Objective:To analyze the identification and typing of bone impediments and the law of medication in ancient books based on the Chinese Medical Dictionary using the latent structure model.Methods:The formulations for b...Objective:To analyze the identification and typing of bone impediments and the law of medication in ancient books based on the Chinese Medical Dictionary using the latent structure model.Methods:The formulations for bone impediment were searched in the Chinese Medical Dictionary(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for bone impediment were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency≥20 were investigated using the latent structure model and association rules,and the medication rules in treating bone impediment were dissected based on the data of frequency.Results:A total of 265 traditional Chinese medicine prescriptions were included,with a total of 289 extracted Chinese medicines,totaling 2789 medication frequencies.Among them,Radix Angelicae Sinensis,Ramulus Cinnamomi,and Radix Glycyrrhizae were the high-frequency medicines for treating bone impediments,and the efficacy of dampness-resolving medicines,and tonic medicines were the higher-frequency medicine categories.The analysis of the evidence through the formula that the Yin deficiency of the liver and kidney pattern,fixed impediment,painful impediment,heat impediment,Intertwined phlegm and blood stasis pattern,wind-cold-dampness with insignificant bias,and migratory impediment of the Bi-impediment disorders for the seven main types,in general,in line with Bi-impediment disorders of wind-cold-dampness invasion,blocked meridians and channels of qi,blood,tendons,bones,joints and the etiology and pathogenesis of the Bi-impediment disorders.This study yielded 32 associative principles for the treatment of bone impediment,and its major compositions were Radix Angelicae Sinensis→Fructus Chaenomelis,Radix Angelicae Sinensis→Achyranthis Bidentatae Radix,Radix Stephaniae Tetrandrae→Semen Armeniacae Amarum+Ramulus Cinnamomi,Radix Angelicae Sinensis→Radix Paeoniae Alba,and Radix Angelicae Sinensis→Rhizoma Ligustici Chuanxiong.Conclusion:The Chinese Medical Dictionary of Bi-impediment disorders in bone impediment medication law is mainly manifested in both dispelling wind-dampness and tonifying deficiency,and emphasizes the use of corresponding drug combinations for the bias of disease and evil,in line with Chinese medicine to reinforce healthy qi to eliminate pathogenic factors and the basic principles of and treating both the tip and root.展开更多
Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The f...Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The formulations for leucorrhea were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for leucorrhea were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating leucorrhea with TCM were dissected based on the data of frequency.Results:For 373 kinds of Chinese medicines retrieved from 236 TCM prescriptions,the total medication frequency was 2522.Chinese Angelica(Angelicae Sinensis Radix),White Peony Root(Paeoniae Radix Alba),Indian Buead Tuckahoe(Poria),Common Oyster Shell(Ostreae Concha),and Largehead Atractylodes Rhizome(Atractylodis Macrocephalae Rhizoma)were high-frequency medicines for leucorrhea.Tonic,heat-clearing,and qi-regulating medicines had a high frequency of usage.According to a formula-based analysis of the evidence,the main syndromes of leucorrhea included liver qi affecting the spleen pattern,damp heat accumulation pattern,liver qi stagnation pattern,liver-stomach disharmony pattern,yin deficiency of the liver and kidney pattern,and spleen deficiency with dampness pattern,which are generally in line with the etiology and pathogenesis of leucorrhea,namely pathogenic dampness as the detrimental factor together with spleen-kidney dysfunction.However,in ancient books,emphasis was laid out on the regulation of the liver.This study determined 31 association rules for treating leucorrhea,where the primary compatible medicines contained Chinese Angelica(Angelicae Sinensis Radix)-Nutgrass Galingale Rhizome(Cyperus rotundus),Chinese Angelica(Angelicae Sinensis Radix)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Adhesive Rehmannia Root Tuber(Rehmanniae Radix)and Tangerine Peel(Citri Reticulatae Pericarpium)-Ternate Pinellia(Rhizoma Pinelliae).Conclusion:The medication rules targeting leucorrhea in the Chinese Medical Code were mainly represented by the regulation of qi and blood,as well as the 3 internal organs-the kidney,spleen,and liver.展开更多
