To study the toxicity of samarium nitrate on male mice＇s testicle tissue, samarium nitrate was administrated to mice at different doses（0, 5, 50, 500, 2000 mg·L^-1） for 3 months. The biochemical index and path...To study the toxicity of samarium nitrate on male mice＇s testicle tissue, samarium nitrate was administrated to mice at different doses（0, 5, 50, 500, 2000 mg·L^-1） for 3 months. The biochemical index and pathological changes were observed. The results show that the construction of testicle, especially in sperms and testis intersitium are broken. LDH enzyme activity in 2000 mg·L^-1 and LDH-X enzyme activity in 500 and 2000 mg·L^- 1dose groups are inhibited obviously. SDH enzyme activity in 50, 500 and 2000 mg·L^-1 dose groups are lower than that in control group, but T-GT enzyme activity is unacted on Sm. With increase of samarium concentration, Na^＋K^＋-ATP, Mg^2＋-ATP enzyme activity tend to ＂promote weakly and inhibited strongly＂, while Ca^2＋-ATPase decrease largely. Subchronic samarium exposure has definite toxicity to gonad of mice.展开更多
文摘To study the toxicity of samarium nitrate on male mice＇s testicle tissue, samarium nitrate was administrated to mice at different doses（0, 5, 50, 500, 2000 mg·L^-1） for 3 months. The biochemical index and pathological changes were observed. The results show that the construction of testicle, especially in sperms and testis intersitium are broken. LDH enzyme activity in 2000 mg·L^-1 and LDH-X enzyme activity in 500 and 2000 mg·L^- 1dose groups are inhibited obviously. SDH enzyme activity in 50, 500 and 2000 mg·L^-1 dose groups are lower than that in control group, but T-GT enzyme activity is unacted on Sm. With increase of samarium concentration, Na^＋K^＋-ATP, Mg^2＋-ATP enzyme activity tend to ＂promote weakly and inhibited strongly＂, while Ca^2＋-ATPase decrease largely. Subchronic samarium exposure has definite toxicity to gonad of mice.
