目的:分析中医药治疗高血压合并高脂血症(HTN-HLP)随机对照试验(RCT)的结局指标,为相关核心指标集的建立提供参考。方法:综合检索万方数据知识服务平台、中国知网、维普、中国生物医学文献服务系统、中国临床试验注册中心、Web of Scie...目的:分析中医药治疗高血压合并高脂血症(HTN-HLP)随机对照试验(RCT)的结局指标,为相关核心指标集的建立提供参考。方法:综合检索万方数据知识服务平台、中国知网、维普、中国生物医学文献服务系统、中国临床试验注册中心、Web of Science、PubMed等中英文数据库2014年1月—2024年1月的相关文献,分析中医药治疗HTN-HLP RCT的结局指标。结果:纳入文献17篇,结局指标分为中医病证指标、血压指标、血脂指标、临床疗效指标、其他实验室检查指标、生活质量指标、安全性指标。结论:中医药治疗HTN-HLP RCT结局指标的选择仍存在一些不足,今后在开展RCT前需明确主要、次要结局指标,选择具有中医特色的结局指标,注重远期疗效、经济学和安全性指标。展开更多
Synthetic aperture radar(SAR) image despeckling has been an attractive problem in remote sensing.The main challenge is to suppress speckle while preserving edges and preventing unnatural artifacts(such as annoying art...Synthetic aperture radar(SAR) image despeckling has been an attractive problem in remote sensing.The main challenge is to suppress speckle while preserving edges and preventing unnatural artifacts(such as annoying artifacts in homogeneous regions and over-smoothed edges).To address these problems,this paper proposes a new variational model with a nonconvex nonsmooth Lp(0 <p<1) norm regularization.It incorporates Lp(0<p<1) norm regularization and I-divergence fidelity term.Due to the nonconvex nonsmooth property,the regularization can better recover neat edges and homogeneous regions.The Ⅰ-divergence fidelity term is used to suppress the multiplicative noise effectively.Moreover,based on variable-splitting and alternating direction method of multipliers(ADMM) method,an efficient algorithm is proposed for solving this model.Intensive experimental results demonstrate that nonconvex nonsmooth model is superior to other state-of-the-art approaches qualitatively and quantitatively.展开更多
目的探究当代中医医家论治出血性中风的学术特点,为临床诊治提供思路与方法。方法全面系统检索当代中医名家论治出血性中风相关文献。依据澳大利亚循证方法学组织(Joanna Briggs Institute,JBI)研发的基于文本和专家意见的系统综述(the ...目的探究当代中医医家论治出血性中风的学术特点,为临床诊治提供思路与方法。方法全面系统检索当代中医名家论治出血性中风相关文献。依据澳大利亚循证方法学组织(Joanna Briggs Institute,JBI)研发的基于文本和专家意见的系统综述(the systematic review of text and opinion,SrTO)方法,对中医脑病领域名医名家诊治出血性中风临证经验、学术思想等相关研究进行证据整合,并从理法方药、因机证治多方面分析其学术特点及影响因素。结果共纳入36名中医医家,医家在华南、华东、华北、华中等医疗发达地区分布多,其中北京地区纳入医家数量最多,为7名;纳入医家的20%有中医家传教育背景,69.4%有师承名医学习经历;36名医家总结归纳形成包括脑髓理论、伏邪理论、毒损脑络在内共计11种新理论;创新性地提出包括通腑化痰、破血化瘀、痰瘀同治在内共计23种新治法。结论当代中医名家将传统理论和现代研究相融合,诊治上经典理论与临床实践并重,学术上传承与创新兼备,对出血性中风的研究逐渐深入。展开更多
文摘目的:分析中医药治疗高血压合并高脂血症(HTN-HLP)随机对照试验(RCT)的结局指标,为相关核心指标集的建立提供参考。方法:综合检索万方数据知识服务平台、中国知网、维普、中国生物医学文献服务系统、中国临床试验注册中心、Web of Science、PubMed等中英文数据库2014年1月—2024年1月的相关文献,分析中医药治疗HTN-HLP RCT的结局指标。结果:纳入文献17篇,结局指标分为中医病证指标、血压指标、血脂指标、临床疗效指标、其他实验室检查指标、生活质量指标、安全性指标。结论:中医药治疗HTN-HLP RCT结局指标的选择仍存在一些不足,今后在开展RCT前需明确主要、次要结局指标,选择具有中医特色的结局指标,注重远期疗效、经济学和安全性指标。
基金Supported by the National Natural Science Foundation of China(No.41971356,41701446)the National Key Research and Development Program of China(No.2018YFB0505500)the Open Fund of Key Laboratory of Urban Land Resources Monitoring and Simulation,Ministry of Natural Resources(No.KF-2020-05-011)。
文摘Synthetic aperture radar(SAR) image despeckling has been an attractive problem in remote sensing.The main challenge is to suppress speckle while preserving edges and preventing unnatural artifacts(such as annoying artifacts in homogeneous regions and over-smoothed edges).To address these problems,this paper proposes a new variational model with a nonconvex nonsmooth Lp(0 <p<1) norm regularization.It incorporates Lp(0<p<1) norm regularization and I-divergence fidelity term.Due to the nonconvex nonsmooth property,the regularization can better recover neat edges and homogeneous regions.The Ⅰ-divergence fidelity term is used to suppress the multiplicative noise effectively.Moreover,based on variable-splitting and alternating direction method of multipliers(ADMM) method,an efficient algorithm is proposed for solving this model.Intensive experimental results demonstrate that nonconvex nonsmooth model is superior to other state-of-the-art approaches qualitatively and quantitatively.
文摘目的探究当代中医医家论治出血性中风的学术特点,为临床诊治提供思路与方法。方法全面系统检索当代中医名家论治出血性中风相关文献。依据澳大利亚循证方法学组织(Joanna Briggs Institute,JBI)研发的基于文本和专家意见的系统综述(the systematic review of text and opinion,SrTO)方法,对中医脑病领域名医名家诊治出血性中风临证经验、学术思想等相关研究进行证据整合,并从理法方药、因机证治多方面分析其学术特点及影响因素。结果共纳入36名中医医家,医家在华南、华东、华北、华中等医疗发达地区分布多,其中北京地区纳入医家数量最多,为7名;纳入医家的20%有中医家传教育背景,69.4%有师承名医学习经历;36名医家总结归纳形成包括脑髓理论、伏邪理论、毒损脑络在内共计11种新理论;创新性地提出包括通腑化痰、破血化瘀、痰瘀同治在内共计23种新治法。结论当代中医名家将传统理论和现代研究相融合,诊治上经典理论与临床实践并重,学术上传承与创新兼备,对出血性中风的研究逐渐深入。
