Cancer remains one of the leading health threats globally,with therapeutic resistance being a long-standing challenge across chemotherapy,radiotherapy,targeted therapy,and immunotherapy.In recent years,the association...Cancer remains one of the leading health threats globally,with therapeutic resistance being a long-standing challenge across chemotherapy,radiotherapy,targeted therapy,and immunotherapy.In recent years,the association between epigenetic modification abnormalities and therapeutic resistance in tumors has garnered widespread attention,spurring interest in the development of approaches to target epigenetic factors.In this review,we explore the widespread dysregulation and crosstalk of various types of epigenetic modifications,including DNA methylation,histone modifications,and non-coding RNA changes,which interact through complex regulatory networks in tumors.Clinically,single-targeted therapy based on epigenetic modification usually has its limited effect against cancer.However,the combination of epigenetic drugs with other treatment modalities,such as chemotherapy,targeted therapy,or immunotherapy,shows potential for synergistically enhancing efficacy and reducing drug resistance.展开更多
基金supported by the National Natural Science Foundation of China(82473574 , 82404200)Projects from Sichuan Province(25QNJJ4600 , 2024ZYD0126).
文摘Cancer remains one of the leading health threats globally,with therapeutic resistance being a long-standing challenge across chemotherapy,radiotherapy,targeted therapy,and immunotherapy.In recent years,the association between epigenetic modification abnormalities and therapeutic resistance in tumors has garnered widespread attention,spurring interest in the development of approaches to target epigenetic factors.In this review,we explore the widespread dysregulation and crosstalk of various types of epigenetic modifications,including DNA methylation,histone modifications,and non-coding RNA changes,which interact through complex regulatory networks in tumors.Clinically,single-targeted therapy based on epigenetic modification usually has its limited effect against cancer.However,the combination of epigenetic drugs with other treatment modalities,such as chemotherapy,targeted therapy,or immunotherapy,shows potential for synergistically enhancing efficacy and reducing drug resistance.
