BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially aff...BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially affecting inflammation and disease progression through the gut-joint axis.Traditional treatments like nonsteroidal anti-inflammatory drugs offer symptom relief but have adverse effects.Emerging therapies like electroacupuncture(EA)and Tuina(TN)have shown promise in alleviating pain and improving joint function by targeting the gut microbiota.AIM To clarify the efficacy of EA with TN in treating KOA and its effect on gut microbiota regulation.METHODS Sixty patients with KOA were allocated to EA or EA+TN(ET)group(n=30 each).Seven acupoints were punctured.The ET group received TN after each EA session.Both groups completed 12 sessions.The visual analog scale(VAS)for assessing pain and the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)for measuring pain intensity,joint stiffness,and functional capacity were employed to assess clinical outcomes.Pre-and post-treatment fecal specimens underwent 16S ribosomal RNA sequencing to analyze the gut microbiota.RESULTS The ET group showed higher rates of“effective”and“markedly effective”outcomes.The VAS score of the ET group remained significantly lower than that of the EA group(P<0.001)immediately after treatment and 1 week post-treatment.The total WOMAC score(P<0.001),pain(P=0.191),stiffness(P=0.015),and function scores(P<0.001)decreased significantly in the ET group post-treatment.The gut microbiota analysis revealed no significant changes in alpha diversity in either group.Beta-diversity analysis indicated distinct patterns in the ET group before and after treatment.Significant changes in microbial abundance were detected in both groups,highlighting variations in Firmicutes,Actinobacteria,Proteobacteria,and Bacteroidetes.CONCLUSION ET outperforms EA alone in improving KOA pain,stiffness,and function,potentially via gut microbiota modulation,intestinal barrier protection,and inflammation reduction.展开更多
BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive...BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive patients require examination.AIM To compare the differences in oncological features,surgical safety,and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and site.METHODS In this retrospective study,we collected data from HIV-positive and-negative patients who underwent radical resection for CRC.Using random stratified sampling,24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were selected.Using propensity score matching,we selected 72 patients,matched 1:2(HIV-positive:negative=24:48).Differences in basic characteristics,HIV acquisition,perioperative serological indicators,surgical safety,oncological features,and long-term prognosis were compared between the two groups.RESULTS Fewer patients with HIV infection underwent chemotherapy compared to patients without.HIV-positive patients had fewer preoperative and postoperative leukocytes,fewer preoperative lymphocytes,lower carcinoembryonic antigen levels,more intraoperative blood loss,more metastatic lymph nodes,higher node stage,higher tumor node metastasis stage,shorter overall survival,and shorter progression-free survival compared to patients who were HIV-negative.CONCLUSION Compared with CRC patients who are HIV-negative,patients with HIV infection have more metastatic lymph nodes and worse long-term survival after surgery.Standard treatment options for HIV-positive patients with CRC should be explored.展开更多
Background:The purpose of this study was to identify the characteristics and principles of acupoints applied for treating chronic hepatitis B infection.Methods:The published clinical studies on acupuncture for the tre...Background:The purpose of this study was to identify the characteristics and principles of acupoints applied for treating chronic hepatitis B infection.Methods:The published clinical studies on acupuncture for the treatment of chronic hepatitis B infection were gathered from various databases,including SinoMed,Chongqing Vip,China National Knowledge Infrastructure,Wanfang,the Cochrane Library,PubMed,Web of Science and Embase.Excel 2019 was utilized to establish a database of acupuncture prescriptions and conduct statistics on the frequency,meridian application,distribution and specific points,as well as SPSS Modeler 18.0 and SPSS Statistics 26.0 to conduct association rule analysis and cluster analysis to investigate the characteristics and patterns of acupoint selection.Results:A total of 42 studies containing 47 acupoints were included,with a total frequency of 286 acupoints.The top five acupoints used were Zusanli(ST36),Ganshu(BL18),Yanglingquan(GB34),Sanyinjiao(SP6)and Taichong(LR3),and the most commonly used meridians was the Bladder Meridian of Foot-Taiyang.The majority of acupuncture points are located in the lower limbs,back,and lumbar regions,with a significant percentage of them being Five-Shu acupoints.The strongest acupoint combination identified was Zusanli(ST36)–Ganshu(BL18),in addition to which 13 association rules and 4 valid clusters were obtained.Conclusion:Zusanli(ST36)–Ganshu(BL18)could be considered a relatively reasonable prescription for treating chronic hepatitis B infection in clinical practice.However,further high-quality studies are needed.展开更多
基金Supported by Chongqing Municipal Health and Family Planning Commission and Chongqing Municipal Science and Technology Commission Jointly Funded Key Research Projects in Traditional Chinese Medicine,No.ZY201801007。
