Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms lig...Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.展开更多
Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR clo...Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration limitations.Here,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption layer.The top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass through.Meanwhile,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric synergy.Through theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ranges.Specifically,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of 0.35.Additionally,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.展开更多
Multifunctional compatible stealth materials have emerged as the focal point of contemporary protection technology research and vanadium-based nanomaterials play a pivotal role in the development of advanced stealth m...Multifunctional compatible stealth materials have emerged as the focal point of contemporary protection technology research and vanadium-based nanomaterials play a pivotal role in the development of advanced stealth materials.Here,a compatible stealth aerogel is successfully synthesized by employing mixed-valence decavanadate as the vanadium oxide(VO_(x))molecular model.Ultralight{V^(Ⅳ)VV_(9)}/MXene aerogel(0.0429 g cm^(-3))exhibits exceptional radar stealth performance with a minimal reflection loss(RL_(min))of−57.74 dB(99.9998%EMW absorption)and a significantly superior radar cross section reduction value of 26.77 dB m2.The aerogel’s exceptional properties,including a low infrared(IR)emissivity(0.479)and a low thermal conductivity of(32.30 mW m^(-1)K^(-1)),are crucial for enabling compatibility with IR and thermal stealth technologies.The presence of a mixed-valence polyoxovanadate cluster leads to an increase in the Schottky barrier and enhances magnetic properties,consequently boosting interfacial polarization and contributing to magnetic losses during electromagnetic wave(EMW)absorption.Consequently,altering the number of valence electrons significantly enhances the compatible stealth capabilities.These findings contribute significantly to our comprehension of how microstructure impacts EMW absorption processes and provide a basis for further research into the development of VO_(x)-based compatible stealth materials.展开更多
Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansi...Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansion often results in electrode disintegration and capacity loss.Herein,a microporous Si anode with the SiO_(x)/C layer functionalized all-surface and high tap density(~0.65 g cm^(-3))is developed by the hydrolysis-driven strategy that avoids the common use of corrosive etchants and toxic siloxane reagents.The functionalized inner pore with superior structural stability can effectively alleviate the volume change and enhance the electrolyte contact.Simultaneously,the outer particle surface forms a continuous network that prevents electrolyte parasitic decomposition,disperses the interface stress of Si matrix and facilitates electron/ion transport.As a result,the micron-sized Si anode shows only~9.94 GPa average stress at full lithiation state and delivers an impressive capacity of 901.1 mAh g^(-1)after 500 cycles at 1 A g^(-1).It also performs excellent rate performance of 1123.0 mAh g^(-1)at 5 A g^(-1)and 850.4 at 8 A g^(-1),far exceeding most of reported literatures.Furthermore,when paired with a commercial LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),the pouch cell demonstrates high capacity and desirable cyclic performance.展开更多
LiNi_(0.5)Mn_(1.5)O_4(LNMO) was prepared by a high-temperature solid phase method,and then Al PO_(4)(AP) was coated on the polyhedral LNMO surface by the wet chemical method.The experimental results showed that the LN...LiNi_(0.5)Mn_(1.5)O_4(LNMO) was prepared by a high-temperature solid phase method,and then Al PO_(4)(AP) was coated on the polyhedral LNMO surface by the wet chemical method.The experimental results showed that the LNMO-1%AP|Li cell prepared with a 1%mass ratio of Al PO_(4and) LNMO had better electrochemical performance;after 450 cycles at 1C,its discharge specific capacity maintained 108.78 m Ah·g^(-1),while that of the LNMO|Li cell was only 86.04 m Ah·g^(-1).Especially at the high rates of 5C and 10C,the electrochemical properties of the former were far superior to the latter.This was attributed to the fact that the AP coating made the surface of LNMO in contact with the electrolyte more stable,effectively promoted the Li~+transport,and reduced the polarization voltage of the electrode.展开更多
Immunosuppressed patients have increased susceptibility to various infections,including opportunistic infections.The risk of infective complications in these patients is significantly higher,which can lead to more sev...Immunosuppressed patients have increased susceptibility to various infections,including opportunistic infections.The risk of infective complications in these patients is significantly higher,which can lead to more severe infections,prolonged illness course,and an increased likelihood of poor outcome,including sepsis,organ failure,and even death.Blue rubber bleb nevus syndrome(BRBNS)is a rare syndrome characterized by venous malformations primarily found in the skin and gastrointestinal(GI)tract.展开更多
