Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the ...Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the introduction of nanomaterials in 1974,their use in various fields has evolved rapidly.In medical applications,nanomaterials can serve as carriers for the delivery of chemotherapeutic drugs to tumour tissues.Additionally,nanomaterials have potential for in vivo tumour imaging.This article covers the properties and uses of several kinds of nanomaterials,focusing on their use in transcatheter arterial chemoembolization for HCC treatment.This paper also discusses the limitations currently associated with the use of nanomaterials.展开更多
Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especial...Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especially continuous wave(CW)THz near-field scanning microscopy(THz-SNOM)with its nanoscale reso⁃lution,can be promising in biomedical imaging.In addition,compared with traditional THz time-domain spec⁃troscopy(TDS),portable solid-state source as the emission has higher power and SNR,lower cost,and can ob⁃tain more precise imaging.In this study,we employ CW THz-SNOM to further break the resolution limitations of conventional THz imaging techniques and successfully achieve the near-field imaging of demineralized enamel at the nanoscale.We keenly observe that the near-field signal of the enamel significantly lowers as demineralization deepens,mainly due to the decrease in permittivity.This new approach offers valuable insights into the micro⁃scopic processes of enamel demineralization,laying the foundation for further research and treatment.展开更多
This corrigendum clarifies information in the article"PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer"by Li et al.(2021).The authors regret that ...This corrigendum clarifies information in the article"PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer"by Li et al.(2021).The authors regret that the image of H526 cells in the schematic illustration in Fig.4A displayed on the Webpage is wrong.The correct image for H526cells inthe schematic illustration is listed below。展开更多
BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electr...BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.展开更多
Direct converting carbon dioxide(CO_(2))and propane(C_(3)H_(8))into aromatics with high carbon utilization offers a desirable opportunity to simultaneously mitigate CO_(2)emission and adequately utilize C_(3)H_(8) in ...Direct converting carbon dioxide(CO_(2))and propane(C_(3)H_(8))into aromatics with high carbon utilization offers a desirable opportunity to simultaneously mitigate CO_(2)emission and adequately utilize C_(3)H_(8) in shale gas.Owing to their thermodynamic resistance,converting CO_(2)and C_(3)H_(8) respectively remains difficult.Here,we achieve 60.2%aromatics selectivity and 48.8%propane conversion over H-ZSM-5-25 via a zeolite-catalyzing the coupling of CO_(2)and C_(3)H_(8).Operando dual-beam FTIR spectroscopy combined with ^(13)C-labeled CO_(2)tracing experiments revealed that CO_(2)is directly involved in the generation of aromatics,with its carbon atoms selectively embedded into the aromatic ring,bypassing the reverse water-gas shift pathway.Accordingly,a cooperative aromatization mechanism is proposed.Thereinto,lactones,produced from CO_(2)and olefins,are proven to be the key intermediate.This work not only provides an opportunity for simultaneous conversion of CO_(2)and C_(3)H_(8),but also expends coupling strategy designing of CO_(2)and alkanes over acidic zeolites.展开更多
Two cross⁃sectional configurations of thin⁃walled square tubes partially filled with lightweight metallic foams are proposed,and termed as double⁃cell configuration partially filled with foam(DC⁃PF)and double⁃tube con...Two cross⁃sectional configurations of thin⁃walled square tubes partially filled with lightweight metallic foams are proposed,and termed as double⁃cell configuration partially filled with foam(DC⁃PF)and double⁃tube configuration partially filled with foam(DT⁃PF),respectively.The bending crashworthiness is investigated based on three⁃point bending tests using finite element ABAQUS/Explicit code.The two key mechanical indicators including Crash Load Efficiency(CLE)and Specific Energy Absorption(SEA)are introduced to evaluate the effect of foams in comparison with empty square tubes and fully filled square tubes.The numerical results show that the two partially filled configurations,especially DT⁃PF,display dramatically excellent bending crashworthiness compared with empty and fully filled square tubes.There exists a foam density threshold,beyond which the CLE of DT⁃PF achieves a maximum constant.In addition,there seems to be another foam density threshold,beyond which the SEA of DT⁃PF gets to the maximum value.It is also shown that the foam density threshold corresponding to the maximum SEA varies with the thickness of thin⁃walled square tubes.展开更多
