Development of novel photosensitizers(PSs)with high biocompatibility and biological uptake is of significance for efficient photodynamic anti-tumor or anti-bacterial.This study presents a smart self-assembly strategy ...Development of novel photosensitizers(PSs)with high biocompatibility and biological uptake is of significance for efficient photodynamic anti-tumor or anti-bacterial.This study presents a smart self-assembly strategy of glyco-photosensitizers with near-infrared(NIR)emission and aggregation-induced generation reactive oxygen species(AIG-ROS)ability for cell imaging and photodynamic therapy(PDT)of both tumor cells and bacteria.Two photosensitizers,KL1 and KL2,are based on a“D-π-A”molecular architecture,featuring a tricyanofuran(TCF)acceptor and a tetraphenylethene(TPE)donor bridged by thiophene derivatives.After self-assembling with TPE-based glycoclusters(TPE-Glc_4),the resulting glyco-nanoparticles(KL1-G and KL2-G)exhibit improved water solubility and AIG-ROS capability,including singlet oxygen(~1O_(2))and superoxide radicals(·O_(2)^(-))upon light irradiation.In cellular studies,TPE-glycoclusters facilitate the cellular uptake of PSs,thereby enhancing the NIR fluorescence signal and PDT efficiency for multiple kinds of cells.KL2-G shows superior phototoxicity,reducing cell viability to less than 5%at a low concentration of<5μM under light irradiation.Additionally,KL2-G exhibits potential for photodynamic anti-bacterial applications against Escherichia coli.This work underscores the importance of glycoclustersmediated delivery in therapeutic efficacy enhancement of PSs and highlights the potential of glyco-nanoparticles in bioimaging and phototherapy applications.展开更多
Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensiti...Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensitizers for enhanced cell imaging and photodynamic therapy”(Sci China Chem,2025,68:5086-5096)contained errors.Specifically,the image in Figure 6d exhibiting the phototoxicity of control group at 0μM was inadvertently taken the incorrect image in the original paper.The correction version is given below.Nevertheless,this correction does not affect the results and conclusion of the paper.展开更多
基金supported by the National Natural Science Foundation of China(22305178,22207086,22107029,22377135)the Shandong Provincial Natural Science Foundation(ZR2023QB248,ZR2022QH060)+5 种基金the Taishan Scholars Program(tsqn202312305)the Young Elite Scientists Sponsorship Program by Chinese Chemical Societythe Fundamental Research Projects of Science&Technology Innovation and Development Plan in Yantai City(2023JCYJ059)the Key R&D Program of Shandong Province,China(2024CXPT028)the Science and Technology Support Plan for Youth Innovation in Universities of Shandong Province(2024KJG029)the Shandong Laboratory Program(SYS202205)。
文摘Development of novel photosensitizers(PSs)with high biocompatibility and biological uptake is of significance for efficient photodynamic anti-tumor or anti-bacterial.This study presents a smart self-assembly strategy of glyco-photosensitizers with near-infrared(NIR)emission and aggregation-induced generation reactive oxygen species(AIG-ROS)ability for cell imaging and photodynamic therapy(PDT)of both tumor cells and bacteria.Two photosensitizers,KL1 and KL2,are based on a“D-π-A”molecular architecture,featuring a tricyanofuran(TCF)acceptor and a tetraphenylethene(TPE)donor bridged by thiophene derivatives.After self-assembling with TPE-based glycoclusters(TPE-Glc_4),the resulting glyco-nanoparticles(KL1-G and KL2-G)exhibit improved water solubility and AIG-ROS capability,including singlet oxygen(~1O_(2))and superoxide radicals(·O_(2)^(-))upon light irradiation.In cellular studies,TPE-glycoclusters facilitate the cellular uptake of PSs,thereby enhancing the NIR fluorescence signal and PDT efficiency for multiple kinds of cells.KL2-G shows superior phototoxicity,reducing cell viability to less than 5%at a low concentration of<5μM under light irradiation.Additionally,KL2-G exhibits potential for photodynamic anti-bacterial applications against Escherichia coli.This work underscores the importance of glycoclustersmediated delivery in therapeutic efficacy enhancement of PSs and highlights the potential of glyco-nanoparticles in bioimaging and phototherapy applications.
文摘Correction to:Sci China Chem,2025,68(10):5086-5096.https://doi.org/10.1007/s11426-025-2730-2 We regret that our article“Smart formation of multifunctional glyco-nanoparticles:glycoclusters delivering NIR photosensitizers for enhanced cell imaging and photodynamic therapy”(Sci China Chem,2025,68:5086-5096)contained errors.Specifically,the image in Figure 6d exhibiting the phototoxicity of control group at 0μM was inadvertently taken the incorrect image in the original paper.The correction version is given below.Nevertheless,this correction does not affect the results and conclusion of the paper.
