To elucidate the cyclic creep mechanisms in China's impure salt rock after high-temperature damage,cyclic nanoindentation and uniaxial cyclic loading tests were conducted at 25℃,100℃,120℃,and 160℃in this study...To elucidate the cyclic creep mechanisms in China's impure salt rock after high-temperature damage,cyclic nanoindentation and uniaxial cyclic loading tests were conducted at 25℃,100℃,120℃,and 160℃in this study.The results revealed that under cyclic nanoindentation,gypsum mineral exhibited significantly lower indentation depths compared to halite and ankerite minerals,indicating superior resistance to deformation.Additionally,the results demonstrated that high temperature significantly enhances the creep behavior.The maximum indentation depth and creep displacement of minerals,as well as the maximum deformation and creep strain of rock cores,all followed an exponential increase with rising temperatures,with the rate of increase accelerating at higher temperatures.Importantly,it was found that mineral deformation is not the dominant factor in the overall deformation of rock cores;however,the behavior of the mineral phases fundamentally governs the salt rock's mechanical response under stress.Based on these findings,a new constitutive model for cyclic creep was established based on fractional derivatives to accurately characterize the nonlinear cyclic creep characteristics of impure salt rocks at different scales.This model was validated against test data,effectively representing the periodic fluctuations in indentation depth or strain,particularly during the accelerated creep stage.Furthermore,a temperature-dependent correction parameter was introduced,along with a modified Mori-Tanaka method,to upscale microscale results to the macroscale across varying temperatures.This study provides a theoretical foundation for predicting deformation and assessing the stability of salt cavern walls under high-temperature and cyclic loading conditions in deep geological settings.展开更多
背景 随着“以患者为中心”的医学模式的转变,患者在医疗服务中的角色和地位越来越重要,患者对自身健康相关信息的报告在识别/监测症状、评估治疗效果以及在医患共享决策等方面体现出其独特的临床价值。然而,我国患者报告结局(PROs)相...背景 随着“以患者为中心”的医学模式的转变,患者在医疗服务中的角色和地位越来越重要,患者对自身健康相关信息的报告在识别/监测症状、评估治疗效果以及在医患共享决策等方面体现出其独特的临床价值。然而,我国患者报告结局(PROs)相关研究还处于起步阶段,尚缺乏基于PROs的文献计量学研究。目的 了解国际PROs研究成果及研究热点,为我国开展相关研究提供借鉴与参考。方法 基于“Web of Science核心合集”数据库,运用文献计量学分析方法和CiteSpaceⅤ软件对PROs相关研究的年度变化、主要国家/地区、机构、期刊、关键词及研究热点进行可视化分析,检索时间为建库至2019年8月。结果 通过检索最终获得3 288篇相关文献;近年来PROs相关研究报道逐年增多,美国发文量最多,为1 815篇(55.20%);发文量最多的研究机构为美国西北大学;相关研究共发表在822种出版物上,以Quality of Life Research发文量最多(148篇);中心性排名靠前的关键词为生活质量(quality of life)、患者报告结局(patient-reported outcome)、量表(questionnaire)、检验(validation)、影响(impact)、信度(reliablity)等,研究热点以PROs、健康相关生活质量、患者报告结局测量、临床应用研究等为主。结论 以美国为首的发达国家在PROs相关研究占有领先地位,我国在该领域的高质量研究还很少,建议国内学者基于我国国情,结合我国传统中医药特色,完善PROs相关研究的发展。展开更多
目的系统评价有关太极拳对心肌梗死患者干预的随机对照试验,以评估太极拳对心肌梗死患者的疗效和安全性。方法检索PubMed、EMbase、Web of Science、Cochrane图书馆、CNKI、维普及万方数据库收集相关研究。检索时间范围从建库到2019年7...目的系统评价有关太极拳对心肌梗死患者干预的随机对照试验,以评估太极拳对心肌梗死患者的疗效和安全性。方法检索PubMed、EMbase、Web of Science、Cochrane图书馆、CNKI、维普及万方数据库收集相关研究。检索时间范围从建库到2019年7月。使用Cochrane偏倚风险评价工具评估纳入文章的偏倚风险。结果共纳入7项RCT,包括591例患者(分为太极拳组和对照组)。Meta分析结果显示:与对照组相比,太极拳组的左室射血分数(LVEF)更高(MD=7.07,95%CI:2.54~11.60,P<0.05);峰值摄氧量(VO2Peak)更高(MD=4.00,95%CI:1.49~6.51,P<0.05);生活质量水平更高[生活质量评价量表(SF-36),MD=23.88,95%CI:16.49~31.27,P<0.05)、明尼苏达生活质量量表(MD=-12.88,95%CI:-17.51^-8.09,P<0.05),其差异有统计学意义。太极拳组在6分钟步行试验(6MWT)距离长短略有改善(MD=91.92,95%CI:1.55~182.28,P=0.05),但在N末端脑钠肽前体(NT-proBNP,MD=-380.84,95%CI:-815.38~53.71,P>0.05)方面,其差异不具有统计学意义。在有安全性报告的研究中,未发生不良事件。结论本研究的证据表明太极拳运动疗法改善心肌梗死患者心功能是有效的,但由于纳入研究的样本量小,研究间显著的异质性较大,上述结论尚需开展更多大规模、高质量的随即对照试验予以证实。展开更多
