Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase t...With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase transitions into account,and as a result,the predictions are usually not accurate enough.In this context,we have established an explicable relationship between alloy compositions and phase transition by feature imputation.A facile machine learning is proposed to screen candidate NiMn-based Heusler alloys with desired magnetic entropy change and magnetic transition temperature with a high accuracy R^(2)≈0.98.As expected,the measured properties of prepared NiMn-based alloys,including phase transition type,magnetic entropy changes and transition temperature,are all in good agreement with the ML predictions.As well as being the first to demonstrate an explicable relationship between alloy compositions,phase transitions and magnetocaloric properties,our proposed ML model is highly predictive and interpretable,which can provide a strong theoretical foundation for identifying high-performance magnetocaloric materials in the future.展开更多
INTRODUCTION.On May 1st,2024,around 2:10 a.m.,a catastrophic collapse occurred along the Meilong Expressway near Meizhou City,Guangdong Province,China,at coordinates 24°29′24″N and 116°40′25″E.This colla...INTRODUCTION.On May 1st,2024,around 2:10 a.m.,a catastrophic collapse occurred along the Meilong Expressway near Meizhou City,Guangdong Province,China,at coordinates 24°29′24″N and 116°40′25″E.This collapse resulted in a pavement failure of approximately 17.9 m in length and covering an area of about 184.3 m^(2)(Chinanews,2024).展开更多
The NOD-like receptor protein 3(NLRP3)inflammasome is essential in innate immune-mediated inflammation,with its overactivation implicated in various autoinflammatory,metabolic,and neurodegenerative diseases.Pharmacolo...The NOD-like receptor protein 3(NLRP3)inflammasome is essential in innate immune-mediated inflammation,with its overactivation implicated in various autoinflammatory,metabolic,and neurodegenerative diseases.Pharmacological inhibition of NLRP3 offers a promising treatment strategy for inflammatory conditions,although no medications targeting the NLRP3 inflammasome are currently available.This study demonstrates that clioquinol(CQ),a clinical drug with chelating properties,effectively inhibits NLRP3 activation,resulting in reduced cytokine secretion and cell pyroptosis in both human and mouse macrophages,with a half maximal inhibitory concentration(IC_(50))of 0.478 mM.Additionally,CQ mitigates experimental acute peritonitis,gouty arthritis,sepsis,and colitis by lowering serum levels of interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α).Mechanistically,CQ covalently binds to Arginine 335(R335)in the NACHT domain,inhibiting NLRP3 inflammasome assembly and blocking the interaction between NLRP3 and its component protein.Collectively,this study identifies CQ as an effective natural NLRP3 inhibitor and a potential therapeutic agent for NLRP3-driven diseases.展开更多
Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,th...Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm.The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control.Then,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy.Precise pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid voltage.Additionally,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee algorithm.These operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load transients.This strategy effectively mitigated transient voltage and current surges during mode transitions.Consequently,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid inverter.The enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.展开更多
0 INTRODUCTION Synthetic Aperture Radar(SAR)remote sensing,particularly with the C-band Sentinel-1 mission,has been widely used for landslide displacement analysis due to its high spatial resolution and revisit freque...0 INTRODUCTION Synthetic Aperture Radar(SAR)remote sensing,particularly with the C-band Sentinel-1 mission,has been widely used for landslide displacement analysis due to its high spatial resolution and revisit frequency(Zhou et al.,2024;Dai et al.,2021).However,in densely vegetated or humid mountainous regions such as the Three Gorges Reservoir(TGR),C-band signals suffer from temporal decorrelation,limiting their effectiveness for landslide monitoring.展开更多
N^(6)-Methyladenosine(m^(6)A)is the most common modification in the transcriptome of biological RNA and plays roles that include maintaining the stability and transportation of mRNA,mRNA precursor shearing,polyadenyla...N^(6)-Methyladenosine(m^(6)A)is the most common modification in the transcriptome of biological RNA and plays roles that include maintaining the stability and transportation of mRNA,mRNA precursor shearing,polyadenylation,and the initiation of translation.With the improving understanding of RNA methylation,m^(6)A modification is known to play vital roles in plant development and growth.The multi-petalization of flowering plants has high ornamental and research value in horticultural landscapes.However,the mechanism of RNA methylation in flower formation in Magnolia wufengensis,a classical multi-petalizational plant,remains unclear.This study compared and analyzed RNA m^(6)A methylation and the transcriptome in floral buds of two varieties with large differences in tepal number at the early stage of development.It was found that the degree of RNA m^(6)A methylation and relative expression levels of MawuAGL6-2,MawuPI-4,and MawuAGL9 in‘Jiaodan’with 36 tepals were significantly higher than those in‘Jiaohong’with 9 tepals during the development of floral organ primordia.Combined with quantitative real-time PCR,the expression levels of MawuAGL6-2,MawuPI-4,and MawuAGL9were positively correlated with the number of tepals.Transgenic experiments showed that MawuAGL6-1/2,and MawuPI-4 can increase the number of petals in Arabidopsis.Moreover,MawuAGL6-2 and MawuPI-4 can restore the missing petal phenotype of mutant Arabidopsis.Yeast two hybrid and yeast three hybrid indicated that MawuAGL6-2,MawuAP3-1/2,and MawuPI-4 could interact with each other under the mediation of the class E protein MawuAGL9.Based on these results,it is hypothesized that m^(6)A methylation influences the multi-petalization of Magnolia wufengensis by affecting the expression levels of MawuAGL6-2,MawuAP3-1/2,MawuPI-4,and MawuAGL9.These findings provide a better understanding of the molecular mechanisms of epigenetic modifications in flower developmental diversity.展开更多
