Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively...Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].展开更多
基金funded by Oklahoma Center for the Advancement of Science and Technology,OCAST-HR19-045Department of Defense,DoD Peer Reviewed Cancer Research Program,CA-210339+2 种基金the National Institutes of Health P20GM103639supported by the National Cancer Institute Cancer Center Support Grant[P30CA225520]a grant from the Oklahoma Tobacco Settlement Endowment Trust[R23-03]both awarded to the OU Health Stephenson Cancer Center.
文摘Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].