Pear fruit corking disorder is a non-infectious physiological condition that primarily occurs during the late developmental stages of pear and significantly impacts fruit quality and economic value in several major cu...Pear fruit corking disorder is a non-infectious physiological condition that primarily occurs during the late developmental stages of pear and significantly impacts fruit quality and economic value in several major cultivars.As the underlying mechanism remains unclear,effective prevention strategies and genetic improvements continue to present major challenges.In this study,‘Akizuki’pear was used as experimental material,and the lignin content in cork-affected tissue was found to be significantly higher than in healthy tissue.Exogenous abscisic acid(ABA)treatment induced cork formation and promoted lignin biosynthesis,a major structural component,in both pear fruits and calli.Through integrated RNA-seq and expression analyses,we identified the ABA-responsive gene PbrMYB8,which was differentially expressed between healthy and diseased tissues and associated with lignin biosynthesis during corking disorder.Stable transformation of PbrMYB8 into pear calli and Arabidopsis confirmed its role in promoting lignin biosynthesis.Notably,PbrMYB8 not only activated lignin biosynthesis genes independently but also interacted with PbrMYB169 to form a protein complex that co-regulated their expression.These findings improve our understanding of lignin biosynthesis in pear fruit corking disorder by identifying a key regulator and its interaction network and provide a theoretical foundation for future strategies aimed at improving pear fruit quality.展开更多
Hypersonic flow over a canonical 25°−55°double-cone configuration with a freestream Mach number of 10.38 is numerically investigated.In contrast to a relatively stable and moderate separation region in exper...Hypersonic flow over a canonical 25°−55°double-cone configuration with a freestream Mach number of 10.38 is numerically investigated.In contrast to a relatively stable and moderate separation region in experiments,axisymmetric calculations in the literature demonstrated that the separation bubble continuously grew and notably exceeded the experimental result.To explain the causes of the discrepancy,time-accurate axisymmetric and Three-Dimensional(3D)simulations are conducted for the double-cone flow to investigate the evolution of three-dimensionality and unsteadiness.Both the axisymmetric calculation and the 3D simulation without external disturbances predict a significantly larger separation region than that in experiments and misrepresent the distributions of surface pressure and heat flux.The random forcing approach with two levels of noise amplitude is then applied to 3D simulations.A better agreement with the measured data is observed for the time-averaged heat flux and pressure when the white noise is enforced.As the forcing amplitude is increased,the agreement is slightly improved.However,discrepancies between the 3D results and experimental data still exist in the prediction of the heat flux and pressure distributions,indicating the essential difference between the injected white noise and the wind tunnel freestream disturbances.Realistic noise models are required to reveal the sources of such discrepancies.展开更多
Roadkill has become a pivotal issue in the global decline of amphibian populations.Conventional research methods have typically relied on the examination of dried carcasses found long after wildlife-vehicle collisions...Roadkill has become a pivotal issue in the global decline of amphibian populations.Conventional research methods have typically relied on the examination of dried carcasses found long after wildlife-vehicle collisions, which influnce the accuracy of the taxonomic classification and assessment of roadkill rates. To overcome these limitations, we conducted a nocturnal survey on National Road G108in the Qinling Mountains immediately following a night rainstorm in July 2016. We employed molecular techniques to distinguish species that are morphologically identical but share overlapping habitats. Our investigation revealed that within five hours, 92 amphibians from five different species were documented across three 2-km road transects. Among these, 31 individuals were identified as roadkill,resulting in an overall rate of 33%, or roughly five fatalities per kilometer. Significantly, the mountain stream frogs Nanorana quadranus and N. taihangnica comprised 40.2% and 30.4% of the total individuals observed, with mortality rates of 35.1% and 25.0%,respectively. We found no significant variation in mortality rates between different age groups or genders for either species. Our research suggests that conducting surveys at night, immediately following summer rainstorms, is an efficient strategy for evaluating the impacts of roadkill. The post-rain foraging behaviors and the dispersal of juveniles are key factors contributing to road crossings outside of the breeding season. Consequently, this study recommends that traffic authorities in mountainous areas take measures to reduce vehicle traffic following summer rainstorms in order to minimize the threat to amphibian lives.展开更多
