctoral Science Foundation(No.2022MD713708)the Science and Technology Research Program of Chongqing Municipal Education Commission(Grant No.KJQN202300408 and KJQN202502811)Chongqing Traditional Chinese Medicine Innovation Team Construction Project(Yuzhongyi[2022]33).
文摘Endothelial cell(EC)-specific coatings for vascular stents are crucial for enhancing their biocompatibility and preventing complications such as restenosis and thrombosis.This study developed an innovative CD47-VE-cadherin-Mfp5(CD47-VE-M)fusion protein coating for cardiovascular stents that integrates three distinct functional domains:endothelial adhesion enhancement(VE-cadherin EC1-2),macrophage inhibitory signaling(CD47),and substrate adhesion reinforcement(Mfp5).In vitro,CD47-VE-M coatings significantly promoted EC adhesion(3.4-fold increase vs.bare-metal stent(BMS)(p<0.001)),directional migration(accelerated 62%compared to BMS at 24 h)and proliferation(2.3-fold increase vs.BMS(p<0.01)),with increased VE-cadherin expression and improved tight junction formation(1.5-fold higher than BMS(p<0.001)).Additionally,the CD47-VE-M coating reduced macrophage phagocytosis by 59%(p<0.01).Compared with BMS,synergistic CD47-VE-M fusion protein-coated stents showed accelerated endothelialization and reduced neointimal hyper-plasia and restenosis by 64.4%(p<0.001)in vivo.Besides,the coating also decreased the presence of M1 pro-inflammatory macrophages(64.74%decrease vs.BMS(p<0.01)),which mitigated the inflammatory response.This novel coating strategy overcomes the limitations of current drug-eluting stent(DES)by simultaneously enhancing endothelial regeneration and suppressing pathological inflammation.
