Hafnia-based ferroelectrics have emerged as promising materials for next-generation nanoelectronics owing to their robust nanoscale properties and compatibility with metal-oxide-semiconductor technology.However,their ...Hafnia-based ferroelectrics have emerged as promising materials for next-generation nanoelectronics owing to their robust nanoscale properties and compatibility with metal-oxide-semiconductor technology.However,their metastable nature remains a key challenge for practical implementation.Utilizing scanning transmission electron microscopy,we investigated the atomic-scale mechanisms governing ferroelectric transitions and the metastability of polar phases in 10-nm-thick Hf_(0.5)Zr_(0.5)O_(2)thin films.Our results demonstrate that oxygen vacancies,coupled with rhombohedral distortions of the cation lattice,facilitate ferroelectric phase transitions and enable robust polar switching through adaptive processes,including cell-by-cell oxygen displacement and domain-wall-mediated nucleation and growth.These findings underscore the pivotal role of oxygen vacancies and lattice distortions in stabilizing polar phases and provide detailed insights into the atomic structures and transition dynamics of polymorphic Hf_(0.5)Zr_(0.5)O_(2-x),thereby advancing its potential for practical device applications.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos.12334001,52461160301,52322311,52427802,12222414)the National Key R&D Program of China (Grant Nos.2024YFA1208201,2021YFA1400500,2021YFA1400204)the Youth Innovation Promotion Association of the CAS (Grant Nos.Y2022003 and 2020009)。
文摘Hafnia-based ferroelectrics have emerged as promising materials for next-generation nanoelectronics owing to their robust nanoscale properties and compatibility with metal-oxide-semiconductor technology.However,their metastable nature remains a key challenge for practical implementation.Utilizing scanning transmission electron microscopy,we investigated the atomic-scale mechanisms governing ferroelectric transitions and the metastability of polar phases in 10-nm-thick Hf_(0.5)Zr_(0.5)O_(2)thin films.Our results demonstrate that oxygen vacancies,coupled with rhombohedral distortions of the cation lattice,facilitate ferroelectric phase transitions and enable robust polar switching through adaptive processes,including cell-by-cell oxygen displacement and domain-wall-mediated nucleation and growth.These findings underscore the pivotal role of oxygen vacancies and lattice distortions in stabilizing polar phases and provide detailed insights into the atomic structures and transition dynamics of polymorphic Hf_(0.5)Zr_(0.5)O_(2-x),thereby advancing its potential for practical device applications.
文摘目的:运用网络药理学方法分析薏苡仁汤治疗膝骨关节炎的作用机制。方法:利用TCMSP数据库中的药动学参数,以口服生物利用度(oral bioavailability,OB)≥30%和药物相似性(drug-likeness,DL)≥0.18筛选薏仁汤的潜在有效成分和作用靶点。通过DrugBank、GeneCard、OMIM、TTD和PharmGkb数据库筛选膝骨关节炎靶基因;通过R语言软件Venn分析法得到疾病与药物共同靶基因。通过Cytoscape 3.8.0软件构建成分-靶点网络图。利用STRING平台构建蛋白-蛋白互作网络(protein-protein interactions,PPI),将得到的文本文件导入Cytoscape中,通过CytoNCA插件获取关键子网络模块。将上述交集基因通过R语言软件进行基因本体(gene ontology,GO)功能富集分析、京都基因和基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。结果:共筛选出薏仁汤有效活性成分168个,包括谷甾醇、β-谷甾醇、香叶木素、汉黄芩素、槲皮素和豆甾醇等。有效作用靶点232个,药物疾病共同靶点129个,核心靶点包括JUN、MAPK3、STAT3、MAPK1、TP53、MAPK14、MYC、ESR1、MAPK8、AKT1、RELA、IL-6、TNF和EGFR。GO富集结果表明目标靶点参与的功能主要有细胞对化学应激的反应、对氧化应激的反应和对脂多糖的反应。KEGG主要富集在IL-17信号通路和TNF信号通路。结论:薏仁汤可能通过多成分、多靶点和多途径对膝骨关节炎发挥治疗作用。
