[Objective] To study current development and utilization of water resources in Yuan'an County and countermeasures. [Method] On the basis of analyzing basic characteristics of water resources in Yuan'an County ...[Objective] To study current development and utilization of water resources in Yuan'an County and countermeasures. [Method] On the basis of analyzing basic characteristics of water resources in Yuan'an County as well as its current development and utilization, problems in the development and utilization of water resources in the study area were pointed out, and feasible countermeasures were proposed correspondingly. [Result] The county is endowed with rich water resources, but the overall use efficiency is low. There are many problems in the development and utilization of local water resources, such as pollution of water source, water and soil loss and so on. [Conclusion] In view of the problems, feasible suggestions were given to provide scientific support for the reasonable development and utilization of water resources in Yuan'an County.展开更多
背景与目的 肺腺癌易发生脑转移,患者预后极差。蛋白磷酸酶1调节亚基13样(protein phosphatase 1 regulatory subunit 13-like, PPP1R13L)基因编码的p53凋亡刺激蛋白家族抑制成员(inhibitor of apoptosis-stimulating protein of p53, i...背景与目的 肺腺癌易发生脑转移,患者预后极差。蛋白磷酸酶1调节亚基13样(protein phosphatase 1 regulatory subunit 13-like, PPP1R13L)基因编码的p53凋亡刺激蛋白家族抑制成员(inhibitor of apoptosis-stimulating protein of p53, iASPP)蛋白是p53通路的关键抑制因子,在多种肿瘤中促癌,但其在肺腺癌脑转移中的作用未知。本研究通过单细胞测序数据整合与临床样本分析,旨在分析肺腺癌脑转移患者的肿瘤微环境特征,并探讨PPP1R13L在脑转移组织中的表达情况及其临床意义。方法 收集2014年1月至2024年12月新疆医科大学附属肿瘤医院就诊的4例肺腺癌脑转移和2例少突胶质细胞瘤患者的脑组织进行单细胞测序,并结合公共数据库中4例肺腺癌样本和4例正常肺组织样本的单细胞测序数据解析肿瘤微环境;另收集此医院50例肺腺癌脑转移患者的临床资料及石蜡切片,采用免疫组化技术检测iASPP蛋白表达,分析其与临床特征及预后的关系。结果 相较于胶质瘤和肺腺癌组,肺腺癌脑转移组特异的上皮细胞主要富集于氧化磷酸化、细胞凋亡、缺氧和p53通路;PPP1R13L作为上调差异基因,在脑转移组特异上皮细胞亚群高表达;PPP1R13L阳性细胞与成纤维细胞交互作用显著,激活细胞-基质黏附相关通路,关键配体-受体对为I型胶原蛋白α1链-白细胞分化抗原44(collagen type I alpha 1 chain-cluster of differentiation 44, COL1A1-CD44)。临床数据分析显示,吸烟史(HR=2.543, 95%CI:1.159-5.583, P=0.020)和iASPP高表达(HR=3.351, 95%CI:1.310-8.575, P=0.012)为肺腺癌脑转移患者预后的独立危险因素。结论 本研究阐明了肺腺癌脑转移微环境中上皮细胞与成纤维细胞的相互作用,提示PPP1R13L可作为潜在预后标志物及治疗靶点,为肺腺癌脑转移的精准治疗提供依据。展开更多
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci...The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.展开更多
To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced materi...To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced material characterization techniques.A suitable laser output mode fell into the transition mode,allowing for the fabrication of nearly full-density samples(porosity=0.85±0.021%)with favorable mechanical properties(yield strength=351 MPa,ultimate tensile strength=417 MPa,the elongation at break=6.5%and microhardness=137.9±6.15 HV_(0.1))using optimal processing parameters(P=80 W,v=250 mm/s and d=50μm).Viscoplastic self-consistent analysis and transmission electron microscopy observations reveal that the plastic deformation response of the SLM Mg-RE alloys is primarily driven by basal and prismatic slips.Starting from a random texture before deformation(maximum multiple of ultimate density,Max.MUD=3.95),plastic stretching led the grains to align with the Z-axis,finally resulting in a{0001}<1010>texture orientation after fracture(Max.MUD=8.755).Main phases of the SLM state are mainly composed ofα-Mg,Mg_(24)Y_(5) andβ'-Mg_(41)Nd_(5),with an average grain size of only 4.27μm(about a quarter of that in the extruded state),resulting in a favorable strength-toughness ratio.Except for the nano-β'phase and semi-coherent Mg_(24)Y_(5) phase(mismatch=16.12%)around the grain boundaries,a small amount of nano-ZrO_(2) and Y_(2)O_(3) particles also play a role in dispersion strengthening.The high mechanical properties of the SLM state are chiefly attributed to precipitation hardening(44.41%),solid solution strengthening(34.06%)and grain boundary strengthening(21.53%),with precipitation hardening being predominantly driven by dislocation strengthening(67.77%).High-performance SLM Mg-RE alloy components were manufactured and showcased at TCT Asia 2024,receiving favorable attention.This work underscores the significant application potential of SLM Mg-RE alloys and establishes a strong foundation for advancing their use in the biomedical fields.展开更多
文摘[Objective] To study current development and utilization of water resources in Yuan'an County and countermeasures. [Method] On the basis of analyzing basic characteristics of water resources in Yuan'an County as well as its current development and utilization, problems in the development and utilization of water resources in the study area were pointed out, and feasible countermeasures were proposed correspondingly. [Result] The county is endowed with rich water resources, but the overall use efficiency is low. There are many problems in the development and utilization of local water resources, such as pollution of water source, water and soil loss and so on. [Conclusion] In view of the problems, feasible suggestions were given to provide scientific support for the reasonable development and utilization of water resources in Yuan'an County.
