[据Journal of Experimental&Clinical Cancer Research 2021年1月报道]题:HBV编码的P蛋白通过FOXO3/miRNA-30b-5p/MINPP1轴启动糖酵解旁路促进HBV相关肝细胞癌的发展(作者Chen W等)HBV慢性感染是引起肝癌的最主要病因,但其发病机...[据Journal of Experimental&Clinical Cancer Research 2021年1月报道]题:HBV编码的P蛋白通过FOXO3/miRNA-30b-5p/MINPP1轴启动糖酵解旁路促进HBV相关肝细胞癌的发展(作者Chen W等)HBV慢性感染是引起肝癌的最主要病因,但其发病机制尚未完全阐明。展开更多
【据Journal of Gastroenterology and Hepatology 2020年6月报道】题:非酒精性脂肪性肝病男性人群患结直肠息肉风险增高:一项系统回顾和荟萃分析(作者Chen W等)该荟萃分析旨在探讨非酒精性脂肪性肝病(NAFLD)患者发生结直肠息肉的风险...【据Journal of Gastroenterology and Hepatology 2020年6月报道】题:非酒精性脂肪性肝病男性人群患结直肠息肉风险增高:一项系统回顾和荟萃分析(作者Chen W等)该荟萃分析旨在探讨非酒精性脂肪性肝病(NAFLD)患者发生结直肠息肉的风险。来自汕头大学医学院第一附属医院的Chen等根据预设的关键词检索了PubMed、EMBASE和Cochrane图书馆数据库,以全面检索、确定符合条件的研究(截至2019年11月7日)。通过标准化的信息收集表格从合格的研究中提取相应数据,并使用随机效应模型进行荟萃分析,同时进行了异质性评估(I 2)、亚组分析、Meta回归分析和发表偏倚分析。展开更多
Dong M,Yu X,Chen W,et a1.Osteopontinpromotes bone destruction in periapieal periodontitisby activating the NF—κB pathway.Cell PhysiolBiochem,2018,49:3.目的:根尖周炎由细菌感染引起.导致牙槽骨破坏和牙脱落。骨桥蛋白(OPN...Dong M,Yu X,Chen W,et a1.Osteopontinpromotes bone destruction in periapieal periodontitisby activating the NF—κB pathway.Cell PhysiolBiochem,2018,49:3.目的:根尖周炎由细菌感染引起.导致牙槽骨破坏和牙脱落。骨桥蛋白(OPN)是一种磷酸化糖蛋白.参与骨代谢。方法:对33例慢性根尖周炎患者和10例因正畸切除健康牙体组织(对照)的患者进行研究.建立小鼠根尖周炎动物模型进行体内实验.分析OPN与根尖周炎中骨质破坏的关系。在体外培养成骨细胞和破骨细胞并用脂多糖处理。NF—κB的抑制剂用于预处理转染的细胞。结果:OPN增加破骨细胞增殖和分化,但减少成骨细胞增殖和分化。OPN在根尖周炎期间激活NF—KB通路.加速P65从细胞质向细胞核的转移和磷酸化。结论:OPN在根尖周炎的发展过程中发挥重要作用.并且在根尖周炎期间骨关节代谢中起双重作用.将破骨细胞与成骨细胞联系起来。其潜在的机制可能与NF—κB途径有关。展开更多
Shrinkage-compensating concrete can enhance the permeability and strength. In addition,expansive admixture can densify concrete to advance the carbonation resistance ability. Due to special quality of ettringite,the r...Shrinkage-compensating concrete can enhance the permeability and strength. In addition,expansive admixture can densify concrete to advance the carbonation resistance ability. Due to special quality of ettringite,the relative humidity of curing environment has significant effect on the carbonation rate of concrete. This paper discusses the influence of environmental humidity on carbonation rate of shrinkage-compensating concrete. Four different curing conditions were set up,namely the natural environment (RH 60%),standard environment (RH 90%),early age water curing environment for 3 d and 7 d. After curing in these four environments for 28 d,an accelerated carbonation test was performed. Micro-hardness analysis was used to evaluate surface hardness,which depends on,to a great degree,the carbonation depth. TG-DSC analysis was used to study Ca(OH)2 content gradient in the surface layer of concrete in different environment. The results show that natural condition lead to a relatively worse carbonation degree,curing in water for 3 d is harmful to the carbonation resistance,while curing in water for 7 d lead to an equivalent carbonation degree with standard condition,which show the most improvement to carbonation resistance ability.展开更多
