Objective To investigate the association between long-term exposure to ambient fine particulate matter(PM_(2.5))and its constituents and the risk of incident type 2 diabetes mellitus(T2DM),and to examine the modificat...Objective To investigate the association between long-term exposure to ambient fine particulate matter(PM_(2.5))and its constituents and the risk of incident type 2 diabetes mellitus(T2DM),and to examine the modification roles of overweight status.Methods This prospective study included 27,507 adults living in rural China.The annual mean residential exposure to PM_(2.5)and its constituents was estimated using a satellite-based statistical model.Cox models were used to estimate the risk of T2DM associated with PM_(2.5)and its constituents.Stratified analysis quantified the role of overweight status in the association between PM_(2.5)constituents and T2DM.Results Over a median follow-up of 9.4 years,3,001 new T2DM cases were identified.The hazard ratio(HR)for a 10μg/m^(3)increase in ambient PM_(2.5)was 1.30(95%confidence interval[CI]:1.17,1.45).Among the constituents,the strongest association was observed with black carbon.Being overweight significantly modified the association between certain constituents and the risk of T2DM.Participants who were overweight and exposed to the highest quartile of PM_(2.5)constituents had the highest risk of T2DM(HR:2.46,95%CI:2.04,2.97).Conclusions Our findings indicate that PM_(2.5)was associated with an increased risk of T2DM,with black carbon potentially being the primary contributor.Being overweight appeared to enhance the association between PM_(2.5)and T2DM.This suggests that controlling both PM_(2.5)exposure and overweight status may reduce the burden of T2DM.展开更多
基金supported by the National Nature Science Foundation of China(82173600)Shanghai Leading Academic Project of Public Health,China(GWVI-8).
文摘Objective To investigate the association between long-term exposure to ambient fine particulate matter(PM_(2.5))and its constituents and the risk of incident type 2 diabetes mellitus(T2DM),and to examine the modification roles of overweight status.Methods This prospective study included 27,507 adults living in rural China.The annual mean residential exposure to PM_(2.5)and its constituents was estimated using a satellite-based statistical model.Cox models were used to estimate the risk of T2DM associated with PM_(2.5)and its constituents.Stratified analysis quantified the role of overweight status in the association between PM_(2.5)constituents and T2DM.Results Over a median follow-up of 9.4 years,3,001 new T2DM cases were identified.The hazard ratio(HR)for a 10μg/m^(3)increase in ambient PM_(2.5)was 1.30(95%confidence interval[CI]:1.17,1.45).Among the constituents,the strongest association was observed with black carbon.Being overweight significantly modified the association between certain constituents and the risk of T2DM.Participants who were overweight and exposed to the highest quartile of PM_(2.5)constituents had the highest risk of T2DM(HR:2.46,95%CI:2.04,2.97).Conclusions Our findings indicate that PM_(2.5)was associated with an increased risk of T2DM,with black carbon potentially being the primary contributor.Being overweight appeared to enhance the association between PM_(2.5)and T2DM.This suggests that controlling both PM_(2.5)exposure and overweight status may reduce the burden of T2DM.
