Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the ...Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the average grain size of forged piece was greatly refined to 5.3μm after 120 forging passes,which was ascribed to the segmenting effect of{10–12}twins and the subsequent multiple rounds of dynamic recrystallization(DRX).A great deal of{10–12}twins were activated at the beginning of MDIF process,which played an important role in grain refinement.With forging proceeding,continuous and discontinuous DRX were successively activated,resulting in the fully DRXed microstructure.Meanwhile,the forged piece exhibited a unique four-peak texture,and the initial<10-10>//ED fiber texture component gradually evolved into multiple texture components composed of<0001>//FFD(first forging direction)and<11–20>//FFD texture.The special strain path was the key to the formation of the unique four-peak texture.The{10–12}twinning and basal slip were two dominant factors to the evolution of texture during MDIF process.Grain strengthening and dislocation strengthening were two main strengthening mechanisms of the forged piece.Besides,the symmetry of yield strength was greatly improved by MDIF process.展开更多
To meet the processing requirements of resin transfer moulding(RTM)technology,reactive diluent containing m-phenylene moiety was synthesized to physically mixed with phenylethynyl terminated cooligoimides with well-de...To meet the processing requirements of resin transfer moulding(RTM)technology,reactive diluent containing m-phenylene moiety was synthesized to physically mixed with phenylethynyl terminated cooligoimides with well-designed molecular weights of 1500-2500 g/mol derived from 4,4’-(hexafluoroisopropylidene)diphthalic anhydride(6 FDA),3,4’-oxydianiline(3,4’-ODA)and m-phenylenediamine(m-PDA).This blend shows low minimum melting viscosity(<1 Pa·s)and enlarged processing temperature window(260–361℃).FPI-R-1 stays below 1 Pa·s for2 h at 270℃.The relationship between the molecular weight of the blend and its melting stability was first explored.Blending oligoimides with lower molecular weights exhibit better melting stability.Upon curing at 380℃for 2 h,the thermosetting polyimide resin demonstrates superior heat resistance(T_(g)=420-426℃).展开更多
In-situ stress is a key reservoir parameter to evaluate reservoir permeability,hydraulic fractures,coal seam deformation and coalbed methane(CBM)recovery.With limited CBM test wells in the Zhengzhuang field,southeast ...In-situ stress is a key reservoir parameter to evaluate reservoir permeability,hydraulic fractures,coal seam deformation and coalbed methane(CBM)recovery.With limited CBM test wells in the Zhengzhuang field,southeast of the Qinshui basin,North China,the in-situ stress data is inadequate for CBM exploration and development.It is necessary to find a method to predicate in-situ stress through other exploration data such as geophysical well loggings.In this study,we provide a new well-logging databased model to predicate the in-situ stress based on 17 sets of well test data and comprehensive logging data.As a distinguished characteristic of this model,different structural compartmentalization of CBM reservoirs was considered.A regional adaptive residual strain index was introduced to the model.Based on the model,the in-situ stress distribution in the Zhengzhuang field were evaluated systematically,and the influences of in-situ stress on permeability and the propagation of hydro-fractures were discussed.Results indicate that the magnitude of the maximum(S_(Hmax),14.19e45.40 MPa)and minimum horizontal stresses(Shmin,10.62e28.38 MPa)and the gravitational stress(Sv,9.58e30.82 MPa)all show positive correlations with burial depths.The in-situ stress fields in the study area are characterized by 1)SHmax>Sv>Shmin in shallow layers(<700 m),indicating a dominant strike-slip faulting stress regime;2)Sv z S_(Hmax)>S_(hmin)and S_(Hmax)>Sv>S_(hmin)in the depth of 700e1050 m,suggesting a transformed regime;and 3)S_(Hmax)>Sv>S_(hmin)in deep layers(>1050 m),indicating a strike-slip faulting stress regime.The S_(Hmax)in the study area is orientated by NE-SW,with a trend of 40e49.Resulted from the change of the in-situ stress regimes from shallow(500 m)to deep layers(~1000 m),the reservoir permeability variation shows a typical increase followed by decrease.The presence of natural fractures significantly affect the propagation pattern of hydraulic fractures,and the length difference between the major and branch fractures increases with increasing stress anisotropy in the Zhengzhuang field.展开更多
In the textile industry,the presence of defects on the surface of fabric is an essential factor in determining fabric quality.Therefore,identifying fabric defects forms a crucial part of the fabric production process....In the textile industry,the presence of defects on the surface of fabric is an essential factor in determining fabric quality.Therefore,identifying fabric defects forms a crucial part of the fabric production process.Traditional fabric defect detection algorithms can only detect specific materials and specific fabric defect types;in addition,their detection efficiency is low,and their detection results are relatively poor.Deep learning-based methods have many advantages in the field of fabric defect detection,however,such methods are less effective in identifying multiscale fabric defects and defects with complex shapes.Therefore,we propose an effective algorithm,namely multilayer feature extraction combined with deformable convolution(MFDC),for fabric defect detection.In MFDC,multi-layer feature extraction is used to fuse the underlying location features with high-level classification features through a horizontally connected top-down architecture to improve the detection of multi-scale fabric defects.On this basis,a deformable convolution is added to solve the problem of the algorithm’s weak detection ability of irregularly shaped fabric defects.In this approach,Roi Align and Cascade-RCNN are integrated to enhance the adaptability of the algorithm in materials with complex patterned backgrounds.The experimental results show that the MFDC algorithm can achieve good detection results for both multi-scale fabric defects and defects with complex shapes,at the expense of a small increase in detection time.展开更多
