Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand...Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.展开更多
传统单颗粒阻尼器存在颗粒半径过大、空间占用率高等局限,多颗粒阻尼器存在启振条件苛刻、动量交换效率低等不足。为提升颗粒阻尼器的减震性能,提出将叠层式单颗粒阻尼器(stacked single particle damper, SSPD),并将其与齿轮齿条惯容...传统单颗粒阻尼器存在颗粒半径过大、空间占用率高等局限,多颗粒阻尼器存在启振条件苛刻、动量交换效率低等不足。为提升颗粒阻尼器的减震性能,提出将叠层式单颗粒阻尼器(stacked single particle damper, SSPD),并将其与齿轮齿条惯容装置相结合,进而形成叠层式单颗粒惯容减振系统(stacked single particle-inerter damping system, SSPIS)。在深入分析颗粒各阶段受力状态的基础上,剖析SSPIS减振机理,构建SSPIS-结构系统力学模型,并提出该力学模型的数值模拟流程。为验证SSPIS理论力学模型与数值模拟分析流程的准确性,并探究SSPIS对受控结构的真实减震控制效果,制作钢框架模型结构,完成地震模拟振动台试验。动力试验与理论结果表明:将惯容装置布置于SSPD中可显著提升颗粒与结构的动量交换效率,增大其表观质量与耗能能力,拓宽SSPIS的减振频带。相较于传统颗粒阻尼器,SSPIS在各类场地地震作用下均可对受控结构产生良好的控制效果,具有良好的工程应用前景。展开更多
基金supported by the National Natural Science Foundation of China(Key Program),No.11932013the National Natural Science Foundation of China(General Program),No.82272255+2 种基金Armed Police Force High-Level Science and Technology Personnel ProjectThe Armed Police Force Focuses on Supporting Scientific and Technological Innovation TeamsKey Project of Tianjin Science and Technology Plan,No.20JCZDJC00570(all to XC)。
文摘Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.
文摘传统单颗粒阻尼器存在颗粒半径过大、空间占用率高等局限,多颗粒阻尼器存在启振条件苛刻、动量交换效率低等不足。为提升颗粒阻尼器的减震性能,提出将叠层式单颗粒阻尼器(stacked single particle damper, SSPD),并将其与齿轮齿条惯容装置相结合,进而形成叠层式单颗粒惯容减振系统(stacked single particle-inerter damping system, SSPIS)。在深入分析颗粒各阶段受力状态的基础上,剖析SSPIS减振机理,构建SSPIS-结构系统力学模型,并提出该力学模型的数值模拟流程。为验证SSPIS理论力学模型与数值模拟分析流程的准确性,并探究SSPIS对受控结构的真实减震控制效果,制作钢框架模型结构,完成地震模拟振动台试验。动力试验与理论结果表明:将惯容装置布置于SSPD中可显著提升颗粒与结构的动量交换效率,增大其表观质量与耗能能力,拓宽SSPIS的减振频带。相较于传统颗粒阻尼器,SSPIS在各类场地地震作用下均可对受控结构产生良好的控制效果,具有良好的工程应用前景。