Angelica L.has attracted global interest for its traditional medicinal uses and commercial values.However,few studies have focused on the metabolomic differences among the Angelica species.In this study,widely targete...Angelica L.has attracted global interest for its traditional medicinal uses and commercial values.However,few studies have focused on the metabolomic differences among the Angelica species.In this study,widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species(Angelicasinensis(Oliv.)Diels(A.sinensis),Angelica biserrata(R.H.Shan &Yuan)C.Q.Yuan & R.H.Shan(A.biserrata),Angelica dahurica(Hoffm.)Benth.& Hook.f.ex Franch.& Sav.(A.dahurica)and Angelica keiskei Koidz.(A.keiskei)).A total of 698 volatile metabolites were identified and classified into fifteen different categories.The metabo-lomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A.sinensis,whereas bornyl acetate showed the opposite pattern.Furthermore,a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species.This study provides a comprehensive biochemical map for the exploitation,application and development of the Angelica species as medicinal plants or health-related dietary supplements.展开更多
We present the application of a machine learning based galaxy group finder to real observational data from the Sloan Digital Sky Survey Data Release 13(SDSS DR13).Originally designed and validated using simulated gala...We present the application of a machine learning based galaxy group finder to real observational data from the Sloan Digital Sky Survey Data Release 13(SDSS DR13).Originally designed and validated using simulated galaxy surveys in redshift space,our method utilizes deep neural networks to recognize galaxy groups and assess their respective halo masses.The model comprises three components:a central galaxy identifier,a group mass estimator,and an iterative group finder.Using mock catalogs from the Millennium Simulation,our model attains above 90%completeness and purity for groups covering a wide range of halo masses from~10^(11)to~10^(15)h^(-1)Me.When applied to SDSS DR13,it successfully identifies over 420,000 galaxy groups,displaying a strong agreement in group abundance,redshift distribution,and halo mass distribution with conventional techniques.The precision in identifying member galaxies is also notably high,with more than 80%of groups with lower mass achieving perfect alignments.The model shows strong performance across different magnitude thresholds,making retraining unnecessary.These results confirm the efficiency and adaptability of our methodology,offering a scalable and accurate solution for upcoming large-scale galaxy surveys and studies of cosmological formations.Our SDSS group catalog and the essential observable properties of galaxies are available at https://github.com/Juntao Ma/SDSS-DR13-group-catalog.git.展开更多
COMPERA 2.0 risk stratification has been demonstrated to be useful in patients with precapillary pulmonary hypertension(PH).However,its suitability for patients at risk for post-capillary PH or PH associated with left...COMPERA 2.0 risk stratification has been demonstrated to be useful in patients with precapillary pulmonary hypertension(PH).However,its suitability for patients at risk for post-capillary PH or PH associated with left heart disease(PH-LHD)is unclear.To investigate the use of COMPERA 2.0 in patients with severe aortic stenosis(SAS)undergoing transcatheter aortic valve replacement(TAVR),who are at risk for post-capillary PH,a total of 327 eligible SAS patients undergoing TAVR at our institution between September 2015 and November 2020 were included in the study.Patients were classified into four strata before and after TAVR using the COMPERA 2.0 risk score.The primary endpoint was all-cause mortality.Survival analysis was performed using Kaplan-Meier curves,log-rank test,and Cox proportional hazards regression model.The study cohort had a median(interquartile range)age of 76(70–80)years and a pulmonary arterial systolic pressure of 33(27–43)mmHg(1 mmHg=0.133 kPa)before TAVR.The overall mortality was 11.9%during 26(15–47)months of follow-up.Before TAVR,cumulative mortality was higher with an increase in the risk stratum level(log-rank,both P<0.001);each increase in the risk stratum level resulted in an increased risk of death(hazard ratio(HR)2.53,95%confidential interval(CI)1.54–4.18,P<0.001),which was independent of age,sex,estimated glomerular filtration rate(eGFR),hemoglobin,albumin,and valve type(HR 1.76,95%CI 1.01–3.07,P=0.047).Similar results were observed at 30 d after TAVR.COMPERA 2.0 can serve as a useful tool for risk stratification in patients with SAS undergoing TAVR,indicating its potential application in the management of PH-LHD.Further validation is needed in patients with confirmed post-capillary PH by right heart catheterization.展开更多
