Affordable,easily recycled organics with electroactive centers have drawn attention in the pursuit of high-performance aqueous zinc organic batteries(AZOBs).However,intrinsic barriers such as high solubility,unde-sira...Affordable,easily recycled organics with electroactive centers have drawn attention in the pursuit of high-performance aqueous zinc organic batteries(AZOBs).However,intrinsic barriers such as high solubility,unde-sirable potential,and inferior conductivity hinder their further development.To this end,we have designed an advanced cathode material for AZOBs,comprising an n-type polymer with a three-dimensional(3D)building block(HAT-TP)formed by polymerizing 2,3,6,7,10,11-hexacyano-1,4,5,8,9,12-hexazepenanthrene(HAT-CN)and 3D 2,3,6,7,14,15-hexaaminotriptycene(THA-NH 2).The introduction of a 3D architecture not only bolsters the insolubility but also exposes redox-active sites for cation coordination,while the material's extended conjugated system promotes electronic delocalization to increase the redox potential and conductivity.As a result,a HAT-TP battery exhibits a notable initial discharge voltage of 1.32 V at 0.1 A g^(-1),followed by a midpoint voltage of 1.17 V.Remarkably,an ultrastable capacity retention ratio of up to 93.4%is achieved,even after 40,000 cycles at 5 A g^(-1).Theoretical simulations reveal that the elevated discharge potential results from the strong electronic delocalization of HAT-TP,which improves the affinity with cations.Ex situ characterizations and theoretical calculations verify that the reversible Zn^(2+)/H^(+)co-storage mechanism involves only electroactive C=N sites and the best possible coordination paths between them.展开更多
Limitations of current electronic textiles(e-textiles),including poor washability,instability,and inferior sensing capability,are concerns hindering their broad and practical applications in personal health care manag...Limitations of current electronic textiles(e-textiles),including poor washability,instability,and inferior sensing capability,are concerns hindering their broad and practical applications in personal health care management,virtual games,sports,and more.Here,we report an RGO/PANI e-textile via alternative coatings of in situ reduced graphene oxides(RGO)and in situ polymerized polyaniline(PANI),establishing a laminated structure on a knitted textile substrate.As a result of an in situ lamination strategy,our e-textile exhibits excellent breathability(1428 mm s^(-1),greater than that of bare cotton fabric)and outstanding sensitivity(gage factor of 39.7)over a wide strain range(~0.0625–200%).Importantly,we observed exceptional sensing durability even after severe mechanical disturbance of stretching,bending,or twisting(>1500 cycles)and daily machine washes.Detailed analysis revealed that our proposed in situ lamination approach enabled the physical and chemical interactions between sensing active materials and the textile substrate.Furthermore,the electromechanical behavior of our RGO/PANI e-textile was thoroughly analyzed based on an equivalent electrical circuit,which agreed well with the experi-mental data.Example applications of the e-textile were demonstrated for personal health care management,including body motion monitoring,emotional sensing,and flatfoot gait correction.The RGO/PANI e-textile presented in this study holds significant implications for the evolution of health care applications utilizing smart e-textiles.展开更多
Thermoelectric technology,which is characterized by the interconversion between heat and electricity,is demonstrated as an efficient and environmentally friendly route for thermal energy harvesting and solid-state coo...Thermoelectric technology,which is characterized by the interconversion between heat and electricity,is demonstrated as an efficient and environmentally friendly route for thermal energy harvesting and solid-state cooling devices.The pursuit for high-performance room temperature thermoelectric materials is of significant interest.Here,we proposed a design strategy to dramatically improve the thermoelectric response by constructing a hierarchical multiscale conductor network(AgNWs/CNT)in polymer matrix(PEDOT:PSS).At the optimized composition,the highest Seebeck coefficient and electrical conductivity of base treated ternary PEDOT:PSS/AgNWs/CNT composite are optimized to be 58.6μV K^(-1)and~1950 S cm-1.Correspondingly,the power factor is thus calculated to be on the order of 670μV m^(-1)K^(-2),which is among one of the highest values compared with previous reports.The underlying mechanism is illustrated based on detailed structure,morphology and electron transport quantification.This work affords a novel strategy for the future development of high-performance room temperature nanocomposite thermoelectrics.展开更多
