Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppressi...Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppression of migration in lung cancer cells (1,2)Focusing on metastatic process, the ability of cancer cells to grow in an anchorage-independent condition determines the success of cancer metastasis [3].展开更多
The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cyto...The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cytokines and reactive species are found to be intensified.Among them,the concentrations of nitric oxide(NO),a reactive nitrogen species synthesized by many cells,such as endothelial,immune,and tumor cells,are found to be dramatically increased in lung cancer environments[1].Additionally,clinical observation has shown that NO levels in the lungs of lung cancer patients were increased in comparison to those of normal subjects[2].Together,these studies strongly support the role of NO in tumorigenesis and metastasis,although the underlying mechanisms remain obscure.展开更多
文摘Physiological effects of ouabain (Fig. 1A), a human endogenous hormone, have been intensively investigated nowadays.Recent studies demonstrate anticancer activity of ouabain in sensitization of apoptosis and suppression of migration in lung cancer cells (1,2)Focusing on metastatic process, the ability of cancer cells to grow in an anchorage-independent condition determines the success of cancer metastasis [3].
文摘The cancer microenvironment has been reported to have a significant impact on cancer cells in many ways.Indeed,in such an active environment,cell signaling molecules as well as mediators including proinflammatory cytokines and reactive species are found to be intensified.Among them,the concentrations of nitric oxide(NO),a reactive nitrogen species synthesized by many cells,such as endothelial,immune,and tumor cells,are found to be dramatically increased in lung cancer environments[1].Additionally,clinical observation has shown that NO levels in the lungs of lung cancer patients were increased in comparison to those of normal subjects[2].Together,these studies strongly support the role of NO in tumorigenesis and metastasis,although the underlying mechanisms remain obscure.
