The supramolecular assembly of platinum(Ⅱ)terpyridine complexes,driven by noncovalent Pt(Ⅱ)⋯Pt(Ⅱ)metallophilic interactions andπ-πstacking,has been demonstrated to exhibit significant potential for advanced appli...The supramolecular assembly of platinum(Ⅱ)terpyridine complexes,driven by noncovalent Pt(Ⅱ)⋯Pt(Ⅱ)metallophilic interactions andπ-πstacking,has been demonstrated to exhibit significant potential for advanced applications.In this study,we present PtATPA,an organoplatinum(Ⅱ)complex with an electrondonor-acceptor structure that self-assembles into nanostructures through Pt⋯Pt andπ-πinteractions,exhibiting enhanced photophysical properties for improved photocatalytic therapy(PCT).The assembly induces a significantly improved singlet-triplet intersystem crossing,thereby amplifying the PCT effect.Upon white light irradiation,the PtATPA complex not only generates a substantial amount of reactive oxygen species(ROS)but also photocatalyzes the oxidation of nicotinamide adenine dinucleotide phosphate(NADPH)-an essential coenzyme.In A549 cells,PtATPA-induced oxidative stress downregulates GLUT1 to disrupt glucose metabolism,leading to NADPH depletion,disulfide stress,F-actin cytoskeleton collapse,and ultimately disulfidptosis.This study provides a promising strategy for leveraging selfassembled metal complexes to improve PCT and induce tumor-specific disulfidptosis,offering new insights into future cancer therapy.展开更多
基金the National Natural Science Foundation of China(NSFC,22477080(P.Z.))the financial support of the Guangdong Basic and Applied Basic Research Foundation(2023B1515020060(P.Z.),2025A1515011507(D.L.))+1 种基金the Science and Technology Foundation of Shenzhen(RCYX20221008092906021(P.Z.))the Shenzhen Medical Research Fund(D2403005(P.Z.)).
文摘The supramolecular assembly of platinum(Ⅱ)terpyridine complexes,driven by noncovalent Pt(Ⅱ)⋯Pt(Ⅱ)metallophilic interactions andπ-πstacking,has been demonstrated to exhibit significant potential for advanced applications.In this study,we present PtATPA,an organoplatinum(Ⅱ)complex with an electrondonor-acceptor structure that self-assembles into nanostructures through Pt⋯Pt andπ-πinteractions,exhibiting enhanced photophysical properties for improved photocatalytic therapy(PCT).The assembly induces a significantly improved singlet-triplet intersystem crossing,thereby amplifying the PCT effect.Upon white light irradiation,the PtATPA complex not only generates a substantial amount of reactive oxygen species(ROS)but also photocatalyzes the oxidation of nicotinamide adenine dinucleotide phosphate(NADPH)-an essential coenzyme.In A549 cells,PtATPA-induced oxidative stress downregulates GLUT1 to disrupt glucose metabolism,leading to NADPH depletion,disulfide stress,F-actin cytoskeleton collapse,and ultimately disulfidptosis.This study provides a promising strategy for leveraging selfassembled metal complexes to improve PCT and induce tumor-specific disulfidptosis,offering new insights into future cancer therapy.