Polyaniline(PANI)-based thermoelectric(TE)materials have attracted considerable attention for flexible electronic energy harvesting devices because of properties such assolution processibility,excellent environmental ...Polyaniline(PANI)-based thermoelectric(TE)materials have attracted considerable attention for flexible electronic energy harvesting devices because of properties such assolution processibility,excellent environmental stability,and low cost.However,the typical opposite dependence between electrical conductivity and Seebeck coefficient impedes their development,and tremendous efforts have been devoted to increasing their TE efficiency.展开更多
Objective:lreversible electroporation(IRE)is emerging as a new therapy for locally advanced pancreatic cancer(LAPC).We aimed to conduct survival and safety analyses in L APC patients after treatment with IRE combined ...Objective:lreversible electroporation(IRE)is emerging as a new therapy for locally advanced pancreatic cancer(LAPC).We aimed to conduct survival and safety analyses in L APC patients after treatment with IRE combined with chemotherapy.Methods:A total of 64 patients with LAPC who had received IRE and chemotherapy were retrospectively collected from August 2015 to March 2019 at Sun Yat-sen University Cancer Center.Overall survival(OS)and progression-free survival(PFS)were evaluated using Kaplan-Meier method and compared by the log-rank test.A multivariate Cox regression model was used to determine the prognostic factors of survival.The perioperative complications of IRE were also evaluated.The study was approved by the Institutional Review Board of Sun Yat-sen University Cancer Center(approval No.C2021-003).Results:The median survival of all included patients were 24.63(95%confidence interval:21.78-27.49)for overall survival and 13.00(95%confidence inteval:8.81-17.19)months for progression-free survival,with 96.8%,51.9%,18.3%;and 52.3%,21.5%,7.9%as the 1-,2-and 3-year OS and PFS rates,respectively.Tumor size[OS,hazard ratio(HR)=1.768,P=0.048;PFS,HR=0.304,P=0.010],neoadjuvant chemotherapy(OS,HR=0338,P=0.030;PFS,HR=0.358,P=0.034),carbohydrate antigen 19-9 variation after IRE(OS,HR=19.320,P=0.003;PFS,HR=14.591,P=0.021)and tumor response after neoadjuvant chemotherapy(OS,HR-8.779,P=0.033;PFS,HR-5.562,P=0.008)were predictive factors of survival in patients with LAPC after IRE.Complications were observed in 20.3%of patients.Grade B pancreatic fistula was the most common complication.The complication rates of the late treatment group(6.1%)were significantly lower than those of the first 15 patients after IRE treatment(66.7%).The median length of hospital stay of late treatment group was 8.6days,which was also shorter than that of the early treatment group(10.0days).Conclusions:IRE combined with chemotherapy could improve survival of LAPC patients with acceptable complication rates.Therefore,it may be a suitable method for LAPC but should be validated in prospective randomized trials.展开更多
Pancreatic cancer is one of the most lethal malignancies,with increasing morbidity and mortality.Only 20%of all cases are candi-dates for surgical resection.Most locally advanced pancreatic cancer(LAPC)is deemed to be...Pancreatic cancer is one of the most lethal malignancies,with increasing morbidity and mortality.Only 20%of all cases are candi-dates for surgical resection.Most locally advanced pancreatic cancer(LAPC)is deemed to be an unresectable disease because of the invasion of major vessels.Irreversible electroporation(IRE)is now increasingly applicable to treat LAPC.For the establish-ment of precise eligibility and the standardization of the IRE technique,a guideline is expected,aiming to improve safety,lead to reproducible outcomes,and facilitate further research into IRE.This article aimed to provide a set of technical recommendations for the treatment of LAPC by open IRE.展开更多
