Objective:To evaluate the detection accuracy of the biomarkers dickkopf-1,DCP and AFP as a serum biomarker panel by comparing the sensitivity of the panel with those of the individual biomarkers.Methods:The study was ...Objective:To evaluate the detection accuracy of the biomarkers dickkopf-1,DCP and AFP as a serum biomarker panel by comparing the sensitivity of the panel with those of the individual biomarkers.Methods:The study was composed of three groups,one with HCC patients,one with non-HCC liver diseases and one with healthy controls.Serum AFP was measured using a chemiluminescence assay and serum dickkopf-1 and DCP were measured with ELISA.The sensitivity and specificity of the biomarkers were analyzed as single parameters and as a serum panel.Results:The HCC group showed higher levels of dickkopf-1,DCP and AFP than the other two groups(P<0.05).Dickkopf-1 showed better sensitivity(73.26%vx.58.13%.P<0.05) and better specificity(44.00%vs.29.00%,P>0.05) than AFP.DCP also had better sensitivity(74.42%vs.58.13%.P<0.05) than AFP,but their specificity was similar(30.00%vs.29.00%.P>0.05).The combination of the biomarkers as a scrum panel produced much better sensitivity(93.02%) and specificity(78.00%) than each of the markers individually(P<0.05).Conclusion:The combination of AFP.DCP and dickkopf-1 as a biomarker panel can significantly improve the detection power with much higher sensitivity and specificity for HCC than any of the biomarkers alone.The tests are convenient and inexpensive,and may serve as a valuable addition to current options for the diagnosis of HCC.展开更多
Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children a...Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group （P〈0.05）, and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group （P〈0.001）. After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group （P〈0.05）. After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher （10.7 g/L vs 7.9 g/L, P〈0.0001）. Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention.展开更多
A large number of positive scientific evidences confirmed that central obesity was highly associated with CVD, diabetes and hypertension. Studies in different countries and ethnic groups demonstrated that waist circum...A large number of positive scientific evidences confirmed that central obesity was highly associated with CVD, diabetes and hypertension. Studies in different countries and ethnic groups demonstrated that waist circumferences （WC）, waist-hip ratio （WHR） and waist circumference-height ratio （WHtR） （or waist circumference-stature ratio WSR） performed as strong predictors when being added to body mass index （BMI）.展开更多
AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string p...AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string pupilloplasty were retrospectively analyzed.Preoperative data and at least 6mo of postoperative data were collected from all the patients.RESULTS:The corrected distance visual acuity(CDVA)before and after surgery was 0.58±0.22 and 0.20±0.10 logMAR,respectively(P=0.002).The pre-and postoperative pupil size was 7.38±0.88 and 3.09±0.71 mm(P=0.000),respectively.The corneal endothelial cell count was 2841±176/mm^(2) before and 2692±143/mm^(2) after surgery(P=0.000).No intraoperative or postoperative complications were reported.During the follow-up period of at least 6mo,all treated pupils were centered and generally or nearly round.Furthermore,the patients did not exhibit photophobia,glare,or diplopia.CONCLUSION:This technique is a simple and effective method for pupil reduction.展开更多
Objective To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 24 months.Methods One thousand and four hundred seventy eight children aged ...Objective To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 24 months.Methods One thousand and four hundred seventy eight children aged 4-12 months were recruited and divided into study groups(formula 1 group and formula 2 group)and control group.In two study groups,in addition to the usual complementary food,children were fed with a sachet of fortified food supplement each day.Protein and micronutrients were provided in formula 1 group.Formula 2 group had the same energy intake as the formula 1 group.In addition to measurement of physical growth and detection of hemoglobin level,Development Quotient(DQ)or Intelligence Quotient(IQ)was assessed.Results The DQ of children aged below 24 months was 97.2,95.5,and 93.8 in formula 1 group,formula 2 group and control group,respectively,and the differences were statistically significant(P〈0.05).The DQ of children in formula 1 group,formula 2 group,and control group was 92.7,90.4,and 88.3 respectively in the first follow up showing