Excellent magnetostrictive properties and processability are the two most important key factors for the practical application of magnetostrictive materials and research directions of continuous concern.In this study,w...Excellent magnetostrictive properties and processability are the two most important key factors for the practical application of magnetostrictive materials and research directions of continuous concern.In this study,we significantly improved the magnetostriction,ductility,and tensile strength of Fe_(83)Ga_(17)B_(x)(x=0,1,2,3,and 4)alloys by adjusting the small-radius boron(B)doping concentration.When x=3,the maximum magnetostriction value reached 193 ppm,approximately twice that of the undoped alloy(x=0),while the ultimate tensile strength and elongation increased by 147%and 238%,respectively,compared to Fe_(83)Ga_(17)alloys.Both first-principles calculations and experimental results indicate that B doping facilitates the alignment of FeGa crystal growth direction with the easy magnetization axis,thereby significantly improving the magnetostrictive properties of the alloy.Additionally,increasing B content progressively refines the grain size and promotes Fe_(2)B phase formation,thereby enhancing both strength and toughness.At x=3,the material exhibits the highest saturation magnetization and the lowest coercivity.Therefore,the results show that doping small-radius atoms in the interstitial sites can effectively enhance the magnetostrictive and mechanical properties of FeGa materials.This work offers a promising strategy for designing magnetostrictive materials with superior overall properties.展开更多
A promising way to realize controlled nuclear fusion involves the use of magnetic fields to control and confine the hot plasma configuration.This approach requires superconductor magnets operating above 15 T for the n...A promising way to realize controlled nuclear fusion involves the use of magnetic fields to control and confine the hot plasma configuration.This approach requires superconductor magnets operating above 15 T for the next generation of fusion devices.Due to their high in-field transport current capacity,rare-Earth barium copper oxide(REBCO)coated conductors are promising materials for manufacturing of cable-in-conduit conductors(CICCs)for fusion.However,the high-aspect-ratio geometry makes it difficult to find a multi-tape CICC configuration that fulfills the high engineering current density requirements while retaining enough flexibility for winding large-scale magnets.Moreover,the multilayer structure and inherent brittleness make the REBCO tapes susceptible to degradation during CICC manufacturing and operation.For more than a decade,the development of a reliable REBCO-based CICC that can sustain the huge combined mechanical,thermal,and Lorentz loads without degradation has been ongoing,albeit with limited progress.In this paper,we report on a prototype REBCO CICC that can withstand an applied cyclic Lorentz load of at least 830 kN·m^(-1),corresponding to a transport current of 80 kA at 10.85 T and 4.5 K.To our knowledge,this is the highest load achieved to date.The CICC uses 288 tapes wound into six strengthened sub-cables,making it capable of having a current sharing temperature,Tcs,of around 39 and 20 K when operated under 10.85 T with a current of 40 and 80 kA,respectively.Scaled to a 20-T peak field and 46.5-kA transport current,this provides a temperature margin of over 10 K with respect to an operating temperature of 4.5 K.In addition,no perceptible transport current performance degradation was observed after cyclic Lorentz loading,cyclic warm-up/cool-down(WUCD),and quench campaigns.The proposed REBCO CICC is a milestone in the development of high-temperature superconductors for large-scale and high-field magnet applications.展开更多
Chronic cerebral hypoperfusion leads to white matter injury(WMI),which plays a significant role in contributing to vascular cognitive impairment.While 13-docosenamide is a type of fatty acid amide,it remains unclear w...Chronic cerebral hypoperfusion leads to white matter injury(WMI),which plays a significant role in contributing to vascular cognitive impairment.While 13-docosenamide is a type of fatty acid amide,it remains unclear whether it has therapeutic effects on chronic cerebral hypoperfusion.In this study,we conducted bilateral common carotid artery stenosis(BCAS)surgery to simulate chronic cerebral hypoperfusion-induced WMI and cognitive impairment.Our findings showed that 13-docosenamide alleviates WMI and cognitive impairment in BCAS mice.Mechanistically,13-docosenamide specifically binds to cannabinoid receptor 1(CNR1)in oligodendrocyte precursor cells(OPCs).This interaction results in an upregulation of ubiquitin-specific peptidase 33(USP33)-mediated CNR1 deubiquitination,subsequently increasing CNR1 protein expression,activating the phosphorylation of the AKT/mTOR pathway,and promoting the differentiation of OPCs.In conclusion,our study suggests that 13-docosenamide can ameliorate chronic cerebral hypoperfusion-induced WMI and cognitive impairment by enhancing OPC differentiation and could serve as a potential therapeutic drug.展开更多
Additive manufacturing (AM) of zinc-based biodegradable materials is a hot research topic,especially for bone-scaffold applications,because of the moderate degradation rate,good biocompatibility,and suitable mechanica...Additive manufacturing (AM) of zinc-based biodegradable materials is a hot research topic,especially for bone-scaffold applications,because of the moderate degradation rate,good biocompatibility,and suitable mechanical properties of these materials.Furthermore,AM enables the fabrication of complex internal structures suitable for implants.Literature on the AM of degradable zinc-based biomaterials from the Web of Science Core Collection was evaluated in this review.The bibliometric tool CiteSpace was used to analyze historical characteristics,evolving research topics,and emerging trends in this field.Our research results predict that the composition,processing techniques,in vitro biocompatibility,and manufacturing quality of biodegradable AM zinc-basedmaterials will continue to be hot topics in recent years.To address implant requirements,particularly for bone-repair materials,the mechanical properties of materials (including the resistance to degradation,creep,and aging),degradation rates,in-vivo biocompatibility,and specialized processing techniques that affect these properties (such as coating processes,heat treatments,material surface structures,and micros truc tural compositions) will become hot research topics in the future.We propose future research directions based on an in-depth analysis of four main topics of AM biodegradable zinc-based materials (manufacturing quality,material composition,unit configuration,and biocompatibility).The findings provide important guidance for future theoretical research and industrial development of AM zinc-based biomaterials.展开更多
Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne disease with high mortality,and clinical practice lacks dynamic tools to assess its rapidly evolving course.This study aims to develop stage-s...Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne disease with high mortality,and clinical practice lacks dynamic tools to assess its rapidly evolving course.This study aims to develop stage-specific machine learning models to predict mortality risk using longitudinal biomarker data.We conducted a retrospective analysis of 5359 laboratory-confirmed SFTS patients from two hospitals in the highly endemic region in China.Serial measurements of 46 clinical and laboratory variables were integrated into a three-stage prognostic model developed using extreme gradient boosting(XGBoost).Within each clinical stage,key predictors and their relative contribution(RC)of mortality risk were assessed.Model performance was assessed based on discrimination,calibration,and decision curve analysis(DCA)in internal and external test sets.XGBoost models were constructed across 10 temporal phases,later consolidated into three clinically distinct stages via hierarchical clustering:early(≤7 days),intermediate(days 8-9),and late(≥10 days).Key predictors included age(dominant in early phase;RC,18.44%),lactate dehydrogenase(LDH;RC peaking at 60.10% in late phase),and monocyte percentage(RC range from 5.25% to 16.04%).Pathophysio-logical shifts across clinical stages were revealed:early viral cytopathy(dominated by age and MONO%),intermediate immunopathology(marked by LDH surge),and late hepatic failure(dominated by LDH,AST,and TBA).The model showed strong discrimination(Area under the receiver operating characteristic curve,AUCs:0.84-0.98 internal;0.91-0.98 external),calibration(Brier scores:0.04-0.11),and clinical utility via DCA.This study introduces a dynamic staging system that lever-ages predictive models and real-time patient data to monitor mortality risk and personalize SFTS care,which enables timely interventions to reduce deaths.展开更多
This study focuses on steeply inclined and extremely thick coal seams(SIETCS)characterized by immense thickness,a steep inclination of coal seams(87°),and high horizontal stress.The geological conditions and mini...This study focuses on steeply inclined and extremely thick coal seams(SIETCS)characterized by immense thickness,a steep inclination of coal seams(87°),and high horizontal stress.The geological conditions and mining technology associated with SIETCS differ significantly from those of generally inclined coal seams,resulting in notable variations in roadway stress distributions.On SIETCS have predominantly examined the impact of rock layers flanking coal seams on rock bursts,with limited emphasis on SIETCS roadways.This study employs comprehensive methods,integrating numerical simulations,theoretical analyses,and field detections to investigate the stress distribution of SIETCS and the mechanisms of rock burst-induced vertical damage,subsequently validated in situ.The vertical stress in SIETCS is minimal,while horizontal stress is concentrated,leading to the formation of layered crack structures(LCS)that distribute above and below the roadways.Additionally,elastic energy significantly concentrates within the LCS.Axial dynamic compressive stress and vertical dynamic tensile stress along the LCS diminish its stability,readily triggering failure.During the LCS failure process,the stored energy is released,converting into kinetic energy required for coal body ejection after reaching the minimum energy for failure and dissipative energy,ultimately leading to rock burst-induced vertical damage in roadways.On-site detection and analysis within SIETCS,along with historical rock burst data,confirm the existence of LCS and its role in inducing vertical rock burst damage.This research establishes essential foundations for preventing rock bursts within SIETCS.展开更多
The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theo...The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.展开更多
The mutual coupling of structure and magnetism is crucial for Heusler alloys.In this paper,Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)alloys were prepared by arc melting.Based on the test results of structure and magnetis...The mutual coupling of structure and magnetism is crucial for Heusler alloys.In this paper,Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)alloys were prepared by arc melting.Based on the test results of structure and magnetism,the magnetic-structural phase diagram of Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)was drawn.The structure changes from cubic to monoclinic and finally to tetragonal as the x increases at room temperature.Its phase diagram shows a morphotropic phase boundary(MPB)starting from a tricritical triple point(around the Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy)of a cubic paramagnetic phase,ferromagnetic monoclinic,and antiferromagnetic tetragonal phases.And Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy has experienced five different phase states:paramagnetic austenite→ferromagnetic austenite→antiferromagnetic martensite→ferromagnetic martensite→spin glass as the temperature decreased.Further study of the alloys’magnetostrictive properties near the MPB showed that as x increases,a negative strain initially appears,followed by a W-type that crosses negative and positive strains,and then a positive strain.This is caused by the inconsistency in the speed and degree of magnetic domain walls response with monoclinic and tetragonal coexisting structures.This indicates that coupling between structure and magnetism is critical to the properties of materials.This work provides valuable insights into the magnetostrictive behavior and structural evolution of Heusler alloys,particularly in the context of MPB systems,and offers guidance for the design and optimization of material properties through controlled magnetic-structural interactions.Kindly check and confirm the edit made in the title.The edit made in the title has been confirmed to be accurate.展开更多
We report the structural,mechanical and electromagnetic properties of the intermetallic compound Mn_(23)C_(6).The bulk Mn_(23)C_(6)sample was synthesized using high temperature high pressure quenching method(HTHPQM),a...We report the structural,mechanical and electromagnetic properties of the intermetallic compound Mn_(23)C_(6).The bulk Mn_(23)C_(6)sample was synthesized using high temperature high pressure quenching method(HTHPQM),and investigated in detail by x-ray diffraction,electron microscope,magnetization and electrical resistivity measurements,etc.First-principles calculation based on density functional theory ab intio simulation was carried out to calculate the bonding and electromagnetic properties of Mn_(23)C_(6).Based on our experimental and simulated results,the Mn_(23)C_(6)in this work is single phase of a faced-centered cubic structure with space group Fm-3m(No.225).Determined by SEM and TEM,the bulk sample consists of monocrystal Mn_(23)C_(6)crystals with 2-15μm grain sizes,it is the quick quenching method in the synthesizing process that brings such small crystal grain size.Archimedes method gives its density of 7.14 g/cm^(3),95.74%of its theoretically calculated density 7.458 g/cm^(3).Owing to the abundant Mn 3d electrons and a framework of strongly linked Mn atoms in Mn_(23)C_(6),the electrical conductivity is up to 8.47×10^(-4)Ω·m,which shows that Mn_(23)C_(6)is a good conductor.Our magnetic susceptibility analyses reveal a magnetization peak in the M-T curve at 104 K,combined with the M-H curve and Curie-Weiss law,this peak usually means the transformation between paramagnetic and antiferromagnetic orders.To gain an insight into the mechanism of the magnetic phase transition,we calculated the magnetic properties,and the results show that different from normal antiferromagnetic order,the magnetic orders in Mn_(23)C_(6)consist of three parts,the direct ferromagnetic and antiferromagnetic exchange coupling interactions between Mn atoms,and the indirect antiferromagnetic super-exchange interaction between Mn and C atoms.Therefore,we reveal that the Mn_(23)C_(6)is a complex magnetic competition system including different magnetic orders and interactions,instead of the normal long-range antiferromagnetic order.展开更多