Making a confident diagnosis is a complex task for a specific form of interstitial lung disease and providing appropriate management in an attempt to achieve normalization of the disease can put up an alarming process...Making a confident diagnosis is a complex task for a specific form of interstitial lung disease and providing appropriate management in an attempt to achieve normalization of the disease can put up an alarming process for the clinicians. A set of diffuse and restrictive lung diseases incorporate with idiopathic interstitial pneumonias, showing inflammation and fibrosis of the interstitium due to parenchymal damage. High-resolution computed tomography (HRCT) has magnified the diagnostic standpoint in stepwise identification and classified various patterns in the evaluation of interstitial lung disease. The aim of our review is to elaborate clinical, radiographic and typical and atypical HRCT findings of idiopathic interstitial pneumonias by correlating with its differential diagnosis. Idiopathic pulmonary fibrosis is the most predominant idiopathic interstitial pneumonias and its diagnosis needs to omit all other well-known causes of interstitial lung diseases. According to the 2011 evidence-based guidelines, usual interstitial pneumonia can be diagnosed by HRCT when all criteria are fulfilled. Non-specific interstitial pneumonia is distinguished by bilateral patchy ground-glass opacities and irregular linear/reticular opacities. Respiratory bronchiolitis associated-interstitial lung disease and desquamative interstitial pneumonia show centrolobular nodules and ground-glass opacities as imaging patterns. Cryptogenic organizing pneumonia consists of patchy peripheral or peribronchial consolidations, while ground-glass opacities with tendency for migration, which is evolving to fibrosis, in acute interstitial pneumonia. Lymphoid interstitial pneumonia and idiopathic pleuro-parenchymal fibroelastosis are classified under rare idiopathic interstitial pneumonias. HRCT images help radiologists in diagnosis and mapping specific patterns of idiopathic interstitial pneumonias. This article reviews the stages of evolution in HRCT features for idiopathic interstitial pneumonias.展开更多
目的系统评价主动脉夹层患者术后发生谵妄的临床预测模型。方法检索the Cochrane Library、PubMed、Web of Science、Embase、中国生物医学文献数据库、中国知网、万方数据库以及维普数据库中与主动脉夹层患者术后谵妄风险预测模型相关...目的系统评价主动脉夹层患者术后发生谵妄的临床预测模型。方法检索the Cochrane Library、PubMed、Web of Science、Embase、中国生物医学文献数据库、中国知网、万方数据库以及维普数据库中与主动脉夹层患者术后谵妄风险预测模型相关的研究,检索时限从建库至2025年3月。两名研究人员独立进行文献筛选、数据提取以及纳入研究的偏倚风险评估。结果最终纳入10项研究,涉及10个主动脉夹层患者术后谵妄临床预测模型。评价结果显示,偏倚风险方面,10项研究均为高风险;适用性方面,1项研究为高风险、6项研究为低风险、3项研究为不清楚。纳入模型曲线下面积为0.771~0.980,标准差为0.005。最常见预测因子包括年龄、肾损伤、深低温停循环持续时间等。结论主动脉夹层患者术后谵妄临床预测模型的整体预测性能一般,模型偏倚风险较高,临床适用性需进一步验证。展开更多
文摘Hepatocellular carcinoma(HCC)remains one of the most common cancers worldwide.Transcatheter arterial chemoembolization has become a common treatment modality for some patients with unresectable advanced HCC.Since the introduction of nanomaterials in 1974,their use in various fields has evolved rapidly.In medical applications,nanomaterials can serve as carriers for the delivery of chemotherapeutic drugs to tumour tissues.Additionally,nanomaterials have potential for in vivo tumour imaging.This article covers the properties and uses of several kinds of nanomaterials,focusing on their use in transcatheter arterial chemoembolization for HCC treatment.This paper also discusses the limitations currently associated with the use of nanomaterials.
基金Supported by the National Natural Science Foundation of China(61988102,62401113,92463308)。
文摘Enamel demineralization often occurs in the early stage of dental caries.Studying the microscopic mechanism of enamel demineralization is essential to prevent and treat dental caries.Terahertz(THz)technolo⁃gy,especially continuous wave(CW)THz near-field scanning microscopy(THz-SNOM)with its nanoscale reso⁃lution,can be promising in biomedical imaging.In addition,compared with traditional THz time-domain spec⁃troscopy(TDS),portable solid-state source as the emission has higher power and SNR,lower cost,and can ob⁃tain more precise imaging.In this study,we employ CW THz-SNOM to further break the resolution limitations of conventional THz imaging techniques and successfully achieve the near-field imaging of demineralized enamel at the nanoscale.We keenly observe that the near-field signal of the enamel significantly lowers as demineralization deepens,mainly due to the decrease in permittivity.This new approach offers valuable insights into the micro⁃scopic processes of enamel demineralization,laying the foundation for further research and treatment.
