ACKGROUND The hemoglobin glycation index(HGI)represents the discrepancy between the glucose management indicator(GMI)based on mean blood glucose levels and laboratory values of glycated hemoglobin(HbA1c).The HGI is a ...ACKGROUND The hemoglobin glycation index(HGI)represents the discrepancy between the glucose management indicator(GMI)based on mean blood glucose levels and laboratory values of glycated hemoglobin(HbA1c).The HGI is a promising indicator for identifying individuals with excessive glycosylation,facilitating personalized evaluation and prediction of diabetic complications.However,the factors influencing the HGI in patients with type 1 diabetes(T1D)remain unclear.Autoimmune destruction of pancreaticβcells is central in T1D pathogenesis,yet insulin resistance can also be a feature of patients with T1D and their coexistence is called“double diabetes”(DD).However,knowledge regarding the relationship between DD features and the HGI in T1D is limited.AIM To assess the association between the HGI and DD features in adults with T1D.METHODS A total of 83 patients with T1D were recruited for this cross-sectional study.Laboratory HbA1c and GMI from continuous glucose monitoring data were collected to calculate the HGI.DD features included a family history of type 2 diabetes,overweight/obesity/central adiposity,hypertension,atherogenic dyslipidemia,an abnormal percentage of body fat(PBF)and/or visceral fat area(VFA)and decreased estimated insulin sensitivity.Skin autofluorescence of advanced glycation end products(SAF-AGEs),diabetic complications,and DD features were assessed,and their association with the HGI was analyzed.RESULTS A discrepancy was observed between HbA1c and GMI among patients with T1D and DD.A higher HGI was associated with an increased number of SAF-AGEs and a higher prevalence of diabetic microangiopathy(P=0.030),particularly retinopathy(P=0.031).Patients with three or more DD features exhibited an eight-fold increased risk of having a high HGI,compared with those without DD features(adjusted odds ratio=8.12;95%confidence interval:1.52-43.47).Specifically,an elevated PBF and/or VFA and decreased estimated insulin sensitivity were associated with high HGI.Regression analysis identified estimated insulin sensitivity and VFA as factors independently associated with HGI.CONCLUSION In patients with T1D,DD features are associated with a higher HGI,which represents a trend toward excessive glycosylation and is associated with a higher prevalence of chronic diabetic complications.展开更多
BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients wi...BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients with type 1 diabetes(T1D).The glycemia risk index(GRI),a composite metric derived from continuous glucose monitoring(CGM),has emerged as a potential solution by systematically in-tegrating both hypoglycemia and hyperglycemia risks into a single interpretable score.The GRI exhibited linear correlations with HbA1c(r=0.53),time in range(r=-0.90),time above range(r=0.63),time below range(TBR)(r=0.37),and co-efficient of variation(CV)(r=0.71).It correlated strongly with TBR and CV than HbA1c.The association between HbA1c levels and GRI was influenced by TBR and CV.At a given HbA1c,each 1%increase in TBR or CV raised GRI by 1.87[95%confidence interval(CI):1.72-2.01]and 1.94(95%CI:1.80-2.10),respectively(P<0.001).Clustering of the CGM data identified four subgroups:Moderate-risk glycemic fluctuations,high-risk hypoglycemia,optimal glycemic control,and high-risk hyperglycemia.The GRI and its components for hypoglycemia and hyperglycemia could distinguish between these subgroups.CONCLUSION The GRI offers a comprehensive view of glycemic control in T1D.Combining HbA1c with the GRI enables accurate assessment for managing glycemic control in patients with T1D.展开更多
The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restrain...The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.展开更多
The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human comfort.However,the development of smart and dynamic fabrics capable of mana...The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human comfort.However,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a challenge.Herein,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/heat.The cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport channel.Subsequently,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability gradient.The fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too cold.In addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic side.This smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.展开更多
The microstructures of {111}<uvw> grain were characterized in detailed and systematically investigated with the aid of electron backscatter diffraction(EBSD) and transmission electron microscope(TEM). The stored...The microstructures of {111}<uvw> grain were characterized in detailed and systematically investigated with the aid of electron backscatter diffraction(EBSD) and transmission electron microscope(TEM). The stored energy in different regions in the grain was evaluated by the band contrast values collected from EBSD. The results show that the distribution of energy is inhomogeneous through the grain. Especially,the regions containing the least and the largest energy were extracted from the EBSD data, and then quantitatively analyzed based on the misorientation and Schmid factor. Many peaks with large misorientation appeared in the region containing larger energy, and these peaks represent the existences of micro-bands and micro-shear bands in {111} grain. The results of Schmid factor suggest that the region containing larger energy is prone to deforming ahead of the region with less stored energy, implying the more serious subdivision of the microstructure of region with larger stored energy.展开更多
Achieving room-temperature superconductivity has been an enduring scientific quest,while hydrogen-rich compounds have emerged as highly promising candidates.Here,we systematically investigated the thermodynamic stabil...Achieving room-temperature superconductivity has been an enduring scientific quest,while hydrogen-rich compounds have emerged as highly promising candidates.Here,we systematically investigated the thermodynamic stability,crystal structure,electronic properties,and superconductivity within the ternary Y-Hf-H system under high pressure.Several distinct hydrides have been revealed,in which the hydrogen atoms are present in various hydrogenic motifs.A15-type hydride P_(m)3-YHfH_(6)with isolated H−is predicted to be dynamically stabilized down to 10GPa.The H atoms form pentagonal graphene-like layered-H10 anions in the Hf plane of P6-YHfH_(19),with aT_(c)of 95K at 100GPa.There are H cages in C_(mmm)-Y_(3)HfH_(24),and attributed to the robust electron–phonon coupling and high electronic density of states of hydrogen at the Fermi level,it demonstrates near-room temperature superconductivity with a T_(c)of 275K at 250GPa.Our work makes contributions to the understanding of the fundamental properties of ternary hydrides under high pressure and provides essential references for further research in this field.展开更多
Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,th...Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,the high hardware costs and data burden associated with the acquisition of neutron ToF signals pose significant challenges.Higher sampling rates increase the data volume,data processing,and storage hardware costs.Compressed sampling can address these challenges,but it faces issues regarding optimal sampling efficiency and high-quality reconstructed signals.This paper proposes a revolutionary deep learning-based compressed sampling(DL-CS)algorithm for reconstructing neutron ToF signals that outperform traditional compressed sampling methods.This approach comprises four modules:random projection,rising dimensions,initial reconstruction,and final reconstruction.Initially,the technique adaptively compresses neutron ToF signals sequentially using three convolutional layers,replacing random measurement matrices in traditional compressed sampling theory.Subsequently,the signals are reconstructed using a modified inception module,long short-term memory,and self-attention.The performance of this deep compressed sampling method was quantified using the percentage root-mean-square difference,correlation coefficient,and reconstruction time.Experimental results showed that our proposed DL-CS approach can significantly enhance signal quality compared with other compressed sampling methods.This is evidenced by a percentage root-mean-square difference,correlation coefficient,and reconstruction time results of 5%,0.9988,and 0.0108 s,respectively,obtained for sampling rates below 10%for the neutron ToF signal generated using an electron-beam-driven photoneutron source.The results showed that the proposed DL-CS approach significantly improves the signal quality compared with other compressed sampling methods,exhibiting excellent reconstruction accuracy and speed.展开更多
A heterogeneous transverse direction(TD)-tilt texture in rare-earth-containing magnesium plates typically results in obvious in-plane anisotropy in their mechanical behavior.In this study,the planar anisotropy of yiel...A heterogeneous transverse direction(TD)-tilt texture in rare-earth-containing magnesium plates typically results in obvious in-plane anisotropy in their mechanical behavior.In this study,the planar anisotropy of yield strength during tension along the rolling direction(RD)and TD is quantified in a Mg-0.1Zn-0.5Gd plate with different grain sizes and texture patterns.Regardless of the grain size,the yield strength along the RD is approximately 33 MPa higher than that along the TD in the plate with the c-axis distributed in an elliptical region.In contrast,a near in-plane isotropy of the mechanical properties is observed in the plate with the c-axis aligned primarily in a circular region.Microstructural analysis and crystal plasticity simulations show that basal slip prevailed during the tension test,with varied complementary deformation modes in different loading directions.Prismatic slip is the main complementary deformation mode during tension along the RD,whereas tensile twinning is important during tension along the TD.The yield anisotropy is primarily attributed to the varied interceptσ_(0)in the Hall-Petch relation during tension along different directions.The invariant Hall-Petch slope k results in grain size independence on the mechanical anisotropy.Finally,a quantitative discussion on the differences ofσ_(0)and the similarity in k related to the relative activity of the deformation modes is provided.展开更多
BACKGROUND Autoimmune gastritis(AIG)is frequently associated with one or more comorbid conditions,among which type I gastric neuroendocrine tumors(gNETs)warrant significant clinical concern.However,risk factors for th...BACKGROUND Autoimmune gastritis(AIG)is frequently associated with one or more comorbid conditions,among which type I gastric neuroendocrine tumors(gNETs)warrant significant clinical concern.However,risk factors for the development of gNETs in AIG populations remain poorly defined.AIM To characterize the clinical and endoscopic profiles of AIG and identify potential risk factors for gNETs development.METHODS In this single-center cross-sectional study carried out at a tertiary hospital,303 patients with AIG over an 8-year period were retrospectively categorized into gNETs(n=116)and non-gNETs(n=187)groups.Endoscopic and clinical pa-rameters were analyzed.Endoscopic features were systematically reevaluated according to the 2023 Japanese diagnostic criteria for AIG.Feature selection was performed using the Boruta algorithm,and the model discriminative ability was evaluated via receiver operating characteristic curve analysis.RESULTS Among the 303 patients with AIG,116 had gNETs and 187 did not.Compared with the non-gNETs group,patients in the gNETs group were younger(54.3 years vs 60.6 years,P<0.001),had higher rate of vitamin B12 deficiency(77.2%vs 55.8%,P<0.001),lower pepsinogen I(4.3 ng/mL vs 7.4 ng/mL,P<0.001)and pepsinogen I/II ratios(0.7 vs.1.1,P<0.001),and lower prior Helicobacter pylori infection rate(3.4%vs 21.4%,P<0.001).Endoscopically,the gNETs group showed a lower incidence of oxyntic mucosal remnants,hyperplastic polyps,and patchy antral redness.The predictive model incorporating age,prior Helicobacter pylori infection,vitamin B12 level,gastric hy-perplastic polyps,and patchy antral redness showed an area under the curve of 0.830.CONCLUSION Patients with AIG or gNETs exhibit specific clinical and endoscopic features.The predictive model demonstrated favorable discriminative ability and may facilitate risk stratification of gNETs in patients with AIG.展开更多
To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engi...To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.展开更多
In this paper, we study the decentralized federated learning problem, which involves the collaborative training of a global model among multiple devices while ensuring data privacy.In classical federated learning, the...In this paper, we study the decentralized federated learning problem, which involves the collaborative training of a global model among multiple devices while ensuring data privacy.In classical federated learning, the communication channel between the devices poses a potential risk of compromising private information. To reduce the risk of adversary eavesdropping in the communication channel, we propose TRADE(transmit difference weight) concept. This concept replaces the decentralized federated learning algorithm's transmitted weight parameters with differential weight parameters, enhancing the privacy data against eavesdropping. Subsequently, by integrating the TRADE concept with the primal-dual stochastic gradient descent(SGD)algorithm, we propose a decentralized TRADE primal-dual SGD algorithm. We demonstrate that our proposed algorithm's convergence properties are the same as those of the primal-dual SGD algorithm while providing enhanced privacy protection. We validate the algorithm's performance on fault diagnosis task using the Case Western Reserve University dataset, and image classification tasks using the CIFAR-10 and CIFAR-100 datasets,revealing model accuracy comparable to centralized federated learning. Additionally, the experiments confirm the algorithm's privacy protection capability.展开更多
