To the Editor:Common symptoms of osteoporosis include low bone mass and deteriorating bone microarchitecture,leading to bone fragility and fractures.Indeed,bone is a complex tissue composed of collagen fibers,vasculat...To the Editor:Common symptoms of osteoporosis include low bone mass and deteriorating bone microarchitecture,leading to bone fragility and fractures.Indeed,bone is a complex tissue composed of collagen fibers,vasculature,and numerous specialized cells.Both cellular metabolism and cellular behavior in bone are regulated by the extracellular matrix(ECM).As the main ECM in the skeletal system,collagen hydrolysates have great potential in alleviating osteoporosis by promoting osteogenesis and angiogenesis.However,the composition and structure of collagen hydrolysate are complex.The peptides in collagen hydrolysates have different sequences and spatial structures,resulting in diverse biological activities.[1]Furthermore,recent studies have focused primarily on alterations in bone metabolism and the validation of specific gene pathways.Gene regulatory mechanism analysis is still scarce.[2]This work investigated the key peptide sequences in the prepared collagen hydrolysate(CH)responsible for osteogenic and angiogenic activities and their molecular mechanisms.Additionally,the protective or restorative effects of CH in osteoporotic mice and the regulation of the CH on osteoporosis-related genes were systematically studied.展开更多
Collagen-based materials,renowned for their biocompatibility and minimal immunogenicity,serve as exemplary substrates in a myriad of biomedical applications.Collagen-based micro/nanogels,in particular,are valued for t...Collagen-based materials,renowned for their biocompatibility and minimal immunogenicity,serve as exemplary substrates in a myriad of biomedical applications.Collagen-based micro/nanogels,in particular,are valued for their increased surface area,tunable degradation rates,and ability to facilitate targeted drug delivery,making them instrumental in advanced therapeutics and tissue engineering endeavors.Although extensive reviews on micro/nanogels exist,they tend to cover a wide range of biomaterials and lack a specific focus on collagen-based materials.The current review offers an in-depth look into the manufacturing technologies,drug release mechanisms,and biomedical applications of collagen-based micro/nanogels to address this gap.First,we provide an overview of the synthetic strategies that allow the precise control of the size,shape,and mechanical strength of these collagen-based micro/nanogels by controlling the degree of cross-linking of the materials.These properties are crucial for their performance in biomedical applications.We then highlight the environmental responsiveness of these collagen-based micro/nanogels,particularly their sensitivity to enzymes and pH,which enables controlled drug release under various pathological conditions.The discussion then expands to include their applications in cancer therapy,antimicrobial treatments,bone tissue repair,and imaging diagnosis,emphasizing their versatility and potential in these critical areas.The challenges and future perspectives of collagen-based micro/nanogels in the field are discussed at the end of the review,with an emphasis on the translation to clinical practice.This comprehensive review serves as a valuable resource for researchers,clinicians,and scientists alike,providing insights into the current state and future directions of collagen-based micro/nanogel research and development.展开更多
To the Editor:Postmenopausal osteoporosis is a typical bone metabolic disruption disease caused by estrogen deficiency,characterized by deteriorated bone structure,reduced bone mineral density(BMD),and thinned sclerot...To the Editor:Postmenopausal osteoporosis is a typical bone metabolic disruption disease caused by estrogen deficiency,characterized by deteriorated bone structure,reduced bone mineral density(BMD),and thinned sclerotin,which has troubled millions of menopausal women worldwide.[1]Additionally,estrogen deficiency is accompanied by oxidative stress and inflammation,thus causing the occurrence and deterioration of osteoporosis.[2]Conventional treatment options have limited efficacy and cannot meet the requirements of long-term treatment.[3]Therefore,in order to alleviate the problem of osteoporosis in human health,innovative strategies should explore the possibilities and alternatives to current ones.In this study.展开更多
Liquid metal(LM)coating on metal anodes is an effective technique used to suppress dendrite formation and electrode corrosion.However,directly coating LM on zinc metal anodes leads to significant mechanical strength d...Liquid metal(LM)coating on metal anodes is an effective technique used to suppress dendrite formation and electrode corrosion.However,directly coating LM on zinc metal anodes leads to significant mechanical strength degradation due to the stress mismatch during LM alloying,which adversely impacts the battery cycle performance.Herein,we present a strategy to encapsulate LM with graphene oxide(GO)to form LM nanocapsules,effectively preventing embrittlement from direct metal anode contact.We found that slightly oxidized LM strongly adsorbed onto GO,with the charge transfer rate of the LM nanocapsules being comparable to pure LM.Consequently,the symmetric battery with a nanocapsule-modified anode achieved over 2800 h of cycling(1 mA cm^(-2)).Further,the full aqueous battery assembled with an LM nanocapsule-modified zinc anode retained 98.89% capacity after 550 cycles at 0.3 A g^(-1) under an ultrahigh cathode loading of 25 mg cm^(-2),significantly outperforming the control group without LM nanocapsules.Overall,this effort emphasizes the intrinsic relationship between LM compatibility with metal anodes and battery performance,paving the way for developing zinc-ion batteries with high capacity and long-cycle stability.展开更多
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.JD2119)the National Natural Science Foundation of China(No.82102038).
