AAV-PHP.eB is an artificial adeno-associated virus(AAV)that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when administered systematically.While AAV-PHP.eB has been used in vario...AAV-PHP.eB is an artificial adeno-associated virus(AAV)that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when administered systematically.While AAV-PHP.eB has been used in various disease models,its cellular tropism in cerebrovascular diseases remains unclear.In the present study,we aimed to elucidate the tropism of AAV-PHP.eB for different cell types in the brain in a mouse model of ischemic stroke and evaluate its effectiveness in mediating basic fibroblast growth factor(bFGF)gene therapy.Mice were injected intravenously with AAV-PHP.eB either 14 days prior to(pre-stroke)or 1 day following(post-stroke)transient middle cerebral artery occlusion.Notably,we observed a shift in tropism from neurons to endothelial cells with post-stroke administration of AAV-PHP.eB-mNeonGreen(mNG).This endothelial cell tropism correlated strongly with expression of the endothelial membrane receptor lymphocyte antigen 6 family member A(Ly6A).Furthermore,AAV-PHP.eB-mediated overexpression of bFGF markedly improved neurobehavioral outcomes and promoted long-term neurogenesis and angiogenesis post-ischemic stroke.Our findings underscore the significance of considering potential tropism shifts when utilizing AAV-PHP.eB-mediated gene therapy in neurological diseases and suggest a promising new strategy for bFGF gene therapy in stroke treatment.展开更多
In response to the urgent demand for lightweight,magnesium(Mg)alloys have garnered considerable attention owing to their low density.Nonetheless,the intrinsic poor room-temperature formability of Mg alloys remains a m...In response to the urgent demand for lightweight,magnesium(Mg)alloys have garnered considerable attention owing to their low density.Nonetheless,the intrinsic poor room-temperature formability of Mg alloys remains a major obstacle in shaping precise complex components,necessitating the development of superplastic Mg alloys.Excellent superplasticity is usually acquired in high-alloyed Mg alloys with enhanced microstructural thermal stability facilitated by abundant optimized second-phase particles.While for cost-effective low-alloyed Mg alloys lacking particles,regulating solute segregation has emerged as a promising approach to achieve superplasticity recently.Moreover,the potential of bimodal-grained Mg alloys for superplastic deformation has been revealed,expanding the options for designing superplastic materials beyond the conventional approach of fine-grained microstructures.This study reviews significant developments in superplastic Mg alloys from the view of alloying strategies,grain structure control and deformation mechanisms,with potential implications for future research and industrial applications of superplastic Mg alloys.展开更多
Two sets of alloys,Mg-Zn-Ca-xNi(0≤x≤5),have been developed with tunable corrosion and mechanical properties,optimized for fracturing materials.High-zinc artificial aged(T6)Mg-12Zn-0.5Ca-x Ni(0≤x≤5)series,featuring...Two sets of alloys,Mg-Zn-Ca-xNi(0≤x≤5),have been developed with tunable corrosion and mechanical properties,optimized for fracturing materials.High-zinc artificial aged(T6)Mg-12Zn-0.5Ca-x Ni(0≤x≤5)series,featuring a straightforward preparation method and the potential for manufacturing large-scale components,exhibit notable corrosion rates up to 29 mg cm^(-2)h^(-1)at 25℃ and 643 mg cm^(-2)h^(-1)at 93℃.The high corrosion rate is primary due to the Ni–containing second phases,which intensify the galvanic corrosion that overwhelms their corrosion barrier effect.Low-zinc rolled Mg-1.5Zn-0.2Ca-x Ni(0≤x≤5)series,characterizing excellent deformability with an elongation to failure of~26%,present accelerated corrosion rates up to 34 mg cm^(-2)h^(-1)at 25℃ and 942 mg cm^(-2)h^(-1)at 93℃.The elimination of corrosion barrier effect via deformation contributes to the further increase of corrosion rate compared to the T6 series.Additionally,Mg-Zn-Ca-xNi(0≤x≤5)alloys exhibit tunable ultimate tensile strengths ranging from~190 to~237 MPa,depending on their specific composition.The adjustable corrosion rate and mechanical properties render the Mg-Zn-Ca-x Ni(0≤x≤5)alloys suitable for fracturing materials.展开更多