statistically significant differences(P〈0.05).And,DQ of children in formula 1 group,formula 2 group and control group were 96.7,94.5,and 93.7 respectively in the second follow up,showing statistically significant differences(P〈0.05).FulI-IQ of children in the formula 1 group was 3.1 and 4.5 points higher than that in formula 2 group and in control group respectively.Verbal IQ of children in the formula 1 group was 2.1 and 5 points higher than that in formula 2 group and control group respectively.Performance IQ was 2.5 and 3.1 points higher than that in formula 2 group and control group respectively.All above mentioned comparisons were statistically significant.Conclusion Fortification of complementary feeding showed persistent effect on intelligence development of young children which could persist to 6 years of age.The critical time for correction of anemia could be under 18 months.展开更多
We study the problem of business model mining and prediction in the e-commerce context. Unlike most existing approaches where this is typically formulated as a regression problem or a time-series prediction problem, w...We study the problem of business model mining and prediction in the e-commerce context. Unlike most existing approaches where this is typically formulated as a regression problem or a time-series prediction problem, we take a different formulation to this problem by noting that these existing approaches fail to consider the potential relationships both among the consumers （consumer influence） and among the shops （competitions or collaborations）. Taking this observation into consideration, we propose a new method for e-commerce business model mining and prediction, called EBMM, which combines regression with community analysis. The challenge is that the links in the network are typically not directly observed, which is addressed by applying information diffusion theory through the consumer-shop network. Extensive evaluations using Alibaba Group e-commerce data demonstrate the promise and superiority of EBMM to the state-of-the-art methods in terms of business model mining and prediction.展开更多
Background The onsets of needling sensation introduced by acupuncture stimulus can vary widely from subject to subject. This should be explicitly accounted for by the model blood oxygenation-level dependent （BOLD） t...Background The onsets of needling sensation introduced by acupuncture stimulus can vary widely from subject to subject. This should be explicitly accounted for by the model blood oxygenation-level dependent （BOLD） time course used in general linear model （GLM） analysis to obtain more consistent across-subject group results. However, in standard GLM analysis, the model BOLD time course obtained by convolving a canonical hemodynamic response function with an experimental paradigm time course is assumed identical across subjects. Although some added-on properties to the model BOLD time course, such as temporal and dispersion derivatives, may be used to account for different BOLD response onsets, they can only account for the BOLD onset deviations to the extent of less than one repetition time （TR）. Methods In this study, we explicitly manipulated the onsets of model BOLD time course by shifting it with -2, -1, or 1 TR and used these temporally shifted BOLD model to analyze the functional magnetic resonance imaging （fMRI） data obtained from three acupuncture fMRI experiments with GLM analysis. One involved acupuncture stimulus on left ST42 acupoint and the other two on left GB40 and left BL64 acupoints. Results The model BOLD time course with temporal shifts, in addition to temporal and dispersion derivatives, could result in better statistical power of the data analysis in terms of the average correlation coefficients between the used BOLD models and extracted BOLD responses from individual subject data and the T-values of the activation clusters in the grouped random effects. Conclusions The GLM analysis with ordinary BOLD model failed to catch the large variability of the onsets of the BOLD responses associated with the acupuncture needling sensation. Shifts in time with more than a TR on model BOLD time course might be required to better extract the acupuncture stimulus-induced BOLD activities from individual fMRI data.展开更多
