Parvoviridae is a family of the smallest viruses known with a wide variety of hosts.The capsid structure of the Aedes albopictus C6/36 cell densovirus(C6/36 DNV)at 1.2-nm resolution was obtained by elec-tron cryomicro...Parvoviridae is a family of the smallest viruses known with a wide variety of hosts.The capsid structure of the Aedes albopictus C6/36 cell densovirus(C6/36 DNV)at 1.2-nm resolution was obtained by elec-tron cryomicroscopy(cryoEM)and three-dimensional(3D)image reconstruction.Structure compari-sons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity be-tween C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other in-sect parvoviruses.The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses.These findings indicate that C6/36 DNV is closely related to the human virus B19,and the former might evolve from the human species other than from other insect viruses.展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.10274106 to Jingqiang Zhang)Welch Foundation(AU-1492 to Z.H.Zhou)Natural Science Foundation of Guangdong Province,China(05300232 to Lingpeng Cheng)
文摘Parvoviridae is a family of the smallest viruses known with a wide variety of hosts.The capsid structure of the Aedes albopictus C6/36 cell densovirus(C6/36 DNV)at 1.2-nm resolution was obtained by elec-tron cryomicroscopy(cryoEM)and three-dimensional(3D)image reconstruction.Structure compari-sons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity be-tween C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other in-sect parvoviruses.The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses.These findings indicate that C6/36 DNV is closely related to the human virus B19,and the former might evolve from the human species other than from other insect viruses.