文摘This corrigendum clarifies information in the article"PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer"by Li et al.(2021).The authors regret that the image of H526 cells in the schematic illustration in Fig.4A displayed on the Webpage is wrong.The correct image for H526cells inthe schematic illustration is listed below。
文摘BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.
文摘Direct converting carbon dioxide(CO_(2))and propane(C_(3)H_(8))into aromatics with high carbon utilization offers a desirable opportunity to simultaneously mitigate CO_(2)emission and adequately utilize C_(3)H_(8) in shale gas.Owing to their thermodynamic resistance,converting CO_(2)and C_(3)H_(8) respectively remains difficult.Here,we achieve 60.2%aromatics selectivity and 48.8%propane conversion over H-ZSM-5-25 via a zeolite-catalyzing the coupling of CO_(2)and C_(3)H_(8).Operando dual-beam FTIR spectroscopy combined with ^(13)C-labeled CO_(2)tracing experiments revealed that CO_(2)is directly involved in the generation of aromatics,with its carbon atoms selectively embedded into the aromatic ring,bypassing the reverse water-gas shift pathway.Accordingly,a cooperative aromatization mechanism is proposed.Thereinto,lactones,produced from CO_(2)and olefins,are proven to be the key intermediate.This work not only provides an opportunity for simultaneous conversion of CO_(2)and C_(3)H_(8),but also expends coupling strategy designing of CO_(2)and alkanes over acidic zeolites.
基金Sponsored by National Natural Science Foundation of China (Grant Nos.12272064 and 12101086)University Natural Science Research Project of Anhui Province (Grant No.KJ2018A0481)+2 种基金Major Project of Basic Science (Natural Science) Research in Jiangsu Universities (Grant Nos.22KJA460001,23KJA580001)Changzhou Science and Technology Plan Project (Grant No.CE20235049)Changzhou Leading Innovative Talents C ultivation Project (Grant No.CQ20220092).
文摘Two cross⁃sectional configurations of thin⁃walled square tubes partially filled with lightweight metallic foams are proposed,and termed as double⁃cell configuration partially filled with foam(DC⁃PF)and double⁃tube configuration partially filled with foam(DT⁃PF),respectively.The bending crashworthiness is investigated based on three⁃point bending tests using finite element ABAQUS/Explicit code.The two key mechanical indicators including Crash Load Efficiency(CLE)and Specific Energy Absorption(SEA)are introduced to evaluate the effect of foams in comparison with empty square tubes and fully filled square tubes.The numerical results show that the two partially filled configurations,especially DT⁃PF,display dramatically excellent bending crashworthiness compared with empty and fully filled square tubes.There exists a foam density threshold,beyond which the CLE of DT⁃PF achieves a maximum constant.In addition,there seems to be another foam density threshold,beyond which the SEA of DT⁃PF gets to the maximum value.It is also shown that the foam density threshold corresponding to the maximum SEA varies with the thickness of thin⁃walled square tubes.
基金funded by the National Science Foundation of China(32230097)the Earmarked Fund for China Agriculture Research System(CARS-28)the Project of Zhongshan Biological Breeding Laboratory(Grant No.ZSBBL-KY2023-08).
文摘Pear fruit corking disorder is a non-infectious physiological condition that primarily occurs during the late developmental stages of pear and significantly impacts fruit quality and economic value in several major cultivars.As the underlying mechanism remains unclear,effective prevention strategies and genetic improvements continue to present major challenges.In this study,‘Akizuki’pear was used as experimental material,and the lignin content in cork-affected tissue was found to be significantly higher than in healthy tissue.Exogenous abscisic acid(ABA)treatment induced cork formation and promoted lignin biosynthesis,a major structural component,in both pear fruits and calli.Through integrated RNA-seq and expression analyses,we identified the ABA-responsive gene PbrMYB8,which was differentially expressed between healthy and diseased tissues and associated with lignin biosynthesis during corking disorder.Stable transformation of PbrMYB8 into pear calli and Arabidopsis confirmed its role in promoting lignin biosynthesis.Notably,PbrMYB8 not only activated lignin biosynthesis genes independently but also interacted with PbrMYB169 to form a protein complex that co-regulated their expression.These findings improve our understanding of lignin biosynthesis in pear fruit corking disorder by identifying a key regulator and its interaction network and provide a theoretical foundation for future strategies aimed at improving pear fruit quality.
