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精子鞭毛形态多发畸形患者行卵细胞质内单精子注射治疗的结局分析 被引量:2
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作者 陈杰 袁贺佳 +7 位作者 崔元庆 闫伟 连花瑜 刘晓妍 张伟 刘雪梅 郝翠芳 王雄 《中华医学杂志》 CAS CSCD 北大核心 2018年第36期2914-2919,共6页
目的分析精子鞭毛形态多发畸形(MMAF)相关的重度弱精子症患者行卵细胞质内单精子注射(ICSI)助孕治疗的临床结局。方法回顾性分析烟台毓璜顶医院生殖医学科自2011年1月至2016年12月收治的15例MMAF患者的临床数据,行低渗法选择“活... 目的分析精子鞭毛形态多发畸形(MMAF)相关的重度弱精子症患者行卵细胞质内单精子注射(ICSI)助孕治疗的临床结局。方法回顾性分析烟台毓璜顶医院生殖医学科自2011年1月至2016年12月收治的15例MMAF患者的临床数据,行低渗法选择“活”精子行ICSI治疗,匹配同一治疗时间30例因梗阻性无精子症(OA)行ICSI的患者。比较两组患者夫妇双方年龄、体质指数(BMI)、不育年限、获卵数、ICSI卵子数、受精率、卵裂率、可移植胚胎率、优质胚胎率、胚胎种植率、临床妊娠率、早期流产率、单胎率及双胎率差异。结果15例MMAF患者经过27个ICSI周期,均实现临床妊娠,其中活产11例,自然流产2例,持续妊娠2例。MMAF组与OA对照组在男、女方年龄、BMI、获卵数、ICSI卵子数等基本情况差异无统计学意义(P〉0.05),但在不育年限上的差异有统计学意义(P〈0.001);MMAF组与OA对照组的ICSI受精率(92.0%比91.6%)、卵裂率(95.4%比96.5%)、优质胚胎率(56.5%比57.5%)、优质囊胚率(23/61比35/94)、胚胎种植率(20/48比35/75)、早期流产率(4/19比8/36)、临床妊娠率(15/27比28/50)、单胎率(10/13比20/25)和双胎率(3/13比5/25)差异均无统计学意义(均P〉0.05)。结论MMAF可能不影响ICSI治疗结局,但遗传缺陷也可以通过ICSI传递,是否选择胚胎植入前遗传学诊断(PGD)应在充分遗传咨询的情况下遵从患者夫妇意愿。 展开更多
关键词 鞭毛 男性不育 弱精子症 临床结局
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Electromechanical cracking in ferroelectrics driven by large scale domain switching 被引量:4
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作者 cui yuanqing YANG Wei 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第5期957-965,共9页
Experimental results indicate three regimes for cracking in a ferroelectric double cantilever beam (DCB) under combined electromechanical loading. In the loading, the maximum amplitude of the applied electric field re... Experimental results indicate three regimes for cracking in a ferroelectric double cantilever beam (DCB) under combined electromechanical loading. In the loading, the maximum amplitude of the applied electric field reaches almost twice the coercive field of ferroelectrics. Thus, the model of small scale domain switching is not applicable any more, which is dictated only by the singular term of the crack tip field. In the DCB test, a large or global scale domain switching takes place instead, which is driven jointly by both the singular and non-singular terms of the crack-tip electric field. Combining a full field solution with an energy based switching criterion, we obtain the switching zone by the large scale model around the tip of a stationary impermeable crack. It is observed that the switching zone by the large scale model is significantly different from that by the small scale model. According to the large scale switching zone, the switch-induced stress intensity factor (SIF) and the transverse stress (T-stress) are evaluated numerically. Via the SIF and T-stress induced by the combined loading and corresponding criteria, we address the crack initiation and crack growth stability simultaneously. The two theoretical predictions roughly coincide with the experimental observations. 展开更多
关键词 ferroelectric ceramics large scale domain switching electromechanical loading crack initiation crack growth stability stress intensity factor transverse stress
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Large scale domain switching around the tip of an impermeable stationary crack in ferroelectric ceramics driven by near-coercive electric field 被引量:3
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作者 cui yuanqing ZHONG Zheng 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2011年第1期121-126,共6页
It is widely accepted that the singular term plays a leading role in driving domain switching around the crack tip of ferroelectric ceramics.When an applied electric field approaches or even exceeds the coercive one,h... It is widely accepted that the singular term plays a leading role in driving domain switching around the crack tip of ferroelectric ceramics.When an applied electric field approaches or even exceeds the coercive one,however,non-singular terms are no longer negligible and the switching of a large or global scale takes place.To analyze the large scale switching,one has to get a full asymptotic solution to the electric field in the vicinity of the crack tip.Take a double cantilever beam specimen as an example.The derivation of the full electric field is simplified as a mixed boundary value problem of an infinite strip containing a semi-infinite impermeable crack.The boundary value problem is solved by an analytic function and a conformal mapping to yield a full electric field solution in a closed form.Based on the full field solution,the large scale domain switching is examined.The switching zones predicted by the large and small scale switching models are illustrated and compared with each other near the tip of a stationary crack. 展开更多
关键词 ferroelectric ceramics domain switching electric field analytic function impermeable crack STRIP
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