As oil and gas development increasingly targets unconventional reservoirs,the limitations of conventional hydraulic fracturing,namely high water consumption and significant reservoir damage,have become more pronounced...As oil and gas development increasingly targets unconventional reservoirs,the limitations of conventional hydraulic fracturing,namely high water consumption and significant reservoir damage,have become more pronounced.This has driven growing interest in the development of clean fracturing fluids that minimize both water usage and formation impairment.In this study,a low-liquid-content viscoelastic surfactant(VES)foam fracturing fluid system was formulated and evaluated through laboratory experiments.The optimized formulation comprises 0.2%foaming agent CTAB(cetyltrimethylammonium bromide)and 2%foam stabilizer EAPB(erucamidopropyl betaine).Laboratory tests demonstrated that the VES foam system achieved a composite foam value of 56,700 mL・s,reflecting excellent foaming performance.Proppant transport experiments revealed minimal variation in suspended sand volume over 120 min across different sand ratios,indicating robust sand-carrying capacity even at high proppant concentrations.Rheological measurements showed that the fluid maintained a viscosity above 120 mPa・s after 120 min of shearing at 70℃ and a shear rate of 170 s−1,with the elastic modulus exceeding the viscous modulus,confirming the system’s exceptional stability and resilience.Furthermore,core damage tests indicated that the VES foam caused only 4.42%formation damage,highlighting its potential for efficient and low-damage stimulation of tight reservoirs.Overall,the findings demonstrate that this low-liquid-content VES foam provides a highly effective,environmentally considerate alternative for hydraulic fracturing in unconventional formations,combining superior proppant transport,rheological stability,and minimal reservoir impairment.展开更多
Maize(Zea mays L.)is one of the world's most important staple crops,and is used for manufacturing food,feed,and industrial products.A key factor in maize yield is the grain weight,which directly influences product...Maize(Zea mays L.)is one of the world's most important staple crops,and is used for manufacturing food,feed,and industrial products.A key factor in maize yield is the grain weight,which directly influences productivity.In this study,we revealed the role of smk23 in maize kernel development.The ethyl methanesulfonate mutant smk23 is characterized by substantially reduced kernel weight.Through map-based cloning,smk23 was found to be located on Chr5 and encode a putative B-type response regulator,Zm RR5.A change from G to A occurs in the coding sequence of Zm RR5,resulting in the early termination of smk23.In Arabidopsis,B-type response regulators are involved in cytokinin signaling.Histological analysis and in situ hybridization of the mutant revealed abnormal endosperm development,particularly in the basal endosperm transfer layer(BETL),a specialized tissue critical for nutrient transport from the maternal tissues to the developing kernel.Zm RR5 positively regulates key genes involved in BETL development and function,including MRP1 and TCRR1.Furthermore,RNA sequencing revealed that several genes closely linked to BETL development,including BETL2,MEG1,and MN1,were significantly downregulated in smk23.These genes are essential for nutrient transport,tissue development and signal transduction.In addition,haploid analysis of Zm RR5 revealed natural variations(Hap 2)that may contribute to the increased kernel yield.Disruption of Zm RR5 function in smk23 leads to defects in BETL development,impairing its ability to transport nutrients,and ultimately resulting in a smaller kernel size.This study provides new insights into the molecular mechanisms through which Zm RR5 regulates maize kernel development and offers potential strategies for improving grain yield.展开更多
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
基金supported by the National Key R&D Program of China(No.2022YFE0109500)the National Natural Science Foundation of China(Nos.52071255,52301250,52171190 and 12304027)+2 种基金the Key R&D Project of Shaanxi Province(No.2022GXLH-01-07)the Fundamental Research Funds for the Central Universities(China)the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities.
文摘With the rapid development of artificial intelligence,magnetocaloric materials as well as other materials are being developed with increased efficiency and enhanced performance.However,most studies do not take phase transitions into account,and as a result,the predictions are usually not accurate enough.In this context,we have established an explicable relationship between alloy compositions and phase transition by feature imputation.A facile machine learning is proposed to screen candidate NiMn-based Heusler alloys with desired magnetic entropy change and magnetic transition temperature with a high accuracy R^(2)≈0.98.As expected,the measured properties of prepared NiMn-based alloys,including phase transition type,magnetic entropy changes and transition temperature,are all in good agreement with the ML predictions.As well as being the first to demonstrate an explicable relationship between alloy compositions,phase transitions and magnetocaloric properties,our proposed ML model is highly predictive and interpretable,which can provide a strong theoretical foundation for identifying high-performance magnetocaloric materials in the future.
基金supported by the National Natural Science Foundation of China(Nos.42371094,41907253)partially supported by the Interdisciplinary Cultivation Program of Xidian University(No.21103240005)the Postdoctoral Fellowship Program of CPSF(No.GZB20240589)。
文摘INTRODUCTION.On May 1st,2024,around 2:10 a.m.,a catastrophic collapse occurred along the Meilong Expressway near Meizhou City,Guangdong Province,China,at coordinates 24°29′24″N and 116°40′25″E.This collapse resulted in a pavement failure of approximately 17.9 m in length and covering an area of about 184.3 m^(2)(Chinanews,2024).