Objective:To analyze the identification and typing of bone flaccidity and the law of medication in ancient books based on the Encyclopaedia of TCM(Traditional Chinese Medicine)using the hidden structure model.Methods:...Objective:To analyze the identification and typing of bone flaccidity and the law of medication in ancient books based on the Encyclopaedia of TCM(Traditional Chinese Medicine)using the hidden structure model.Methods:The formulations for bone flaccidity were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for bone flaccidity were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating bone flaccidity with TCM were dissected based on the data of frequency.Results:A total of 223 TCM prescriptions were included,with 270 extracted TCM and a total medication frequency of 2340 times.Among them are Achyranthis Bidentatae Radix,Poria,Angelicae Sinensis Radix,Eucommiae Cortex,Rehmanniae Radix Praeparata,and Ginseng Radix Et Rhizoma.They were the high-frequency medicines for treating bone flaccidity,and the efficacy of tonifying medicinal,heat-clearing medicinal,and blood activating and stasis-resolving medicinal were high-frequency medicinal categories.Through the analysis of the evidence by formula,it was concluded that spleen-kidney yang deficiency,kidney deficiency and blood stasis,kidney yang deficiency,qi deficiency/qi stagnation and blood stasis,and liver and kidney yin deficiency were the 6 main types of bone flaccidity,which was generally in line with the etiology of bone flaccidity,which was caused by kidney yang deficiency and accompanied by malfunction of the liver and kidneys.In ancient books,the regulation of the kidney is put into an important position.In this study,19 correlative principles for the treatment of bone flaccidity were derived,whose main combinations are Paeoniae Radix Alba-Angelicae Sinensis Radix,Eucommiae Cortex+Poria-Ginseng Radix Et Rhizoma,Dioscoreae Spongiosae Rhizoma+Cuscutae Semen-Eucommiae Cortex.Conclusions:The medication law of bone flaccidity in the Encyclopaedia of TCM mainly shows that it attaches importance to the regulation of tonifying the liver and kidney to strengthen the tendons and bones and emphasizes that the regulation of the 3 Zang–fu organs,namely the kidney,the liver and the spleen,can play an important role in the treatment of bone flaccidity.展开更多
基金supported by China Academy of Chinese Medical Science and Technology Innovation Project Heidihuang Pill Major Research Project(No.CI2021A00606)China Academy of Chinese Medical Sciences Self-selected projects(YZX202237,YZX202241,YZX202246,YZ2020042,YZ202225,YZ2020019,KJX202417,KJS202416)Beijing Traditional TCM Science and Technology Development Fund Project(No.JJ2018-99).
文摘Objective:To analyze the identification and typing of bone impediments and the law of medication in ancient books based on the Chinese Medical Dictionary using the latent structure model.Methods:The formulations for bone impediment were searched in the Chinese Medical Dictionary(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for bone impediment were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency≥20 were investigated using the latent structure model and association rules,and the medication rules in treating bone impediment were dissected based on the data of frequency.Results:A total of 265 traditional Chinese medicine prescriptions were included,with a total of 289 extracted Chinese medicines,totaling 2789 medication frequencies.Among them,Radix Angelicae Sinensis,Ramulus Cinnamomi,and Radix Glycyrrhizae were the high-frequency medicines for treating bone impediments,and the efficacy of dampness-resolving medicines,and tonic medicines were the higher-frequency medicine categories.The analysis of the evidence through the formula that the Yin deficiency of the liver and kidney pattern,fixed impediment,painful impediment,heat impediment,Intertwined phlegm and blood stasis pattern,wind-cold-dampness with insignificant bias,and migratory impediment of the Bi-impediment disorders for the seven main types,in general,in line with Bi-impediment disorders of wind-cold-dampness invasion,blocked meridians and channels of qi,blood,tendons,bones,joints and the etiology and pathogenesis of the Bi-impediment disorders.This study yielded 32 associative principles for the treatment of bone impediment,and its major compositions were Radix Angelicae Sinensis→Fructus Chaenomelis,Radix Angelicae Sinensis→Achyranthis Bidentatae Radix,Radix Stephaniae Tetrandrae→Semen Armeniacae Amarum+Ramulus Cinnamomi,Radix Angelicae Sinensis→Radix Paeoniae Alba,and Radix Angelicae Sinensis→Rhizoma Ligustici Chuanxiong.Conclusion:The Chinese Medical Dictionary of Bi-impediment disorders in bone impediment medication law is mainly manifested in both dispelling wind-dampness and tonifying deficiency,and emphasizes the use of corresponding drug combinations for the bias of disease and evil,in line with Chinese medicine to reinforce healthy qi to eliminate pathogenic factors and the basic principles of and treating both the tip and root.
基金This study was supported by a grant from the China Academy of Chinese Medical Sciences(No.C12021A00404).