Mapping mineral prospectivity in vegetated areas is a challenge. For this reason, we aimed to map spatial distribution characteristics of linear structures detected in remote sensing images using fractal and multifrac...Mapping mineral prospectivity in vegetated areas is a challenge. For this reason, we aimed to map spatial distribution characteristics of linear structures detected in remote sensing images using fractal and multifractal models. The selected study area was the Pinghe District of the Fujian Province（China）, located in the Shanghang-Yunxiao polymetallic and alunite ore belt（within the Wuyishan polymetallic belt）, where mineral resources such as copper, molybdenum, gold, silver, iron, lead, zinc, alunite and pyrophyllite have been discovered. The results of our study showed that：（1） the values of fractal dimension for all lineaments, NW-trending lineaments, and NE-trending lineaments, are 1.36, 1.32, and 1.23, respectively, indicating that these lineaments are statistically self-similar;（2） the fractal dimensions of the spatial distribution of the linear structures in the four selected hydrothermal-type ore deposits of the Pinghe District, named Zhongteng, Panchi, Xiaofanshan and Fanshan, are 1.43, 1.52, 1.37 and 1.37, respectively, which are higher than the mean value in South China;（3） the spatial distribution of the linear structures extracted from the remote sensing image and displayed by the contour map of fractal dimensions, correlates well with the known hydrothermal ore deposits; and（4） the results of the anomaly map decomposed by the spectrum-area（S-A） multifractal model is much better than the original fractal dimension contour map, which showed most of the known hydrothermal-type deposits occur in the high anomalous area. It is suggested that a high step tendency possibly matches with the boundary of the volcanic edifice and the deep fault controlling the development of the rock mass and the volcanic edifice. The complexity of the spatial distribution of mapped lineations（faults） in the Pinghe District, characterized by high values in the anomaly map, may be associated with the hydrothermal polymetallic ore mineralization in the study area.展开更多
In response to the challenge posed by low recognition accuracy in rugged terrains with diverse topography as well as feature recognition agricultural settings,this paper presents an optimized version of the YOLOv5 alg...In response to the challenge posed by low recognition accuracy in rugged terrains with diverse topography as well as feature recognition agricultural settings,this paper presents an optimized version of the YOLOv5 algorithm alongside the development of a specialized laser weeding experimental platform designed for precise identification of corn seedlings and weeds.The enhanced YOLOv5 algorithm integrates the effective channel attention(CBAM)mechanism while incorporating the DeepSort tracking algorithm to reduce parameter count for seamless mobile deployment.Ablation tests validated this model’s achievement of 96.2%accuracy along with superior mAP values compared to standard YOLOv5 by margins of 3.1%and 0.7%,respectively.Additionally,three distinct datasets captured different scenarios,and their amalgamation resulted in an impressive recognition rate reaching up to 96.13%.Through comparative assessments against YOLOv8,the model demonstrated lightweight performance improvements,including a notable enhancement of 2.1%in recognition rate coupled with a marginal increase of 0.2%in mAP value,thus ensuring heightened precision and robustness during dynamic object detection within intricate backgrounds.展开更多
Investigation into the role of cells with respect to extracellular matrix(ECM)remodeling is still in its infancy.Particularly,ECM degradation is an indispensable process during the recovery from fibrosis.Cells with EC...Investigation into the role of cells with respect to extracellular matrix(ECM)remodeling is still in its infancy.Particularly,ECM degradation is an indispensable process during the recovery from fibrosis.Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases(MMPs)have emerged as novel contributors to the treatment of fibrotic diseases.In this review,we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition.Besides,innovative approaches to engineering and characterizing cells with degradation ability,as well as elucidating the mechanism of the ECM degradation,are also illustrated.Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized.Finally,we discuss the therapeutic potential of cells with high degradation ability,hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12402488)the China Postdoctoral Science Foundation(Grant No.2023M742898)the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(Grant No.GZC20232193).