Dislocations and disclinations are fundamental topological defects within crystals,which determine the mechanical properties of metals and alloys.Despite their important roles in multiple physical mechanisms,e.g.,dyna...Dislocations and disclinations are fundamental topological defects within crystals,which determine the mechanical properties of metals and alloys.Despite their important roles in multiple physical mechanisms,e.g.,dynamic recovery and grain boundary mediated plasticity,the intrinsic coupling and correlation between disclinations and dislocations,and their impacts on the deformation behavior of metallic materials still remain obscure,partially due to the lack of a theoretical tool to capture the rotational nature of disclinations.By using a Lie-algebra-based theoretical framework,we obtain a general equation to quantify the intrinsic coupling of disclinations and dislocations.Through quasi in-situ electron backscatter diffraction characterizations and disclination/dislocation density analyses in Mg alloys,the generation,coevolution and reactions of disclinations and dislocations during dynamic recovery and superplastic deformation have been quantitatively analyzed.It has been demonstrated that the obtained governing equation can capture multiple physical processes associated with mechanical deformation of metals,e.g.,grain rotation and grain boundary migration,at both room temperature and high temperature.By establishing the disclination-dislocation coupling equation within a Lie algebra description,our work provides new insights for exploring the coevolution and reaction of disclinations/dislocations,with profound implications for elucidating the microstructure-property relationship and underlying deformation mechanisms in metallic materials.展开更多
Sodium-ion batteries(SIBs)hold great promise for large-scale energy storage in the post-lithium-ion battery era due to their high rate performance and long lifespan,although their sluggish Na^(+) transformation kineti...Sodium-ion batteries(SIBs)hold great promise for large-scale energy storage in the post-lithium-ion battery era due to their high rate performance and long lifespan,although their sluggish Na^(+) transformation kinetics still require improvement.Encouraged by the excellent electrochemical performance of titanium-based anode materials,here,we present a novel titanium vanadate@carbon(TVO@C)material as anode for SIBs.Our TVO@C material is synthesized via a facile coprecipitation method,with the following annealing process in an acetylene atomosphere.The opened ion channel and the oxygen vacancies within TVO@C facilitate the diffusion of Na^(+) ions,reducing their diffusion barrier.Thus,an ultrahigh rate of 100 A g^(-1)and long life of 10,000 cycles have been achieved.Furthermore,the TVO@C electrode exhibits stable performance,not only at room temperature,but also at temperatures as low as 20 C.The TVO@CjjNa_(3)V_(2)(PO_(4))_(3)@C full cells have also achieved stable discharge/charge for 500 cycles.It is believed that this strategy provides new insight into the development of advanced electrodes and provides a new opportunity for constructing novel high rate electrodes.展开更多
Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting...Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting method based on a three-layer K-nearest neighbor non-parametric regression algorithm is proposed. Specifically, two screening layers based on shape similarity were introduced in K-nearest neighbor non-parametric regression method, and the forecasting results were output using the weighted averaging on the reciprocal values of the shape similarity distances and the most-similar-point distance adjustment method. According to the experimental results, the proposed algorithm has improved the predictive ability of the traditional K-nearest neighbor non-parametric regression method, and greatly enhanced the accuracy and real-time performance of short-term traffic flow forecasting.展开更多
Precise experimental control and characterization of electron wave packet dynamics driven by external optical fields remain a fundamental challenge,particularly at ultrafast temporal and sub-microscopic spatial scales...Precise experimental control and characterization of electron wave packet dynamics driven by external optical fields remain a fundamental challenge,particularly at ultrafast temporal and sub-microscopic spatial scales.To overcome these challenges,we introduce a photon-based simulation platform employing a traveling-wave electrooptic phase-modulated waveguide.In our setup,the incident electromagnetic pulse serves as an analog to the electron wave packet,while the traveling-wave modulation simulates the external optical driving field.Our