针对复杂海况下无人船位姿估计的精度改善问题,提出一种基于非高斯特征识别和高斯和容积粒子滤波(Gaussian sum cubature particle filter,GSCPF)的无人船位姿估计算法。首先,基于正态性检验思想将无人船位姿测量数据的样本分布函数与...针对复杂海况下无人船位姿估计的精度改善问题,提出一种基于非高斯特征识别和高斯和容积粒子滤波(Gaussian sum cubature particle filter,GSCPF)的无人船位姿估计算法。首先,基于正态性检验思想将无人船位姿测量数据的样本分布函数与标准高斯累积分布函数之间的最大垂直差和样本偏度峰度两种指标进行结合,从多角度分析数据的分布特征;然后,若数据表现为非高斯分布特征,则采用一种基于高斯和与容积粒子滤波结合的无人船位姿估计方法,否则直接使用容积卡尔曼滤波方法来获得无人船的位姿估计;最后,两类仿真实验结果表明,所提算法能明显改善无人船的位置、速度以及航向等参数的估计精度。展开更多
Connective tissue growth factor(CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis(IPF). This study presents a groundbreaking supramolecular cryoshock bone marrow mononuclear cell system for ta...Connective tissue growth factor(CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis(IPF). This study presents a groundbreaking supramolecular cryoshock bone marrow mononuclear cell system for targeted drug delivery in IPF. We incorporated antisense oligonucleotides(ASO) to inhibit CTGF and simultaneously encapsulated nintedanib using the ZMO-E5-NPs carrier for synergistic delivery. The cryoshock treatment enhances cellular structural integrity and preserves receptor functionality,thereby extending cell viability. By modifying the E5 peptide and conjugating it with DSPEPEG-MAL, we developed a composite carrier, ZMO-E5-NPs, which demonstrates efficient lung-targeting capability. This system enables rapid nanoparticle capture by fibroblasts through matrix metalloproteinase 2(MMP2) recognition, ensuring precise delivery of both ASO and nintedanib. In a bleomycin-induced pulmonary fibrosis mouse model, ZMOE5-NPs-ASO(nintedanib-containing group) significantly attenuated fibrosis progression,improved lung function, and exhibited excellent biocompatibility and safety, highlighting its potential as a novel therapeutic strategy for respiratory diseases.展开更多
Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of in...Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of insufficient therapeutic efficiency and the potential for drug resistance.In this study,a multimodal synergistic antibacterial nanoplatform by coupling a carbon monoxide(CO)donor(4-(3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid(4-BA))with carbon dots(CDs)is developed,referred to as CDs-CO,which integrates multiple antibacterial modes of aPDT,PTT,and gas therapy.This nanoplatform is designed for highly efficient antibacterial action with a low risk of inducing drug resistance.CDs are engineered to possess tailored functions,including deep-red light-triggered heat and singlet oxygen(^(1)O_(2))production.After modification with 4-BA and exposure to 660 nm laser irradiation,CDs-CO exhibits favorable photothermal conversion efficiency(η=52.7%),robust ^(1)O_(2) generation,and ^(1)O_(2)-activated CO release.Antibacterial experiments demonstrated the excellent sterilization effects of CDs-CO against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),underscoring the enhanced antibacterial efficiency of this multimodal nanoplatform.This study offers a rational approach for designing multimodal synergistic antibacterial platforms,highlighting their potential for effectively treating bacterial infections.展开更多
Azobenzene-winged phenanthrolines(L1 and L2)were designed,synthesized,and fully characterized.Ligand L1 forms an in-situ cobalt complex,which has been effectively employed as a circular dichroism(CD)-active chiral sen...Azobenzene-winged phenanthrolines(L1 and L2)were designed,synthesized,and fully characterized.Ligand L1 forms an in-situ cobalt complex,which has been effectively employed as a circular dichroism(CD)-active chiral sensor.The resulting ternary complex(L1-Co^(2+)-amino alcohol)exhibits pronounced exciton-coupled circular dichroism(ECCD)signals at the characteristic azobenzene absorption bands.These signals arise from efficient chirality transfer from the chiral amino alcohol to the azobenzene chromophores,enabling the determination of the absolute configuration of chiral amino alcohols.Accordingly,the L1-Co^(2+)coordination system demonstrates considerably potential in chirality sensing applications.Remarkably,the induced ECCD signals are highly responsive to multiple external stimuli,including photoirradiation,solvent polarity,temperature,and redox conditions.In particular,temperature and redox changes can induce a reversible inversion of the ECCD signal,thereby establishing this system as a multifunctional,stimuli-responsive chiroptical molecular switch.展开更多