文摘To elucidate the cyclic creep mechanisms in China's impure salt rock after high-temperature damage,cyclic nanoindentation and uniaxial cyclic loading tests were conducted at 25℃,100℃,120℃,and 160℃in this study.The results revealed that under cyclic nanoindentation,gypsum mineral exhibited significantly lower indentation depths compared to halite and ankerite minerals,indicating superior resistance to deformation.Additionally,the results demonstrated that high temperature significantly enhances the creep behavior.The maximum indentation depth and creep displacement of minerals,as well as the maximum deformation and creep strain of rock cores,all followed an exponential increase with rising temperatures,with the rate of increase accelerating at higher temperatures.Importantly,it was found that mineral deformation is not the dominant factor in the overall deformation of rock cores;however,the behavior of the mineral phases fundamentally governs the salt rock's mechanical response under stress.Based on these findings,a new constitutive model for cyclic creep was established based on fractional derivatives to accurately characterize the nonlinear cyclic creep characteristics of impure salt rocks at different scales.This model was validated against test data,effectively representing the periodic fluctuations in indentation depth or strain,particularly during the accelerated creep stage.Furthermore,a temperature-dependent correction parameter was introduced,along with a modified Mori-Tanaka method,to upscale microscale results to the macroscale across varying temperatures.This study provides a theoretical foundation for predicting deformation and assessing the stability of salt cavern walls under high-temperature and cyclic loading conditions in deep geological settings.
文摘背景 随着“以患者为中心”的医学模式的转变,患者在医疗服务中的角色和地位越来越重要,患者对自身健康相关信息的报告在识别/监测症状、评估治疗效果以及在医患共享决策等方面体现出其独特的临床价值。然而,我国患者报告结局(PROs)相关研究还处于起步阶段,尚缺乏基于PROs的文献计量学研究。目的 了解国际PROs研究成果及研究热点,为我国开展相关研究提供借鉴与参考。方法 基于“Web of Science核心合集”数据库,运用文献计量学分析方法和CiteSpaceⅤ软件对PROs相关研究的年度变化、主要国家/地区、机构、期刊、关键词及研究热点进行可视化分析,检索时间为建库至2019年8月。结果 通过检索最终获得3 288篇相关文献;近年来PROs相关研究报道逐年增多,美国发文量最多,为1 815篇(55.20%);发文量最多的研究机构为美国西北大学;相关研究共发表在822种出版物上,以Quality of Life Research发文量最多(148篇);中心性排名靠前的关键词为生活质量(quality of life)、患者报告结局(patient-reported outcome)、量表(questionnaire)、检验(validation)、影响(impact)、信度(reliablity)等,研究热点以PROs、健康相关生活质量、患者报告结局测量、临床应用研究等为主。结论 以美国为首的发达国家在PROs相关研究占有领先地位,我国在该领域的高质量研究还很少,建议国内学者基于我国国情,结合我国传统中医药特色,完善PROs相关研究的发展。
文摘目的系统评价有关太极拳对心肌梗死患者干预的随机对照试验,以评估太极拳对心肌梗死患者的疗效和安全性。方法检索PubMed、EMbase、Web of Science、Cochrane图书馆、CNKI、维普及万方数据库收集相关研究。检索时间范围从建库到2019年7月。使用Cochrane偏倚风险评价工具评估纳入文章的偏倚风险。结果共纳入7项RCT,包括591例患者(分为太极拳组和对照组)。Meta分析结果显示:与对照组相比,太极拳组的左室射血分数(LVEF)更高(MD=7.07,95%CI:2.54~11.60,P<0.05);峰值摄氧量(VO2Peak)更高(MD=4.00,95%CI:1.49~6.51,P<0.05);生活质量水平更高[生活质量评价量表(SF-36),MD=23.88,95%CI:16.49~31.27,P<0.05)、明尼苏达生活质量量表(MD=-12.88,95%CI:-17.51^-8.09,P<0.05),其差异有统计学意义。太极拳组在6分钟步行试验(6MWT)距离长短略有改善(MD=91.92,95%CI:1.55~182.28,P=0.05),但在N末端脑钠肽前体(NT-proBNP,MD=-380.84,95%CI:-815.38~53.71,P>0.05)方面,其差异不具有统计学意义。在有安全性报告的研究中,未发生不良事件。结论本研究的证据表明太极拳运动疗法改善心肌梗死患者心功能是有效的,但由于纳入研究的样本量小,研究间显著的异质性较大,上述结论尚需开展更多大规模、高质量的随即对照试验予以证实。
基金supported by the“Quantitative Models for Prediction of Strategic Mineral Resources in China”(No.201211022)by the Ministry of Land and Resources of China and“Integrated Prediction Theory for Mineral Resource in Desert and Grassland Covered Areas and Geoinformation Extraction of Buried Mineral Resource”(No.41430320)by the National Natural Science Foundation of China
文摘Mapping mineral prospectivity in vegetated areas is a challenge. For this reason, we aimed to map spatial distribution characteristics of linear structures detected in remote sensing images using fractal and multifractal models. The selected study area was the Pinghe District of the Fujian Province（China）, located in the Shanghang-Yunxiao polymetallic and alunite ore belt（within the Wuyishan polymetallic belt）, where mineral resources such as copper, molybdenum, gold, silver, iron, lead, zinc, alunite and pyrophyllite have been discovered. The results of our study showed that：（1） the values of fractal dimension for all lineaments, NW-trending lineaments, and NE-trending lineaments, are 1.36, 1.32, and 