The human brain undergoes a complex and dynamic developmental process from birth through adolescence,driven by molecular and cellular mechanisms that shape its structure and function.Magnetic resonance imaging(MRI)has...The human brain undergoes a complex and dynamic developmental process from birth through adolescence,driven by molecular and cellular mechanisms that shape its structure and function.Magnetic resonance imaging(MRI)has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders.However,pediatric neuroimaging presents unique challenges,including motion artifacts,small anatomical structures,and immature tissue properties,necessitating specialized MRI techniques.This review provides an overview of recent advancements in MRI hardware,acquisition strategies,and analytical methods optimized for pediatric brain imaging.Furthermore,it summarizes the applications of these techniques in understanding normal brain development,neurodevelopmental disorders,and the impact of early-life risk factors.This review highlights the progresses in pediatric MRI,emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health.It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility.展开更多
基金supported by the National Natural Science Foundation of China,Grant No.3242780005 and U24 A20754(DW)Key project of Agriculture and social development of Hangzhou,Grant No.20231203 A13(DW)+1 种基金Zhejiang Provincial Natural Science Foundation of China,Grant No.LY24H180002(HXZ)Shanghai Pilot Program for Basic Research—Chinese Academy of Science,Shanghai Branch,Grant No.JCYJ-SHFY-2022-014(HZ).
文摘The human brain undergoes a complex and dynamic developmental process from birth through adolescence,driven by molecular and cellular mechanisms that shape its structure and function.Magnetic resonance imaging(MRI)has become an essential non-invasive tool for studying pediatric brain development and detecting neurological disorders.However,pediatric neuroimaging presents unique challenges,including motion artifacts,small anatomical structures,and immature tissue properties,necessitating specialized MRI techniques.This review provides an overview of recent advancements in MRI hardware,acquisition strategies,and analytical methods optimized for pediatric brain imaging.Furthermore,it summarizes the applications of these techniques in understanding normal brain development,neurodevelopmental disorders,and the impact of early-life risk factors.This review highlights the progresses in pediatric MRI,emphasizing its critical role in advancing our understanding of pediatric brain development and neurological health.It also outlines the challenges and future directions in pediatric MRI to further improve imaging precision and clinical utility.