基金supported by the Hong Kong Research Grants Council,China(Nos.15206519,15204322 and 25203721)the National Natural Science Foundation of China(No.12102377)。
文摘Hypersonic flow over a canonical 25°−55°double-cone configuration with a freestream Mach number of 10.38 is numerically investigated.In contrast to a relatively stable and moderate separation region in experiments,axisymmetric calculations in the literature demonstrated that the separation bubble continuously grew and notably exceeded the experimental result.To explain the causes of the discrepancy,time-accurate axisymmetric and Three-Dimensional(3D)simulations are conducted for the double-cone flow to investigate the evolution of three-dimensionality and unsteadiness.Both the axisymmetric calculation and the 3D simulation without external disturbances predict a significantly larger separation region than that in experiments and misrepresent the distributions of surface pressure and heat flux.The random forcing approach with two levels of noise amplitude is then applied to 3D simulations.A better agreement with the measured data is observed for the time-averaged heat flux and pressure when the white noise is enforced.As the forcing amplitude is increased,the agreement is slightly improved.However,discrepancies between the 3D results and experimental data still exist in the prediction of the heat flux and pressure distributions,indicating the essential difference between the injected white noise and the wind tunnel freestream disturbances.Realistic noise models are required to reveal the sources of such discrepancies.
基金supported by the National Natural Science Foundation of China (32170435)。
文摘Roadkill has become a pivotal issue in the global decline of amphibian populations.Conventional research methods have typically relied on the examination of dried carcasses found long after wildlife-vehicle collisions, which influnce the accuracy of the taxonomic classification and assessment of roadkill rates. To overcome these limitations, we conducted a nocturnal survey on National Road G108in the Qinling Mountains immediately following a night rainstorm in July 2016. We employed molecular techniques to distinguish species that are morphologically identical but share overlapping habitats. Our investigation revealed that within five hours, 92 amphibians from five different species were documented across three 2-km road transects. Among these, 31 individuals were identified as roadkill,resulting in an overall rate of 33%, or roughly five fatalities per kilometer. Significantly, the mountain stream frogs Nanorana quadranus and N. taihangnica comprised 40.2% and 30.4% of the total individuals observed, with mortality rates of 35.1% and 25.0%,respectively. We found no significant variation in mortality rates between different age groups or genders for either species. Our research suggests that conducting surveys at night, immediately following summer rainstorms, is an efficient strategy for evaluating the impacts of roadkill. The post-rain foraging behaviors and the dispersal of juveniles are key factors contributing to road crossings outside of the breeding season. Consequently, this study recommends that traffic authorities in mountainous areas take measures to reduce vehicle traffic following summer rainstorms in order to minimize the threat to amphibian lives.
基金supported by the National Science Foundation of China,Grant 32470245.
文摘Angelica L.has attracted global interest for its traditional medicinal uses and commercial values.However,few studies have focused on the metabolomic differences among the Angelica species.In this study,widely targeted metabolomics based on gas chromatography-tandem mass spectrometry was employed to analyze the metabolomes of four Angelica species(Angelicasinensis(Oliv.)Diels(A.sinensis),Angelica biserrata(R.H.Shan &Yuan)C.Q.Yuan & R.H.Shan(A.biserrata),Angelica dahurica(Hoffm.)Benth.& Hook.f.ex Franch.& Sav.(A.dahurica)and Angelica keiskei Koidz.(A.keiskei)).A total of 698 volatile metabolites were identified and classified into fifteen different categories.The metabo-lomic analysis indicated that 7-hydroxycoumarin and Z-ligustilide accumulated at significantly higher levels in A.sinensis,whereas bornyl acetate showed the opposite pattern.Furthermore,a high correspondence between the dendrogram of metabolite contents and phylogenetic positions of the four species.This study provides a comprehensive biochemical map for the exploitation,application and development of the Angelica species as medicinal plants or health-related dietary supplements.