Lignin,as a major by-product of pulp and paper industry,has attracted extensive interest for the preparation of high value-added products,due to the merits of abundant,sustainable,inexpensive,and unique functional gro...Lignin,as a major by-product of pulp and paper industry,has attracted extensive interest for the preparation of high value-added products,due to the merits of abundant,sustainable,inexpensive,and unique functional groups.This review focuses on the strategies to develop high performance polyurethane(PU)materials from lignin on the basis of main reports,in which lignin was used not only as macromonomer to substitute petroleum-based polyols,but also as blending filler for PU industry.Pre-treatment approaches,especially lignin fractions extracted with various solvents and chemical modifications,e.g.,depolymerization,hydroxyalkylation,dealkylation,and esterication,were widely explored to enable lignin more reactive and available to synthesize PU products.In addition,lignin/PU blends were also prepared to fulfill industrial demand.With adjustment of lignin structure,the PU formulation,and synthesis procedures,various lignin-based PU products with advanced properties and a higher bio-substitution ratio have been developed,demonstrating the potential industrial application of lignin for high value-added sustainable materials.展开更多
Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and mo...Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their potential.Here we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)printing.The mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional fillers.By taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic structures.In particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic field.This study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices.展开更多
基金supported by the National Natural Science Foundation of China(52203215)the Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(Grant No.NY225035).
文摘Affordable,easily recycled organics with electroactive centers have drawn attention in the pursuit of high-performance aqueous zinc organic batteries(AZOBs).However,intrinsic barriers such as high solubility,unde-sirable potential,and inferior conductivity hinder their further development.To this end,we have designed an advanced cathode material for AZOBs,comprising an n-type polymer with a three-dimensional(3D)building block(HAT-TP)formed by polymerizing 2,3,6,7,10,11-hexacyano-1,4,5,8,9,12-hexazepenanthrene(HAT-CN)and 3D 2,3,6,7,14,15-hexaaminotriptycene(THA-NH 2).The introduction of a 3D architecture not only bolsters the insolubility but also exposes redox-active sites for cation coordination,while the material's extended conjugated system promotes electronic delocalization to increase the redox potential and conductivity.As a result,a HAT-TP battery exhibits a notable initial discharge voltage of 1.32 V at 0.1 A g^(-1),followed by a midpoint voltage of 1.17 V.Remarkably,an ultrastable capacity retention ratio of up to 93.4%is achieved,even after 40,000 cycles at 5 A g^(-1).Theoretical simulations reveal that the elevated discharge potential results from the strong electronic delocalization of HAT-TP,which improves the affinity with cations.Ex situ characterizations and theoretical calculations verify that the reversible Zn^(2+)/H^(+)co-storage mechanism involves only electroactive C=N sites and the best possible coordination paths between them.
基金supported by the Public Welfare Project of Zhejiang Province(LGF21E030005)the National Natural Science Foundation of China(NSFC 51803185)+2 种基金the Fundamental Research Funds of Zhejiang Sci-Tech University(22202301-Y)the Opening Project of Key Laboratory of Clean Dyeing and Finishing Technology of Zhejiang Province(QJRZ2214)the China Scholarships Council for the overseas scholarship(202008330177).