Subdiaphragmatic abscess is the accumulation of pus in the space between the diaphragm and the transverse colon and its mesentery.[1]Subdiaphragmatic abscess is clinically characterized by fever and local pain.Its cli...Subdiaphragmatic abscess is the accumulation of pus in the space between the diaphragm and the transverse colon and its mesentery.[1]Subdiaphragmatic abscess is clinically characterized by fever and local pain.Its clinical manifestations are often vague and diverse,and its symptoms and signs together constitute thoracoabdominal syndrome,leading to delayed diagnosis and a high incidence rate and mortality.[2]Subdiaphragmatic abscess is often secondary to acute peritonitis or remote infection with hematogenous dissemination.The bacteriological characteristics of these abscesses include aerobic and facultative bacteria,such as Escherichia coli,group D Enterococcus and Staphylococcus aureus,as well as less common anaerobic organisms,such as Bacteroides.展开更多
Objective:Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer.The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver ...Objective:Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer.The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver cancer and reduce the resistance to sorafenib.Methods:Sorafenib-resistant cells were established based on HepG2 and Huh7 cell lines.And the anti-tumor effect of sorafenib combined with cryptotanshinone on the sorafenib-resistant cells was verified by MTT,colony formation,transwell assays and tumor growth xenograft model.Moreover,the effects of the combined treatment on the expression of phosphorylated(p)-STAT3,as well as epithelial mesenchymal transition(EMT)and apoptosis related proteins of cells were evaluated by western blot analysis.Results:It was identified that cryptotanshinone inhibited the viability of both HepG2 and Huh7 cells in a dose-and time-dependent manner,and decreased p-STAT3 expression rather than total STAT3 expression at a concentration of 40μmol/L.In the sorafenib-resistant cells,sorafenib in combination with cryptotanshinone markedly inhibited cell viability,invasion and migration compared with sorafenib alone.In contrast,increased p-STAT3 level by colivelin led to the inhibition of the synergistic effect of cryptotanshinone and sorafenib not only on cell viability,but also on EMT and apoptosis,suggesting that cryptotanshinone and sorafenib may act by downregulating STAT3 signaling.Further,the inhibition of carcinogenicity effect was also verified in xenografted tumor models.Conclusion:The present results indicated that cryptotanshinone could synergize with sorafenib to inhibit the proliferative,invasive,and migratory abilities of sorafenib-resistant cells by downregulating STAT3 signaling.展开更多
Cross-Regional city construction is not only the inevitable trend of urbanization development in China.It is also an important way to improve the comprehensive competitive power of urban economy.Starting from the curr...Cross-Regional city construction is not only the inevitable trend of urbanization development in China.It is also an important way to improve the comprehensive competitive power of urban economy.Starting from the current situation of cross-regional city development,this paper puts forward the strategy of cross regional urban integration development,and probes into the implementation measures of integrative development,mainly in the integration of development planning,infrastructure,regional market,ecological construction and public service,and analyzes the significance of the development of trans-regional urban integration.In order to promote the coordinated development mechanism of cross-regional cities and strengthen the international competitiveness of China's urban agglomeration.展开更多
The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling re...The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well understood.Inhibitory(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of Smad7.Mis-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene expression.VprBP was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 poly-ubiquitination.In multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced responses.In the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish embryogenesis.Our findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction.展开更多
基金supported by National Natural Science Foundation of China(Grant No.51975146)Key Research and Development Plan in Shandong Province(Grant No.2018JMRH0412,2019JZZY010364)National Defense Basic Scientific Research of China(Grant no.JCK2018603C017)。
文摘Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the average grain size of forged piece was greatly refined to 5.3μm after 120 forging passes,which was ascribed to the segmenting effect of{10–12}twins and the subsequent multiple rounds of dynamic recrystallization(DRX).A great deal of{10–12}twins were activated at the beginning of MDIF process,which played an important role in grain refinement.With forging proceeding,continuous and discontinuous DRX were successively activated,resulting in the fully DRXed microstructure.Meanwhile,the forged piece exhibited a unique four-peak texture,and the initial<10-10>//ED fiber texture component gradually evolved into multiple texture components composed of<0001>//FFD(first forging direction)and<11–20>//FFD texture.The special strain path was the key to the formation of the unique four-peak texture.The{10–12}twinning and basal slip were two dominant factors to the evolution of texture during MDIF process.Grain strengthening and dislocation strengthening were two main strengthening mechanisms of the forged piece.Besides,the symmetry of yield strength was greatly improved by MDIF process.
