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对吸入大剂量糖皮质激素治疗哮喘的儿童进行生长发育监测,不能预测其对肾上腺的抑制情况
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作者 Dunlop K.A. carson d.j. +2 位作者 Steen H.J. M.D.Shields 刘健 《世界核心医学期刊文摘(儿科学分册)》 2005年第1期8-9,共2页
目的:本文旨在确定是否可以通过对常规门诊患者生长发育情况监测的方法,来预测吸入大剂量糖皮质激素治疗患有哮喘的青春期前儿童其肾上腺的抑制情况。方法:35名青春期前儿童(4-10岁),每天至少吸入1000 μg布地奈德气雾剂或等效力的糖皮... 目的:本文旨在确定是否可以通过对常规门诊患者生长发育情况监测的方法,来预测吸入大剂量糖皮质激素治疗患有哮喘的青春期前儿童其肾上腺的抑制情况。方法:35名青春期前儿童(4-10岁),每天至少吸入1000 μg布地奈德气雾剂或等效力的糖皮质激素6个月以上。主要观察指标:肾上腺功能测试前6个月和前12个月期间的身高标准差积分(HtSDS)变化,低剂量二十四肽促皮质素刺激后皮质醇的增量和峰值变化。在皮质醇的峰值≤500 nmol/L时,确定为肾上腺抑制。 展开更多
关键词 肾上腺功能 糖皮质激素 青春期前 布地奈德气雾剂 促皮质素 生长发育情况 等效力 四肽 相似比 特异性
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北爱尔兰的糖尿病保健提供和血糖控制:一项英国区域性调查
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作者 Cardwell C.R. Patterson C.C. +2 位作者 Allen M. carson d.j. 郭战宏 《世界核心医学期刊文摘(儿科学分册)》 2005年第10期11-12,共2页
Aims: To assess the care received, compared to national guidelines, and to inv estigate factors associated with glycaemic control in children and adolescents w ith type 1 diabetes attending clinics in Northern Ireland... Aims: To assess the care received, compared to national guidelines, and to inv estigate factors associated with glycaemic control in children and adolescents w ith type 1 diabetes attending clinics in Northern Ireland. Methods: An audit of the care provided to all patients attending 11 paediatric diabetes clinics comme nced in 2002. A research nurse interviewed 914 patients completing a questionnai re recording characteristics, social circumstances, and aspects of diabetes mana gement, including the monitoring of complications and access tomembers of the di abetes team. Glycaemic control was measured by glycosylated haemoglobin (HbA1c), determined at aDCCT aligned central laboratory. Results: The average HbA1c concentration was 8.8%(SD 1.5%), with 20%of patients achiev ing recommended HbA1c levels of less than 7.5%. In the year prior to the audit, 76%of patients were reviewed by a diabetes specialist nurse and 42%were teste d for microalbuminuria. After adjustment for confounding factors, better glycaem ic control was identified, particularly in patients who had attended exactly fou r diabetes clinics in the previous year, were members of the patient association Diabetes UK, and lived with both natural parents. Conclusions: In Northern Irel and only a minority of patients achieved recommended HbA1c levels. Furthermore, children and adolescents with diabetes were reviewed by fewer specialists and we re less intensively monitored for microvascular complications than recommended. There was evidence of better control in children who were members of Diabetes UK , suggesting that parental attitude and involvement could lead to benefits. 展开更多
关键词 DCCT 实验室测定 影响因子 微量蛋白尿 混杂因素
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