Nanocomposite hydrogels based on carbon dots(CDs)and polymers have emerged as new materials with integrated properties of individual components,leading to their important applications in the field of soft nanomaterial...Nanocomposite hydrogels based on carbon dots(CDs)and polymers have emerged as new materials with integrated properties of individual components,leading to their important applications in the field of soft nanomaterials.This perspective highlights recent advances in the development of nanocomposite hydrogels from CDs and polymers.We review the preparation methods of nanocomposite hydrogels based on CDs and polymers,and emerging applications of these nanocomposite hydrogels such as environmental remediation,energy storage,sensing,drug delivery and bioimaging.We conclude with the discussion of new research directions in the development of new type of nanocomposite hydrogels based on CDs and polymers.展开更多
Dendrobium officinale Kimura et Migo has been used extensively in functional foods and garnered significant attention because of its therapeutic properties and nutritional value.Anthocyanins are prone to degradation i...Dendrobium officinale Kimura et Migo has been used extensively in functional foods and garnered significant attention because of its therapeutic properties and nutritional value.Anthocyanins are prone to degradation in environmental and biological conditions,leading to color fading and loss of bioactivity.Forming complexes with endogenous polysaccharides can enhance their stability and protect the color of anthocyanin products.In this study,anthocyanins extracted from D.officinale(DOA)were complexed with D.officinale polysaccharide extract(DOP)to investigate the effects of complexation on the physicochemical properties of the anthocyanins.DOA-DOP complexes were characterized by scanning/transmission electron microscopies,differential scanning calorimetry,dynamic light scattering,and multiple spectroscopies.Stability assessments and simulated in vitro gastrointestinal digestion were performed.Bioactivity was evaluated using a human colon epithelial(Caco-2)cell monolayer model.Spectral analyses revealed hydrogen bonding as the primary interaction in the DOA-DOP complexes.Complexation significantly enhanced DOA retention under light exposure,heat treatment,pH variation,and exposure to metal ions.DOP improved the in vitro antioxidant capacity of DOA.Furthermore,the DOA-DOP complexes exhibited prolonged resistance to upper gastrointestinal digestion and restored lipopolysaccharide-induced epithelial hyperpermeability in the Caco-2 cell model.Collectively,DOA-DOP complexation enhanced D.officinale anthocyanin stability,bioactivity,and colonic bioavailability.展开更多
基金financially supported by the National Natural Science Foundation of China(NSFC,Nos.21774041,51433003)the National Key Research and Development Program of China(No.2016YFB0401701)+1 种基金the Fundamental Research Funds for the Central Universities,Program for JLU Science and Technology Innovative Research Team(JLUSTIRT,No.2017TD-06)the opening funds of State Key Laboratory of Applied Optics,Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences。
文摘Nanocomposite hydrogels based on carbon dots(CDs)and polymers have emerged as new materials with integrated properties of individual components,leading to their important applications in the field of soft nanomaterials.This perspective highlights recent advances in the development of nanocomposite hydrogels from CDs and polymers.We review the preparation methods of nanocomposite hydrogels based on CDs and polymers,and emerging applications of these nanocomposite hydrogels such as environmental remediation,energy storage,sensing,drug delivery and bioimaging.We conclude with the discussion of new research directions in the development of new type of nanocomposite hydrogels based on CDs and polymers.
基金supported by the National Key Research and Development Program(NKRDP)of China(No.2021YFD1600903-02).
文摘Dendrobium officinale Kimura et Migo has been used extensively in functional foods and garnered significant attention because of its therapeutic properties and nutritional value.Anthocyanins are prone to degradation in environmental and biological conditions,leading to color fading and loss of bioactivity.Forming complexes with endogenous polysaccharides can enhance their stability and protect the color of anthocyanin products.In this study,anthocyanins extracted from D.officinale(DOA)were complexed with D.officinale polysaccharide extract(DOP)to investigate the effects of complexation on the physicochemical properties of the anthocyanins.DOA-DOP complexes were characterized by scanning/transmission electron microscopies,differential scanning calorimetry,dynamic light scattering,and multiple spectroscopies.Stability assessments and simulated in vitro gastrointestinal digestion were performed.Bioactivity was evaluated using a human colon epithelial(Caco-2)cell monolayer model.Spectral analyses revealed hydrogen bonding as the primary interaction in the DOA-DOP complexes.Complexation significantly enhanced DOA retention under light exposure,heat treatment,pH variation,and exposure to metal ions.DOP improved the in vitro antioxidant capacity of DOA.Furthermore,the DOA-DOP complexes exhibited prolonged resistance to upper gastrointestinal digestion and restored lipopolysaccharide-induced epithelial hyperpermeability in the Caco-2 cell model.Collectively,DOA-DOP complexation enhanced D.officinale anthocyanin stability,bioactivity,and colonic bioavailability.