Dear Editor,Hepatitis B virus(HBV)is a small,enveloped DNA virus and a member of the Hepadnaviridae family(Zhao et al.,2020).It is a major human pathogen causing chronic liver disease,leading to significant morbidity ...Dear Editor,Hepatitis B virus(HBV)is a small,enveloped DNA virus and a member of the Hepadnaviridae family(Zhao et al.,2020).It is a major human pathogen causing chronic liver disease,leading to significant morbidity and mortality worldwide(Xia and Liang,2019).According to the World Health Organization(WHO),an estimated 296 million people live with chronic HBV infection,contributing to around 820,000 deaths annually due to complications such as liver cirrhosis and hepatocellular carcinoma(HCC)(Easterbrook et al.,2021).展开更多
Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,...Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,can be an adjuvant therapy to benefit patients with ICH by improving clinical efficacy.However,in theory,using PBCRBS to treat ICH carries the risk of hematoma enlargement and rebleeding,which has led to controversy over its application in ICH treatment.To demonstrate the effectiveness and safety of PBCRBS in treating ICH,this review first analyzes the pathological and physiological basis of ICH and secondly,the cascade of response after ICH and the involvement of cytokines and signaling pathways in this process.Finally,experimental and clinical studies on the treatment of ICH with PBCRBS over the past decade were retrieved from the Pub Med and China National Knowledge Infrastructure databases,and the content of these studies was used to summarize commonly used herbs with PBCRBS effects and their mechanisms of action.Through analysis,hypertension has been identified as the most common cause of ICH.Heme,interleukin,reactive oxygen species,coagulation promoting particles and other induced mass effects,inflammation,oxidative stress,and coagulation cascade reactions lead to brain damage following ICH.This review includes 56 experimental studies and 83 clinical studies summarizing 28 commonly used herbs,demonstrating the positive impact of PBCRBS as an adjuvant therapy for ICH.In summary,PBCRBS appears effective and safe for treating ICH.展开更多
To accurately identify the factors affecting the formation of stable aggregates in bauxite residue during the soil formation process,the comprehensive effects of a combined chemical-biological amelioration strategy in...To accurately identify the factors affecting the formation of stable aggregates in bauxite residue during the soil formation process,the comprehensive effects of a combined chemical-biological amelioration strategy including solid wastes and a functional microorganism on aggregate size distribution and its stability in bauxite residue were investigated during a 365-d simulation experiment.The results showed that the combined amelioration effectively reduced the saline alkalinity of bauxite residue,and markedly changed the contents of aggregate-associated chemical binding agents.Desulfurization gypsum and maize straw-Penicillium oxalicum(P.oxalicum)differentiated the formation of aggregates within different sizes.Maize straw-P.oxalicum stimulated the formation of water-stable macroaggregates with more durable erosion resistance by the wet-sieving and laser dynamic diffraction analysis.The Pearson correlation analysis showed that exchangeable polyvalent metal ions,pyrophosphate extractable Fe oxide,and organic carbon exhibited positive correlations with aggregate stability during the 365-d incubation.The findings in this study may provide data support and engineering practical reference for ecological restoration in the disposal areas.展开更多
Quorum sensing(QS)represents a mechanism through which bacteria engage in communication via chemical signals,a phenomenon prevalent across diverse bacterial species.Recent investigations have elucidated that QS signal...Quorum sensing(QS)represents a mechanism through which bacteria engage in communication via chemical signals,a phenomenon prevalent across diverse bacterial species.Recent investigations have elucidated that QS signaling pathways are pivotal in governing bacterial physiological processes,collective behaviors,and the emergence of drug resistance.Escherichia coli(E.coli),a prominent pathogenic bacterium,is increasingly exhibiting severe drug resistance issues,posing substantial hurdles for clinical interventions.Presently,a burgeoning body of research is exploring the connection between QS signaling pathways and the drug resistance mechanisms in E.coli,unveiling the coordinating function of QS within bacterial communities and its influence on antibiotic resistance.Despite some research advancements,the precise mechanisms underlying the QS signaling pathway remain ambiguous,and its potential applications are somewhat constrained.This article endeavors to systematically review the research progress concerning the QS signaling pathway in the context of clinical drug resistance mechanisms in E.coli,delving into its potential clinical applications and future research avenues,with the aim of offering novel insights and strategies to counteract drug resistance.展开更多