This work presents air-coupled piezoelectric micromachined ultrasonic transducers(pMUTs)with high sound pressure level(SPL)under low-driving voltages by utilizing sputtered potassium sodium niobate K0.34Na0.66NbO3(KNN...This work presents air-coupled piezoelectric micromachined ultrasonic transducers(pMUTs)with high sound pressure level(SPL)under low-driving voltages by utilizing sputtered potassium sodium niobate K0.34Na0.66NbO3(KNN)films.A prototype single KNN pMUT has been tested to show a resonant frequency at 106.3 kHz under 4 Vp-p with outstanding characteristics:(1)a large vibration amplitude of 3.74μm/V,and(2)a high acoustic root mean square(RMS)sound pressure level of 105.5 dB/V at 10 cm,which is 5–10 times higher than those of AlN-based pMUTs at a similar frequency.There are various potential sensing and actuating applications,such as fingerprint sensing,touch point,and gesture recognition.In this work,we present demonstrations in three fields:haptics,loudspeakers,and rangefinders.For haptics,an array of 15×15 KNN pMUTs is used as a non-contact actuator to provide a focal pressure of around 160.3 dB RMS SPL at a distance of 15 mm.This represents the highest output pressure achieved by an airborne pMUT for haptic sensation on human palms.When used as a loudspeaker,a single pMUT element with a resonant frequency close to the audible range at 22.8 kHz is characterized.It is shown to be able to generate a uniform acoustic output with an amplitude modulation scheme.In the rangefinder application,pulse-echo measurements using a single pMUT element demonstrate good transceiving results,capable of detecting objects up to 2.82 m away.As such,this new class of high-SPL and low-driving-voltage pMUTs could be further extended to other applications requiring high acoustic pressure and a small form factor.展开更多
基金supported by an Applied Research and Development Promotion grant of Hainan Province(No.:ZDXM2014074)a grant from the Program of Social and Scientific & Technological Development Projects of Hainan Province(No.:SF201422)
文摘Objective:To evaluate the detection accuracy of the biomarkers dickkopf-1,DCP and AFP as a serum biomarker panel by comparing the sensitivity of the panel with those of the individual biomarkers.Methods:The study was composed of three groups,one with HCC patients,one with non-HCC liver diseases and one with healthy controls.Serum AFP was measured using a chemiluminescence assay and serum dickkopf-1 and DCP were measured with ELISA.The sensitivity and specificity of the biomarkers were analyzed as single parameters and as a serum panel.Results:The HCC group showed higher levels of dickkopf-1,DCP and AFP than the other two groups(P<0.05).Dickkopf-1 showed better sensitivity(73.26%vx.58.13%.P<0.05) and better specificity(44.00%vs.29.00%,P>0.05) than AFP.DCP also had better sensitivity(74.42%vs.58.13%.P<0.05) than AFP,but their specificity was similar(30.00%vs.29.00%.P>0.05).The combination of the biomarkers as a scrum panel produced much better sensitivity(93.02%) and specificity(78.00%) than each of the markers individually(P<0.05).Conclusion:The combination of AFP.DCP and dickkopf-1 as a biomarker panel can significantly improve the detection power with much higher sensitivity and specificity for HCC than any of the biomarkers alone.The tests are convenient and inexpensive,and may serve as a valuable addition to current options for the diagnosis of HCC.
文摘Objective To assess the effectiveness of complementary food supplements with protein and multi-micronutrients on hemoglobin and anemia in infants and young children. Methods In 5 poor counties of Gansu, 984 children aged 6-12 months were enrolled and divided into two groups. In addition to the usual home-made complementary food, all the children were fed one sachet of either Formula Ⅰ or Formula Ⅱ supplements each day. Protein and micronutrients were provided in Formula Ⅰ, while the same energy intake was secured in Formula Ⅱ as in Formula Ⅰ. A massive dose of vitamin A was supplemented to all the children every 6 months. Hemoglobin test was done at the same time. Results Prevalence of anemia was about 35% in both Formula Ⅰ and Formula Ⅱ group at baseline, and there were no differences in hemoglobin concentration between the two groups, During the 6-month and 12-month supplementation, hemoglobin of children in Formula Ⅰ group was higher than that in Formula Ⅱ group （P〈0.05）, and hemoglobin increase in Formula Ⅰ group was significantly higher than that in Formula Ⅱ group （P〈0.001）. After 6- and 12-mouth supplementation, the prevalence of anemia in Formula Ⅰ group dropped to 19.1% and 8.2% respectively, and it was 28.0% and 12.4% in Formula 2 group. The prevalence of anemia in Formula Ⅰ group was significantly lower than that in Formula Ⅱ group （P〈0.05）. After adjusting age and hemoglobin level at baseline, the hemoglobin increase at age of 24 months in formula 1 group was higher （10.7 g/L vs 7.9 g/L, P〈0.0001）. Conclusion Micronutrient fortified complementary food supplements, with large-dose vitamin A, is effective for children aged 6-12 months in terms of iron deficiency prevention.
