Background:Myasthenia gravis(MG)and neuromyelitis optica(NMO,also known as Devic disease)are rare autoimmune disorders,with upper-limit prevalence estimates in the general population of 15 per 100 000 and 5 per 100 00...Background:Myasthenia gravis(MG)and neuromyelitis optica(NMO,also known as Devic disease)are rare autoimmune disorders,with upper-limit prevalence estimates in the general population of 15 per 100 000 and 5 per 100 000,respectively.To our knowledge,an association between these diseases has not been previously reported.Objectives:To describe 4 patients with MG who developed NMO after thymectomy and to analyze possible causes of apparent increased prevalence of NMO among patients with MG.Design:Case series.Patients:Four patients with MG who underwent thymectomy.Interventions:None.Results:The prevalence of MG within the published cohort of patients with NMO is more than 150 times higher than that in the general population.Conclusion:Dysregulation of B-cell autoimmunity in myasthenia,possibly exacerbated by loss of control over autoreactive cells as a result of thymectomy,may predispose patients to the development of NMO.展开更多
The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizur...The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.展开更多
文摘Background:Myasthenia gravis(MG)and neuromyelitis optica(NMO,also known as Devic disease)are rare autoimmune disorders,with upper-limit prevalence estimates in the general population of 15 per 100 000 and 5 per 100 000,respectively.To our knowledge,an association between these diseases has not been previously reported.Objectives:To describe 4 patients with MG who developed NMO after thymectomy and to analyze possible causes of apparent increased prevalence of NMO among patients with MG.Design:Case series.Patients:Four patients with MG who underwent thymectomy.Interventions:None.Results:The prevalence of MG within the published cohort of patients with NMO is more than 150 times higher than that in the general population.Conclusion:Dysregulation of B-cell autoimmunity in myasthenia,possibly exacerbated by loss of control over autoreactive cells as a result of thymectomy,may predispose patients to the development of NMO.
文摘The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.