文摘[据Journal of Experimental&Clinical Cancer Research 2021年1月报道]题:HBV编码的P蛋白通过FOXO3/miRNA-30b-5p/MINPP1轴启动糖酵解旁路促进HBV相关肝细胞癌的发展(作者Chen W等)HBV慢性感染是引起肝癌的最主要病因,但其发病机制尚未完全阐明。
文摘【据Journal of Gastroenterology and Hepatology 2020年6月报道】题:非酒精性脂肪性肝病男性人群患结直肠息肉风险增高:一项系统回顾和荟萃分析(作者Chen W等)该荟萃分析旨在探讨非酒精性脂肪性肝病(NAFLD)患者发生结直肠息肉的风险。来自汕头大学医学院第一附属医院的Chen等根据预设的关键词检索了PubMed、EMBASE和Cochrane图书馆数据库,以全面检索、确定符合条件的研究(截至2019年11月7日)。通过标准化的信息收集表格从合格的研究中提取相应数据,并使用随机效应模型进行荟萃分析,同时进行了异质性评估(I 2)、亚组分析、Meta回归分析和发表偏倚分析。
文摘Dong M,Yu X,Chen W,et a1.Osteopontinpromotes bone destruction in periapieal periodontitisby activating the NF—κB pathway.Cell PhysiolBiochem,2018,49:3.目的:根尖周炎由细菌感染引起.导致牙槽骨破坏和牙脱落。骨桥蛋白(OPN)是一种磷酸化糖蛋白.参与骨代谢。方法:对33例慢性根尖周炎患者和10例因正畸切除健康牙体组织(对照)的患者进行研究.建立小鼠根尖周炎动物模型进行体内实验.分析OPN与根尖周炎中骨质破坏的关系。在体外培养成骨细胞和破骨细胞并用脂多糖处理。NF—κB的抑制剂用于预处理转染的细胞。结果:OPN增加破骨细胞增殖和分化,但减少成骨细胞增殖和分化。OPN在根尖周炎期间激活NF—KB通路.加速P65从细胞质向细胞核的转移和磷酸化。结论:OPN在根尖周炎的发展过程中发挥重要作用.并且在根尖周炎期间骨关节代谢中起双重作用.将破骨细胞与成骨细胞联系起来。其潜在的机制可能与NF—κB途径有关。
基金supported by the National Fundamental Scientific Research Project(PR China),relevant to"Basic research in Environmentally Friendly Concrete (2009CB623201)"
文摘Shrinkage-compensating concrete can enhance the permeability and strength. In addition,expansive admixture can densify concrete to advance the carbonation resistance ability. Due to special quality of ettringite,the relative humidity of curing environment has significant effect on the carbonation rate of concrete. This paper discusses the influence of environmental humidity on carbonation rate of shrinkage-compensating concrete. Four different curing conditions were set up,namely the natural environment (RH 60%),standard environment (RH 90%),early age water curing environment for 3 d and 7 d. After curing in these four environments for 28 d,an accelerated carbonation test was performed. Micro-hardness analysis was used to evaluate surface hardness,which depends on,to a great degree,the carbonation depth. TG-DSC analysis was used to study Ca(OH)2 content gradient in the surface layer of concrete in different environment. The results show that natural condition lead to a relatively worse carbonation degree,curing in water for 3 d is harmful to the carbonation resistance,while curing in water for 7 d lead to an equivalent carbonation degree with standard condition,which show the most improvement to carbonation resistance ability.