Estrogen affects the generation and transmission of neuropathic pain,but the specific regulatory mechanism is still unclear.Activation of the N-methyl-D-aspartate acid receptor 1（NMDAR1） plays an important role in t...Estrogen affects the generation and transmission of neuropathic pain,but the specific regulatory mechanism is still unclear.Activation of the N-methyl-D-aspartate acid receptor 1（NMDAR1） plays an important role in the production and maintenance of hyperalgesia and allodynia.The present study was conducted to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain.A chronic sciatic nerve constriction injury model of chronic neuropathic pain was established in rats.These rats were then subcutaneously injected with 17β-estradiol,the NMDAR1 antagonist D（-）-2-amino-5-phosphonopentanoic acid（AP-5）,or both once daily for 15 days.Compared with injured drug na？ve rats,rats with chronic sciatic nerve injury that were administered estradiol showed a lower paw withdrawal mechanical threshold and a shorter paw withdrawal thermal latency,indicating increased sensitivity to mechanical and thermal pain.Estrogen administration was also associated with increased expression of NMDAR1 immunoreactivity（as assessed by immunohistochemistry） and protein（as determined by western blot assay） in spinal dorsal root ganglia.This 17β-estradiol-induced increase in NMDAR1 expression was blocked by co-administration with AP-5,whereas AP-5 alone did not affect NMDAR1 expression.These results suggest that 17β-estradiol administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve,and that the mechanism for this increased sensitivity may be related to the upregulation of NMDAR1 expression in dorsal root ganglia.展开更多
Objective:To observe the therapeutic effect of combined scalp and body acupuncture on the motor symptoms in Parkinson’s disease(PD),and on the score of levodopa equivalent dose(LED).Methods:This is a randomized,singl...Objective:To observe the therapeutic effect of combined scalp and body acupuncture on the motor symptoms in Parkinson’s disease(PD),and on the score of levodopa equivalent dose(LED).Methods:This is a randomized,single blind trial.Sixty-six patients with PD were randomized into an acupuncture+medication group(33 patients)and a medication group(33 patients).The patients were aware of allocation and the assessors were blinded to group assignment and therapeutic regimen.AntiPD drugs were administered in both groups.In the acupuncture+medication group,scalp and body acupuncture therapy was added.Treatments were applied for 8 weeks.In scalp acupuncture,the anterior oblique line of the vertex-temporal(MS6),lateral line 1 of the vertex(MS8),lateral line 2 of the vertex(MS9),and lower-lateral line of the occiput(MS14)were selected.In the body acupuncture,the acupoints included Bǎihuì(百会GV20),Sìshéncōng(四神聪EX-HN1),and Dàzhuī(大椎GV14),as well as the bilateral Fēngchí(风池GB20),Nèiguān(内关PC6),Hégǔ(合谷LI4),Gānshū(肝俞BL18),Shènshū(肾俞BL23),Yánglíngquán(阳陵泉GB34),Zúsānlǐ(足三里ST36),Fēnglóng(丰隆ST40),Sānyīnjiāo(三阴交SP6),Tàixī(太溪KI3),and Tàichōng(太冲LR3).Before and after treatments,the unified Parkinson’s disease rating scale(UPDRS),3section of the UPDRS(UPDRS-Ⅲ),and motor dysfunction rating scale for Parkinson’s disease(MDRSPD)were scored in the patients.The therapeutic effect of traditional Chinese medicine(TCM)and LED score were compared between both groups.Results:Thirty-three cases were included in data analysis in each group.After treatment,UPDRS scores were(28.77±8.85)and(36.58±10.16)points,UPDRS-Ⅲscores were(12.16±1.97)and(17.47±2.93)points and MDRSPD scores were(15.56±3.31)and(19.13±4.87)points in the acupuncture+medication and medication groups respectively.The UPDRS,UPDRS-Ⅲ,and MDRSPD scores all reduced after treatments in both groups(all P<0.05).All three scores were lower in the acupuncture+medication group than in the medication group(all P<0.05).When examining the therapeutic effects of TCM,the total effective rate was 87.88%in the acupuncture+medication group and 75.76%in the medication group(P<0.05).After treatment,the LED scores were(387.55±146.24)points and(437.42±183.16)points in the acupuncture+medication and medication groups,respectively.The LED dose differences before and after treatment for the acupuncture+medication and medication groups were(40.36±16.33)points and(95.88±35.79)points,respectively.The LED scores in both groups were higher than the pre-treatment scores(P<0.05).However,the post-treatment LED score was lower in the acupuncture+medication group than in the medication group(P<0.05),as was the dose difference before and after treatment(P<0.05).No relevant adverse reaction was found in each group.Conclusion:In addition to anti-PD medication,the scalp and body acupuncture may effectively relieve the motor symptoms of PD and improve the control of LED score.展开更多
In this paper, we consider the distributed adaptive fault-tolerant output regulation problem for heterogeneous multiagent systems with matched system uncertainties and mismatched coupling uncertainties among subsystem...In this paper, we consider the distributed adaptive fault-tolerant output regulation problem for heterogeneous multiagent systems with matched system uncertainties and mismatched coupling uncertainties among subsystems under the influence of actuator faults. First, distributed finite-time observers are proposed for all subsystems to observe the state of the exosystem. Then, a novel fault-tolerant controller is designed to compensate for the influence of matched system uncertainties and actuator faults. By using the linear matrix inequality technique, a sufficient condition is provided to guarantee the solvability of the considered problem in the presence of mismatched coupling uncertainties. Moreover, it is shown that the system in closed-loop with the developed controller can achieve output regulation by using the Lyapunov stability theory and cyclic-small-gain theory.Finally, a numerical example is given to illustrate the effectiveness of the obtained result.展开更多
Hot compression was performed on a multilayered Au−20Sn eutectic alloy to investigate the deformation behavior and microstructure evolution.During hot compression,microstructural spheroidization was initiated from pla...Hot compression was performed on a multilayered Au−20Sn eutectic alloy to investigate the deformation behavior and microstructure evolution.During hot compression,microstructural spheroidization was initiated from plastic instability regions,and it was preferentially activated in vertical lamellae with a growth direction parallel to the compressive direction.Continuous dynamic recrystallization associated with lattice dislocations was the mechanism in both AuSn and Au5Sn multilayers.After spheroidization,strain accumulations were weakened in both of the equiaxed phases,and the deformation mechanism was substantially replaced by grain boundary sliding and migration.Based on these findings,hot rolling was conducted on an as-cast Au−20Sn alloy and a foil with a thickness of~50μm was successfully prepared.The present study can promote the development of Au−20Sn foils,and provide insights into the deformation behavior and microstructure evolution of multilayered eutectic alloys.展开更多
For sputtering targets, through-thickness texture is critical for assuring reliable sputtering performance.In this paper, through-thickness texture gradient of a rolled and subsequently annealed tantalum sputtering ta...For sputtering targets, through-thickness texture is critical for assuring reliable sputtering performance.In this paper, through-thickness texture gradient of a rolled and subsequently annealed tantalum sputtering target was investigated. The results show that by carefully controlling the rolling process, shear-related components at the surface of the rolled sample could be avoided. Both the rolled sample and the annealed target develop a through-thickness texture gradient with the formation of a stronger {1 1 1}fiber in the center layer compared with that in the surface layer.展开更多