experimental study systematically explores pulse evolution under three distinct regimes defined by the relation between the pulse duration(Δt)and the modulation period(T).When the pulse duration is significantly shorter than the modulation period,we observe a uniform spectral shift analogous to electron acceleration in dielectric laser accelerators,where spectral phase gradients represent electron momentum accumulation.Conversely,when the pulse duration greatly exceeds the modulation period,discrete diffraction patterns emerge,closely resembling the discrete sideband features of electron-photon coupling observed in photon-induced near-field electron microscopy.Notably,in the intermediate regime(T/4<Δt<T/2),the pulse spectrum exhibits Airy-function-type characteristics with self-healing effects.These experimental results provide critical insights into electron-wave interactions under external optical fields and establish a robust,programmable framework for further investigation.展开更多
High-aspect-ratio aircraft are widely used in military and civilian fields,such as reconnaissance,surveillance,and attacks,due to their high lift-to-drag ratio,strong payload capability,significant endurance effect,an...High-aspect-ratio aircraft are widely used in military and civilian fields,such as reconnaissance,surveillance,and attacks,due to their high lift-to-drag ratio,strong payload capability,significant endurance effect,and good stealth performance.However,compared to conventional aircraft,high-aspect-ratio aircraft are more susceptible to gust disturbances during flight.In response to this phenomenon,a full-scale dynamic model of a high-aspect-ratio unmanned aerial vehicle was developed.Considering the coupling among control surfaces,structural forces,and aerodynamic forces,along with sensor,actuator,and delay effects,an H_(∞)control law was designed using the principle of singular value energy flow reduction and weighted function,with a PID(Proportional-Integral-Derivative)control law for comparison.The two controllers were then subjected to pulse-response and jury stability tests.Finally,wind tunnel tests were conducted to investigate the gust alleviation principle,in which gust disturbances were generated using gust generators and control surface self-excitation.The results present that the average wing root bending moment and wing tip overload under the PID control law decrease by approximately 30%,while under the H_(∞)control law,both the average wing root bending moment and wing tip overload reduction rate exceed 50%,with peaks reaching 60%.This validates the feasibility and efficiency of the designed H_(∞)controller.展开更多
The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and f...The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.展开更多
The application of radiofrequency(RF)electron guns operating at cryogenic temperatures can enhance the performance of a photoinjector.The low emittance and increased brightness of the electron beams resulting from the...The application of radiofrequency(RF)electron guns operating at cryogenic temperatures can enhance the performance of a photoinjector.The low emittance and increased brightness of the electron beams resulting from the high gradient in the cryogenic photoinjector make it possible to improve the performance of new light sources.As an upgrading scheme for the Shanghai Soft X-ray Free-Electron Laser,this study explores a novel photocathode RF gun by introducing the TM_(02)mode into the cathode cell of a 2.6-cell electron gun,which improves the RF performance,particularly in terms of the monopole field.Furthermore,the optimized cathode cell with the TM_(02)mode can reduce the errors resulting from installation and decrease the dark current with alternative cathodes.In this study,the beam dynamics in a photoinjector were optimized using a 500-pC,5-ps beam,and its feasibility was examined.This paper presents the entire RF design process,including the adjustment of the RF structure,coupler design,local field,and multipole mode suppression to provide theoretical guidance for subsequent manufacturing and assembly.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81870921(to YW),81974179(to ZZ),82271320(to ZZ),82071284(to YT)National Key R&D Program of China,No.2022YFA1603600(to ZZ),2019YFA0112000(to YT)+1 种基金Scientific Research and Innovation Program of Shanghai Education Commission,No.2019-01-07-00-02-E00064(to GYY)Scientific and Technological Innovation Act Program of Shanghai Science and Technology Commission,No.20JC1411900(to GYY).