基金supported by the National Natural Science Foundation of China(Grant Nos.:82101417,81920108017,and 82130036)the STI2030-Major Projects(Project No.:2022ZD0211800)+2 种基金Jiangsu Province Key Medical Discipline(Grant No.:ZDXK202216)the Key Research and Development Program of Jiangsu Province of China(Program No.:BE2020620)Nanjing Medical Science and technology development Foundation,China(Grant No.:YKK20061).
文摘The NOD-like receptor protein 3(NLRP3)inflammasome is essential in innate immune-mediated inflammation,with its overactivation implicated in various autoinflammatory,metabolic,and neurodegenerative diseases.Pharmacological inhibition of NLRP3 offers a promising treatment strategy for inflammatory conditions,although no medications targeting the NLRP3 inflammasome are currently available.This study demonstrates that clioquinol(CQ),a clinical drug with chelating properties,effectively inhibits NLRP3 activation,resulting in reduced cytokine secretion and cell pyroptosis in both human and mouse macrophages,with a half maximal inhibitory concentration(IC_(50))of 0.478 mM.Additionally,CQ mitigates experimental acute peritonitis,gouty arthritis,sepsis,and colitis by lowering serum levels of interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α).Mechanistically,CQ covalently binds to Arginine 335(R335)in the NACHT domain,inhibiting NLRP3 inflammasome assembly and blocking the interaction between NLRP3 and its component protein.Collectively,this study identifies CQ as an effective natural NLRP3 inhibitor and a potential therapeutic agent for NLRP3-driven diseases.
基金received funding from the Postgraduate Research&Practice Innovation Program of Jiangsu Province(SJCX23_1633)2023 University Student Innovation and Entrepreneurship Training Program(202311463009Z)+1 种基金Changzhou Science and Technology Support Project(CE20235045)Open Project of Jiangsu Key Laboratory of Power Transmission&Distribution Equipment Technology(2021JSSPD12).
文摘Uneven power distribution,transient voltage,and frequency deviations are observed in the photovoltaic storage hybrid inverter during the switching between grid-connected and island modes.In response to these issues,this paper proposes a grid-connected/island switching control strategy for photovoltaic storage hybrid inverters based on the modified chimpanzee optimization algorithm.The proposed strategy incorporates coupling compensation and power differentiation elements based on the traditional droop control.Then,it combines the angular frequency and voltage amplitude adjustments provided by the phase-locked loop-free pre-synchronization control strategy.Precise pre-synchronization is achieved by regulating the virtual current to zero and aligning the photovoltaic storage hybrid inverter with the grid voltage.Additionally,two novel operators,learning and emotional behaviors are introduced to enhance the optimization precision of the chimpanzee algorithm.These operators ensure high-precision and high-reliability optimization of the droop control parameters for photovoltaic storage hybrid inverters.A Simulink model was constructed for simulation analysis,which validated the optimized control strategy’s ability to evenly distribute power under load transients.This strategy effectively mitigated transient voltage and current surges during mode transitions.Consequently,seamless and efficient switching between gridconnected and island modes was achieved for the photovoltaic storage hybrid inverter.The enhanced energy utilization efficiency,in turn,offers robust technical support for grid stability.
基金supported by the National Natural Science Foundation of China(Nos.42371094,41907253)the Fundamental Research Funds for the Central Universities(No.B250201054).
文摘0 INTRODUCTION Synthetic Aperture Radar(SAR)remote sensing,particularly with the C-band Sentinel-1 mission,has been widely used for landslide displacement analysis due to its high spatial resolution and revisit frequency(Zhou et al.,2024;Dai et al.,2021).However,in densely vegetated or humid mountainous regions such as the Three Gorges Reservoir(TGR),C-band signals suffer from temporal decorrelation,limiting their effectiveness for landslide monitoring.
基金supported by the National Natural Science Foundation of China(Grant No.31570651)。
文摘N^(6)-Methyladenosine(m^(6)A)is the most common modification in the transcriptome of biological RNA and plays roles that include maintaining the stability and transportation of mRNA,mRNA precursor shearing,polyadenylation,and the initiation of translation.With the improving understanding of RNA methylation,m^(6)A modification is known to play vital roles in plant development and growth.The multi-petalization of flowering plants has high ornamental and research value in horticultural landscapes.However,the mechanism of RNA methylation in flower formation in Magnolia wufengensis,a classical multi-petalizational plant,remains unclear.This study compared and analyzed RNA m^(6)A methylation and the transcriptome in floral buds of two varieties with large differences in tepal number at the early stage of development.It was found that the degree of RNA m^(6)A methylation and relative expression levels of MawuAGL6-2,MawuPI-4,and MawuAGL9 in‘Jiaodan’with 36 tepals were significantly higher than those in‘Jiaohong’with 9 tepals during the development of floral organ primordia.Combined with quantitative real-time PCR,the expression levels of MawuAGL6-2,MawuPI-4,and MawuAGL9were positively correlated with the number of tepals.Transgenic experiments showed that MawuAGL6-1/2,and MawuPI-4 can increase the number of petals in Arabidopsis.Moreover,MawuAGL6-2 and MawuPI-4 can restore the missing petal phenotype of mutant Arabidopsis.Yeast two hybrid and yeast three hybrid indicated that MawuAGL6-2,MawuAP3-1/2,and MawuPI-4 could interact with each other under the mediation of the class E protein MawuAGL9.Based on these results,it is hypothesized that m^(6)A methylation influences the multi-petalization of Magnolia wufengensis by affecting the expression levels of MawuAGL6-2,MawuAP3-1/2,MawuPI-4,and MawuAGL9.These findings provide a better understanding of the molecular mechanisms of epigenetic modifications in flower developmental diversity.