Helicobacter pylori(H.pylori)infection is prevalent among Chinese military personnel,with regional rates exceeding 40%,and is a well-established risk factor for gastric cancer.Addressing this infection is vital for im...Helicobacter pylori(H.pylori)infection is prevalent among Chinese military personnel,with regional rates exceeding 40%,and is a well-established risk factor for gastric cancer.Addressing this infection is vital for improving soldiers'health and operational readiness while reducing the long-term healthcare burden.This commentary explores the feasibility and advantages of incorporating traditional Chinese medicine(TCM)into strategies for managing and preventing H.pylori infections within the military.TCM offers a multi-target mechanism that not only combats bacterial infections but also enhances gastrointestinal health and boosts immunity,making it particularly effective in high-stress environments like the military.Unlike antibiotics,TCM is less likely to induce resistance even with large-scale use,providing a sustainable treatment option.Its affordability and cultural acceptance among Chinese personnel further enhance its feasibility.Additionally,TCM's history in military medicine supports its credibility,and its flexibility allows for personalized treatment tailored to individual soldiers'needs.TCM's convenient storage and deployment make it ideal for remote and challenging environments.Integrating TCM into military healthcare systems could provide a holistic,cost-effective,and sustainable approach to managing H.pylori infections,reducing prevalence and associated risks such as gastric cancer.Future research and pilot programs are essential to validate TCM's effectiveness and implementation in military settings.展开更多
The commercialization of polymer electrolyte membrane water splitting technology significantly depends on the oxygen/hydrogen evolution reaction(OER/HER)electrocatalysts;customarily catalyzed by platinum(Pt)and ruthen...The commercialization of polymer electrolyte membrane water splitting technology significantly depends on the oxygen/hydrogen evolution reaction(OER/HER)electrocatalysts;customarily catalyzed by platinum(Pt)and ruthenium/iridium oxides(RuO_(2)/IrO_(2)).In this work,we have devised a novel strategy to improve the catalytic activities towards OER and HER catalysis via the decoration of RuO_(2)with Pt.Pt dopants in ruthenium oxides(Pt-RuO_(2))create more oxygen vacancies inducing a weaker interaction between active site and oxygen reaction intermediates,evidenced by downshifted d band center and increment in e_(g)orbital filling of Ru atom;thereby,the acidic OER performance of Pt-RuO_(2)is enhanced by 3.5-fold than commercial RuO_(2)by mean of turnover frequency at 1.6 V vs.RHE.Moreover,Pt-RuO_(2)exhibits a similar HER performance to commercial Pt/C.The potential for overall water splitting is decreased by 0.18 V at100 mA/cm^(2);besides,an excellent stability is also recorded after the incorporation of Pt dopants.TheΔ_(ε_(d-p))value of Pt-RuO_(2)was 1.76 e V,which is lower than the counterpart of RuO_(2),suggesting easy electron transition between d and p orbitals,suppressing the over-oxidation of RuO_(2);thereby,a higher stability is achieved for Pt-RuO_(2).The invitation of Pt dopants to boost catalytic activity and stability has also been extended to IrO_(2).展开更多
文摘Herein,3‑aminopropyltriethoxysilane(APTES)was used to modify F‑containing silica slag(SS)by simple grafting and served as a multifunctional barrier layer.The amino group(—NH2)in the amino‑modified SS(NH2‑SS)forms ligand bonds or hydrogen bonds with sulfur ions in lithium polysulfides(LiPSs),thus inhibiting the shuttle effect.Electrochemical analyses demonstrated that lithium‑sulfur(Li‑S)batteries employing the NH2‑SS interlayer exhibited discharge specific capacities of 1048 and 789 mAh·g^(-1) at 0.2C and 2C,respectively,and even at 4C,the initial discharge specific capacity remained at 590 mAh·g^(-1),outperforming the Li‑S battery with unmodified SS as the interlayer.
基金financial support from the National Nature Science Foundation of China(No.52273247)the National Science and Technology Major Project of China(J2019-VI-0017-0132).
文摘Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration limitations.Here,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption layer.The top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass through.Meanwhile,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric synergy.Through theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ranges.Specifically,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of 0.35.Additionally,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.
基金supported by the Natural Science Foundation of Hunan Province(No.2024JJ5419)the Hunan Provincial Key Research and Development Plan Project in 2024(No.2024JK2074)+1 种基金the Natural Science Foundation of Changsha(No.2023-197)the Open project of the Key Laboratory of digital flavor research of Hunan China Tobacco Industry Co.,Ltd(No.202143000834024).