BACKGROUND For the past few years,preventive interventional therapy has been widely used domestically and overseas,bringing great benefits to pregnant women at high-risk for complications,such as pernicious placenta p...BACKGROUND For the past few years,preventive interventional therapy has been widely used domestically and overseas,bringing great benefits to pregnant women at high-risk for complications,such as pernicious placenta previa(PPP)and placenta accreta.Nevertheless,there are still few reports on surgical complications related to interventional therapy,and its safety should be a concern.CASE SUMMARY We report a 36-year-old pregnant woman with PPP who underwent balloon implantation in the lower segment of the abdominal aorta before caesarean section.However,the balloon shifted during the operation,which damaged the arterial vessels after filling,resulting in severe postpartum haemorrhage in the patient.Fortunately,after emergency interventional stent implantation,the pa-tient was successfully relieved of the massive haemorrhage crisis.CONCLUSION It seems that massive postoperative bleeding has been largely avoided in preventive interventional therapy in high-risk pregnant women with placenta-related diseases,but surgical complications related to intervention therapy can also cause adverse consequences.It is equally important for clinical doctors to learn how to promptly identify and effectively treat these rare complications.展开更多
The electronic and functional synergies between the twin metal centers make dual single-atom catalysts(DACs)attractive for oxygen electrocatalysis.The catalytic activities of DACs are largely decided by their surround...The electronic and functional synergies between the twin metal centers make dual single-atom catalysts(DACs)attractive for oxygen electrocatalysis.The catalytic activities of DACs are largely decided by their surrounding micro-environment and supporting substrates.Modulating the micro-environment as well as engineering the efficient support is challenging tasks.Moreover,both are critical to optimizing the performance of DACs.Herein,a novel bio-cooperative strategy is developed to synthesize Fe Ni-DAC wherein Fe-Ni dual-atom sites are embedded in the N,P codoped tyre shaped carbon matrix.The configuration matching of Fe-Ni dual centers together with the local electronic engineering of N,P heteroatoms synergistically boost the catalytic activity on the oxygen reaction.Furthermore,the central-hollow highlyporous carbon matrix not only gives rise to a large amount of active sites,but also facilitates fast kinetics.Taking advantage of both the DAC and the substrate,the Fe Ni-NPC hollow tyre(HT)catalyst scores high in both oxygen reduction and evolution reactions,which exhibits the narrow potential difference and excellent durability.The aqueous Zn-air full battery(ZAB)integrating the Fe Ni-NPC HT air cathode has a high power density and a good stability over long-term cycling.Moreover,the flexible solid-state ZAB assembled with the polymer electrolyte obtains the high reliability over a wide range of temperatures or under diverse outside deformations.Therefore,this work offers a new green approach to prepare highly efficient DACs with built-in modulated micro-environment and tailor-made substrates.Moreover,it also paves a new way to develop highly-pliable power source for flexible electronics.展开更多
The exploration of low-strain and high-performance electrode is a crucial issue for aqueous potassiumion battery(AKIB).Herein,a novel potassium mediated iron/manganese binary hexacyanoferrate nanocuboid,i.e.,K_(x)Fe_(...The exploration of low-strain and high-performance electrode is a crucial issue for aqueous potassiumion battery(AKIB).Herein,a novel potassium mediated iron/manganese binary hexacyanoferrate nanocuboid,i.e.,K_(x)Fe_(y)Mn_(1-y)[Fe(CN)_(6)]·nH_(2)O(KFeMnHCF)nanocuboid,with the concentration-gradient(CG)structure is designed as a high-performance cathode for AKIB.Internal the CG-KFeMnHCF nanocuboids,the manganese content gradually decreases from the interior to the surface and the iron content changes reverse,resulting in the concentration-gradient structure.Both experimental and finite element simulation(FEA)results demonstrate the lower internal stress and better mechanical characteristics of CG structured nanocuboid than the homogenous structured one upon ion intercalation/deintercalation processes.Meanwhile,the electrochemical testing and theoretical calculation(DFT)results disclose the substitution of Fe to Mn in the KMnHCF crystal results in the enhanced electronic conductivity,potassium migration and electrochemical kinetics.Taken both advantages from the well-designed architecture and optimized crystal structure,the CG-KFeMnHCF achieves the superior rate capability and ultrahigh stability in aqueous potassium ion system.In particular,the CG-KFe_(0.31)Mn_(0.69)HCF achieves the best comprehensive properties among all the samples.The full AKIBs based on CG-KFe_(0.31)Mn_(0.69)HCF cathode achieves the high energy density(83 Wh kg^(-1)),superior power density,high capacity retention(83%)over high-rate long-term cycles,good adaptation to a wide temperature range(-20 to 40℃)and high reliability even under outside deformations.Therefore,this work not only provides a new clue to design the highperformance cathode,but also promotes the applications of AKIBs for diverse electronics and wide working environments.展开更多
基金Supported by the National Key R D Program of China,No.2022YFC2010102Natural Science Foundation of Hunan Province,No.2021JC0003+1 种基金National Natural Science Foundation of China,No.82070812the Sinocare Diabetes Foundation,No.LYF2022039.
文摘ACKGROUND The hemoglobin glycation index(HGI)represents the discrepancy between the glucose management indicator(GMI)based on mean blood glucose levels and laboratory values of glycated hemoglobin(HbA1c).The HGI is a promising indicator for identifying individuals with excessive glycosylation,facilitating personalized evaluation and prediction of diabetic complications.However,the factors influencing the HGI in patients with type 1 diabetes(T1D)remain unclear.Autoimmune destruction of pancreaticβcells is central in T1D pathogenesis,yet insulin resistance can also be a feature of patients with T1D and their coexistence is called“double diabetes”(DD).However,knowledge regarding the relationship between DD features and the HGI in T1D is limited.AIM To assess the association between the HGI and DD features in adults with T1D.METHODS A total of 83 patients with T1D were recruited for this cross-sectional study.Laboratory HbA1c and GMI from continuous glucose monitoring data were collected to calculate the HGI.DD features included a family history of type 2 diabetes,overweight/obesity/central adiposity,hypertension,atherogenic dyslipidemia,an abnormal percentage of body fat(PBF)and/or visceral fat area(VFA)and decreased estimated insulin sensitivity.Skin autofluorescence of advanced glycation end products(SAF-AGEs),diabetic complications,and DD features were assessed,and their association with the HGI was analyzed.RESULTS A discrepancy was observed between HbA1c and GMI among patients with T1D and DD.A higher HGI was associated with an increased number of SAF-AGEs and a higher prevalence of diabetic microangiopathy(P=0.030),particularly retinopathy(P=0.031).Patients with three or more DD features exhibited an eight-fold increased risk of having a high HGI,compared with those without DD features(adjusted odds ratio=8.12;95%confidence interval:1.52-43.47).Specifically,an elevated PBF and/or VFA and decreased estimated insulin sensitivity were associated with high HGI.Regression analysis identified estimated insulin sensitivity and VFA as factors independently associated with HGI.CONCLUSION In patients with T1D,DD features are associated with a higher HGI,which represents a trend toward excessive glycosylation and is associated with a higher prevalence of chronic diabetic complications.
