Cholangiocarcinoma(CCA)ranks among the most prevalent and aggressive tumors,with both its incidence and mortality rates rising each year.Long non-coding RNAs(lncRNAs)have surfaced as essential contributors to the regu...Cholangiocarcinoma(CCA)ranks among the most prevalent and aggressive tumors,with both its incidence and mortality rates rising each year.Long non-coding RNAs(lncRNAs)have surfaced as essential contributors to the regulation of gene expression and various cellular processes.These RNA molecules,exceeding 200 nucleotides in length and lacking protein-coding capabilities,have been associated with numerous biological functions,such as development,differentiation,and various diseases.In this mini-review,we focus on the involvement of lncRNAs in CCA,scrutinizing their roles,mechanisms of action,and possible therapeutic implications.By shedding light on the complex interactions between lncRNAs and CCA,our goal is to facilitate future investigations and the creation of targeted therapies that can enhance patient outcomes.展开更多
基金funded by National Natural Science Foundation of China(8247274382300921)+11 种基金Beijing Xisike Clinical Oncology Research Foundation(Y-QL202201-0020)Beijing Science and Technology Innovation Medical Development Foundation(KC2023-JX-0186-FM046)Anhui Engineering Technology Research Center of Biochemical Pharmaceutical,Bengbu Medical University(2024SYKFD01)Opening Project of the Scientific and Technological Innovation Major Base of Guangxi(2022-36-Z05-GXSWBX202201)Key Laboratory of Human Development and Disease Research(Guangxi Medical University),Education Department of Guangxi Zhuang Autonomous Region(RTFY202301)Opening Project of Fujian Provincial Key Laboratory of Tumor Biotherapy(FJZL2023001)Opening Project of Fujian Provincial Key Laboratory of Translational Cancer Medicine(TCM2024-3)Opening Project of Fujian Provincial Key Laboratory of Innovative Drug Target Research(FJ-YW-2024KF02)Thematic Research Support Scheme of State Key Laboratory of Liver Research,The University of Hong Kong(SKLLR/TRSS/2022/08)Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province(CXPJJH123003-005)Postgraduate Research&Practice Innovation Program of Harbin Medical University(YJSCX2024-110HYD)Opening Project of Key Laboratory of Functional and Clinical Translational Medicine,Fujian Province University(XMMC-OP2024012).
文摘Cholangiocarcinoma(CCA)ranks among the most prevalent and aggressive tumors,with both its incidence and mortality rates rising each year.Long non-coding RNAs(lncRNAs)have surfaced as essential contributors to the regulation of gene expression and various cellular processes.These RNA molecules,exceeding 200 nucleotides in length and lacking protein-coding capabilities,have been associated with numerous biological functions,such as development,differentiation,and various diseases.In this mini-review,we focus on the involvement of lncRNAs in CCA,scrutinizing their roles,mechanisms of action,and possible therapeutic implications.By shedding light on the complex interactions between lncRNAs and CCA,our goal is to facilitate future investigations and the creation of targeted therapies that can enhance patient outcomes.