基金supported by the National Key R&D Program of China(2022YFA1602901)the National Natural Science Foundation of China(NSFC,grant Nos.11988101,11873051,12125302,and 11903043)+2 种基金CAS Project for Young Scientists in Basic Research(grant No.YSBR-062)the China Manned Space Program(grant Nos.CMS-CSST2025-A03 and CMS-CSST-2025-A10)the K.C.Wong Education Foundation。
文摘We present the application of a machine learning based galaxy group finder to real observational data from the Sloan Digital Sky Survey Data Release 13(SDSS DR13).Originally designed and validated using simulated galaxy surveys in redshift space,our method utilizes deep neural networks to recognize galaxy groups and assess their respective halo masses.The model comprises three components:a central galaxy identifier,a group mass estimator,and an iterative group finder.Using mock catalogs from the Millennium Simulation,our model attains above 90%completeness and purity for groups covering a wide range of halo masses from~10^(11)to~10^(15)h^(-1)Me.When applied to SDSS DR13,it successfully identifies over 420,000 galaxy groups,displaying a strong agreement in group abundance,redshift distribution,and halo mass distribution with conventional techniques.The precision in identifying member galaxies is also notably high,with more than 80%of groups with lower mass achieving perfect alignments.The model shows strong performance across different magnitude thresholds,making retraining unnecessary.These results confirm the efficiency and adaptability of our methodology,offering a scalable and accurate solution for upcoming large-scale galaxy surveys and studies of cosmological formations.Our SDSS group catalog and the essential observable properties of galaxies are available at https://github.com/Juntao Ma/SDSS-DR13-group-catalog.git.
基金supported by the National Key R&D Program of China(Nos.2019YFA0110400 and 2016YFC13010204)the National Natural Science Foundation of China(Nos.81870292,81570233,81770252,and 82100060)+2 种基金the China Postdoctoral Science Foundation(Nos.2020M680079 and 2021T140598)the Zhejiang Province Science and Technology Department Key R&D Program(Nos.2021C03097 and 2022C03063)the Zhejiang Provincial Natural Science Foundation of China(No.LQ21H020005).
文摘COMPERA 2.0 risk stratification has been demonstrated to be useful in patients with precapillary pulmonary hypertension(PH).However,its suitability for patients at risk for post-capillary PH or PH associated with left heart disease(PH-LHD)is unclear.To investigate the use of COMPERA 2.0 in patients with severe aortic stenosis(SAS)undergoing transcatheter aortic valve replacement(TAVR),who are at risk for post-capillary PH,a total of 327 eligible SAS patients undergoing TAVR at our institution between September 2015 and November 2020 were included in the study.Patients were classified into four strata before and after TAVR using the COMPERA 2.0 risk score.The primary endpoint was all-cause mortality.Survival analysis was performed using Kaplan-Meier curves,log-rank test,and Cox proportional hazards regression model.The study cohort had a median(interquartile range)age of 76(70–80)years and a pulmonary arterial systolic pressure of 33(27–43)mmHg(1 mmHg=0.133 kPa)before TAVR.The overall mortality was 11.9%during 26(15–47)months of follow-up.Before TAVR,cumulative mortality was higher with an increase in the risk stratum level(log-rank,both P<0.001);each increase in the risk stratum level resulted in an increased risk of death(hazard ratio(HR)2.53,95%confidential interval(CI)1.54–4.18,P<0.001),which was independent of age,sex,estimated glomerular filtration rate(eGFR),hemoglobin,albumin,and valve type(HR 1.76,95%CI 1.01–3.07,P=0.047).Similar results were observed at 30 d after TAVR.COMPERA 2.0 can serve as a useful tool for risk stratification in patients with SAS undergoing TAVR,indicating its potential application in the management of PH-LHD.Further validation is needed in patients with confirmed post-capillary PH by right heart catheterization.