文摘Multifunctional compatible stealth materials have emerged as the focal point of contemporary protection technology research and vanadium-based nanomaterials play a pivotal role in the development of advanced stealth materials.Here,a compatible stealth aerogel is successfully synthesized by employing mixed-valence decavanadate as the vanadium oxide(VO_(x))molecular model.Ultralight{V^(Ⅳ)VV_(9)}/MXene aerogel(0.0429 g cm^(-3))exhibits exceptional radar stealth performance with a minimal reflection loss(RL_(min))of−57.74 dB(99.9998%EMW absorption)and a significantly superior radar cross section reduction value of 26.77 dB m2.The aerogel’s exceptional properties,including a low infrared(IR)emissivity(0.479)and a low thermal conductivity of(32.30 mW m^(-1)K^(-1)),are crucial for enabling compatibility with IR and thermal stealth technologies.The presence of a mixed-valence polyoxovanadate cluster leads to an increase in the Schottky barrier and enhances magnetic properties,consequently boosting interfacial polarization and contributing to magnetic losses during electromagnetic wave(EMW)absorption.Consequently,altering the number of valence electrons significantly enhances the compatible stealth capabilities.These findings contribute significantly to our comprehension of how microstructure impacts EMW absorption processes and provide a basis for further research into the development of VO_(x)-based compatible stealth materials.
基金supported by the National Natural Science Foundation of China Projects(Nos.52271213,52202299).
文摘Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansion often results in electrode disintegration and capacity loss.Herein,a microporous Si anode with the SiO_(x)/C layer functionalized all-surface and high tap density(~0.65 g cm^(-3))is developed by the hydrolysis-driven strategy that avoids the common use of corrosive etchants and toxic siloxane reagents.The functionalized inner pore with superior structural stability can effectively alleviate the volume change and enhance the electrolyte contact.Simultaneously,the outer particle surface forms a continuous network that prevents electrolyte parasitic decomposition,disperses the interface stress of Si matrix and facilitates electron/ion transport.As a result,the micron-sized Si anode shows only~9.94 GPa average stress at full lithiation state and delivers an impressive capacity of 901.1 mAh g^(-1)after 500 cycles at 1 A g^(-1).It also performs excellent rate performance of 1123.0 mAh g^(-1)at 5 A g^(-1)and 850.4 at 8 A g^(-1),far exceeding most of reported literatures.Furthermore,when paired with a commercial LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),the pouch cell demonstrates high capacity and desirable cyclic performance.
文摘LiNi_(0.5)Mn_(1.5)O_4(LNMO) was prepared by a high-temperature solid phase method,and then Al PO_(4)(AP) was coated on the polyhedral LNMO surface by the wet chemical method.The experimental results showed that the LNMO-1%AP|Li cell prepared with a 1%mass ratio of Al PO_(4and) LNMO had better electrochemical performance;after 450 cycles at 1C,its discharge specific capacity maintained 108.78 m Ah·g^(-1),while that of the LNMO|Li cell was only 86.04 m Ah·g^(-1).Especially at the high rates of 5C and 10C,the electrochemical properties of the former were far superior to the latter.This was attributed to the fact that the AP coating made the surface of LNMO in contact with the electrolyte more stable,effectively promoted the Li~+transport,and reduced the polarization voltage of the electrode.
基金funded by Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-007A).
文摘Immunosuppressed patients have increased susceptibility to various infections,including opportunistic infections.The risk of infective complications in these patients is significantly higher,which can lead to more severe infections,prolonged illness course,and an increased likelihood of poor outcome,including sepsis,organ failure,and even death.Blue rubber bleb nevus syndrome(BRBNS)is a rare syndrome characterized by venous malformations primarily found in the skin and gastrointestinal(GI)tract.
基金supported by the National Key Research and Development Program of China(No.2023YFC2308500)the Fundamental Research Funds for the Central Universities(project no.2042024kf0026),the Open Grant from the Pingyuan Laboratory(2023PY-OP-0101)+3 种基金the National Natural Science Foundation of China(project no.81971936,32100125 and 32300131)Hubei Province's Outstanding Medical Academic Leader Program,East Lake Hi-tech Development Zone Unveiling and Commanding Project(No.2023KJB219)Science and Technology Talent Service Enterprise Project(No.2024DJC064)Basic and Clinical Medical Research Joint Fund of Zhongnan Hospital,Wuhan University.
