There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must o...There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must overcome.In this study,we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to cartilage.To this aim,we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome dispersion.The efficiency of drug delivery was evaluated using frozen sections.The results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in cartilage explants can be tracked dynamically.Thus,ex vivo cartilage explants provide an effective and economic system to evaluate therapeutic drugs encapsulated in chondrocyte-targeted exosomes in preclinical studies.展开更多
Sustainable development for our life is important task,which is driven by key materials and technologies.In this roadmap,we discuss three main aspects in addressing environmental questions,green chemical processes and...Sustainable development for our life is important task,which is driven by key materials and technologies.In this roadmap,we discuss three main aspects in addressing environmental questions,green chemical processes and energy challenges.They are included,such as gas treatment and separation,wastewater treatment,waste gas treatment,solid waste treatment,lithium extraction,hydrogen production,water splitting,CO_(2) reduction,photocatalytic clean technologies,plastic degradation,fuel cells,lithium batteries,sodium batteries,aqueous batteries,solid state batteries,metal air batteries and supercapacitors.Their status,challenges,progress and future perspectives are also discussed.We hope that this paper can give clear views on sustainable development in materials and technologies.展开更多
基金National Natural Science Foundation of China(Nos.81972116,81972085,81772394,31900046)Key Program of Natural Science Foundation of Guangdong Province(No.2018B0303110003)+3 种基金Guangdong International Cooperation Project(No.2021A0505030011)Shenzhen Science and Technology Projects(Nos.GJHZ20200731095606019,JCYJ20170817172023838,JCYJ20170306092215436,JCYJ20170413161649437)China Postdoctoral Science Foundation(No.2020M682907)Special Funds for the Construction of High Level Hospitals in Guangdong Province.
文摘There is no efficient tracking system available for the therapeutic molecules delivered to cartilage.The dense matrix covering the cartilage surface is the main biological barrier that the therapeutic molecules must overcome.In this study,we aimed to establish a system that can dynamically and effectively track the therapeutic molecules delivered to cartilage.To this aim,we adopted bovine and human cartilage explants as ex vivo models for chondrocyte-targeted exosome dispersion.The efficiency of drug delivery was evaluated using frozen sections.The results of this study showed that the penetration and distribution of chondrocyte-targeted exosomes in cartilage explants can be tracked dynamically.Thus,ex vivo cartilage explants provide an effective and economic system to evaluate therapeutic drugs encapsulated in chondrocyte-targeted exosomes in preclinical studies.
基金supported by the Russian Science Foundation(No.22-13-00035)the National Outstanding Young Scientists Fund(No.52125002)+14 种基金the National Key Research and Development Program of China(Nos.2023YFC3904800 and 2022YFB4002501)the National Natural Science Foundation of China(Nos.52400228,52300139,22308063,52103340,U22A20418,22578302,52202208,52400163,52205054,22075171,52177214,22405201,52371072,52171078,52377218)the Key Research and Development Project of Science and Technology Department of Zhejiang Province(No.2024C03284(SD2))the Research Development Fund of Zhejiang A&F University(No.2024LFR042)the President Research Funds from Xiamen University(No.ZK1111)Nanqiang Youth Scholar program of Xiamen University,the Young Elite Scientists Sponsorship Program by CAST(No.2023QNRC001)Natural Science Foundation of Xiamen(No.3502z202471037)Open Fund of the State Environmental Protection Key Laboratory of Urban Air Particulate Matter Pollution Prevention and Control,College of Environmental Science and Engineering,Nankai University(No.NKPMLF202409)the Key Project of Research and Development Plan of Jiangxi Province(No.20243BBI91001)Natural Science Foundation of Shanghai(No.23ZR1423400)the Postdoctoral Science Research Program of Shaanxi(No.2023BSHEDzZ159)Xidian University Specially Funded Project for Interdisciplinary Exploration(No.TZJH2024062)the Open Project of Yunnan Precious Metals Laboratory Co.,Ltd.(No.YPML-20240502058)the Fundamental Research Program of Shanxi Province(No.202303021212159)the Natural Science Foundation of Shanxi Normal University(No.JCYJ2024017).
文摘Sustainable development for our life is important task,which is driven by key materials and technologies.In this roadmap,we discuss three main aspects in addressing environmental questions,green chemical processes and energy challenges.They are included,such as gas treatment and separation,wastewater treatment,waste gas treatment,solid waste treatment,lithium extraction,hydrogen production,water splitting,CO_(2) reduction,photocatalytic clean technologies,plastic degradation,fuel cells,lithium batteries,sodium batteries,aqueous batteries,solid state batteries,metal air batteries and supercapacitors.Their status,challenges,progress and future perspectives are also discussed.We hope that this paper can give clear views on sustainable development in materials and technologies.