文摘Making a confident diagnosis is a complex task for a specific form of interstitial lung disease and providing appropriate management in an attempt to achieve normalization of the disease can put up an alarming process for the clinicians. A set of diffuse and restrictive lung diseases incorporate with idiopathic interstitial pneumonias, showing inflammation and fibrosis of the interstitium due to parenchymal damage. High-resolution computed tomography (HRCT) has magnified the diagnostic standpoint in stepwise identification and classified various patterns in the evaluation of interstitial lung disease. The aim of our review is to elaborate clinical, radiographic and typical and atypical HRCT findings of idiopathic interstitial pneumonias by correlating with its differential diagnosis. Idiopathic pulmonary fibrosis is the most predominant idiopathic interstitial pneumonias and its diagnosis needs to omit all other well-known causes of interstitial lung diseases. According to the 2011 evidence-based guidelines, usual interstitial pneumonia can be diagnosed by HRCT when all criteria are fulfilled. Non-specific interstitial pneumonia is distinguished by bilateral patchy ground-glass opacities and irregular linear/reticular opacities. Respiratory bronchiolitis associated-interstitial lung disease and desquamative interstitial pneumonia show centrolobular nodules and ground-glass opacities as imaging patterns. Cryptogenic organizing pneumonia consists of patchy peripheral or peribronchial consolidations, while ground-glass opacities with tendency for migration, which is evolving to fibrosis, in acute interstitial pneumonia. Lymphoid interstitial pneumonia and idiopathic pleuro-parenchymal fibroelastosis are classified under rare idiopathic interstitial pneumonias. HRCT images help radiologists in diagnosis and mapping specific patterns of idiopathic interstitial pneumonias. This article reviews the stages of evolution in HRCT features for idiopathic interstitial pneumonias.
文摘目的明确脓毒症相关脑病(sepsis-associated encephalopathy,SAE)急性期(发病6 h)海马突触损伤的关键分子及其作用机制,阐释脓毒症认知障碍(sepsis-induced cognitive impairment,SICI)的早期神经元损伤途径。方法采用蛋白质组学对脂多糖(lipopolysaccharide,LPS)处理6 h后小鼠海马组织进行差异蛋白筛查并确定候选靶点,在体外构建干扰素诱导蛋白含四肽重复序列3(interferon-induced protein with tetratricopeptide repeats 3,IFIT3)过表达的HT22神经元细胞模型,分为对照组、LPS组、IFIT3过表达组、LPS+IFIT3组、Visomitin预处理组及CY-09共处理组6组。检测线粒体活性氧(mitochondrial reactive oxygen species,mtROS)水平、白细胞介素-1β(IL-1β)释放及突触后致密蛋白95(postsynaptic density protein 95,PSD95)和突触素(synaptophysin,SYN)表达变化。结果LPS处理6 h后小鼠海马中IFIT3表达显著上调。在炎症背景下,IFIT3过表达进一步促进mtROS积累,增强IL-1β释放,并导致PSD95和SYN表达下降。上游清除mtROS的Visomitin能够显著改善突触蛋白丢失,其保护效应优于单纯阻断NOD样受体家族含pyrin结构域蛋白3(NOD-like receptor family pyrin domain containing 3,NLRP3)活化的CY-09。结论IFIT3在炎症背景下参与并放大急性期海马突触损伤过程,其效应与mtROS-NLRP3炎症小体相关级联激活密切相关,提示急诊脓毒症早期脑保护策略中,早期上游靶向mtROS的脑保护策略可能优于单点抑制NLRP3。
文摘目的系统评价主动脉夹层患者术后发生谵妄的临床预测模型。方法检索the Cochrane Library、PubMed、Web of Science、Embase、中国生物医学文献数据库、中国知网、万方数据库以及维普数据库中与主动脉夹层患者术后谵妄风险预测模型相关的研究,检索时限从建库至2025年3月。两名研究人员独立进行文献筛选、数据提取以及纳入研究的偏倚风险评估。结果最终纳入10项研究,涉及10个主动脉夹层患者术后谵妄临床预测模型。评价结果显示,偏倚风险方面,10项研究均为高风险;适用性方面,1项研究为高风险、6项研究为低风险、3项研究为不清楚。纳入模型曲线下面积为0.771~0.980,标准差为0.005。最常见预测因子包括年龄、肾损伤、深低温停循环持续时间等。结论主动脉夹层患者术后谵妄临床预测模型的整体预测性能一般,模型偏倚风险较高,临床适用性需进一步验证。