基金financially supported by the National Natural Science Foundation of China(No.51803222)Science and Technology Service Network Initiative,Chinese Academy of Sciences。
文摘To meet the processing requirements of resin transfer moulding(RTM)technology,reactive diluent containing m-phenylene moiety was synthesized to physically mixed with phenylethynyl terminated cooligoimides with well-designed molecular weights of 1500-2500 g/mol derived from 4,4’-(hexafluoroisopropylidene)diphthalic anhydride(6 FDA),3,4’-oxydianiline(3,4’-ODA)and m-phenylenediamine(m-PDA).This blend shows low minimum melting viscosity(<1 Pa·s)and enlarged processing temperature window(260–361℃).FPI-R-1 stays below 1 Pa·s for2 h at 270℃.The relationship between the molecular weight of the blend and its melting stability was first explored.Blending oligoimides with lower molecular weights exhibit better melting stability.Upon curing at 380℃for 2 h,the thermosetting polyimide resin demonstrates superior heat resistance(T_(g)=420-426℃).
基金We acknowledge financial support from the National Natural Science Foundation of China(4183042741872123)the National Major Research Programfor Science and Technology in China(2016ZX05043-001).
文摘In-situ stress is a key reservoir parameter to evaluate reservoir permeability,hydraulic fractures,coal seam deformation and coalbed methane(CBM)recovery.With limited CBM test wells in the Zhengzhuang field,southeast of the Qinshui basin,North China,the in-situ stress data is inadequate for CBM exploration and development.It is necessary to find a method to predicate in-situ stress through other exploration data such as geophysical well loggings.In this study,we provide a new well-logging databased model to predicate the in-situ stress based on 17 sets of well test data and comprehensive logging data.As a distinguished characteristic of this model,different structural compartmentalization of CBM reservoirs was considered.A regional adaptive residual strain index was introduced to the model.Based on the model,the in-situ stress distribution in the Zhengzhuang field were evaluated systematically,and the influences of in-situ stress on permeability and the propagation of hydro-fractures were discussed.Results indicate that the magnitude of the maximum(S_(Hmax),14.19e45.40 MPa)and minimum horizontal stresses(Shmin,10.62e28.38 MPa)and the gravitational stress(Sv,9.58e30.82 MPa)all show positive correlations with burial depths.The in-situ stress fields in the study area are characterized by 1)SHmax>Sv>Shmin in shallow layers(<700 m),indicating a dominant strike-slip faulting stress regime;2)Sv z S_(Hmax)>S_(hmin)and S_(Hmax)>Sv>S_(hmin)in the depth of 700e1050 m,suggesting a transformed regime;and 3)S_(Hmax)>Sv>S_(hmin)in deep layers(>1050 m),indicating a strike-slip faulting stress regime.The S_(Hmax)in the study area is orientated by NE-SW,with a trend of 40e49.Resulted from the change of the in-situ stress regimes from shallow(500 m)to deep layers(~1000 m),the reservoir permeability variation shows a typical increase followed by decrease.The presence of natural fractures significantly affect the propagation pattern of hydraulic fractures,and the length difference between the major and branch fractures increases with increasing stress anisotropy in the Zhengzhuang field.