基金financially supported by Shaanxi Provincial Key Laboratory Open Project(No.2022ZY2JCY1-01-05)the National Key Research and Development Program of China(No.2021YFB3501401)+3 种基金the National Natural Science Foundation of China(Nos.52171190 and 52301250)the Key Scientific and Technological Innovation Team of Shaanxi Province(No.2020TD001)the Innovation Capability Support Program of Shaanxi(Nos.2018PT-28 and 2017KTPT-04)the support from the High Performance Computing Center at Xi'an Jiaotong University
文摘Excellent magnetostrictive properties and processability are the two most important key factors for the practical application of magnetostrictive materials and research directions of continuous concern.In this study,we significantly improved the magnetostriction,ductility,and tensile strength of Fe_(83)Ga_(17)B_(x)(x=0,1,2,3,and 4)alloys by adjusting the small-radius boron(B)doping concentration.When x=3,the maximum magnetostriction value reached 193 ppm,approximately twice that of the undoped alloy(x=0),while the ultimate tensile strength and elongation increased by 147%and 238%,respectively,compared to Fe_(83)Ga_(17)alloys.Both first-principles calculations and experimental results indicate that B doping facilitates the alignment of FeGa crystal growth direction with the easy magnetization axis,thereby significantly improving the magnetostrictive properties of the alloy.Additionally,increasing B content progressively refines the grain size and promotes Fe_(2)B phase formation,thereby enhancing both strength and toughness.At x=3,the material exhibits the highest saturation magnetization and the lowest coercivity.Therefore,the results show that doping small-radius atoms in the interstitial sites can effectively enhance the magnetostrictive and mechanical properties of FeGa materials.This work offers a promising strategy for designing magnetostrictive materials with superior overall properties.
基金supported by the Comprehensive Research Facility for the Fusion Technology Program of China(2018-000052-73-01-001228)the National Key Research and Development Program of China(2022YFE03150200)+3 种基金the Institute of Energy,Hefei Comprehensive National Science Center(21KZS207)the National Natural Science Foundation of China(52077212)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2021444)the European–China collaboration program on the FUSION magnet.
文摘A promising way to realize controlled nuclear fusion involves the use of magnetic fields to control and confine the hot plasma configuration.This approach requires superconductor magnets operating above 15 T for the next generation of fusion devices.Due to their high in-field transport current capacity,rare-Earth barium copper oxide(REBCO)coated conductors are promising materials for manufacturing of cable-in-conduit conductors(CICCs)for fusion.However,the high-aspect-ratio geometry makes it difficult to find a multi-tape CICC configuration that fulfills the high engineering current density requirements while retaining enough flexibility for winding large-scale magnets.Moreover,the multilayer structure and inherent brittleness make the REBCO tapes susceptible to degradation during CICC manufacturing and operation.For more than a decade,the development of a reliable REBCO-based CICC that can sustain the huge combined mechanical,thermal,and Lorentz loads without degradation has been ongoing,albeit with limited progress.In this paper,we report on a prototype REBCO CICC that can withstand an applied cyclic Lorentz load of at least 830 kN·m^(-1),corresponding to a transport current of 80 kA at 10.85 T and 4.5 K.To our knowledge,this is the highest load achieved to date.The CICC uses 288 tapes wound into six strengthened sub-cables,making it capable of having a current sharing temperature,Tcs,of around 39 and 20 K when operated under 10.85 T with a current of 40 and 80 kA,respectively.Scaled to a 20-T peak field and 46.5-kA transport current,this provides a temperature margin of over 10 K with respect to an operating temperature of 4.5 K.In addition,no perceptible transport current performance degradation was observed after cyclic Lorentz loading,cyclic warm-up/cool-down(WUCD),and quench campaigns.The proposed REBCO CICC is a milestone in the development of high-temperature superconductors for large-scale and high-field magnet applications.
基金supported by the National Natural Science Foundation of China(82130036)the STI2030-Major Projects(2022ZD0211800)Jiangsu Province Key Medical Discipline(ZDXK202216).
文摘Chronic cerebral hypoperfusion leads to white matter injury(WMI),which plays a significant role in contributing to vascular cognitive impairment.While 13-docosenamide is a type of fatty acid amide,it remains unclear whether it has therapeutic effects on chronic cerebral hypoperfusion.In this study,we conducted bilateral common carotid artery stenosis(BCAS)surgery to simulate chronic cerebral hypoperfusion-induced WMI and cognitive impairment.Our findings showed that 13-docosenamide alleviates WMI and cognitive impairment in BCAS mice.Mechanistically,13-docosenamide specifically binds to cannabinoid receptor 1(CNR1)in oligodendrocyte precursor cells(OPCs).This interaction results in an upregulation of ubiquitin-specific peptidase 33(USP33)-mediated CNR1 deubiquitination,subsequently increasing CNR1 protein expression,activating the phosphorylation of the AKT/mTOR pathway,and promoting the differentiation of OPCs.In conclusion,our study suggests that 13-docosenamide can ameliorate chronic cerebral hypoperfusion-induced WMI and cognitive impairment by enhancing OPC differentiation and could serve as a potential therapeutic drug.
基金financially supported by grants from the National Key Technology R&D Program of China(No.2023YFB3810100)the National Natural Science Foundation of China(Nos.32471366,12302406,82270535)+2 种基金Science and Technology Innovation Project of JinFeng LaboratoryChongqingChina(No.jfkyjf202203001)
文摘Additive manufacturing (AM) of zinc-based biodegradable materials is a hot research topic,especially for bone-scaffold applications,because of the moderate degradation rate,good biocompatibility,and suitable mechanical properties of these materials.Furthermore,AM enables the fabrication of complex internal structures suitable for implants.Literature on the AM of degradable zinc-based biomaterials from the Web of Science Core Collection was evaluated in this review.The bibliometric tool CiteSpace was used to analyze historical characteristics,evolving research topics,and emerging trends in this field.Our research results predict that the composition,processing techniques,in vitro biocompatibility,and manufacturing quality of biodegradable AM zinc-basedmaterials will continue to be hot topics in recent years.To address implant requirements,particularly for bone-repair materials,the mechanical properties of materials (including the resistance to degradation,creep,and aging),degradation rates,in-vivo biocompatibility,and specialized processing techniques that affect these properties (such as coating processes,heat treatments,material surface structures,and micros truc tural compositions) will become hot research topics in the future.We propose future research directions based on an in-depth analysis of four main topics of AM biodegradable zinc-based materials (manufacturing quality,material composition,unit configuration,and biocompatibility).The findings provide important guidance for future theoretical research and industrial development of AM zinc-based biomaterials.