基金Supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0508201the National Key R and D Program of China,No.2022YFC2010100+3 种基金the National Natural Science Foundation of China,No.82070812the Natural Science Foundation of Hunan Province,No.2024JJ9049,No.2023JJ30762 and No.2021JC0003Sinocare Diabetes Foundation,No.2020SD08the National Clinical Research Center for Metabolic Diseases Clinical Diagnosis and Treatment Capacity Enhancement Program,No.2023ZLNL003.
文摘BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients with type 1 diabetes(T1D).The glycemia risk index(GRI),a composite metric derived from continuous glucose monitoring(CGM),has emerged as a potential solution by systematically in-tegrating both hypoglycemia and hyperglycemia risks into a single interpretable score.The GRI exhibited linear correlations with HbA1c(r=0.53),time in range(r=-0.90),time above range(r=0.63),time below range(TBR)(r=0.37),and co-efficient of variation(CV)(r=0.71).It correlated strongly with TBR and CV than HbA1c.The association between HbA1c levels and GRI was influenced by TBR and CV.At a given HbA1c,each 1%increase in TBR or CV raised GRI by 1.87[95%confidence interval(CI):1.72-2.01]and 1.94(95%CI:1.80-2.10),respectively(P<0.001).Clustering of the CGM data identified four subgroups:Moderate-risk glycemic fluctuations,high-risk hypoglycemia,optimal glycemic control,and high-risk hyperglycemia.The GRI and its components for hypoglycemia and hyperglycemia could distinguish between these subgroups.CONCLUSION The GRI offers a comprehensive view of glycemic control in T1D.Combining HbA1c with the GRI enables accurate assessment for managing glycemic control in patients with T1D.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘The girder end restraint devices such as bearings and dampers on long span suspension bridge will deteriorate over time.However,it is difficult to achieve the quantitative assessment of the performance of the restraint device through existing detection methods in actual inspections,making it difficult to obtain the impact of changes in the performance of the restraint device on the bridge structure.In this paper,a random vehicle load model is firstly established based on the WIM data of Jiangyin Bridge,and the displacement of girder end under the actual traffic flow is simulated by using finite element dynamic time history analysis.On this basis,according to the performance test data of the bearings and dampers,the performance degradation laws of the above two restraint devices are summarized,and the performance degradation process of the two restraint devices and the effects of different restraint parameters on the bridge structure are simulated.The results show that the performance degradation of the damper will significantly reduce the damping force at low speed,resulting in a significant increase in the cumulative displacement of the girder end;in the presence of longitudinal dampers,the increase in the friction coefficient caused by the deterioration of the bearing sliding plate has little effect on the cumulative displacement,but excessive wear of the bearing sliding plate adversely affects the structural dynamic performance.
基金support of this work by National Key Research and Development Program of China(2019YFC19059003)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJB430024)+1 种基金Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB680)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)are gratefully acknowledged.
文摘The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human comfort.However,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a challenge.Herein,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/heat.The cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport channel.Subsequently,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability gradient.The fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too cold.In addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic side.This smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.
基金supported by the National Natural Science Foundation of China(Grants 51421001,51504051 and 51701032)the Chongqing Science and Technology Commission in China(CSTC,2017jcyjAX0094 and cstc2015jcyjA90001
文摘The microstructures of {111}<uvw> grain were characterized in detailed and systematically investigated with the aid of electron backscatter diffraction(EBSD) and transmission electron microscope(TEM). The stored energy in different regions in the grain was evaluated by the band contrast values collected from EBSD. The results show that the distribution of energy is inhomogeneous through the grain. Especially,the regions containing the least and the largest energy were extracted from the EBSD data, and then quantitatively analyzed based on the misorientation and Schmid factor. Many peaks with large misorientation appeared in the region containing larger energy, and these peaks represent the existences of micro-bands and micro-shear bands in {111} grain. The results of Schmid factor suggest that the region containing larger energy is prone to deforming ahead of the region with less stored energy, implying the more serious subdivision of the microstructure of region with larger stored energy.
基金supported by the National Natural Science Foundation of China(Grant Nos.52072188,12122405,and 12274169)Program for Science and Technology Innovation Team in Zhejiang Province,China(Grant No.2021R01004)+2 种基金Natural Science Foundation of Zhejiang Province,China(Grant No.LQ24A040001)the Natural Science Foundation of Ningbo City,China(Grant No.2024J200)the Fundamental Research Funds for the Provincial Universities of Zhejiang(Grant No.SJLY2023003)。
文摘Achieving room-temperature superconductivity has been an enduring scientific quest,while hydrogen-rich compounds have emerged as highly promising candidates.Here,we systematically investigated the thermodynamic stability,crystal structure,electronic properties,and superconductivity within the ternary Y-Hf-H system under high pressure.Several distinct hydrides have been revealed,in which the hydrogen atoms are present in various hydrogenic motifs.A15-type hydride P_(m)3-YHfH_(6)with isolated H−is predicted to be dynamically stabilized down to 10GPa.The H atoms form pentagonal graphene-like layered-H10 anions in the Hf plane of P6-YHfH_(19),with aT_(c)of 95K at 100GPa.There are H cages in C_(mmm)-Y_(3)HfH_(24),and attributed to the robust electron–phonon coupling and high electronic density of states of hydrogen at the Fermi level,it demonstrates near-room temperature superconductivity with a T_(c)of 275K at 250GPa.Our work makes contributions to the understanding of the fundamental properties of ternary hydrides under high pressure and provides essential references for further research in this field.
基金supported by the National Defense Technology Foundation Program of China(No.JSJT2022209A001-3)Sichuan Science and Technology Program(No.2021JDRC0011)+1 种基金Nuclear Energy Development Research Program of China(Research on High Energy X-ray Imaging of Nuclear Fuel)Scientific Research and Innovation Team Program of Sichuan University of Science and Engineering(No.SUSE652A001).
文摘Neutron time-of-flight(ToF)measurement is a highly accurate method for obtaining the kinetic energy of a neutron by measuring its velocity,but requires precise acquisition of the neutron signal arrival time.However,the high hardware costs and data burden associated with the acquisition of neutron ToF signals pose significant challenges.Higher sampling rates increase the data volume,data processing,and storage hardware costs.Compressed sampling can address these challenges,but it faces issues regarding optimal sampling efficiency and high-quality reconstructed signals.This paper proposes a revolutionary deep learning-based compressed sampling(DL-CS)algorithm for reconstructing neutron ToF signals that outperform traditional compressed sampling methods.This approach comprises four modules:random projection,rising dimensions,initial reconstruction,and final reconstruction.Initially,the technique adaptively compresses neutron ToF signals sequentially using three convolutional layers,replacing random measurement matrices in traditional compressed sampling theory.Subsequently,the signals are reconstructed using a modified inception module,long short-term memory,and self-attention.The performance of this deep compressed sampling method was quantified using the percentage root-mean-square difference,correlation coefficient,and reconstruction time.Experimental results showed that our proposed DL-CS approach can significantly enhance signal quality compared with other compressed sampling methods.This is evidenced by a percentage root-mean-square difference,correlation coefficient,and reconstruction time results of 5%,0.9988,and 0.0108 s,respectively,obtained for sampling rates below 10%for the neutron ToF signal generated using an electron-beam-driven photoneutron source.The results showed that the proposed DL-CS approach significantly improves the signal quality compared with other compressed sampling methods,exhibiting excellent reconstruction accuracy and speed.
