Objective:To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney...Objective:To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Methods:Using convenience sampling,100 elderly patients with diabetes mellitus complicated by chronic kidney disease who received treatment in the endocrinology department of a tertiary A-level hospital from May 2024 to May 2025 were selected as the study subjects.They were randomly divided into an experimental group(50 cases)and a control group(50 cases)using a random number table method.The control group received routine health education and telephone follow-up,while the experimental group,in addition to the control group’s interventions,underwent combined exercise intervention based on the hospital-community-family model.Remote medical guidance was utilized to monitor and study the application effect of exercise intervention on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores in five dimensions of intrinsic capacity(exercise,cognition,psychology,vitality,and sensation)were measured before the intervention,at 4 weeks of intervention,and at 12 weeks of intervention for both groups.Results:Before the exercise intervention,there were no statistically significant differences(p>0.05)between the two groups in terms of fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores across five dimensions of intrinsic capacity:mobility,cognition,psychology,vitality,and sensation.After 12 weeks of intervention,the experimental group demonstrated significantly higher scores than the control group in glomerular filtration rate,6-minute walk distance,and the dimensions of mobility,cognition,and vitality within intrinsic capacity,with all differences being statistically significant(p<0.05).Conversely,the experimental group showed significantly lower scores than the control group in fasting blood glucose,2-hour postprandial blood glucose,and the psychological dimension of intrinsic capacity,with these differences also being statistically significant(p<0.05).Conclusion:Continuous nursing care utilizing telemedicine based on a hospital-community-family model combined with exercise intervention can effectively enhance exercise tolerance and intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease,thereby improving their quality of life.The effectiveness of the intervention is positively correlated with the duration of the intervention.展开更多
Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the ...Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the convenience sampling method,80 patients in the stable stage of CKD who were treated in the nephrology department of a tertiary hospital from May 2022 to June 2023 were selected as the research subjects.They were divided into the experimental group(40 cases)and the control group(40 cases)by random number table method.The control group received conventional exercise intervention plus telephone follow-up,while the experimental group received combined hospital-community-family modelbased exercise intervention in addition to the control group,using remote medical guidance and monitoring of the application effect of exercise rehabilitation on middle-aged and elderly patients with chronic kidney disease.The glomerular filtration rate,6-minute walking distance,fatigue and social support scores of the two groups of patients were measured before the intervention,4 weeks after the intervention,and 12 weeks after the intervention.Results:Before the intervention,there were no statistically significant differences in glomerular filtration rate,6-minute walking distance,fatigue and social support scores between the two groups(p>0.05).After 12 weeks of intervention,the glomerular filtration rate,6-minute walking distance and social support scores of the experimental group were higher than those of the control group;the differences were statistically significant(p<0.05).The behavioral,emotional,sensory and cognitive scores of the Piper-Fatigue Revised Scale of the experimental group were lower than those of the control group,and the differences were statistically significant(p<0.05).Conclusion:Based on the hospital-community-family model combined rehabilitation exercise,using remote medical guidance for the continuous care of middle-aged and elderly patients in the stable stage of chronic kidney disease can effectively improve the exercise endurance and social support level of patients,improve the fatigue condition,and the implementation effect is positively correlated with the intervention time.展开更多
Light-field microscopy(LFM)enables rapid volumetric imaging through single-frame acquisition and fast 3D reconstruction algorithms.The high speed and low phototoxicity of LFM make it highly suitable for real-time 3D f...Light-field microscopy(LFM)enables rapid volumetric imaging through single-frame acquisition and fast 3D reconstruction algorithms.The high speed and low phototoxicity of LFM make it highly suitable for real-time 3D fluorescence imaging,such as studies of neural activity monitoring and blood flow analysis.However,in in vivo fluorescence imaging scenarios,the light intensity needs to be reduced as much as possible to achieve longer-term observations.The resulting low signal-to-noise ratio(SNR)caused by reduced light intensity significantly degrades the quality of 3D reconstruction in LFM.Existing deep-learning-based methods struggle to incorporate the structured intensity distribution and noise characteristics inherent to LFM data,often leading to artifacts and uneven energy distributions.To address these challenges,we propose the denoise-weighted view-channel-depth(DNW-VCD)network,integrating a two-step noise model and energy weight matrix into an LFM reconstruction framework.Additionally,we developed an attenuator-induced imaging system for dual-SNR image acquisition to validate DNW-VCD’s performance.Experimental results show that our method achieves artifact-reduced,realtime 3D imaging with isotropic resolution and lower phototoxicity,as verified through imaging of fluorescent beads,algae,and zebrafish heart.展开更多
基金2024 Medical Science Research Project Plan of Hebei Province:Research on the Rehabilitation Effect of Combined Exercise Intervention Based on a Hospital-Community-Family Model for Elderly Patients with Chronic Diseases(Project No.:20240083)Youth Science and Technology Project of the Hebei Provincial Health Department:Research on the Standardization Level of Self-Management in Patients with Diabetic Foot and Related Factors Affecting Wound Healing(Project No.:20190002)。