Marine pollution and overfishing induced the biodiversity loss and ecological degradation of the Beibu Gulf ecosystem in Guangxi,SE China.In an effort to restore the ecosystem and fishery resources,artificial reefs we...Marine pollution and overfishing induced the biodiversity loss and ecological degradation of the Beibu Gulf ecosystem in Guangxi,SE China.In an effort to restore the ecosystem and fishery resources,artificial reefs were deployed in the Beibu Gulf as the marine ranching area and their ecological performance need to be investigated.We constructed Ecopath ecological trophic models for the marine ranching area and a nearby control area to compare their ecosystem throughput and food web structure difference,and to calculate the ecological carrying capacity of various functional groups.Results indicate that the total system throughput of the marine ranching area was significantly higher than the control area,and the majority of system throughput occurred at trophic levelsⅠandⅡin both ecosystems.The system connectance indices for the marine ranching and control areas were 0.27 and 0.32,and the omnivory indices were 0.16 and 0.19,indicating simple food web structures;both areas are in a developmental stage with TPP/TR ratios of 2.69 and 9.36,respectively.Compared to the control area,marine ranching area exhibited a higher system maturity,and the ecological carrying capacity of“large and medium-sized demersal fish”and“other bivalves”functional groups in the marine ranching area increased by 43.83%and 233.62%,respectively,allowing for more high-trophic-level predators and large benthic animals.This study provided a reference for the formulation of fishery management policies in the Beibu Gulf,to maintain ecosystem stability and biodiversity.展开更多
文摘针对复杂海况下无人船位姿估计的精度改善问题,提出一种基于非高斯特征识别和高斯和容积粒子滤波(Gaussian sum cubature particle filter,GSCPF)的无人船位姿估计算法。首先,基于正态性检验思想将无人船位姿测量数据的样本分布函数与标准高斯累积分布函数之间的最大垂直差和样本偏度峰度两种指标进行结合,从多角度分析数据的分布特征;然后,若数据表现为非高斯分布特征,则采用一种基于高斯和与容积粒子滤波结合的无人船位姿估计方法,否则直接使用容积卡尔曼滤波方法来获得无人船的位姿估计;最后,两类仿真实验结果表明,所提算法能明显改善无人船的位置、速度以及航向等参数的估计精度。
基金supported by The National Natural Science Foundation of China (Grant Numbers 82400094, 82270069, 82370073)National High Level Hospital Clinical Research Funding (2022-PUMCH-B-108)。
文摘Connective tissue growth factor(CTGF) is a key driver in the pathogenesis of idiopathic pulmonary fibrosis(IPF). This study presents a groundbreaking supramolecular cryoshock bone marrow mononuclear cell system for targeted drug delivery in IPF. We incorporated antisense oligonucleotides(ASO) to inhibit CTGF and simultaneously encapsulated nintedanib using the ZMO-E5-NPs carrier for synergistic delivery. The cryoshock treatment enhances cellular structural integrity and preserves receptor functionality,thereby extending cell viability. By modifying the E5 peptide and conjugating it with DSPEPEG-MAL, we developed a composite carrier, ZMO-E5-NPs, which demonstrates efficient lung-targeting capability. This system enables rapid nanoparticle capture by fibroblasts through matrix metalloproteinase 2(MMP2) recognition, ensuring precise delivery of both ASO and nintedanib. In a bleomycin-induced pulmonary fibrosis mouse model, ZMOE5-NPs-ASO(nintedanib-containing group) significantly attenuated fibrosis progression,improved lung function, and exhibited excellent biocompatibility and safety, highlighting its potential as a novel therapeutic strategy for respiratory diseases.