文摘Objective:To analyze syndrome differentiation and medication rules for leucorrhea in ancient books of traditional Chinese medicine(TCM)based on the“Chinese Medical Code”using the latent structure model.Methods:The formulations for leucorrhea were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for leucorrhea were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating leucorrhea with TCM were dissected based on the data of frequency.Results:For 373 kinds of Chinese medicines retrieved from 236 TCM prescriptions,the total medication frequency was 2522.Chinese Angelica(Angelicae Sinensis Radix),White Peony Root(Paeoniae Radix Alba),Indian Buead Tuckahoe(Poria),Common Oyster Shell(Ostreae Concha),and Largehead Atractylodes Rhizome(Atractylodis Macrocephalae Rhizoma)were high-frequency medicines for leucorrhea.Tonic,heat-clearing,and qi-regulating medicines had a high frequency of usage.According to a formula-based analysis of the evidence,the main syndromes of leucorrhea included liver qi affecting the spleen pattern,damp heat accumulation pattern,liver qi stagnation pattern,liver-stomach disharmony pattern,yin deficiency of the liver and kidney pattern,and spleen deficiency with dampness pattern,which are generally in line with the etiology and pathogenesis of leucorrhea,namely pathogenic dampness as the detrimental factor together with spleen-kidney dysfunction.However,in ancient books,emphasis was laid out on the regulation of the liver.This study determined 31 association rules for treating leucorrhea,where the primary compatible medicines contained Chinese Angelica(Angelicae Sinensis Radix)-Nutgrass Galingale Rhizome(Cyperus rotundus),Chinese Angelica(Angelicae Sinensis Radix)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Szechwan Lovage Rhizome(Ligusticum chuanxiong Hort.),White Peony Root(Paeoniae Radix Alba)-Adhesive Rehmannia Root Tuber(Rehmanniae Radix)and Tangerine Peel(Citri Reticulatae Pericarpium)-Ternate Pinellia(Rhizoma Pinelliae).Conclusion:The medication rules targeting leucorrhea in the Chinese Medical Code were mainly represented by the regulation of qi and blood,as well as the 3 internal organs-the kidney,spleen,and liver.
基金supported by China Academy of Chinese Medical Science and Technology Innovation Project Heidihuang Pill Major Research Project(No.CI2021A00606)China Academy of Chinese Medical Sciences Self-selected projects(YZX202237,YZX202241,YZX202246,YZ2020042,YZ202225,YZ2020019)Beijing Traditional TCM Science and Technology Development Fund Project(No.JJ2018-99).
文摘Objective:To analyze the identification and typing of bone flaccidity and the law of medication in ancient books based on the Encyclopaedia of TCM(Traditional Chinese Medicine)using the hidden structure model.Methods:The formulations for bone flaccidity were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for bone flaccidity were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating bone flaccidity with TCM were dissected based on the data of frequency.Results:A total of 223 TCM prescriptions were included,with 270 extracted TCM and a total medication frequency of 2340 times.Among them are Achyranthis Bidentatae Radix,Poria,Angelicae Sinensis Radix,Eucommiae Cortex,Rehmanniae Radix Praeparata,and Ginseng Radix Et Rhizoma.They were the high-frequency medicines for treating bone flaccidity,and the efficacy of tonifying medicinal,heat-clearing medicinal,and blood activating and stasis-resolving medicinal were high-frequency medicinal categories.Through the analysis of the evidence by formula,it was concluded that spleen-kidney yang deficiency,kidney deficiency and blood stasis,kidney yang deficiency,qi deficiency/qi stagnation and blood stasis,and liver and kidney yin deficiency were the 6 main types of bone flaccidity,which was generally in line with the etiology of bone flaccidity,which was caused by kidney yang deficiency and accompanied by malfunction of the liver and kidneys.In ancient books,the regulation of the kidney is put into an important position.In this study,19 correlative principles for the treatment of bone flaccidity were derived,whose main combinations are Paeoniae Radix Alba-Angelicae Sinensis Radix,Eucommiae Cortex+Poria-Ginseng Radix Et Rhizoma,Dioscoreae Spongiosae Rhizoma+Cuscutae Semen-Eucommiae Cortex.Conclusions:The medication law of bone flaccidity in the Encyclopaedia of TCM mainly shows that it attaches importance to the regulation of tonifying the liver and kidney to strengthen the tendons and bones and emphasizes that the regulation of the 3 Zang–fu organs,namely the kidney,the liver and the spleen,can play an important role in the treatment of bone flaccidity.