基金supported by the National Natural Science Foundation of China(82330103)the Yantai Science and Technology Innovation Development Plan(2021YT06000862).
文摘Severe fever with thrombocytopenia syndrome(SFTS)is an emerging tick-borne disease with high mortality,and clinical practice lacks dynamic tools to assess its rapidly evolving course.This study aims to develop stage-specific machine learning models to predict mortality risk using longitudinal biomarker data.We conducted a retrospective analysis of 5359 laboratory-confirmed SFTS patients from two hospitals in the highly endemic region in China.Serial measurements of 46 clinical and laboratory variables were integrated into a three-stage prognostic model developed using extreme gradient boosting(XGBoost).Within each clinical stage,key predictors and their relative contribution(RC)of mortality risk were assessed.Model performance was assessed based on discrimination,calibration,and decision curve analysis(DCA)in internal and external test sets.XGBoost models were constructed across 10 temporal phases,later consolidated into three clinically distinct stages via hierarchical clustering:early(≤7 days),intermediate(days 8-9),and late(≥10 days).Key predictors included age(dominant in early phase;RC,18.44%),lactate dehydrogenase(LDH;RC peaking at 60.10% in late phase),and monocyte percentage(RC range from 5.25% to 16.04%).Pathophysio-logical shifts across clinical stages were revealed:early viral cytopathy(dominated by age and MONO%),intermediate immunopathology(marked by LDH surge),and late hepatic failure(dominated by LDH,AST,and TBA).The model showed strong discrimination(Area under the receiver operating characteristic curve,AUCs:0.84-0.98 internal;0.91-0.98 external),calibration(Brier scores:0.04-0.11),and clinical utility via DCA.This study introduces a dynamic staging system that lever-ages predictive models and real-time patient data to monitor mortality risk and personalize SFTS care,which enables timely interventions to reduce deaths.
基金support of the National Natural Science Foundation of China(52374180,52327804).
文摘This study focuses on steeply inclined and extremely thick coal seams(SIETCS)characterized by immense thickness,a steep inclination of coal seams(87°),and high horizontal stress.The geological conditions and mining technology associated with SIETCS differ significantly from those of generally inclined coal seams,resulting in notable variations in roadway stress distributions.On SIETCS have predominantly examined the impact of rock layers flanking coal seams on rock bursts,with limited emphasis on SIETCS roadways.This study employs comprehensive methods,integrating numerical simulations,theoretical analyses,and field detections to investigate the stress distribution of SIETCS and the mechanisms of rock burst-induced vertical damage,subsequently validated in situ.The vertical stress in SIETCS is minimal,while horizontal stress is concentrated,leading to the formation of layered crack structures(LCS)that distribute above and below the roadways.Additionally,elastic energy significantly concentrates within the LCS.Axial dynamic compressive stress and vertical dynamic tensile stress along the LCS diminish its stability,readily triggering failure.During the LCS failure process,the stored energy is released,converting into kinetic energy required for coal body ejection after reaching the minimum energy for failure and dissipative energy,ultimately leading to rock burst-induced vertical damage in roadways.On-site detection and analysis within SIETCS,along with historical rock burst data,confirm the existence of LCS and its role in inducing vertical rock burst damage.This research establishes essential foundations for preventing rock bursts within SIETCS.
基金support from the National Natural Science Foundation of China(Grant Nos.52374180 and 52327804).
文摘The principal stresses will increase or decrease during mining,leading to variations in surrounding rock strength and subsequently an influence on the risk of rockbursts.To address this issue,this study conducted theoretical analysis,numerical simulation,and field monitoring.A rockburst risk analysis method that integrates dynamic changes in the stress and strength of surrounding rock was proposed and verified in the field.The dynamic changes in maximum(σ_(1))and minimum(σ_(3))principal stresses are represented by the σ_(1) and σ_(3) differentials,respectively.The difference in principal stress differential(DPSD),defined as the difference between σ_(1) and σ_(3),was introduced as a novel indicator for rockburst risk analysis.The findings of this study demonstrate a positive correlation between increases in DPSD and heightened risks of rockbursts,as evidenced by an increase in both the frequency of rockbursts and the occurrence of large-energy microseismic events.Conversely,a decrease in DPSD is associated with a reduction in risk.Specifically,in the W1123 panel of a coal mine susceptible to rockbursts,areas exhibiting higher DPSD values experienced more frequent and severe rockbursts.The DPSD-based analysis aligned well with the observed rockburst occurrences.Subsequent optimization of rockburst prevention measures in areas with elevated DPSD led to a reduction in DPSD.Following these adjustments,the W1123 panel predominantly experienced low-energy microseismic events,with a significant decrease in large-energy microseismic events and no further rockbursts.The DPSD analysis is a valuable tool for evaluating rockburst risk and aiding in prevention,which is of great significance for disaster prevention.
基金supported by the National Key Research and Development Program of China(Nos.2022YFE0109500 and 2021YFB3501401)the National Natural Science Foundation of China(Nos.52171190 and 52301250).
