There are abundant hydrothermal events within the Dengying Formation dolomite of the Precambrian system in southwest China.Methods including petrography identification,fluid-inclusion observation,in-situ U-Pb dating,a...There are abundant hydrothermal events within the Dengying Formation dolomite of the Precambrian system in southwest China.Methods including petrography identification,fluid-inclusion observation,in-situ U-Pb dating,and in-situ measurement of rare earth element(REE),etc.are integrated to characterize hydrothermal activity process within the Dengying Formation dolomite.The hydrothermal activity therein can be divided into four stages on the basis of in-situ U-Pb dating results of saddle dolomite cements.The 1st-stage(415.0-400.0 Ma)and 2nd-stage(259.4-248.0 Ma)hydrothermal events are characterized by saddle dolomite filling along the margin of fractures,or filling within dilational breccia and zebra textures.Compared with matrix dolomite and seawater-derived fibrous dolomite,saddle dolomite exhibits obvious negative anomalies of Ce elements.The 3rd-stage(225.6-199.0 Ma)hydrothermal event is represented by galena,sphalerite and other Mississipppi Valley-type(MVT)mineral cements in residual space.The formation of lead-zinc ore is due to the precipitation of metal sulfide caused by the thermo-chemical sulfate reduction(TSR)reaction between hydrothermal fluids and hydrocarbons during the large-scale hydrocarbon charging period.The 4th-stage(130.0-41.0 Ma)hydrothermal event is characterized by quartz and a small amount of fluorite filling the residual pores with dolomites.Quartz and fluorite record the migration of deep high-temperature hydrothermal fluid along early fractures and residual pores.During this period,the hydrothermal fluids result in the heterogeneous structure of bitumen,which is a clear response to high-temperature hydrothermal activity.展开更多
The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic b...The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic biomarkers.Gene expression data of breast cancer patients and their metastases were downloaded from the GEO,TCGA database.R language package was used to screen for differentially expressed genes,enrichment analysis of genes,PPI network construction,and also to elucidate key genes for diagnostic and prognostic survival.Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells.We screened 25 hub genes,FN1,CLEC5A,ATP8B4,TLR7,LY86,PTGER3 and other genes were differentially expressed in cancer and paraneoplastic tissues.However,patients with higher expression of CD1C,IL-18 breast cancer had a better prognosis in the 10 years survival period,while patients with high expression of FN1,EIF4EBP1 tumors had a worse prognosis.In addition,TP53 and HIF1 genes are closely related to the signaling pathway of breast cancer metastasis.In this study,gene expression of ATP8B4 and CD1C were correlated with cancer tissue infiltration of CD8^(+)T lymphocytes,while GSE43816,GSE62327 and TCGA databases showed that CD8^(+)T lymphocytes were closely associated with breast cancer progression.Functional enrichment analysis of genes based on expression differences yielded key genes of prognostic value in the breast cancer microenvironment.展开更多
During the development of shale gas,various issues such as low individual well production,rapid decline,limited reservoir control,and low recovery rates have arisen.Enhancing shale gas reservoir recovery rates has con...During the development of shale gas,various issues such as low individual well production,rapid decline,limited reservoir control,and low recovery rates have arisen.Enhancing shale gas reservoir recovery rates has consistently been a focal point and challenge within the industry.Therefore,this paper employs molecular dynamic(MD)simulation methods to study the adsorption and diffusion characteristics of CH_(4)/CO_(2)at different temperatures and mixing ratios.It compares the effects of temperature and CH_(4)/CO_(2)molar ratio changes on the selectivity coefficient,adsorption capacity,and diffusion coefficient of CH_(4)/CO_(2).The paper also plots the displacement interface and the function of CH_(4)/CO_(2)injection/residual amounts over time.Furthermore,it analyzes the adsorption capacity of molecules on the graphene surface,the migration capacity of molecules in the slit,and the displacement process of CH_(4)by CO_(2)on the nanoscale,revealing the microscopic mechanism of CH_(4)/CO_(2)competitive adsorption and displacement.The research results indicate that the influence of temperature on the selectivity coefficient is not significant,with an average decrease of 3%for every 20 K rise in temperature.Pressure has a more pronounced effect on the selectivity coefficient,with values around 1.4 at low pressures and around 1.2 at high pressures.Elevating the mole fraction of CO_(2)in the binary gas mixture results in an increase in the total adsorption amount and an accelerated variation of adsorption amount with pressure.As the CH_(4)mole fraction rises,the diffusion coefficient of CH_(4)increases,while the diffusion coefficient of CO_(2)diminishes with an increasing CO_(2)mole fraction.Under identical conditions,CO_(2)exhibits a stronger adsorption capacity over CH_(4)in shale organic nanopores,resulting in a concave moon-shaped displacement interface in the model.The larger the pre-adsorption pressure of CO_(2),the more intense the movement of CO_(2)along the graphene surface,and the faster the diffusion speed of CO_(2)along the wall.In a displacement pore(the pore space used to provide the displacement location or site)with a diameter of 3 nm,at smaller pressure differentials(≤10 MPa),the residual amount of CH_(4)remains relatively stable without substantial alteration.However,at a pressure differential of 20 MPa,the residual amount of CH_(4)decreases rapidly,and the displacement efficiency significantly improves.展开更多
文摘There are abundant hydrothermal events within the Dengying Formation dolomite of the Precambrian system in southwest China.Methods including petrography identification,fluid-inclusion observation,in-situ U-Pb dating,and in-situ measurement of rare earth element(REE),etc.are integrated to characterize hydrothermal activity process within the Dengying Formation dolomite.The hydrothermal activity therein can be divided into four stages on the basis of in-situ U-Pb dating results of saddle dolomite cements.The 1st-stage(415.0-400.0 Ma)and 2nd-stage(259.4-248.0 Ma)hydrothermal events are characterized by saddle dolomite filling along the margin of fractures,or filling within dilational breccia and zebra textures.Compared with matrix dolomite and seawater-derived fibrous dolomite,saddle dolomite exhibits obvious negative anomalies of Ce elements.The 3rd-stage(225.6-199.0 Ma)hydrothermal event is represented by galena,sphalerite and other Mississipppi Valley-type(MVT)mineral cements in residual space.The formation of lead-zinc ore is due to the precipitation of metal sulfide caused by the thermo-chemical sulfate reduction(TSR)reaction between hydrothermal fluids and hydrocarbons during the large-scale hydrocarbon charging period.The 4th-stage(130.0-41.0 Ma)hydrothermal event is characterized by quartz and a small amount of fluorite filling the residual pores with dolomites.Quartz and fluorite record the migration of deep high-temperature hydrothermal fluid along early fractures and residual pores.During this period,the hydrothermal fluids result in the heterogeneous structure of bitumen,which is a clear response to high-temperature hydrothermal activity.