文摘AAV-PHP.eB is an artificial adeno-associated virus(AAV)that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when administered systematically.While AAV-PHP.eB has been used in various disease models,its cellular tropism in cerebrovascular diseases remains unclear.In the present study,we aimed to elucidate the tropism of AAV-PHP.eB for different cell types in the brain in a mouse model of ischemic stroke and evaluate its effectiveness in mediating basic fibroblast growth factor(bFGF)gene therapy.Mice were injected intravenously with AAV-PHP.eB either 14 days prior to(pre-stroke)or 1 day following(post-stroke)transient middle cerebral artery occlusion.Notably,we observed a shift in tropism from neurons to endothelial cells with post-stroke administration of AAV-PHP.eB-mNeonGreen(mNG).This endothelial cell tropism correlated strongly with expression of the endothelial membrane receptor lymphocyte antigen 6 family member A(Ly6A).Furthermore,AAV-PHP.eB-mediated overexpression of bFGF markedly improved neurobehavioral outcomes and promoted long-term neurogenesis and angiogenesis post-ischemic stroke.Our findings underscore the significance of considering potential tropism shifts when utilizing AAV-PHP.eB-mediated gene therapy in neurological diseases and suggest a promising new strategy for bFGF gene therapy in stroke treatment.
基金primarily supported by The National Natural Science Foundation of China(under Nos.52234009 and 52271103)Partial financial support came from the Program for the Central University Youth Innovation Team(No.419021423505)the Fundamental Research Funds for the Central Universities,JLU.
文摘In response to the urgent demand for lightweight,magnesium(Mg)alloys have garnered considerable attention owing to their low density.Nonetheless,the intrinsic poor room-temperature formability of Mg alloys remains a major obstacle in shaping precise complex components,necessitating the development of superplastic Mg alloys.Excellent superplasticity is usually acquired in high-alloyed Mg alloys with enhanced microstructural thermal stability facilitated by abundant optimized second-phase particles.While for cost-effective low-alloyed Mg alloys lacking particles,regulating solute segregation has emerged as a promising approach to achieve superplasticity recently.Moreover,the potential of bimodal-grained Mg alloys for superplastic deformation has been revealed,expanding the options for designing superplastic materials beyond the conventional approach of fine-grained microstructures.This study reviews significant developments in superplastic Mg alloys from the view of alloying strategies,grain structure control and deformation mechanisms,with potential implications for future research and industrial applications of superplastic Mg alloys.
基金supported by the National Key Research and Development Program(No.2022YFE0122000)National Natural Science Foundation of China under Grant Nos.52234009,52274383,52222409,and 52201113。
文摘Two sets of alloys,Mg-Zn-Ca-xNi(0≤x≤5),have been developed with tunable corrosion and mechanical properties,optimized for fracturing materials.High-zinc artificial aged(T6)Mg-12Zn-0.5Ca-x Ni(0≤x≤5)series,featuring a straightforward preparation method and the potential for manufacturing large-scale components,exhibit notable corrosion rates up to 29 mg cm^(-2)h^(-1)at 25℃ and 643 mg cm^(-2)h^(-1)at 93℃.The high corrosion rate is primary due to the Ni–containing second phases,which intensify the galvanic corrosion that overwhelms their corrosion barrier effect.Low-zinc rolled Mg-1.5Zn-0.2Ca-x Ni(0≤x≤5)series,characterizing excellent deformability with an elongation to failure of~26%,present accelerated corrosion rates up to 34 mg cm^(-2)h^(-1)at 25℃ and 942 mg cm^(-2)h^(-1)at 93℃.The elimination of corrosion barrier effect via deformation contributes to the further increase of corrosion rate compared to the T6 series.Additionally,Mg-Zn-Ca-xNi(0≤x≤5)alloys exhibit tunable ultimate tensile strengths ranging from~190 to~237 MPa,depending on their specific composition.The adjustable corrosion rate and mechanical properties render the Mg-Zn-Ca-x Ni(0≤x≤5)alloys suitable for fracturing materials.
基金Financial supports from the National Natural Science Foundation of China(Nos.52171116,U22A20109,52334010 and T2325013)are greatly acknowledgedPartial financial support came from The Program for the Central University Youth Innovation Team,and the Fundamental Research Funds for the Central Universities,JLU.