文摘The mutual coupling of structure and magnetism is crucial for Heusler alloys.In this paper,Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)alloys were prepared by arc melting.Based on the test results of structure and magnetism,the magnetic-structural phase diagram of Ni_(50)Mn_(34)Sb_(16-x)Ga_(x)(0≤x≤16)was drawn.The structure changes from cubic to monoclinic and finally to tetragonal as the x increases at room temperature.Its phase diagram shows a morphotropic phase boundary(MPB)starting from a tricritical triple point(around the Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy)of a cubic paramagnetic phase,ferromagnetic monoclinic,and antiferromagnetic tetragonal phases.And Ni_(50)Mn_(34)Sb_(5)Ga_(11)alloy has experienced five different phase states:paramagnetic austenite→ferromagnetic austenite→antiferromagnetic martensite→ferromagnetic martensite→spin glass as the temperature decreased.Further study of the alloys’magnetostrictive properties near the MPB showed that as x increases,a negative strain initially appears,followed by a W-type that crosses negative and positive strains,and then a positive strain.This is caused by the inconsistency in the speed and degree of magnetic domain walls response with monoclinic and tetragonal coexisting structures.This indicates that coupling between structure and magnetism is critical to the properties of materials.This work provides valuable insights into the magnetostrictive behavior and structural evolution of Heusler alloys,particularly in the context of MPB systems,and offers guidance for the design and optimization of material properties through controlled magnetic-structural interactions.Kindly check and confirm the edit made in the title.The edit made in the title has been confirmed to be accurate.
文摘We report the structural,mechanical and electromagnetic properties of the intermetallic compound Mn_(23)C_(6).The bulk Mn_(23)C_(6)sample was synthesized using high temperature high pressure quenching method(HTHPQM),and investigated in detail by x-ray diffraction,electron microscope,magnetization and electrical resistivity measurements,etc.First-principles calculation based on density functional theory ab intio simulation was carried out to calculate the bonding and electromagnetic properties of Mn_(23)C_(6).Based on our experimental and simulated results,the Mn_(23)C_(6)in this work is single phase of a faced-centered cubic structure with space group Fm-3m(No.225).Determined by SEM and TEM,the bulk sample consists of monocrystal Mn_(23)C_(6)crystals with 2-15μm grain sizes,it is the quick quenching method in the synthesizing process that brings such small crystal grain size.Archimedes method gives its density of 7.14 g/cm^(3),95.74%of its theoretically calculated density 7.458 g/cm^(3).Owing to the abundant Mn 3d electrons and a framework of strongly linked Mn atoms in Mn_(23)C_(6),the electrical conductivity is up to 8.47×10^(-4)Ω·m,which shows that Mn_(23)C_(6)is a good conductor.Our magnetic susceptibility analyses reveal a magnetization peak in the M-T curve at 104 K,combined with the M-H curve and Curie-Weiss law,this peak usually means the transformation between paramagnetic and antiferromagnetic orders.To gain an insight into the mechanism of the magnetic phase transition,we calculated the magnetic properties,and the results show that different from normal antiferromagnetic order,the magnetic orders in Mn_(23)C_(6)consist of three parts,the direct ferromagnetic and antiferromagnetic exchange coupling interactions between Mn atoms,and the indirect antiferromagnetic super-exchange interaction between Mn and C atoms.Therefore,we reveal that the Mn_(23)C_(6)is a complex magnetic competition system including different magnetic orders and interactions,instead of the normal long-range antiferromagnetic order.
文摘As oil and gas development increasingly targets unconventional reservoirs,the limitations of conventional hydraulic fracturing,namely high water consumption and significant reservoir damage,have become more pronounced.This has driven growing interest in the development of clean fracturing fluids that minimize both water usage and formation impairment.In this study,a low-liquid-content viscoelastic surfactant(VES)foam fracturing fluid system was formulated and evaluated through laboratory experiments.The optimized formulation comprises 0.2%foaming agent CTAB(cetyltrimethylammonium bromide)and 2%foam stabilizer EAPB(erucamidopropyl betaine).Laboratory tests demonstrated that the VES foam system achieved a composite foam value of 56,700 mL・s,reflecting excellent foaming performance.Proppant transport experiments revealed minimal variation in suspended sand volume over 120 min across different sand ratios,indicating robust sand-carrying capacity even at high proppant concentrations.Rheological measurements showed that the fluid maintained a viscosity above 120 mPa・s after 120 min of shearing at 70℃ and a shear rate of 170 s−1,with the elastic modulus exceeding the viscous modulus,confirming the system’s exceptional stability and resilience.Furthermore,core damage tests indicated that the VES foam caused only 4.42%formation damage,highlighting its potential for efficient and low-damage stimulation of tight reservoirs.Overall,the findings demonstrate that this low-liquid-content VES foam provides a highly effective,environmentally considerate alternative for hydraulic fracturing in unconventional formations,combining superior proppant transport,rheological stability,and minimal reservoir impairment.
基金supported by National Key Research and Development Program of China(2023YFD1200500,2022YFD1201700)the National Natural Science Foundation of China(32071921)+1 种基金Key Research and Development Program of Shandong Province,China(2021LZGC022)the Taishan Scholars Project。
文摘Maize(Zea mays L.)is one of the world's most important staple crops,and is used for manufacturing food,feed,and industrial products.A key factor in maize yield is the grain weight,which directly influences productivity.In this study,we revealed the role of smk23 in maize kernel development.The ethyl methanesulfonate mutant smk23 is characterized by substantially reduced kernel weight.Through map-based cloning,smk23 was found to be located on Chr5 and encode a putative B-type response regulator,Zm RR5.A change from G to A occurs in the coding sequence of Zm RR5,resulting in the early termination of smk23.In Arabidopsis,B-type response regulators are involved in cytokinin signaling.Histological analysis and in situ hybridization of the mutant revealed abnormal endosperm development,particularly in the basal endosperm transfer layer(BETL),a specialized tissue critical for nutrient transport from the maternal tissues to the developing kernel.Zm RR5 positively regulates key genes involved in BETL development and function,including MRP1 and TCRR1.Furthermore,RNA sequencing revealed that several genes closely linked to BETL development,including BETL2,MEG1,and MN1,were significantly downregulated in smk23.These genes are essential for nutrient transport,tissue development and signal transduction.In addition,haploid analysis of Zm RR5 revealed natural variations(Hap 2)that may contribute to the increased kernel yield.Disruption of Zm RR5 function in smk23 leads to defects in BETL development,impairing its ability to transport nutrients,and ultimately resulting in a smaller kernel size.This study provides new insights into the molecular mechanisms through which Zm RR5 regulates maize kernel development and offers potential strategies for improving grain yield.