文摘A large number of positive scientific evidences confirmed that central obesity was highly associated with CVD, diabetes and hypertension. Studies in different countries and ethnic groups demonstrated that waist circumferences （WC）, waist-hip ratio （WHR） and waist circumference-height ratio （WHtR） （or waist circumference-stature ratio WSR） performed as strong predictors when being added to body mass index （BMI）.
基金Supported by the Changzhou Science and Technology Bureau(No.CJ20239004).
文摘AIM:To observe the clinical outcomes of 30-gauge(G)needle-guided 10-0 prolene suture purse-string pupilloplasty for atonic pupil management.METHODS:Eight patients with atonic pupils who underwent suture purse-string pupilloplasty were retrospectively analyzed.Preoperative data and at least 6mo of postoperative data were collected from all the patients.RESULTS:The corrected distance visual acuity(CDVA)before and after surgery was 0.58±0.22 and 0.20±0.10 logMAR,respectively(P=0.002).The pre-and postoperative pupil size was 7.38±0.88 and 3.09±0.71 mm(P=0.000),respectively.The corneal endothelial cell count was 2841±176/mm^(2) before and 2692±143/mm^(2) after surgery(P=0.000).No intraoperative or postoperative complications were reported.During the follow-up period of at least 6mo,all treated pupils were centered and generally or nearly round.Furthermore,the patients did not exhibit photophobia,glare,or diplopia.CONCLUSION:This technique is a simple and effective method for pupil reduction.
基金supported by Center for Health Promotion,International Life Science Institute.
文摘Objective To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 24 months.Methods One thousand and four hundred seventy eight children aged 4-12 months were recruited and divided into study groups(formula 1 group and formula 2 group)and control group.In two study groups,in addition to the usual complementary food,children were fed with a sachet of fortified food supplement each day.Protein and micronutrients were provided in formula 1 group.Formula 2 group had the same energy intake as the formula 1 group.In addition to measurement of physical growth and detection of hemoglobin level,Development Quotient(DQ)or Intelligence Quotient(IQ)was assessed.Results The DQ of children aged below 24 months was 97.2,95.5,and 93.8 in formula 1 group,formula 2 group and control group,respectively,and the differences were statistically significant(P〈0.05).The DQ of children in formula 1 group,formula 2 group,and control group was 92.7,90.4,and 88.3 respectively in the first follow up showing statistically significant differences(P〈0.05).And,DQ of children in formula 1 group,formula 2 group and control group were 96.7,94.5,and 93.7 respectively in the second follow up,showing statistically significant differences(P〈0.05).FulI-IQ of children in the formula 1 group was 3.1 and 4.5 points higher than that in formula 2 group and in control group respectively.Verbal IQ of children in the formula 1 group was 2.1 and 5 points higher than that in formula 2 group and control group respectively.Performance IQ was 2.5 and 3.1 points higher than that in formula 2 group and control group respectively.All above mentioned comparisons were statistically significant.Conclusion Fortification of complementary feeding showed persistent effect on intelligence development of young children which could persist to 6 years of age.The critical time for correction of anemia could be under 18 months.