文摘To the Editor:Common symptoms of osteoporosis include low bone mass and deteriorating bone microarchitecture,leading to bone fragility and fractures.Indeed,bone is a complex tissue composed of collagen fibers,vasculature,and numerous specialized cells.Both cellular metabolism and cellular behavior in bone are regulated by the extracellular matrix(ECM).As the main ECM in the skeletal system,collagen hydrolysates have great potential in alleviating osteoporosis by promoting osteogenesis and angiogenesis.However,the composition and structure of collagen hydrolysate are complex.The peptides in collagen hydrolysates have different sequences and spatial structures,resulting in diverse biological activities.[1]Furthermore,recent studies have focused primarily on alterations in bone metabolism and the validation of specific gene pathways.Gene regulatory mechanism analysis is still scarce.[2]This work investigated the key peptide sequences in the prepared collagen hydrolysate(CH)responsible for osteogenic and angiogenic activities and their molecular mechanisms.Additionally,the protective or restorative effects of CH in osteoporotic mice and the regulation of the CH on osteoporosis-related genes were systematically studied.
基金This study was supported by grants from the National Natural Science Foundation of China(No.52242208)the National Natural Science Foundation of China(No.82371964)+1 种基金the Sigrid Jusélius Foundation,the Research Council of Finland(Academy Research Fellowship Grant No.354421)the European Union(ERC,BioLure,No.101115752).
文摘Collagen-based materials,renowned for their biocompatibility and minimal immunogenicity,serve as exemplary substrates in a myriad of biomedical applications.Collagen-based micro/nanogels,in particular,are valued for their increased surface area,tunable degradation rates,and ability to facilitate targeted drug delivery,making them instrumental in advanced therapeutics and tissue engineering endeavors.Although extensive reviews on micro/nanogels exist,they tend to cover a wide range of biomaterials and lack a specific focus on collagen-based materials.The current review offers an in-depth look into the manufacturing technologies,drug release mechanisms,and biomedical applications of collagen-based micro/nanogels to address this gap.First,we provide an overview of the synthetic strategies that allow the precise control of the size,shape,and mechanical strength of these collagen-based micro/nanogels by controlling the degree of cross-linking of the materials.These properties are crucial for their performance in biomedical applications.We then highlight the environmental responsiveness of these collagen-based micro/nanogels,particularly their sensitivity to enzymes and pH,which enables controlled drug release under various pathological conditions.The discussion then expands to include their applications in cancer therapy,antimicrobial treatments,bone tissue repair,and imaging diagnosis,emphasizing their versatility and potential in these critical areas.The challenges and future perspectives of collagen-based micro/nanogels in the field are discussed at the end of the review,with an emphasis on the translation to clinical practice.This comprehensive review serves as a valuable resource for researchers,clinicians,and scientists alike,providing insights into the current state and future directions of collagen-based micro/nanogel research and development.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.JD2231)the National Natural Science Foundation of China(No.82102038).
文摘To the Editor:Postmenopausal osteoporosis is a typical bone metabolic disruption disease caused by estrogen deficiency,characterized by deteriorated bone structure,reduced bone mineral density(BMD),and thinned sclerotin,which has troubled millions of menopausal women worldwide.[1]Additionally,estrogen deficiency is accompanied by oxidative stress and inflammation,thus causing the occurrence and deterioration of osteoporosis.[2]Conventional treatment options have limited efficacy and cannot meet the requirements of long-term treatment.[3]Therefore,in order to alleviate the problem of osteoporosis in human health,innovative strategies should explore the possibilities and alternatives to current ones.In this study.
基金supported by the National Natural Science Foundation of China(grant nos.52273081,52433002,and 22278329)the Postdoctoral Research Project of Shaanxi Province,China,and the Open Funds from the Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education),Nankai University,China.
文摘Liquid metal(LM)coating on metal anodes is an effective technique used to suppress dendrite formation and electrode corrosion.However,directly coating LM on zinc metal anodes leads to significant mechanical strength degradation due to the stress mismatch during LM alloying,which adversely impacts the battery cycle performance.Herein,we present a strategy to encapsulate LM with graphene oxide(GO)to form LM nanocapsules,effectively preventing embrittlement from direct metal anode contact.We found that slightly oxidized LM strongly adsorbed onto GO,with the charge transfer rate of the LM nanocapsules being comparable to pure LM.Consequently,the symmetric battery with a nanocapsule-modified anode achieved over 2800 h of cycling(1 mA cm^(-2)).Further,the full aqueous battery assembled with an LM nanocapsule-modified zinc anode retained 98.89% capacity after 550 cycles at 0.3 A g^(-1) under an ultrahigh cathode loading of 25 mg cm^(-2),significantly outperforming the control group without LM nanocapsules.Overall,this effort emphasizes the intrinsic relationship between LM compatibility with metal anodes and battery performance,paving the way for developing zinc-ion batteries with high capacity and long-cycle stability.