文摘Dislocations and disclinations are fundamental topological defects within crystals,which determine the mechanical properties of metals and alloys.Despite their important roles in multiple physical mechanisms,e.g.,dynamic recovery and grain boundary mediated plasticity,the intrinsic coupling and correlation between disclinations and dislocations,and their impacts on the deformation behavior of metallic materials still remain obscure,partially due to the lack of a theoretical tool to capture the rotational nature of disclinations.By using a Lie-algebra-based theoretical framework,we obtain a general equation to quantify the intrinsic coupling of disclinations and dislocations.Through quasi in-situ electron backscatter diffraction characterizations and disclination/dislocation density analyses in Mg alloys,the generation,coevolution and reactions of disclinations and dislocations during dynamic recovery and superplastic deformation have been quantitatively analyzed.It has been demonstrated that the obtained governing equation can capture multiple physical processes associated with mechanical deformation of metals,e.g.,grain rotation and grain boundary migration,at both room temperature and high temperature.By establishing the disclination-dislocation coupling equation within a Lie algebra description,our work provides new insights for exploring the coevolution and reaction of disclinations/dislocations,with profound implications for elucidating the microstructure-property relationship and underlying deformation mechanisms in metallic materials.
基金supported by National Nature Science Foundation of China(22105118)Nature Science Foundation of Shandong Provinces(ZR2021QB095)China Postdoctoral Science Foundation(2020TQ0183 and 2021M701979).
文摘Sodium-ion batteries(SIBs)hold great promise for large-scale energy storage in the post-lithium-ion battery era due to their high rate performance and long lifespan,although their sluggish Na^(+) transformation kinetics still require improvement.Encouraged by the excellent electrochemical performance of titanium-based anode materials,here,we present a novel titanium vanadate@carbon(TVO@C)material as anode for SIBs.Our TVO@C material is synthesized via a facile coprecipitation method,with the following annealing process in an acetylene atomosphere.The opened ion channel and the oxygen vacancies within TVO@C facilitate the diffusion of Na^(+) ions,reducing their diffusion barrier.Thus,an ultrahigh rate of 100 A g^(-1)and long life of 10,000 cycles have been achieved.Furthermore,the TVO@C electrode exhibits stable performance,not only at room temperature,but also at temperatures as low as 20 C.The TVO@CjjNa_(3)V_(2)(PO_(4))_(3)@C full cells have also achieved stable discharge/charge for 500 cycles.It is believed that this strategy provides new insight into the development of advanced electrodes and provides a new opportunity for constructing novel high rate electrodes.
文摘Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting method based on a three-layer K-nearest neighbor non-parametric regression algorithm is proposed. Specifically, two screening layers based on shape similarity were introduced in K-nearest neighbor non-parametric regression method, and the forecasting results were output using the weighted averaging on the reciprocal values of the shape similarity distances and the most-similar-point distance adjustment method. According to the experimental results, the proposed algorithm has improved the predictive ability of the traditional K-nearest neighbor non-parametric regression method, and greatly enhanced the accuracy and real-time performance of short-term traffic flow forecasting.
基金supported by the National Natural Science Foundation of China(Grant No.12174260)the Shanghai Rising-Star Program(Grant No.21QA1406400)+1 种基金the Shanghai Science and Technology Development Fund(Grant Nos.21ZR1443500 and 21ZR1443600)supported by Research Grants Council,University Grants Committee(Grant Nos.STG3/E-704/23-N,CityU 11212721,and CityU 11204523).