基金support of the National Key Research and Development Program of China(No.2022YFB3707102)the Key Project of Jiangsu Basic Research Program(No.BK20243005)the Basic Research Program of Jiangsu(No.BK20232025).
文摘A heterogeneous transverse direction(TD)-tilt texture in rare-earth-containing magnesium plates typically results in obvious in-plane anisotropy in their mechanical behavior.In this study,the planar anisotropy of yield strength during tension along the rolling direction(RD)and TD is quantified in a Mg-0.1Zn-0.5Gd plate with different grain sizes and texture patterns.Regardless of the grain size,the yield strength along the RD is approximately 33 MPa higher than that along the TD in the plate with the c-axis distributed in an elliptical region.In contrast,a near in-plane isotropy of the mechanical properties is observed in the plate with the c-axis aligned primarily in a circular region.Microstructural analysis and crystal plasticity simulations show that basal slip prevailed during the tension test,with varied complementary deformation modes in different loading directions.Prismatic slip is the main complementary deformation mode during tension along the RD,whereas tensile twinning is important during tension along the TD.The yield anisotropy is primarily attributed to the varied interceptσ_(0)in the Hall-Petch relation during tension along different directions.The invariant Hall-Petch slope k results in grain size independence on the mechanical anisotropy.Finally,a quantitative discussion on the differences ofσ_(0)and the similarity in k related to the relative activity of the deformation modes is provided.
文摘BACKGROUND Autoimmune gastritis(AIG)is frequently associated with one or more comorbid conditions,among which type I gastric neuroendocrine tumors(gNETs)warrant significant clinical concern.However,risk factors for the development of gNETs in AIG populations remain poorly defined.AIM To characterize the clinical and endoscopic profiles of AIG and identify potential risk factors for gNETs development.METHODS In this single-center cross-sectional study carried out at a tertiary hospital,303 patients with AIG over an 8-year period were retrospectively categorized into gNETs(n=116)and non-gNETs(n=187)groups.Endoscopic and clinical pa-rameters were analyzed.Endoscopic features were systematically reevaluated according to the 2023 Japanese diagnostic criteria for AIG.Feature selection was performed using the Boruta algorithm,and the model discriminative ability was evaluated via receiver operating characteristic curve analysis.RESULTS Among the 303 patients with AIG,116 had gNETs and 187 did not.Compared with the non-gNETs group,patients in the gNETs group were younger(54.3 years vs 60.6 years,P<0.001),had higher rate of vitamin B12 deficiency(77.2%vs 55.8%,P<0.001),lower pepsinogen I(4.3 ng/mL vs 7.4 ng/mL,P<0.001)and pepsinogen I/II ratios(0.7 vs.1.1,P<0.001),and lower prior Helicobacter pylori infection rate(3.4%vs 21.4%,P<0.001).Endoscopically,the gNETs group showed a lower incidence of oxyntic mucosal remnants,hyperplastic polyps,and patchy antral redness.The predictive model incorporating age,prior Helicobacter pylori infection,vitamin B12 level,gastric hy-perplastic polyps,and patchy antral redness showed an area under the curve of 0.830.CONCLUSION Patients with AIG or gNETs exhibit specific clinical and endoscopic features.The predictive model demonstrated favorable discriminative ability and may facilitate risk stratification of gNETs in patients with AIG.
基金supported by the National Key Research and Development Program of China(No.2022YFB3706704)the Academician Special Science Research Project of CCCC(No.YSZX-03-2022-01-B).
文摘To investigate the influence of different longitudinal constraint systems on the longitudinal displacement at the girder ends of a three-tower suspension bridge,this study takes the Cangrong Xunjiang Bridge as an engineering case for finite element analysis.This bridge employs an unprecedented tower-girder constraintmethod,with all vertical supports placed at the transition piers at both ends.This paper aims to study the characteristics of longitudinal displacement control at the girder ends under this novel structure,relying on finite element(FE)analysis.Initially,based on the Weigh In Motion(WIM)data,a random vehicle load model is generated and applied to the finite elementmodel.Several longitudinal constraint systems are proposed,and their effects on the structural response of the bridge are compared.The most reasonable system,balancing girder-end displacement and transitional pier stress,is selected.Subsequently,the study examines the impact of different viscous damper parameters on key structural response indicators,including cumulative longitudinal displacement at the girder ends,maximum longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,maximum longitudinal displacement at the pier tops,longitudinal acceleration at the pier tops,and maximum bending moment at the pier bottoms.Finally,the coefficient of variation(CV)-TOPSIS method is used to optimize the viscous damper parameters for multiple objectives.The results show that adding viscous dampers at the side towers,in addition to the existing longitudinal limit bearings at the central tower,can most effectively reduce the response of structural indicators.The changes in these indicators are not entirely consistent with variations in damping coefficient and velocity exponent.The damper parameters significantly influence cumulative longitudinal displacement at the girder ends,cumulative longitudinal displacement at the pier tops,and maximum bending moments at the pier bottoms.The optimal damper parameters are found to be a damping coefficient of 5000 kN/(m/s)0.2 and a velocity exponent of 0.2.
基金supported by the National Key Research and Development Program of China(2022YFB3305904)the National Natural Science Foundation of China(62133003,61991403,61991400)+4 种基金the Open Project of State Key Laboratory of Synthetical Automation for Process Industries(SAPI-2024-KFKT-05,SAPI-2024-KFKT-08)China Academy of Engineering Institute of Land Cooperation Consulting Project(2023-DFZD-60-02,N2424004)the Fundamental Research Funds for the Central UniversitiesShanghai Municipal Science and Technology Major Project(2021SHZDZX0100)the Key Research and Development Program of Liaoning Province(2023JH26/10200011)
文摘In this paper, we study the decentralized federated learning problem, which involves the collaborative training of a global model among multiple devices while ensuring data privacy.In classical federated learning, the communication channel between the devices poses a potential risk of compromising private information. To reduce the risk of adversary eavesdropping in the communication channel, we propose TRADE(transmit difference weight) concept. This concept replaces the decentralized federated learning algorithm's transmitted weight parameters with differential weight parameters, enhancing the privacy data against eavesdropping. Subsequently, by integrating the TRADE concept with the primal-dual stochastic gradient descent(SGD)algorithm, we propose a decentralized TRADE primal-dual SGD algorithm. We demonstrate that our proposed algorithm's convergence properties are the same as those of the primal-dual SGD algorithm while providing enhanced privacy protection. We validate the algorithm's performance on fault diagnosis task using the Case Western Reserve University dataset, and image classification tasks using the CIFAR-10 and CIFAR-100 datasets,revealing model accuracy comparable to centralized federated learning. Additionally, the experiments confirm the algorithm's privacy protection capability.