1.23, respectively, indicating that these lineaments are statistically self-similar;（2） the fractal dimensions of the spatial distribution of the linear structures in the four selected hydrothermal-type ore deposits of the Pinghe District, named Zhongteng, Panchi, Xiaofanshan and Fanshan, are 1.43, 1.52, 1.37 and 1.37, respectively, which are higher than the mean value in South China;（3） the spatial distribution of the linear structures extracted from the remote sensing image and displayed by the contour map of fractal dimensions, correlates well with the known hydrothermal ore deposits; and（4） the results of the anomaly map decomposed by the spectrum-area（S-A） multifractal model is much better than the original fractal dimension contour map, which showed most of the known hydrothermal-type deposits occur in the high anomalous area. It is suggested that a high step tendency possibly matches with the boundary of the volcanic edifice and the deep fault controlling the development of the rock mass and the volcanic edifice. The complexity of the spatial distribution of mapped lineations（faults） in the Pinghe District, characterized by high values in the anomaly map, may be associated with the hydrothermal polymetallic ore mineralization in the study area.
基金supported by Chongqing Science and Technology Bureau Key R&D Projects in Agriculture and Rural Areas(Grant No.cstc2021jscx-gksbX0003)Chongqing Municipal Education Commission Science and Technology Research Project(Grant No.KJZD-M202201302)+2 种基金Chongqing Municipal Science and Technology Bureau Excellence Programme Project(Grant No.20231102)Chongqing Municipal Science and Technology Bureau Innovation and Development Joint Fund Project(Grant No.CSTB2022NSCQ-LZX0024)the 2024 Chongqing Natural Science Foundation Joint Fund for Innovation and Development(Municipal Education Commission)Project(Grant No.CSTB2024NSCQ-LZX0091).
文摘In response to the challenge posed by low recognition accuracy in rugged terrains with diverse topography as well as feature recognition agricultural settings,this paper presents an optimized version of the YOLOv5 algorithm alongside the development of a specialized laser weeding experimental platform designed for precise identification of corn seedlings and weeds.The enhanced YOLOv5 algorithm integrates the effective channel attention(CBAM)mechanism while incorporating the DeepSort tracking algorithm to reduce parameter count for seamless mobile deployment.Ablation tests validated this model’s achievement of 96.2%accuracy along with superior mAP values compared to standard YOLOv5 by margins of 3.1%and 0.7%,respectively.Additionally,three distinct datasets captured different scenarios,and their amalgamation resulted in an impressive recognition rate reaching up to 96.13%.Through comparative assessments against YOLOv8,the model demonstrated lightweight performance improvements,including a notable enhancement of 2.1%in recognition rate coupled with a marginal increase of 0.2%in mAP value,thus ensuring heightened precision and robustness during dynamic object detection within intricate backgrounds.
基金financially supported by the National Natural Science Foundation of China(82125018).
文摘Investigation into the role of cells with respect to extracellular matrix(ECM)remodeling is still in its infancy.Particularly,ECM degradation is an indispensable process during the recovery from fibrosis.Cells with ECM degradation ability due to the secretion of various matrix metalloproteinases(MMPs)have emerged as novel contributors to the treatment of fibrotic diseases.In this review,we focus on the ECM degradation ability of cells associated with the repertoire of MMPs that facilitate the attenuation of fibrosis through the inhibition of ECM deposition.Besides,innovative approaches to engineering and characterizing cells with degradation ability,as well as elucidating the mechanism of the ECM degradation,are also illustrated.Studies conducted to date on the use of cell-based degradation for therapeutic purposes to combat fibrosis are summarized.Finally,we discuss the therapeutic potential of cells with high degradation ability,hoping to bridge the gap between benchside research and bedside applications in treating fibrotic diseases.