文摘背景与目的 肺腺癌易发生脑转移,患者预后极差。蛋白磷酸酶1调节亚基13样(protein phosphatase 1 regulatory subunit 13-like, PPP1R13L)基因编码的p53凋亡刺激蛋白家族抑制成员(inhibitor of apoptosis-stimulating protein of p53, iASPP)蛋白是p53通路的关键抑制因子,在多种肿瘤中促癌,但其在肺腺癌脑转移中的作用未知。本研究通过单细胞测序数据整合与临床样本分析,旨在分析肺腺癌脑转移患者的肿瘤微环境特征,并探讨PPP1R13L在脑转移组织中的表达情况及其临床意义。方法 收集2014年1月至2024年12月新疆医科大学附属肿瘤医院就诊的4例肺腺癌脑转移和2例少突胶质细胞瘤患者的脑组织进行单细胞测序,并结合公共数据库中4例肺腺癌样本和4例正常肺组织样本的单细胞测序数据解析肿瘤微环境;另收集此医院50例肺腺癌脑转移患者的临床资料及石蜡切片,采用免疫组化技术检测iASPP蛋白表达,分析其与临床特征及预后的关系。结果 相较于胶质瘤和肺腺癌组,肺腺癌脑转移组特异的上皮细胞主要富集于氧化磷酸化、细胞凋亡、缺氧和p53通路;PPP1R13L作为上调差异基因,在脑转移组特异上皮细胞亚群高表达;PPP1R13L阳性细胞与成纤维细胞交互作用显著,激活细胞-基质黏附相关通路,关键配体-受体对为I型胶原蛋白α1链-白细胞分化抗原44(collagen type I alpha 1 chain-cluster of differentiation 44, COL1A1-CD44)。临床数据分析显示,吸烟史(HR=2.543, 95%CI:1.159-5.583, P=0.020)和iASPP高表达(HR=3.351, 95%CI:1.310-8.575, P=0.012)为肺腺癌脑转移患者预后的独立危险因素。结论 本研究阐明了肺腺癌脑转移微环境中上皮细胞与成纤维细胞的相互作用,提示PPP1R13L可作为潜在预后标志物及治疗靶点,为肺腺癌脑转移的精准治疗提供依据。
基金the National Natural Science:Foundation of China(52375370)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University(2023-DXSSKF-Z02)+2 种基金the Nat-ural Science Foundation of Shanxi(202103021224049)GDAS Projects of International cooperation platform of Sci-ence and Technology(2022GDASZH-2022010203-003)Guangdong province Science and Technology Plan Projects(2023B1212060045).
文摘The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.
基金supported by the National Key Research and Development Program of China(No.2022YFC2406000)the Guangdong Basic and Applied Basic Research Foundation(2024A1515011024)+5 种基金the Guangzhou Science and Technology Project(2024A04J4943)the Guangdong Academy of Sciences Development Special Fund Project(2022GDASZH-2022010107)the Guangdong province Science and Technology Plan Projects(2023B1212120008,2023B1212060045)the GDAS Projects of International cooperation platform of Science and Technology(2022GDASZH-2022010203-003)Special Support Foundation of Guangdong Province(2023TQ07Z559)Shenzhen Basic Research Project(JCYJ20210324120001003 and JCYJ20220531091802006)。
文摘To clarify the densification behavior,deformation response and strengthening mechanisms of selective laser melted(SLM)Mg-RE alloys,this study systematically investigates a representative WE43 alloy via advanced material characterization techniques.A suitable laser output mode fell into the transition mode,allowing for the fabrication of nearly full-density samples(porosity=0.85±0.021%)with favorable mechanical properties(yield strength=351 MPa,ultimate tensile strength=417 MPa,the elongation at break=6.5%and microhardness=137.9±6.15 HV_(0.1))using optimal processing parameters(P=80 W,v=250 mm/s and d=50μm).Viscoplastic self-consistent analysis and transmission electron microscopy observations reveal that the plastic deformation response of the SLM Mg-RE alloys is primarily driven by basal and prismatic slips.Starting from a random texture before deformation(maximum multiple of ultimate density,Max.MUD=3.95),plastic stretching led the grains to align with the Z-axis,finally resulting in a{0001}<1010>texture orientation after fracture(Max.MUD=8.755).Main phases of the SLM state are mainly composed ofα-Mg,Mg_(24)Y_(5) andβ'-Mg_(41)Nd_(5),with an average grain size of only 4.27μm(about a quarter of that in the extruded state),resulting in a favorable strength-toughness ratio.Except for the nano-β'phase and semi-coherent Mg_(24)Y_(5) phase(mismatch=16.12%)around the grain boundaries,a small amount of nano-ZrO_(2) and Y_(2)O_(3) particles also play a role in dispersion strengthening.The high mechanical properties of the SLM state are chiefly attributed to precipitation hardening(44.41%),solid solution strengthening(34.06%)and grain boundary strengthening(21.53%),with precipitation hardening being predominantly driven by dislocation strengthening(67.77%).High-performance SLM Mg-RE alloy components were manufactured and showcased at TCT Asia 2024,receiving favorable attention.This work underscores the significant application potential of SLM Mg-RE alloys and establishes a strong foundation for advancing their use in the biomedical fields.