基金supported by the Youth Shihezi University Applied Basic Research Project of China,No.2015ZRKYQ-LH19
文摘Estrogen affects the generation and transmission of neuropathic pain,but the specific regulatory mechanism is still unclear.Activation of the N-methyl-D-aspartate acid receptor 1（NMDAR1） plays an important role in the production and maintenance of hyperalgesia and allodynia.The present study was conducted to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain.A chronic sciatic nerve constriction injury model of chronic neuropathic pain was established in rats.These rats were then subcutaneously injected with 17β-estradiol,the NMDAR1 antagonist D（-）-2-amino-5-phosphonopentanoic acid（AP-5）,or both once daily for 15 days.Compared with injured drug na？ve rats,rats with chronic sciatic nerve injury that were administered estradiol showed a lower paw withdrawal mechanical threshold and a shorter paw withdrawal thermal latency,indicating increased sensitivity to mechanical and thermal pain.Estrogen administration was also associated with increased expression of NMDAR1 immunoreactivity（as assessed by immunohistochemistry） and protein（as determined by western blot assay） in spinal dorsal root ganglia.This 17β-estradiol-induced increase in NMDAR1 expression was blocked by co-administration with AP-5,whereas AP-5 alone did not affect NMDAR1 expression.These results suggest that 17β-estradiol administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve,and that the mechanism for this increased sensitivity may be related to the upregulation of NMDAR1 expression in dorsal root ganglia.
基金Supported by Funding Scientific Project of Education Division,Henan Province21C0374Inheritance Studio of"Hunan Provincial Academic School of Five-Meridian Combined with Acupuncture and Tuina",State Administration of Traditional Chinese MedicineLP0118041。
文摘Objective:To observe the therapeutic effect of combined scalp and body acupuncture on the motor symptoms in Parkinson’s disease(PD),and on the score of levodopa equivalent dose(LED).Methods:This is a randomized,single blind trial.Sixty-six patients with PD were randomized into an acupuncture+medication group(33 patients)and a medication group(33 patients).The patients were aware of allocation and the assessors were blinded to group assignment and therapeutic regimen.AntiPD drugs were administered in both groups.In the acupuncture+medication group,scalp and body acupuncture therapy was added.Treatments were applied for 8 weeks.In scalp acupuncture,the anterior oblique line of the vertex-temporal(MS6),lateral line 1 of the vertex(MS8),lateral line 2 of the vertex(MS9),and lower-lateral line of the occiput(MS14)were selected.In the body acupuncture,the acupoints included Bǎihuì(百会GV20),Sìshéncōng(四神聪EX-HN1),and Dàzhuī(大椎GV14),as well as the bilateral Fēngchí(风池GB20),Nèiguān(内关PC6),Hégǔ(合谷LI4),Gānshū(肝俞BL18),Shènshū(肾俞BL23),Yánglíngquán(阳陵泉GB34),Zúsānlǐ(足三里ST36),Fēnglóng(丰隆ST40),Sānyīnjiāo(三阴交SP6),Tàixī(太溪KI3),and Tàichōng(太冲LR3).Before and after treatments,the unified Parkinson’s disease rating scale(UPDRS),3section of the UPDRS(UPDRS-Ⅲ),and motor dysfunction rating scale for Parkinson’s disease(MDRSPD)were scored in the patients.The therapeutic effect of traditional Chinese medicine(TCM)and LED score were compared between both groups.Results:Thirty-three cases were included in data analysis in each group.After treatment,UPDRS scores were(28.77±8.85)and(36.58±10.16)points,UPDRS-Ⅲscores were(12.16±1.97)and(17.47±2.93)points and MDRSPD scores were(15.56±3.31)and(19.13±4.87)points in the acupuncture+medication and medication groups respectively.The UPDRS,UPDRS-Ⅲ,and MDRSPD scores all reduced after treatments in both groups(all P<0.05).All three scores were lower in the acupuncture+medication group than in the medication group(all P<0.05).When examining the therapeutic effects of TCM,the total effective rate was 87.88%in the acupuncture+medication group and 75.76%in the medication group(P<0.05).After treatment,the LED scores were(387.55±146.24)points and(437.42±183.16)points in the acupuncture+medication and medication groups,respectively.The LED dose differences before and after treatment for the acupuncture+medication and medication groups were(40.36±16.33)points and(95.88±35.79)points,respectively.The LED scores in both groups were higher than the pre-treatment scores(P<0.05).However,the post-treatment LED score was lower in the acupuncture+medication group than in the medication group(P<0.05),as was the dose difference before and after treatment(P<0.05).No relevant adverse reaction was found in each group.Conclusion:In addition to anti-PD medication,the scalp and body acupuncture may effectively relieve the motor symptoms of PD and improve the control of LED score.
基金supported in part by the National Natural Science Foundation of China(61473195,61603081,61773131,61773056,61873306,U1966202,61803305,61873338)the China Postdoctoral Science Foundation(2015M580513)Research Fund for the Taishan Scholar Project of Shandong Province of China(TSQN201812052)。
文摘In this paper, we consider the distributed adaptive fault-tolerant output regulation problem for heterogeneous multiagent systems with matched system uncertainties and mismatched coupling uncertainties among subsystems under the influence of actuator faults. First, distributed finite-time observers are proposed for all subsystems to observe the state of the exosystem. Then, a novel fault-tolerant controller is designed to compensate for the influence of matched system uncertainties and actuator faults. By using the linear matrix inequality technique, a sufficient condition is provided to guarantee the solvability of the considered problem in the presence of mismatched coupling uncertainties. Moreover, it is shown that the system in closed-loop with the developed controller can achieve output regulation by using the Lyapunov stability theory and cyclic-small-gain theory.Finally, a numerical example is given to illustrate the effectiveness of the obtained result.