文摘Limitations of current electronic textiles(e-textiles),including poor washability,instability,and inferior sensing capability,are concerns hindering their broad and practical applications in personal health care management,virtual games,sports,and more.Here,we report an RGO/PANI e-textile via alternative coatings of in situ reduced graphene oxides(RGO)and in situ polymerized polyaniline(PANI),establishing a laminated structure on a knitted textile substrate.As a result of an in situ lamination strategy,our e-textile exhibits excellent breathability(1428 mm s^(-1),greater than that of bare cotton fabric)and outstanding sensitivity(gage factor of 39.7)over a wide strain range(~0.0625–200%).Importantly,we observed exceptional sensing durability even after severe mechanical disturbance of stretching,bending,or twisting(>1500 cycles)and daily machine washes.Detailed analysis revealed that our proposed in situ lamination approach enabled the physical and chemical interactions between sensing active materials and the textile substrate.Furthermore,the electromechanical behavior of our RGO/PANI e-textile was thoroughly analyzed based on an equivalent electrical circuit,which agreed well with the experi-mental data.Example applications of the e-textile were demonstrated for personal health care management,including body motion monitoring,emotional sensing,and flatfoot gait correction.The RGO/PANI e-textile presented in this study holds significant implications for the evolution of health care applications utilizing smart e-textiles.
基金supported by the Start-up Funding of Wuhan University of Technology(Grant No.40120490)。
文摘Thermoelectric technology,which is characterized by the interconversion between heat and electricity,is demonstrated as an efficient and environmentally friendly route for thermal energy harvesting and solid-state cooling devices.The pursuit for high-performance room temperature thermoelectric materials is of significant interest.Here,we proposed a design strategy to dramatically improve the thermoelectric response by constructing a hierarchical multiscale conductor network(AgNWs/CNT)in polymer matrix(PEDOT:PSS).At the optimized composition,the highest Seebeck coefficient and electrical conductivity of base treated ternary PEDOT:PSS/AgNWs/CNT composite are optimized to be 58.6μV K^(-1)and~1950 S cm-1.Correspondingly,the power factor is thus calculated to be on the order of 670μV m^(-1)K^(-2),which is among one of the highest values compared with previous reports.The underlying mechanism is illustrated based on detailed structure,morphology and electron transport quantification.This work affords a novel strategy for the future development of high-performance room temperature nanocomposite thermoelectrics.
基金supported by Ministry of Education,Singapore(grant no.MOE2019-T2-126)the National Natural Science Foundation of China(grant nos.51803156 and 51903194)Scientific Research Program of Hubei Provincial Department of Education(grant no.B2020055).
文摘Polyaniline(PANI)-based thermoelectric(TE)materials have attracted considerable attention for flexible electronic energy harvesting devices because of properties such assolution processibility,excellent environmental stability,and low cost.However,the typical opposite dependence between electrical conductivity and Seebeck coefficient impedes their development,and tremendous efforts have been devoted to increasing their TE efficiency.
基金This work was supported by the National Natural Science Funds(Nos.82102166,81972299)Guangdong Basic and Applied Basic Research Foundation(No.2020A1515110954).
文摘Objective:lreversible electroporation(IRE)is emerging as a new therapy for locally advanced pancreatic cancer(LAPC).We aimed to conduct survival and safety analyses in L APC patients after treatment with IRE combined with chemotherapy.Methods:A total of 64 patients with LAPC who had received IRE and chemotherapy were retrospectively collected from August 2015 to March 2019 at Sun Yat-sen University Cancer Center.Overall survival(OS)and progression-free survival(PFS)were evaluated using Kaplan-Meier method and compared by the log-rank test.A multivariate Cox regression model was used to determine the prognostic factors of survival.The perioperative complications of IRE were also evaluated.The study was approved by the Institutional Review Board of Sun Yat-sen University Cancer Center(approval No.C2021-003).Results:The median survival of all included patients were 24.63(95%confidence interval:21.78-27.49)for overall survival and 13.00(95%confidence inteval:8.81-17.19)months for progression-free survival,with 96.8%,51.9%,18.3%;and 52.3%,21.5%,7.9%as the 1-,2-and 3-year OS and PFS rates,respectively.Tumor size[OS,hazard ratio(HR)=1.768,P=0.048;PFS,HR=0.304,P=0.010],neoadjuvant chemotherapy(OS,HR=0338,P=0.030;PFS,HR=0.358,P=0.034),carbohydrate antigen 19-9 variation after IRE(OS,HR=19.320,P=0.003;PFS,HR=14.591,P=0.021)and tumor response after neoadjuvant chemotherapy(OS,HR-8.779,P=0.033;PFS,HR-5.562,P=0.008)were predictive factors of survival in patients with LAPC after IRE.Complications were observed in 20.3%of patients.Grade B pancreatic fistula was the most common complication.The complication rates of the late treatment group(6.1%)were significantly lower than those of the first 15 patients after IRE treatment(66.7%).The median length of hospital stay of late treatment group was 8.6days,which was also shorter than that of the early treatment group(10.0days).Conclusions:IRE combined with chemotherapy could improve survival of LAPC patients with acceptable complication rates.Therefore,it may be a suitable method for LAPC but should be validated in prospective randomized trials.