文摘Dear Editor,Hepatitis B virus(HBV)is a small,enveloped DNA virus and a member of the Hepadnaviridae family(Zhao et al.,2020).It is a major human pathogen causing chronic liver disease,leading to significant morbidity and mortality worldwide(Xia and Liang,2019).According to the World Health Organization(WHO),an estimated 296 million people live with chronic HBV infection,contributing to around 820,000 deaths annually due to complications such as liver cirrhosis and hepatocellular carcinoma(HCC)(Easterbrook et al.,2021).
基金National Natural Science Foundation of China:Study on the Intervention Mechanism of Zhilong Huoxue Tongyu Capsule in Hypertensive Myocardial Fibrosis by Regulating Transforming Growth Factor-β/Smad3/Erbb4-IR/miR29b Loop (No.82074378)Project of Science & Technology Department of Sichuan Province:Research on the Optimization of Basic and Clinical Plans for Treating Coronary Heart Disease and Heart Failure based on Xuanfu Theory (No.2022YFS0618)+1 种基金Luzhou Science and Technology Bureau Project:the Mechanism of Hirudin Inhibiting AngⅡInduced Myocardial Hypertrophy by Regulating Autophagy and NOD-like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome (No.2023JYJ029)Southwest Medical University Project:Study on the Mechanism of Zhilong Huoxue Tongyu Capsules in Improving NOD-like Receptor Family Pyrin Domain Containing Protein 3 Inflammasome Mediated Cardiomyocyte Pyroptosis in Heart Failure by Regulating the HippoYes-Associated Protein Pathway (No.2023ZYYQ04)。
文摘Intracerebral hemorrhage(ICH) is a significant and growing threat to human health,with increasing incidence.Promoting blood circulation and removing blood stasis therapy(PBCRBS),a Traditional Chinese Medicine therapy,can be an adjuvant therapy to benefit patients with ICH by improving clinical efficacy.However,in theory,using PBCRBS to treat ICH carries the risk of hematoma enlargement and rebleeding,which has led to controversy over its application in ICH treatment.To demonstrate the effectiveness and safety of PBCRBS in treating ICH,this review first analyzes the pathological and physiological basis of ICH and secondly,the cascade of response after ICH and the involvement of cytokines and signaling pathways in this process.Finally,experimental and clinical studies on the treatment of ICH with PBCRBS over the past decade were retrieved from the Pub Med and China National Knowledge Infrastructure databases,and the content of these studies was used to summarize commonly used herbs with PBCRBS effects and their mechanisms of action.Through analysis,hypertension has been identified as the most common cause of ICH.Heme,interleukin,reactive oxygen species,coagulation promoting particles and other induced mass effects,inflammation,oxidative stress,and coagulation cascade reactions lead to brain damage following ICH.This review includes 56 experimental studies and 83 clinical studies summarizing 28 commonly used herbs,demonstrating the positive impact of PBCRBS as an adjuvant therapy for ICH.In summary,PBCRBS appears effective and safe for treating ICH.
基金Projects(42177391,42477437)supported by the National Natural Science Foundation of ChinaProject(2024RC3041)supported by the Science and Technology Innovation Program of Hunan Province,China+1 种基金Project(2023CXQD064)supported by the Innovation-Driven Research Programme of Central South University,ChinaProject(242102321124)supported by the Henan Provincal Science and Technology Research Project,China。
文摘To accurately identify the factors affecting the formation of stable aggregates in bauxite residue during the soil formation process,the comprehensive effects of a combined chemical-biological amelioration strategy including solid wastes and a functional microorganism on aggregate size distribution and its stability in bauxite residue were investigated during a 365-d simulation experiment.The results showed that the combined amelioration effectively reduced the saline alkalinity of bauxite residue,and markedly changed the contents of aggregate-associated chemical binding agents.Desulfurization gypsum and maize straw-Penicillium oxalicum(P.oxalicum)differentiated the formation of aggregates within different sizes.Maize straw-P.oxalicum stimulated the formation of water-stable macroaggregates with more durable erosion resistance by the wet-sieving and laser dynamic diffraction analysis.The Pearson correlation analysis showed that exchangeable polyvalent metal ions,pyrophosphate extractable Fe oxide,and organic carbon exhibited positive correlations with aggregate stability during the 365-d incubation.The findings in this study may provide data support and engineering practical reference for ecological restoration in the disposal areas.