基金financial supports from the National Natural Science Foundation of China(Nos.U1502272,51901204)the Precious Metal Materials Genome Engineering in Yunnan Province,China(Nos.2019ZE001,202002AB080001)。
文摘Hot compression was performed on a multilayered Au−20Sn eutectic alloy to investigate the deformation behavior and microstructure evolution.During hot compression,microstructural spheroidization was initiated from plastic instability regions,and it was preferentially activated in vertical lamellae with a growth direction parallel to the compressive direction.Continuous dynamic recrystallization associated with lattice dislocations was the mechanism in both AuSn and Au5Sn multilayers.After spheroidization,strain accumulations were weakened in both of the equiaxed phases,and the deformation mechanism was substantially replaced by grain boundary sliding and migration.Based on these findings,hot rolling was conducted on an as-cast Au−20Sn alloy and a foil with a thickness of~50μm was successfully prepared.The present study can promote the development of Au−20Sn foils,and provide insights into the deformation behavior and microstructure evolution of multilayered eutectic alloys.
基金financially supported by the National Natural Science Foundation of China (No.51301212)the Major National Science and Technology Projects of China (No.2011ZX02705)+1 种基金the Chongqing Science and Technology Commission in China (No.2012jj A50023)the Fundamental Research Funds for the Central Universities of China (No.CDJZR11130010)
文摘For sputtering targets, through-thickness texture is critical for assuring reliable sputtering performance.In this paper, through-thickness texture gradient of a rolled and subsequently annealed tantalum sputtering target was investigated. The results show that by carefully controlling the rolling process, shear-related components at the surface of the rolled sample could be avoided. Both the rolled sample and the annealed target develop a through-thickness texture gradient with the formation of a stronger {1 1 1}fiber in the center layer compared with that in the surface layer.
基金Curriculum Case Base Construction Project of the First Affiliated Hospital of Xinjiang Shihezi University,No.2021Y-AL15.
文摘BACKGROUND For the past few years,preventive interventional therapy has been widely used domestically and overseas,bringing great benefits to pregnant women at high-risk for complications,such as pernicious placenta previa(PPP)and placenta accreta.Nevertheless,there are still few reports on surgical complications related to interventional therapy,and its safety should be a concern.CASE SUMMARY We report a 36-year-old pregnant woman with PPP who underwent balloon implantation in the lower segment of the abdominal aorta before caesarean section.However,the balloon shifted during the operation,which damaged the arterial vessels after filling,resulting in severe postpartum haemorrhage in the patient.Fortunately,after emergency interventional stent implantation,the pa-tient was successfully relieved of the massive haemorrhage crisis.CONCLUSION It seems that massive postoperative bleeding has been largely avoided in preventive interventional therapy in high-risk pregnant women with placenta-related diseases,but surgical complications related to intervention therapy can also cause adverse consequences.It is equally important for clinical doctors to learn how to promptly identify and effectively treat these rare complications.
基金supported by the Innovation Foundation of Graduate Student of Harbin Normal University(HSDSSCX2022-111)the Natural Science Foundation of Heilongjiang Province of China(TD2020B001)the Opening Project of State Key Laboratory of Advanced Chemical Power Sources(SKL-ACPS-C-25)。
文摘The electronic and functional synergies between the twin metal centers make dual single-atom catalysts(DACs)attractive for oxygen electrocatalysis.The catalytic activities of DACs are largely decided by their surrounding micro-environment and supporting substrates.Modulating the micro-environment as well as engineering the efficient support is challenging tasks.Moreover,both are critical to optimizing the performance of DACs.Herein,a novel bio-cooperative strategy is developed to synthesize Fe Ni-DAC wherein Fe-Ni dual-atom sites are embedded in the N,P codoped tyre shaped carbon matrix.The configuration matching of Fe-Ni dual centers together with the local electronic engineering of N,P heteroatoms synergistically boost the catalytic activity on the oxygen reaction.Furthermore,the central-hollow highlyporous carbon matrix not only gives rise to a large amount of active sites,but also facilitates fast kinetics.Taking advantage of both the DAC and the substrate,the Fe Ni-NPC hollow tyre(HT)catalyst scores high in both oxygen reduction and evolution reactions,which exhibits the narrow potential difference and excellent durability.The aqueous Zn-air full battery(ZAB)integrating the Fe Ni-NPC HT air cathode has a high power density and a good stability over long-term cycling.Moreover,the flexible solid-state ZAB assembled with the polymer electrolyte obtains the high reliability over a wide range of temperatures or under diverse outside deformations.Therefore,this work offers a new green approach to prepare highly efficient DACs with built-in modulated micro-environment and tailor-made substrates.Moreover,it also paves a new way to develop highly-pliable power source for flexible electronics.
基金supported by the Innovation Foundation of Graduate Student of Harbin Normal University(Grant No.HSDSSCX2020-18)the Natural Science Foundation of Heilongjiang Province,China(Grant No.TD2020B001)the Opening Project of State Key Laboratory of Advanced Chemical Power Sources(Grant No.SKL-ACPS-C-25)。
文摘The exploration of low-strain and high-performance electrode is a crucial issue for aqueous potassiumion battery(AKIB).Herein,a novel potassium mediated iron/manganese binary hexacyanoferrate nanocuboid,i.e.,K_(x)Fe_(y)Mn_(1-y)[Fe(CN)_(6)]·nH_(2)O(KFeMnHCF)nanocuboid,with the concentration-gradient(CG)structure is designed as a high-performance cathode for AKIB.Internal the CG-KFeMnHCF nanocuboids,the manganese content gradually decreases from the interior to the surface and the iron content changes reverse,resulting in the concentration-gradient structure.Both experimental and finite element simulation(FEA)results demonstrate the lower internal stress and better mechanical characteristics of CG structured nanocuboid than the homogenous structured one upon ion intercalation/deintercalation processes.Meanwhile,the electrochemical testing and theoretical calculation(DFT)results disclose the substitution of Fe to Mn in the KMnHCF crystal results in the enhanced electronic conductivity,potassium migration and electrochemical kinetics.Taken both advantages from the well-designed architecture and optimized crystal structure,the CG-KFeMnHCF achieves the superior rate capability and ultrahigh stability in aqueous potassium ion system.In particular,the CG-KFe_(0.31)Mn_(0.69)HCF achieves the best comprehensive properties among all the samples.The full AKIBs based on CG-KFe_(0.31)Mn_(0.69)HCF cathode achieves the high energy density(83 Wh kg^(-1)),superior power density,high capacity retention(83%)over high-rate long-term cycles,good adaptation to a wide temperature range(-20 to 40℃)and high reliability even under outside deformations.Therefore,this work not only provides a new clue to design the highperformance cathode,but also promotes the applications of AKIBs for diverse electronics and wide working environments.
