Acute myeloid leukemia(AML)is an aggressive hematological malignancy with a poor prognosis.Cytarabine(Ara-C),a cornerstone of AML chemotherapy,causes DNA damage.1 However,patient AML blasts can develop Ara-C resistanc...Acute myeloid leukemia(AML)is an aggressive hematological malignancy with a poor prognosis.Cytarabine(Ara-C),a cornerstone of AML chemotherapy,causes DNA damage.1 However,patient AML blasts can develop Ara-C resistance.Therefore,there is an urgent need to explore new targets for the treatment of AML.展开更多
基金supported by grants from the Natural Science Foundation of Shandong Province(Youth Program,ZR2023QH249)National Natural Science Foundation of China(No.82370173,32241005,81873439).
文摘Acute myeloid leukemia(AML)is an aggressive hematological malignancy with a poor prognosis.Cytarabine(Ara-C),a cornerstone of AML chemotherapy,causes DNA damage.1 However,patient AML blasts can develop Ara-C resistance.Therefore,there is an urgent need to explore new targets for the treatment of AML.