基金This work was supported by Hainan Provincial Natural Science Foundation of China(No.820RC765).
文摘The aim of this study was to reveal genes associated with breast cancer metastasis,to investigate their intrinsic relationship with immune cell infiltration in the tumor microenvironment,and to screen for prognostic biomarkers.Gene expression data of breast cancer patients and their metastases were downloaded from the GEO,TCGA database.R language package was used to screen for differentially expressed genes,enrichment analysis of genes,PPI network construction,and also to elucidate key genes for diagnostic and prognostic survival.Spearman’s r correlation was used to analyze the correlation between key genes and infiltrating immune cells.We screened 25 hub genes,FN1,CLEC5A,ATP8B4,TLR7,LY86,PTGER3 and other genes were differentially expressed in cancer and paraneoplastic tissues.However,patients with higher expression of CD1C,IL-18 breast cancer had a better prognosis in the 10 years survival period,while patients with high expression of FN1,EIF4EBP1 tumors had a worse prognosis.In addition,TP53 and HIF1 genes are closely related to the signaling pathway of breast cancer metastasis.In this study,gene expression of ATP8B4 and CD1C were correlated with cancer tissue infiltration of CD8^(+)T lymphocytes,while GSE43816,GSE62327 and TCGA databases showed that CD8^(+)T lymphocytes were closely associated with breast cancer progression.Functional enrichment analysis of genes based on expression differences yielded key genes of prognostic value in the breast cancer microenvironment.
基金supported by the National Natural Science Foundation of China(Grant No.52222402,52234003 and 52074235)Sichuan Science and Technology Program(NO:2022JDJQ0009 and No.2023NSFSC0934)+2 种基金the Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(Grant No.2020CX020202)the Deep Marine Shale Gas Efficient Development Overseas Expertise Introduction Center for Discipline Innovation(111 Center)the China Postdoctoral Science Foundation(Grant No.2022M722638).
文摘During the development of shale gas,various issues such as low individual well production,rapid decline,limited reservoir control,and low recovery rates have arisen.Enhancing shale gas reservoir recovery rates has consistently been a focal point and challenge within the industry.Therefore,this paper employs molecular dynamic(MD)simulation methods to study the adsorption and diffusion characteristics of CH_(4)/CO_(2)at different temperatures and mixing ratios.It compares the effects of temperature and CH_(4)/CO_(2)molar ratio changes on the selectivity coefficient,adsorption capacity,and diffusion coefficient of CH_(4)/CO_(2).The paper also plots the displacement interface and the function of CH_(4)/CO_(2)injection/residual amounts over time.Furthermore,it analyzes the adsorption capacity of molecules on the graphene surface,the migration capacity of molecules in the slit,and the displacement process of CH_(4)by CO_(2)on the nanoscale,revealing the microscopic mechanism of CH_(4)/CO_(2)competitive adsorption and displacement.The research results indicate that the influence of temperature on the selectivity coefficient is not significant,with an average decrease of 3%for every 20 K rise in temperature.Pressure has a more pronounced effect on the selectivity coefficient,with values around 1.4 at low pressures and around 1.2 at high pressures.Elevating the mole fraction of CO_(2)in the binary gas mixture results in an increase in the total adsorption amount and an accelerated variation of adsorption amount with pressure.As the CH_(4)mole fraction rises,the diffusion coefficient of CH_(4)increases,while the diffusion coefficient of CO_(2)diminishes with an increasing CO_(2)mole fraction.Under identical conditions,CO_(2)exhibits a stronger adsorption capacity over CH_(4)in shale organic nanopores,resulting in a concave moon-shaped displacement interface in the model.The larger the pre-adsorption pressure of CO_(2),the more intense the movement of CO_(2)along the graphene surface,and the faster the diffusion speed of CO_(2)along the wall.In a displacement pore(the pore space used to provide the displacement location or site)with a diameter of 3 nm,at smaller pressure differentials(≤10 MPa),the residual amount of CH_(4)remains relatively stable without substantial alteration.However,at a pressure differential of 20 MPa,the residual amount of CH_(4)decreases rapidly,and the displacement efficiency significantly improves.