基金supported in part by the National Science Foundation of China under Grant 62001236in part by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China under Grant 20KJA520003.
文摘In the textile industry,the presence of defects on the surface of fabric is an essential factor in determining fabric quality.Therefore,identifying fabric defects forms a crucial part of the fabric production process.Traditional fabric defect detection algorithms can only detect specific materials and specific fabric defect types;in addition,their detection efficiency is low,and their detection results are relatively poor.Deep learning-based methods have many advantages in the field of fabric defect detection,however,such methods are less effective in identifying multiscale fabric defects and defects with complex shapes.Therefore,we propose an effective algorithm,namely multilayer feature extraction combined with deformable convolution(MFDC),for fabric defect detection.In MFDC,multi-layer feature extraction is used to fuse the underlying location features with high-level classification features through a horizontally connected top-down architecture to improve the detection of multi-scale fabric defects.On this basis,a deformable convolution is added to solve the problem of the algorithm’s weak detection ability of irregularly shaped fabric defects.In this approach,Roi Align and Cascade-RCNN are integrated to enhance the adaptability of the algorithm in materials with complex patterned backgrounds.The experimental results show that the MFDC algorithm can achieve good detection results for both multi-scale fabric defects and defects with complex shapes,at the expense of a small increase in detection time.
文摘Subdiaphragmatic abscess is the accumulation of pus in the space between the diaphragm and the transverse colon and its mesentery.[1]Subdiaphragmatic abscess is clinically characterized by fever and local pain.Its clinical manifestations are often vague and diverse,and its symptoms and signs together constitute thoracoabdominal syndrome,leading to delayed diagnosis and a high incidence rate and mortality.[2]Subdiaphragmatic abscess is often secondary to acute peritonitis or remote infection with hematogenous dissemination.The bacteriological characteristics of these abscesses include aerobic and facultative bacteria,such as Escherichia coli,group D Enterococcus and Staphylococcus aureus,as well as less common anaerobic organisms,such as Bacteroides.
文摘Objective:Sorafenib resistance has been a major factor limiting its clinical use as a targeted drug in liver cancer.The present study aimed to investigate whether cryptotanshinone can enhance the sensitivity of liver cancer and reduce the resistance to sorafenib.Methods:Sorafenib-resistant cells were established based on HepG2 and Huh7 cell lines.And the anti-tumor effect of sorafenib combined with cryptotanshinone on the sorafenib-resistant cells was verified by MTT,colony formation,transwell assays and tumor growth xenograft model.Moreover,the effects of the combined treatment on the expression of phosphorylated(p)-STAT3,as well as epithelial mesenchymal transition(EMT)and apoptosis related proteins of cells were evaluated by western blot analysis.Results:It was identified that cryptotanshinone inhibited the viability of both HepG2 and Huh7 cells in a dose-and time-dependent manner,and decreased p-STAT3 expression rather than total STAT3 expression at a concentration of 40μmol/L.In the sorafenib-resistant cells,sorafenib in combination with cryptotanshinone markedly inhibited cell viability,invasion and migration compared with sorafenib alone.In contrast,increased p-STAT3 level by colivelin led to the inhibition of the synergistic effect of cryptotanshinone and sorafenib not only on cell viability,but also on EMT and apoptosis,suggesting that cryptotanshinone and sorafenib may act by downregulating STAT3 signaling.Further,the inhibition of carcinogenicity effect was also verified in xenografted tumor models.Conclusion:The present results indicated that cryptotanshinone could synergize with sorafenib to inhibit the proliferative,invasive,and migratory abilities of sorafenib-resistant cells by downregulating STAT3 signaling.
文摘Cross-Regional city construction is not only the inevitable trend of urbanization development in China.It is also an important way to improve the comprehensive competitive power of urban economy.Starting from the current situation of cross-regional city development,this paper puts forward the strategy of cross regional urban integration development,and probes into the implementation measures of integrative development,mainly in the integration of development planning,infrastructure,regional market,ecological construction and public service,and analyzes the significance of the development of trans-regional urban integration.In order to promote the coordinated development mechanism of cross-regional cities and strengthen the international competitiveness of China's urban agglomeration.
基金This research was supported by Cancer Genomics Centre Netherlands and a grant from the National Natural Science Foundation of China(31471315).
文摘The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well understood.Inhibitory(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of Smad7.Mis-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene expression.VprBP was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 poly-ubiquitination.In multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced responses.In the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish embryogenesis.Our findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction.
