China’s environmental governance strategy provides a distinctive pathway for integrating sustainable development into national policy.Understanding its policy trajectory is essential for assessing China’s contributi...China’s environmental governance strategy provides a distinctive pathway for integrating sustainable development into national policy.Understanding its policy trajectory is essential for assessing China’s contribution to global sustainable development and the United Nations Sustainable Development Goals(SDGs).This study constructs a comprehensive database of 425 national environmental governance policy documents issued between 1978 and 2022 and applies Latent Dirichlet Allocation(LDA)modeling to examine the evolution of policy themes and discourse.The results show that China’s environmental governance has undergone four stages-initial exploration,detailed development,transformative leap,and diverse prosperity-reflecting a progressive shift toward more integrated and coordinated governance.Policy priorities have evolved from a primary focus on pollution control and energy transition to an emphasis on institutional construction and organizational reform,thereby strengthening alignment with the SDGs.This transformation is characterized by recurring developmental themes and increasingly preventive,forward-looking,and system-oriented governance approaches.Moreover,the co-evolution of policy concepts and implementation has driven a transition from localized,end-of-pipe responses to comprehensive governance frameworks,alongside a shift from normative guidance towards effectiveness-oriented policy design.By employing a data-driven text analysis approach,this study offers a systematic framework for tracing long-term policy evolution and assessing its implications for sustainable development.展开更多
目的基于静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)系统性探究帕金森病(Parkinson’s disease,PD)患者运动网络的功能连接(functional connectivity,FC)改变,并观察频率特异性FC模式。材料...目的基于静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)系统性探究帕金森病(Parkinson’s disease,PD)患者运动网络的功能连接(functional connectivity,FC)改变,并观察频率特异性FC模式。材料与方法经过严格质控,最终前瞻性纳入28例PD患者与34例性别、年龄、受教育年限匹配的健康对照者。整合来自模板的双侧小脑(Ⅳ~Ⅴ、Ⅵ、Ⅷ小叶)、黑质、基底节(尾状核、壳核、苍白球)、丘脑、运动皮层(中央前回、中央后回、中央旁小叶)共计36个感兴趣区(regions of interest,ROI)组成PD特异性运动网络,使用常规低频(0.01~0.1 Hz)以及slow-3(0.073~0.198 Hz)、slow-4(0.027~0.073 Hz)、slow-5(0.01~0.027 Hz)子频段下的FC分别构建连边。经过基于网络的统计分析,探究频率特异性FC改变模式。使用Spearman偏相关分析观察异常FC与临床运动及认知评分的相关性。结果PD患者在常规低频下展现了广泛的FC减低。在P=0.01的连边阈值与P=0.05的子图阈值下,观察到包含22个ROI和29条连边的子图(P=0.017),其中网络间连接以丘脑-小脑-基底节为著,以及黑质-壳核、中央后回-小脑的连接。网络内连接主要集中于小脑双侧Ⅵ小叶间、双侧壳核间、双侧中央旁小叶与右侧中央后回。在P=0.05的连边与子图阈值下与常规低频对比,slow-4展现了更多的丘脑-基底节的FC改变。slow-5频段的特异连边主要集中在“小脑-黑质-基底节-丘脑”的网络间连接。slow-3频段未发现异常FC。常规低频下,丘脑-苍白球及壳核间FC与统一帕金森病评分量表第三部分(Unified Parkinson’s Disease Rating ScaleⅢ,UPDRS-Ⅲ)呈负相关(P_(corrected)=0.04及P_(corrected)<0.01)。结论PD患者表现了整合运动网络复杂且广泛的FC受损,并且具有频率特异性改变模式。包含“小脑黑质-基底节-丘脑-运动皮层”多环路的脑网络功能异常可能是PD运动障碍的神经病理学机制之一,而纹状体、丘脑等皮层下结构可能具有疾病诊断与监测的潜在生物学价值。展开更多
本文为回顾性研究,经过兰州大学第二医院医学伦理委员会批准,免除受试者知情同意,批准文号:2021A-489。软组织肉瘤是一组异质性肿瘤,至少包含70个组织学实体[1]。腺泡状软组织肉瘤(alveolar soft part sarcoma,ASPS)约占所有软组织肉瘤...本文为回顾性研究,经过兰州大学第二医院医学伦理委员会批准,免除受试者知情同意,批准文号:2021A-489。软组织肉瘤是一组异质性肿瘤,至少包含70个组织学实体[1]。腺泡状软组织肉瘤(alveolar soft part sarcoma,ASPS)约占所有软组织肉瘤的0.5%~1.0%[2-3]。展开更多
基金supported by the Key Project of Jiangsu Social Science Fund and the Key Project of Jiangsu Research Center for Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era(Grant No.26ZXZA017).
文摘China’s environmental governance strategy provides a distinctive pathway for integrating sustainable development into national policy.Understanding its policy trajectory is essential for assessing China’s contribution to global sustainable development and the United Nations Sustainable Development Goals(SDGs).This study constructs a comprehensive database of 425 national environmental governance policy documents issued between 1978 and 2022 and applies Latent Dirichlet Allocation(LDA)modeling to examine the evolution of policy themes and discourse.The results show that China’s environmental governance has undergone four stages-initial exploration,detailed development,transformative leap,and diverse prosperity-reflecting a progressive shift toward more integrated and coordinated governance.Policy priorities have evolved from a primary focus on pollution control and energy transition to an emphasis on institutional construction and organizational reform,thereby strengthening alignment with the SDGs.This transformation is characterized by recurring developmental themes and increasingly preventive,forward-looking,and system-oriented governance approaches.Moreover,the co-evolution of policy concepts and implementation has driven a transition from localized,end-of-pipe responses to comprehensive governance frameworks,alongside a shift from normative guidance towards effectiveness-oriented policy design.By employing a data-driven text analysis approach,this study offers a systematic framework for tracing long-term policy evolution and assessing its implications for sustainable development.
文摘本文为回顾性研究,经过兰州大学第二医院医学伦理委员会批准,免除受试者知情同意,批准文号:2021A-489。软组织肉瘤是一组异质性肿瘤,至少包含70个组织学实体[1]。腺泡状软组织肉瘤(alveolar soft part sarcoma,ASPS)约占所有软组织肉瘤的0.5%~1.0%[2-3]。