基金Research on the Resistance Mechanism of Carbapenem-Resistant Escherichia coli in Patients with Urosepsis Based on Bacterial Droplet Single-Cell RNA Sequencing(Project No.:MTyk2024-34,2024.01-2026-12)。
文摘Quorum sensing(QS)represents a mechanism through which bacteria engage in communication via chemical signals,a phenomenon prevalent across diverse bacterial species.Recent investigations have elucidated that QS signaling pathways are pivotal in governing bacterial physiological processes,collective behaviors,and the emergence of drug resistance.Escherichia coli(E.coli),a prominent pathogenic bacterium,is increasingly exhibiting severe drug resistance issues,posing substantial hurdles for clinical interventions.Presently,a burgeoning body of research is exploring the connection between QS signaling pathways and the drug resistance mechanisms in E.coli,unveiling the coordinating function of QS within bacterial communities and its influence on antibiotic resistance.Despite some research advancements,the precise mechanisms underlying the QS signaling pathway remain ambiguous,and its potential applications are somewhat constrained.This article endeavors to systematically review the research progress concerning the QS signaling pathway in the context of clinical drug resistance mechanisms in E.coli,delving into its potential clinical applications and future research avenues,with the aim of offering novel insights and strategies to counteract drug resistance.
基金Supported by Shenzhen Science and Technology Program,No.RCBS20231211090733052 and No.JCYJ20240813150221028Guangdong Basic and Applied Basic Research Foundation,No.2023A1515111044and Postdoctoral Fellowship Program of CPSF,No.GZC20233233.
文摘Helicobacter pylori(H.pylori)infection is prevalent among Chinese military personnel,with regional rates exceeding 40%,and is a well-established risk factor for gastric cancer.Addressing this infection is vital for improving soldiers'health and operational readiness while reducing the long-term healthcare burden.This commentary explores the feasibility and advantages of incorporating traditional Chinese medicine(TCM)into strategies for managing and preventing H.pylori infections within the military.TCM offers a multi-target mechanism that not only combats bacterial infections but also enhances gastrointestinal health and boosts immunity,making it particularly effective in high-stress environments like the military.Unlike antibiotics,TCM is less likely to induce resistance even with large-scale use,providing a sustainable treatment option.Its affordability and cultural acceptance among Chinese personnel further enhance its feasibility.Additionally,TCM's history in military medicine supports its credibility,and its flexibility allows for personalized treatment tailored to individual soldiers'needs.TCM's convenient storage and deployment make it ideal for remote and challenging environments.Integrating TCM into military healthcare systems could provide a holistic,cost-effective,and sustainable approach to managing H.pylori infections,reducing prevalence and associated risks such as gastric cancer.Future research and pilot programs are essential to validate TCM's effectiveness and implementation in military settings.
基金supported by the National Natural Science Foundation of China(No.22209126)the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices,Ministry of Education,Jianghan University(No.JDGD-202314)。
文摘The commercialization of polymer electrolyte membrane water splitting technology significantly depends on the oxygen/hydrogen evolution reaction(OER/HER)electrocatalysts;customarily catalyzed by platinum(Pt)and ruthenium/iridium oxides(RuO_(2)/IrO_(2)).In this work,we have devised a novel strategy to improve the catalytic activities towards OER and HER catalysis via the decoration of RuO_(2)with Pt.Pt dopants in ruthenium oxides(Pt-RuO_(2))create more oxygen vacancies inducing a weaker interaction between active site and oxygen reaction intermediates,evidenced by downshifted d band center and increment in e_(g)orbital filling of Ru atom;thereby,the acidic OER performance of Pt-RuO_(2)is enhanced by 3.5-fold than commercial RuO_(2)by mean of turnover frequency at 1.6 V vs.RHE.Moreover,Pt-RuO_(2)exhibits a similar HER performance to commercial Pt/C.The potential for overall water splitting is decreased by 0.18 V at100 mA/cm^(2);besides,an excellent stability is also recorded after the incorporation of Pt dopants.TheΔ_(ε_(d-p))value of Pt-RuO_(2)was 1.76 e V,which is lower than the counterpart of RuO_(2),suggesting easy electron transition between d and p orbitals,suppressing the over-oxidation of RuO_(2);thereby,a higher stability is achieved for Pt-RuO_(2).The invitation of Pt dopants to boost catalytic activity and stability has also been extended to IrO_(2).