基金supported by the National Basic Research Program(973)of China(No.2012CB316400)Zhejiang University-Alibaba Financial Joint Lab,Zhejiang Provincial Engineering Center on Media Data Cloud Processing and Analysis,Chinathe US National Science Foundation(No.CCF-1017828)
文摘We study the problem of business model mining and prediction in the e-commerce context. Unlike most existing approaches where this is typically formulated as a regression problem or a time-series prediction problem, we take a different formulation to this problem by noting that these existing approaches fail to consider the potential relationships both among the consumers （consumer influence） and among the shops （competitions or collaborations）. Taking this observation into consideration, we propose a new method for e-commerce business model mining and prediction, called EBMM, which combines regression with community analysis. The challenge is that the links in the network are typically not directly observed, which is addressed by applying information diffusion theory through the consumer-shop network. Extensive evaluations using Alibaba Group e-commerce data demonstrate the promise and superiority of EBMM to the state-of-the-art methods in terms of business model mining and prediction.
文摘Background The onsets of needling sensation introduced by acupuncture stimulus can vary widely from subject to subject. This should be explicitly accounted for by the model blood oxygenation-level dependent （BOLD） time course used in general linear model （GLM） analysis to obtain more consistent across-subject group results. However, in standard GLM analysis, the model BOLD time course obtained by convolving a canonical hemodynamic response function with an experimental paradigm time course is assumed identical across subjects. Although some added-on properties to the model BOLD time course, such as temporal and dispersion derivatives, may be used to account for different BOLD response onsets, they can only account for the BOLD onset deviations to the extent of less than one repetition time （TR）. Methods In this study, we explicitly manipulated the onsets of model BOLD time course by shifting it with -2, -1, or 1 TR and used these temporally shifted BOLD model to analyze the functional magnetic resonance imaging （fMRI） data obtained from three acupuncture fMRI experiments with GLM analysis. One involved acupuncture stimulus on left ST42 acupoint and the other two on left GB40 and left BL64 acupoints. Results The model BOLD time course with temporal shifts, in addition to temporal and dispersion derivatives, could result in better statistical power of the data analysis in terms of the average correlation coefficients between the used BOLD models and extracted BOLD responses from individual subject data and the T-values of the activation clusters in the grouped random effects. Conclusions The GLM analysis with ordinary BOLD model failed to catch the large variability of the onsets of the BOLD responses associated with the acupuncture needling sensation. Shifts in time with more than a TR on model BOLD time course might be required to better extract the acupuncture stimulus-induced BOLD activities from individual fMRI data.
基金supported in part by BSAC(Berkeley Sensor and Actuator Center)and the NSF grant ECCS-2128311.
文摘This work presents air-coupled piezoelectric micromachined ultrasonic transducers(pMUTs)with high sound pressure level(SPL)under low-driving voltages by utilizing sputtered potassium sodium niobate K0.34Na0.66NbO3(KNN)films.A prototype single KNN pMUT has been tested to show a resonant frequency at 106.3 kHz under 4 Vp-p with outstanding characteristics:(1)a large vibration amplitude of 3.74μm/V,and(2)a high acoustic root mean square(RMS)sound pressure level of 105.5 dB/V at 10 cm,which is 5–10 times higher than those of AlN-based pMUTs at a similar frequency.There are various potential sensing and actuating applications,such as fingerprint sensing,touch point,and gesture recognition.In this work,we present demonstrations in three fields:haptics,loudspeakers,and rangefinders.For haptics,an array of 15×15 KNN pMUTs is used as a non-contact actuator to provide a focal pressure of around 160.3 dB RMS SPL at a distance of 15 mm.This represents the highest output pressure achieved by an airborne pMUT for haptic sensation on human palms.When used as a loudspeaker,a single pMUT element with a resonant frequency close to the audible range at 22.8 kHz is characterized.It is shown to be able to generate a uniform acoustic output with an amplitude modulation scheme.In the rangefinder application,pulse-echo measurements using a single pMUT element demonstrate good transceiving results,capable of detecting objects up to 2.82 m away.As such,this new class of high-SPL and low-driving-voltage pMUTs could be further extended to other applications requiring high acoustic pressure and a small form factor.