基金supported by the National Natural Science Foundation of China(No.52173126)China Postdoctoral Science Foundation(No.2024M751152).
文摘Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of insufficient therapeutic efficiency and the potential for drug resistance.In this study,a multimodal synergistic antibacterial nanoplatform by coupling a carbon monoxide(CO)donor(4-(3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid(4-BA))with carbon dots(CDs)is developed,referred to as CDs-CO,which integrates multiple antibacterial modes of aPDT,PTT,and gas therapy.This nanoplatform is designed for highly efficient antibacterial action with a low risk of inducing drug resistance.CDs are engineered to possess tailored functions,including deep-red light-triggered heat and singlet oxygen(^(1)O_(2))production.After modification with 4-BA and exposure to 660 nm laser irradiation,CDs-CO exhibits favorable photothermal conversion efficiency(η=52.7%),robust ^(1)O_(2) generation,and ^(1)O_(2)-activated CO release.Antibacterial experiments demonstrated the excellent sterilization effects of CDs-CO against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),underscoring the enhanced antibacterial efficiency of this multimodal nanoplatform.This study offers a rational approach for designing multimodal synergistic antibacterial platforms,highlighting their potential for effectively treating bacterial infections.
基金the support of this work by the National Natural Science Foundation of China(Nos.22471182,22271201,22422108,22171194)the Science&Technology Department of Sichuan Province(No.2025ZNSFSC0125)+1 种基金the Fundamental Research Funds for the Central Universities(No.20826041D4117)the Comprehensive Training Platform of Specialized Laboratory,College of Chemistry.
文摘Azobenzene-winged phenanthrolines(L1 and L2)were designed,synthesized,and fully characterized.Ligand L1 forms an in-situ cobalt complex,which has been effectively employed as a circular dichroism(CD)-active chiral sensor.The resulting ternary complex(L1-Co^(2+)-amino alcohol)exhibits pronounced exciton-coupled circular dichroism(ECCD)signals at the characteristic azobenzene absorption bands.These signals arise from efficient chirality transfer from the chiral amino alcohol to the azobenzene chromophores,enabling the determination of the absolute configuration of chiral amino alcohols.Accordingly,the L1-Co^(2+)coordination system demonstrates considerably potential in chirality sensing applications.Remarkably,the induced ECCD signals are highly responsive to multiple external stimuli,including photoirradiation,solvent polarity,temperature,and redox conditions.In particular,temperature and redox changes can induce a reversible inversion of the ECCD signal,thereby establishing this system as a multifunctional,stimuli-responsive chiroptical molecular switch.
基金Supported by the National Key R&D Program of China(No.2022YFD2401301)the Primary Research and Development Plan of Guangxi Province(No.GuiKe AB21220064)+1 种基金the National Natural Science Foundation of China(Nos.42106102,42306151)the Shandong Postdoctoral Science Foundation(No.SDCXZG202301009)。
文摘Marine pollution and overfishing induced the biodiversity loss and ecological degradation of the Beibu Gulf ecosystem in Guangxi,SE China.In an effort to restore the ecosystem and fishery resources,artificial reefs were deployed in the Beibu Gulf as the marine ranching area and their ecological performance need to be investigated.We constructed Ecopath ecological trophic models for the marine ranching area and a nearby control area to compare their ecosystem throughput and food web structure difference,and to calculate the ecological carrying capacity of various functional groups.Results indicate that the total system throughput of the marine ranching area was significantly higher than the control area,and the majority of system throughput occurred at trophic levelsⅠandⅡin both ecosystems.The system connectance indices for the marine ranching and control areas were 0.27 and 0.32,and the omnivory indices were 0.16 and 0.19,indicating simple food web structures;both areas are in a developmental stage with TPP/TR ratios of 2.69 and 9.36,respectively.Compared to the control area,marine ranching area exhibited a higher system maturity,and the ecological carrying capacity of“large and medium-sized demersal fish”and“other bivalves”functional groups in the marine ranching area increased by 43.83%and 233.62%,respectively,allowing for more high-trophic-level predators and large benthic animals.This study provided a reference for the formulation of fishery management policies in the Beibu Gulf,to maintain ecosystem stability and biodiversity.
