Topological polymers play a major role in their inter-action with intracellular organelles to affect their cellular activities owing to their large surface area and multilevel branched structures.Yet,the existing stud...Topological polymers play a major role in their inter-action with intracellular organelles to affect their cellular activities owing to their large surface area and multilevel branched structures.Yet,the existing studies on these polymers mainly focus on the topo-chemical polymerization outside the cells and how these topological polymers interact with the cell outer membrane.Herein,we established an intracel-lular topological polymerization based on the 2′-Te modified oligonucleotides(DNA-Te2),containing two tellurium as polymerization active sites that un-dergo oxidative polymerization inside living cells.The highly oxidized polytelluoxane effectively dis-turbed antioxidant systems by an interaction be-tween Te(IV)and selenoproteins,thus leading to the effective inhibition of cancer cells.More impor-tantly,the generated topological polymer networks were shown to interfere with organelles in cells,ef-fectively affecting the substrate communication be-tween organelles and the cytoplasm,eventually modulating their cellular behavior and killing cancer cells.Biological evaluation showed that our strategy exhibited efficient tumor inhibition effect and good biosafety.Ultimately,we believe our approach pro-vides a new possibility for chemists and biologists to manipulate cellular activity in the realm of topologi-cal polymerization.展开更多
Two-dimensional(2D)ferroelectric materials,which possess electrically switchable spontaneous polarization and can be easily integrated with semiconductor technologies,is of utmost importance in the advancement of high...Two-dimensional(2D)ferroelectric materials,which possess electrically switchable spontaneous polarization and can be easily integrated with semiconductor technologies,is of utmost importance in the advancement of high-integration low-power nanoelectronics.Despite the experimental discovery of certain 2D ferroelectric materials such as CuInP2S6 and In2Se3,achieving stable ferroelectricity at room temperature in these materials continues to present a significant challenge.Herein,stable ferroelectric order at room temperature in the 2D limit is demonstrated in van der Waals SnP_(2)S_(6) atom layers,which can be fabricated via mechanical exfoliation of bulk SnP_(2)S_(6) crystals.Switchable polarization is observed in thin SnP_(2)S_(6) of~7 nm.Importantly,a van der Waals ferroelectric field-effect transistor(Fe-FET)with ferroelectric SnP_(2)S_(6) as top-gate insulator and ptype WTe0.6Se1.4 as the channel was designed and fabricated successfully,which exhibits a clear clockwise hysteresis loop in transfer characteristics,demonstrating ferroelectric properties of SnP_(2)S_(6) atomic layers.In addition,a multilayer graphene/SnP_(2)S_(6)/multilayer graphene van der Waals vertical heterostructure phototransistor was also fabricated successfully,exhibiting improved optoelectronic performances with a responsivity(R)of 2.9 A/W and a detectivity(D)of 1.4×10^(12) Jones.Our results show that SnP_(2)S_(6) is a promising 2D ferroelectric material for ferroelectric-integrated low-power 2D devices.展开更多
基金supported by the National Key R&D Program of China(grant no.2023YFA0915300)the National Natural Science Foundation of China(grant no.52233012)+2 种基金the Funds for Creative Research Groups of China of the National Natural Science Foundation of China(grant no.21821001)the China Postdoctoral Science Foundation(grant no.2022M721799)the Beijing Municipal Natural Science Foundation(grant no.2234086),and the XPLORER PRIZE.
文摘Topological polymers play a major role in their inter-action with intracellular organelles to affect their cellular activities owing to their large surface area and multilevel branched structures.Yet,the existing studies on these polymers mainly focus on the topo-chemical polymerization outside the cells and how these topological polymers interact with the cell outer membrane.Herein,we established an intracel-lular topological polymerization based on the 2′-Te modified oligonucleotides(DNA-Te2),containing two tellurium as polymerization active sites that un-dergo oxidative polymerization inside living cells.The highly oxidized polytelluoxane effectively dis-turbed antioxidant systems by an interaction be-tween Te(IV)and selenoproteins,thus leading to the effective inhibition of cancer cells.More impor-tantly,the generated topological polymer networks were shown to interfere with organelles in cells,ef-fectively affecting the substrate communication be-tween organelles and the cytoplasm,eventually modulating their cellular behavior and killing cancer cells.Biological evaluation showed that our strategy exhibited efficient tumor inhibition effect and good biosafety.Ultimately,we believe our approach pro-vides a new possibility for chemists and biologists to manipulate cellular activity in the realm of topologi-cal polymerization.
基金This work was supported by the National Key Research and Development Program of China(Nos.2021YFE0194200 and 2021YFA1200903)the National Natural Science Foundation of China(No.22175203)+2 种基金the Natural Science Foundation of Guangdong Province(Nos.2022B1515020065 and 2020A1515110821)the Guangzhou Science and Technology Project(No.202102020126)This work was also supported by the Plan Fostering Project of State Key Laboratory of Optoelectronic Materials and Technologies,of Sun Yatsen University(No.OEMT-2021-PZ-02).
文摘Two-dimensional(2D)ferroelectric materials,which possess electrically switchable spontaneous polarization and can be easily integrated with semiconductor technologies,is of utmost importance in the advancement of high-integration low-power nanoelectronics.Despite the experimental discovery of certain 2D ferroelectric materials such as CuInP2S6 and In2Se3,achieving stable ferroelectricity at room temperature in these materials continues to present a significant challenge.Herein,stable ferroelectric order at room temperature in the 2D limit is demonstrated in van der Waals SnP_(2)S_(6) atom layers,which can be fabricated via mechanical exfoliation of bulk SnP_(2)S_(6) crystals.Switchable polarization is observed in thin SnP_(2)S_(6) of~7 nm.Importantly,a van der Waals ferroelectric field-effect transistor(Fe-FET)with ferroelectric SnP_(2)S_(6) as top-gate insulator and ptype WTe0.6Se1.4 as the channel was designed and fabricated successfully,which exhibits a clear clockwise hysteresis loop in transfer characteristics,demonstrating ferroelectric properties of SnP_(2)S_(6) atomic layers.In addition,a multilayer graphene/SnP_(2)S_(6)/multilayer graphene van der Waals vertical heterostructure phototransistor was also fabricated successfully,exhibiting improved optoelectronic performances with a responsivity(R)of 2.9 A/W and a detectivity(D)of 1.4×10^(12) Jones.Our results show that SnP_(2)S_(6) is a promising 2D ferroelectric material for ferroelectric-integrated low-power 2D devices.