文摘BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially affecting inflammation and disease progression through the gut-joint axis.Traditional treatments like nonsteroidal anti-inflammatory drugs offer symptom relief but have adverse effects.Emerging therapies like electroacupuncture(EA)and Tuina(TN)have shown promise in alleviating pain and improving joint function by targeting the gut microbiota.AIM To clarify the efficacy of EA with TN in treating KOA and its effect on gut microbiota regulation.METHODS Sixty patients with KOA were allocated to EA or EA+TN(ET)group(n=30 each).Seven acupoints were punctured.The ET group received TN after each EA session.Both groups completed 12 sessions.The visual analog scale(VAS)for assessing pain and the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)for measuring pain intensity,joint stiffness,and functional capacity were employed to assess clinical outcomes.Pre-and post-treatment fecal specimens underwent 16S ribosomal RNA sequencing to analyze the gut microbiota.RESULTS The ET group showed higher rates of“effective”and“markedly effective”outcomes.The VAS score of the ET group remained significantly lower than that of the EA group(P<0.001)immediately after treatment and 1 week post-treatment.The total WOMAC score(P<0.001),pain(P=0.191),stiffness(P=0.015),and function scores(P<0.001)decreased significantly in the ET group post-treatment.The gut microbiota analysis revealed no significant changes in alpha diversity in either group.Beta-diversity analysis indicated distinct patterns in the ET group before and after treatment.Significant changes in microbial abundance were detected in both groups,highlighting variations in Firmicutes,Actinobacteria,Proteobacteria,and Bacteroidetes.CONCLUSION ET outperforms EA alone in improving KOA pain,stiffness,and function,potentially via gut microbiota modulation,intestinal barrier protection,and inflammation reduction.
基金Supported by General Plan of the Future Medical Youth Innovation Team Development Support Plan of Chongqing Medical University,No.03030299QC-W0007.
文摘BACKGROUND Due to the prolonged life expectancy and increased risk of colorectal cancer(CRC)among patients with human immunodeficiency virus(HIV)infection,the prognosis and pathological features of CRC in HIV-positive patients require examination.AIM To compare the differences in oncological features,surgical safety,and prognosis between patients with and without HIV infection who have CRC at the same tumor stage and site.METHODS In this retrospective study,we collected data from HIV-positive and-negative patients who underwent radical resection for CRC.Using random stratified sampling,24 HIV-positive and 363 HIV-negative patients with colorectal adenocarcinoma after radical resection were selected.Using propensity score matching,we selected 72 patients,matched 1:2(HIV-positive:negative=24:48).Differences in basic characteristics,HIV acquisition,perioperative serological indicators,surgical safety,oncological features,and long-term prognosis were compared between the two groups.RESULTS Fewer patients with HIV infection underwent chemotherapy compared to patients without.HIV-positive patients had fewer preoperative and postoperative leukocytes,fewer preoperative lymphocytes,lower carcinoembryonic antigen levels,more intraoperative blood loss,more metastatic lymph nodes,higher node stage,higher tumor node metastasis stage,shorter overall survival,and shorter progression-free survival compared to patients who were HIV-negative.CONCLUSION Compared with CRC patients who are HIV-negative,patients with HIV infection have more metastatic lymph nodes and worse long-term survival after surgery.Standard treatment options for HIV-positive patients with CRC should be explored.
基金supported by Chongqing Municipal Health and Family Planning Commission and Chongqing Municipal Science and Technology Commission Jointly Funded Key Research Projects in Traditional Chinese Medicine(ZY201801007).
文摘Background:The purpose of this study was to identify the characteristics and principles of acupoints applied for treating chronic hepatitis B infection.Methods:The published clinical studies on acupuncture for the treatment of chronic hepatitis B infection were gathered from various databases,including SinoMed,Chongqing Vip,China National Knowledge Infrastructure,Wanfang,the Cochrane Library,PubMed,Web of Science and Embase.Excel 2019 was utilized to establish a database of acupuncture prescriptions and conduct statistics on the frequency,meridian application,distribution and specific points,as well as SPSS Modeler 18.0 and SPSS Statistics 26.0 to conduct association rule analysis and cluster analysis to investigate the characteristics and patterns of acupoint selection.Results:A total of 42 studies containing 47 acupoints were included,with a total frequency of 286 acupoints.The top five acupoints used were Zusanli(ST36),Ganshu(BL18),Yanglingquan(GB34),Sanyinjiao(SP6)and Taichong(LR3),and the most commonly used meridians was the Bladder Meridian of Foot-Taiyang.The majority of acupuncture points are located in the lower limbs,back,and lumbar regions,with a significant percentage of them being Five-Shu acupoints.The strongest acupoint combination identified was Zusanli(ST36)–Ganshu(BL18),in addition to which 13 association rules and 4 valid clusters were obtained.Conclusion:Zusanli(ST36)–Ganshu(BL18)could be considered a relatively reasonable prescription for treating chronic hepatitis B infection in clinical practice.However,further high-quality studies are needed.