基金supported by the Key New Clinical Technology Program of Guangzhou.
文摘Pancreatic cancer is one of the most lethal malignancies,with increasing morbidity and mortality.Only 20%of all cases are candi-dates for surgical resection.Most locally advanced pancreatic cancer(LAPC)is deemed to be an unresectable disease because of the invasion of major vessels.Irreversible electroporation(IRE)is now increasingly applicable to treat LAPC.For the establish-ment of precise eligibility and the standardization of the IRE technique,a guideline is expected,aiming to improve safety,lead to reproducible outcomes,and facilitate further research into IRE.This article aimed to provide a set of technical recommendations for the treatment of LAPC by open IRE.
基金National Natural Science Foundation of China(No.51803156,No.51903194)Hubei Provincial Natural Science Foundation of China(No.2019CFB190)Youths Science Foundation of Wuhan Institute of Technology(No.K201803).
文摘Lignin,as a major by-product of pulp and paper industry,has attracted extensive interest for the preparation of high value-added products,due to the merits of abundant,sustainable,inexpensive,and unique functional groups.This review focuses on the strategies to develop high performance polyurethane(PU)materials from lignin on the basis of main reports,in which lignin was used not only as macromonomer to substitute petroleum-based polyols,but also as blending filler for PU industry.Pre-treatment approaches,especially lignin fractions extracted with various solvents and chemical modifications,e.g.,depolymerization,hydroxyalkylation,dealkylation,and esterication,were widely explored to enable lignin more reactive and available to synthesize PU products.In addition,lignin/PU blends were also prepared to fulfill industrial demand.With adjustment of lignin structure,the PU formulation,and synthesis procedures,various lignin-based PU products with advanced properties and a higher bio-substitution ratio have been developed,demonstrating the potential industrial application of lignin for high value-added sustainable materials.
基金Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200375National Natural Science Foundation of China,Grant/Award Number:22109021+2 种基金Fundamental Research Funds for the Central Universities,Grant/Award Number:2242021R10023Ministry of Education,Singapore,Grant/Award Number:R284000193114Jiangsu Shuangchuang Talent Program,Grant/Award Number:JSSCBS20210100。
文摘Polydimethylsiloxane(PDMS)has been widely used in flexible electronics,soft robotics,and bioelectronics.However,the fabrication of PDMS-based devices has mostly relied on conventional approaches,such as casting and molding,thereby limiting their potential.Here we fabricate PDMS-based composites with programmable microstructures by direct ink writing and realize their practical functionalities of four-dimensional(4D)printing.The mechanical,thermomechanical and magnetic properties of the three-dimensional-printed composites can be well tailored by using carbon,metal,or ceramic functional fillers.By taking advantage of the printable,flexible,and magnetic PDMS composites,we demonstrate new practical functionalities of 4D printing by designing programmable architectures,including magnetic-field-driven battery cases and patchworks,as well as arbitrary morphing ceramic structures.In particular,4D-printed batteries are constructed by PDMS-based battery cases for the first time,which can be actuated via external magnetic field.This study broadens the paradigm of 4D printing for prospective applications,such as implant batteries,biomimetic engineering,and customized biomedical devices.
