The parallelization of the diagnostics for climate research has been an important goal in the performance testing and improvement of the diagnostics for the Department of Energy’s (DOE’s) Accelerated Climate Modelin...The parallelization of the diagnostics for climate research has been an important goal in the performance testing and improvement of the diagnostics for the Department of Energy’s (DOE’s) Accelerated Climate Modeling for Energy (ACME) project [1]. The primary mission of the ACME project is to build and test the next-generation Earth system model for current and future generations of computing systems operated by the DOE office of science computing facilities, including the envisioned exascale systems foreseen in the early part of the next decade. As part of the underpinning workflow environment, a diagnostics, model metrics, and intercomparison Python framework, called UVC Metrics was created to aid in testing and production execution of the model. This framework builds on common methods and similar metrics to accommodate and diagnose individual component models, such as atmosphere, land, ocean, sea ice, and land ice. This paper reports on initial parallelization of UVC Metrics for the atmosphere model component using two popular frameworks: MPI and SPARK. A timing study is presented to assess the performance of each method in which significant improvement was achieved for both frameworks despite I/O contentions with NFS. The advantages and disadvantages of each framework are also presented.展开更多
A variety of skin substitutes are used in the treatment of full-thickness burns. Substitutes made from skin can harbor latent viruses, and artificial skin grafts can heal with extensive scarring, failing to regenerate...A variety of skin substitutes are used in the treatment of full-thickness burns. Substitutes made from skin can harbor latent viruses, and artificial skin grafts can heal with extensive scarring, failing to regenerate structures such as glands, nerves, and hair follicles. Biodegradable and biocompatible hydrogels, however, rarely mimic the strength of the epidermis. Therefore, novel and practical skin scaffold materials remain to be developed. Polysaccharides form hydrogels with predicted inherent biocompatibility. This paper describes the preparation and biocompatibility of unique hydrogel skin scaffolds from plant-extracted polysaccharide mixtures of specific sources, types, and molecular weight fractions. These hydrogels have a range of mechanical and degradation properties with the potential to fulfill the multiple, diverse functions of artificial skin, including protection, compatibility with different cell types, biodegradation, and release of needed signals for cell growth and wound healing.展开更多
文摘The parallelization of the diagnostics for climate research has been an important goal in the performance testing and improvement of the diagnostics for the Department of Energy’s (DOE’s) Accelerated Climate Modeling for Energy (ACME) project [1]. The primary mission of the ACME project is to build and test the next-generation Earth system model for current and future generations of computing systems operated by the DOE office of science computing facilities, including the envisioned exascale systems foreseen in the early part of the next decade. As part of the underpinning workflow environment, a diagnostics, model metrics, and intercomparison Python framework, called UVC Metrics was created to aid in testing and production execution of the model. This framework builds on common methods and similar metrics to accommodate and diagnose individual component models, such as atmosphere, land, ocean, sea ice, and land ice. This paper reports on initial parallelization of UVC Metrics for the atmosphere model component using two popular frameworks: MPI and SPARK. A timing study is presented to assess the performance of each method in which significant improvement was achieved for both frameworks despite I/O contentions with NFS. The advantages and disadvantages of each framework are also presented.
文摘A variety of skin substitutes are used in the treatment of full-thickness burns. Substitutes made from skin can harbor latent viruses, and artificial skin grafts can heal with extensive scarring, failing to regenerate structures such as glands, nerves, and hair follicles. Biodegradable and biocompatible hydrogels, however, rarely mimic the strength of the epidermis. Therefore, novel and practical skin scaffold materials remain to be developed. Polysaccharides form hydrogels with predicted inherent biocompatibility. This paper describes the preparation and biocompatibility of unique hydrogel skin scaffolds from plant-extracted polysaccharide mixtures of specific sources, types, and molecular weight fractions. These hydrogels have a range of mechanical and degradation properties with the potential to fulfill the multiple, diverse functions of artificial skin, including protection, compatibility with different cell types, biodegradation, and release of needed signals for cell growth and wound healing.