文摘Precise experimental control and characterization of electron wave packet dynamics driven by external optical fields remain a fundamental challenge,particularly at ultrafast temporal and sub-microscopic spatial scales.To overcome these challenges,we introduce a photon-based simulation platform employing a traveling-wave electrooptic phase-modulated waveguide.In our setup,the incident electromagnetic pulse serves as an analog to the electron wave packet,while the traveling-wave modulation simulates the external optical driving field.Our experimental study systematically explores pulse evolution under three distinct regimes defined by the relation between the pulse duration(Δt)and the modulation period(T).When the pulse duration is significantly shorter than the modulation period,we observe a uniform spectral shift analogous to electron acceleration in dielectric laser accelerators,where spectral phase gradients represent electron momentum accumulation.Conversely,when the pulse duration greatly exceeds the modulation period,discrete diffraction patterns emerge,closely resembling the discrete sideband features of electron-photon coupling observed in photon-induced near-field electron microscopy.Notably,in the intermediate regime(T/4<Δt<T/2),the pulse spectrum exhibits Airy-function-type characteristics with self-healing effects.These experimental results provide critical insights into electron-wave interactions under external optical fields and establish a robust,programmable framework for further investigation.
基金supported by the National Natural Science Foundation of China(Nos.12272104,U22B2013).
文摘High-aspect-ratio aircraft are widely used in military and civilian fields,such as reconnaissance,surveillance,and attacks,due to their high lift-to-drag ratio,strong payload capability,significant endurance effect,and good stealth performance.However,compared to conventional aircraft,high-aspect-ratio aircraft are more susceptible to gust disturbances during flight.In response to this phenomenon,a full-scale dynamic model of a high-aspect-ratio unmanned aerial vehicle was developed.Considering the coupling among control surfaces,structural forces,and aerodynamic forces,along with sensor,actuator,and delay effects,an H_(∞)control law was designed using the principle of singular value energy flow reduction and weighted function,with a PID(Proportional-Integral-Derivative)control law for comparison.The two controllers were then subjected to pulse-response and jury stability tests.Finally,wind tunnel tests were conducted to investigate the gust alleviation principle,in which gust disturbances were generated using gust generators and control surface self-excitation.The results present that the average wing root bending moment and wing tip overload under the PID control law decrease by approximately 30%,while under the H_(∞)control law,both the average wing root bending moment and wing tip overload reduction rate exceed 50%,with peaks reaching 60%.This validates the feasibility and efficiency of the designed H_(∞)controller.
基金supported by the Scientific Research Project of China Three Gorges Group Co.LTD(Contract Number:202103368).
文摘The frequency regulation reserve setting of wind-PV-storage power stations is crucial.However,the existing grid codes set up the station reserve in a static manner,where the synchronous generator characteristics and frequency-step disturbance scenario are considered.Thus,the advantages of flexible regulation of renewable generations are wasted,resulting in excessive curtailment of wind and solar resources.In this study,a method for optimizing the frequency regulation reserve of wind PV storage power stations was developed.Moreover,a station frequency regulation model was constructed,considering the field dynamic response and the coupling between the station and system frequency dynamics.Furthermore,a method for the online evaluation of the station frequency regulation was proposed based on the benchmark governor fitting.This method helps in overcoming the capacity-based reserve static setting.Finally,an optimization model was developed,along with the proposal of the linearized solving algorithm.The field data from the JH4#station in China’s MX power grid was considered for validation.The proposed method achieves a 24.77%increase in the station income while ensuring the system frequency stability when compared with the grid code-based method.
基金supported by the National Natural Science Foundation of China(Nos.12222513 and 12405178)。
文摘The application of radiofrequency(RF)electron guns operating at cryogenic temperatures can enhance the performance of a photoinjector.The low emittance and increased brightness of the electron beams resulting from the high gradient in the cryogenic photoinjector make it possible to improve the performance of new light sources.As an upgrading scheme for the Shanghai Soft X-ray Free-Electron Laser,this study explores a novel photocathode RF gun by introducing the TM_(02)mode into the cathode cell of a 2.6-cell electron gun,which improves the RF performance,particularly in terms of the monopole field.Furthermore,the optimized cathode cell with the TM_(02)mode can reduce the errors resulting from installation and decrease the dark current with alternative cathodes.In this study,the beam dynamics in a photoinjector were optimized using a 500-pC,5-ps beam,and its feasibility was examined.This paper presents the entire RF design process,including the adjustment of the RF structure,coupler design,local field,and multipole mode suppression to provide theoretical guidance for subsequent manufacturing and assembly.