文摘Objective:To explore the application effect of combined exercise intervention based on the hospital-community-family model on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Methods:Using convenience sampling,100 elderly patients with diabetes mellitus complicated by chronic kidney disease who received treatment in the endocrinology department of a tertiary A-level hospital from May 2024 to May 2025 were selected as the study subjects.They were randomly divided into an experimental group(50 cases)and a control group(50 cases)using a random number table method.The control group received routine health education and telephone follow-up,while the experimental group,in addition to the control group’s interventions,underwent combined exercise intervention based on the hospital-community-family model.Remote medical guidance was utilized to monitor and study the application effect of exercise intervention on intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease.Fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores in five dimensions of intrinsic capacity(exercise,cognition,psychology,vitality,and sensation)were measured before the intervention,at 4 weeks of intervention,and at 12 weeks of intervention for both groups.Results:Before the exercise intervention,there were no statistically significant differences(p>0.05)between the two groups in terms of fasting blood glucose,2-hour postprandial blood glucose,glomerular filtration rate,6-minute walk distance,and scores across five dimensions of intrinsic capacity:mobility,cognition,psychology,vitality,and sensation.After 12 weeks of intervention,the experimental group demonstrated significantly higher scores than the control group in glomerular filtration rate,6-minute walk distance,and the dimensions of mobility,cognition,and vitality within intrinsic capacity,with all differences being statistically significant(p<0.05).Conversely,the experimental group showed significantly lower scores than the control group in fasting blood glucose,2-hour postprandial blood glucose,and the psychological dimension of intrinsic capacity,with these differences also being statistically significant(p<0.05).Conclusion:Continuous nursing care utilizing telemedicine based on a hospital-community-family model combined with exercise intervention can effectively enhance exercise tolerance and intrinsic capacity in elderly patients with diabetes mellitus complicated by chronic kidney disease,thereby improving their quality of life.The effectiveness of the intervention is positively correlated with the duration of the intervention.
基金2024 Annual Medical Science Research Project of Hebei Province,Research on the Rehabilitation Effect of Joint Exercise Intervention Based on Hospital-Community-Family Model for Elderly Patients with Chronic Diseases(Project No.:20240083)。
文摘Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the convenience sampling method,80 patients in the stable stage of CKD who were treated in the nephrology department of a tertiary hospital from May 2022 to June 2023 were selected as the research subjects.They were divided into the experimental group(40 cases)and the control group(40 cases)by random number table method.The control group received conventional exercise intervention plus telephone follow-up,while the experimental group received combined hospital-community-family modelbased exercise intervention in addition to the control group,using remote medical guidance and monitoring of the application effect of exercise rehabilitation on middle-aged and elderly patients with chronic kidney disease.The glomerular filtration rate,6-minute walking distance,fatigue and social support scores of the two groups of patients were measured before the intervention,4 weeks after the intervention,and 12 weeks after the intervention.Results:Before the intervention,there were no statistically significant differences in glomerular filtration rate,6-minute walking distance,fatigue and social support scores between the two groups(p>0.05).After 12 weeks of intervention,the glomerular filtration rate,6-minute walking distance and social support scores of the experimental group were higher than those of the control group;the differences were statistically significant(p<0.05).The behavioral,emotional,sensory and cognitive scores of the Piper-Fatigue Revised Scale of the experimental group were lower than those of the control group,and the differences were statistically significant(p<0.05).Conclusion:Based on the hospital-community-family model combined rehabilitation exercise,using remote medical guidance for the continuous care of middle-aged and elderly patients in the stable stage of chronic kidney disease can effectively improve the exercise endurance and social support level of patients,improve the fatigue condition,and the implementation effect is positively correlated with the intervention time.
基金National Natural Science Foundation of China(T2221003,62025108,62071219,62371006)China Postdoctoral Science Foundation(GZC20230057)。
文摘Light-field microscopy(LFM)enables rapid volumetric imaging through single-frame acquisition and fast 3D reconstruction algorithms.The high speed and low phototoxicity of LFM make it highly suitable for real-time 3D fluorescence imaging,such as studies of neural activity monitoring and blood flow analysis.However,in in vivo fluorescence imaging scenarios,the light intensity needs to be reduced as much as possible to achieve longer-term observations.The resulting low signal-to-noise ratio(SNR)caused by reduced light intensity significantly degrades the quality of 3D reconstruction in LFM.Existing deep-learning-based methods struggle to incorporate the structured intensity distribution and noise characteristics inherent to LFM data,often leading to artifacts and uneven energy distributions.To address these challenges,we propose the denoise-weighted view-channel-depth(DNW-VCD)network,integrating a two-step noise model and energy weight matrix into an LFM reconstruction framework.Additionally,we developed an attenuator-induced imaging system for dual-SNR image acquisition to validate DNW-VCD’s performance.Experimental results show that our method achieves artifact-reduced,realtime 3D imaging with isotropic resolution and lower phototoxicity,as verified through imaging of fluorescent beads,algae,and zebrafish heart.
