Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict...Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict their practical application.Herein,the CsPbBr_(3)/CsPb_(2)Br_(5)heteronanocrystals(HNCs)were successfully encapsulated into ZIF-8 through a thermal injection method via controlling the molar ratio of Cs^(+)/Pb2^(+).The surface of ZIF-8 was then modified with hydrophobic copolymer of poly(methyl methacrylate)(PMMA)to improve the water stability.Benefiting from the intimate interfacial interaction and staggered energy band structure,the type-II heterojunction of CsPb Br_(3)/CsPb_(2)Br_(5)guarantees efficient separation and migration of photogenerated electron/hole pairs.Meanwhile,the formation of Z-scheme heterojunction between ZIF-8 and CsPbBr_(3)/CsPb_(2)Br_(5)HNCs contributes to the adsorption and enrichment of pollutants,further accelerates the photocatalytic antibiotic degradation efficiency towards tetracycline hydrochloride(TCH)in aqueous solution.Nearly 87%of TCH(40 mg/L,50 mL)was degraded by 40 mg catalyst within 100 min.This work offers a feasible approach in assembling high-performance MHP NCsbased efficient photocatalyst with expanding application in aqueous solution.展开更多
Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous ...Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.展开更多
Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells （UCMSCs） and Schwann cells （SCs） can repair spinal nerve injury, but few studies have investigated their use in pe...Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells （UCMSCs） and Schwann cells （SCs） can repair spinal nerve injury, but few studies have investigated their use in peripheral nerve regeneration. In the present study, we cotransplanted UCMSCs and SCs to repair 5-mm left sciatic nerve defects in rats, and compared the effects of UCMSCs ＋ SCs transplantation with UCMSCs or SCs transplantation alone. After UCMSCs ＋ SCs transplantation, nerve conduction velocity of the left sciatic nerve and gait were both improved. Retrograde tracing analysis demonstrated that the mean count of fluorogold-labeled neurons, as well as the mean axon count and axon density, were significantly greater in the left sciatic nerve after UCMSCs ＋ SCs transplantation, compared with UCMSCs or SCs transplantation alone. Improvements in conduction velocity and increased sheath thickness in the left sciatic nerve were similar after UCMSCs transplantation and UCMSCs ＋ SCs transplantation. These findings suggest that UCMSCs transplantation can promote the repair of sciatic nerve defects to some extent, but that combined UCMSCs ＋ SCs transplantation has a significantly greater regenerative effect.展开更多
Enhancing Schwann cell proliferation may be beneficial for peripheral nerve repair and nerve regeneration. A traditional herbal formula composed of Fuling （poria cocos）, Baizhu （Atractylodes macrocephala）, and Dan...Enhancing Schwann cell proliferation may be beneficial for peripheral nerve repair and nerve regeneration. A traditional herbal formula composed of Fuling （poria cocos）, Baizhu （Atractylodes macrocephala）, and Danggui （Angelica sinensis） （FBD） improves neuronal survival and growth, and FBD may promote the secretion of brain-derived neurotrophic factor. However, the mechanism underlying Schwann cell proliferation remains unclear. We tested whether FBD enhanced the proliferation of human Schwann cells. FBD （20 ug/mL） increased Schwann cell viability and survival and increased the number of cells at G2/M and S phases. FBD also increased nerve growth factor and brain-derived neurotrophic factor expression in Schwann cells, with maximum efficacy at 20 ug/mL.展开更多
Transition metal sulfides(TMSs)are widely recognized for their potential as anode materials in the develop-ment of flexible lithium-ion capacitors(FLICs)owing to their high theoretical capacity.However,their practical...Transition metal sulfides(TMSs)are widely recognized for their potential as anode materials in the develop-ment of flexible lithium-ion capacitors(FLICs)owing to their high theoretical capacity.However,their practical application has been significantly limited by rapid capacity decay and sluggish kinetics associated with TMS volume variation.In response to these challenges,we have prepared ZnS/CuS nanoparticles embedded in continuous and multichannel carbon fibers(CFs).This was achieved through a process involving blow-spin-ning and subsequent sulfidation.Notably,the electrochemical performance of these materials was largely improved,owing to the synergistic effect of bimetallic sulfides.The ZnS/CuS-CF anode material demon-strated a high specific capacity of over 900 mAh g^(−1)at a current density of 0.2 A g^(−1).Furthermore,it exhibited superior rate capacity(300 mAh g^(−1)at 20 A g^(−1))and excellent cyclic stability,maintaining its performance over 1000 cycles at 10 A g^(−1).We also prepared lithium-ion capacitors(LICs)using the same method.These LICs exhibited a maximum energy density of 136 Wh kg^(−1),a high power density of 43.5 kW kg^(−1),and an impres-sive cyclic stability over 4000 cycles.In addition,the FLICs,when configured in the form of a pouch cell,demonstrated significant potential for the development of smart,flexible electronic devices.展开更多
Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs)...Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs),which have widely interested scholars in the shipping industry due to their safety,high efficiency,and energy-saving qualities.Considering the current development of USVs,the types of USVs and applications domestically and internationally are being investigated.USVs emerged with technological developments and their characteristics show some differences from traditional vessels,which brings some problems and advantages for their application.Certain maritime regulations are not applicable to USVs and must be changed.The key technologies in the current development of USVs are being investigated.While the level of intelligence is improving,the protection of cargo cannot be neglected.An innovative approach to the internal structure of USVs is proposed,where the inner hull can automatically recover its original state in case of outer hull tilting.Finally,we summarize the development status of USVs,which are an inevitable direction of development in the marine field.展开更多
Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rar...Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy.展开更多
As the main target cells of immune regulation,macrophages play an important role in the bone regeneration process.Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors.They h...As the main target cells of immune regulation,macrophages play an important role in the bone regeneration process.Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors.They have proinflammatory and anti-inflammatory effects,respectively,and play key roles in different stages of bone regeneration.The ratio of M1 to M2 macrophages can be regulated by immunomodulatory biomaterials to promote bone repair and regeneration.In this paper,we review the recent literature on the chemical,physical and biological properties of biomaterials and the regulation of macrophage polarization under the influence of other factors.We also cover new methods for preparing immunomodulatory biomaterials for bone regeneration.This paper will provide new design ideas for the development of biomaterials with immunological properties and will support the clinical translation of bone-related medical biomaterials.展开更多
Image Super-Resolution(SR)research has achieved great success with powerful neural networks.The deeper networks with more parameters improve the restoration quality but add the computation complexity,which means more ...Image Super-Resolution(SR)research has achieved great success with powerful neural networks.The deeper networks with more parameters improve the restoration quality but add the computation complexity,which means more inference time would be cost,hindering image SR from practical usage.Noting the spatial distribution of the objects or things in images,a twostage local objects SR system is proposed,which consists of two modules,the object detection module and the SR module.Firstly,You Only Look Once(YOLO),which is efficient in generic object detection tasks,is selected to detect the input images for obtaining objects of interest,then put them into the SR module and output corresponding High-Resolution(HR)subimages.The computational power consumption of image SR is optimized by reducing the resolution of input images.In addition,we establish a dataset,TrafficSign500,for our experiment.Finally,the performance of the proposed system is evaluated under several State-Of-The-Art(SOTA)YOLOv5 and SISR models.Results show that our system can achieve a tremendous computation improvement in image SR.展开更多
The rigid structure of the traditional relational database leads to data redundancy,which seriously affects the efficiency of the data query and cannot effectively manage massive data.To solve this problem,we use dist...The rigid structure of the traditional relational database leads to data redundancy,which seriously affects the efficiency of the data query and cannot effectively manage massive data.To solve this problem,we use distributed storage and parallel computing technology to query RDF data.In order to achieve efficient storage and retrieval of large-scale RDF data,we combine the respective advantage of the storage model of the relational database and the distributed query.To overcome the disadvantages of storing and querying RDF data,we design and implement a breadth-first path search algorithm based on the keyword query on a distributed platform.We conduct the LUBM query statements respectively with the selected data sets.In experiments,we compare query response time in different conditions to evaluate the feasibility and correctness of our approaches.The results show that the proposed scheme can reduce the storage cost and improve query efficiency.展开更多
Pathway selection in a complex chemical reaction network(CRN)enables organisms to adapt,evolve,and even learn in response to changing environments.Inspired by this,herein we report an artificial system,where light sig...Pathway selection in a complex chemical reaction network(CRN)enables organisms to adapt,evolve,and even learn in response to changing environments.Inspired by this,herein we report an artificial system,where light signal was used to manipulate the reaction pathways in a disulfide-based nonequilibrium CRN.By changing the photon energy and irradiation window,the anion or new radical-mediated pathways were selectively triggered,resulting in a user-defined evolution pathway.Additional photodissipative cycles were achieved by UV(365 nm)irradiation,increasing the total number of reactions from 3 to 7.The emerging pathway selection of the CRN is accurately predictable and controllable even in complex organo-hydrogel materials.We demonstrate up to five-state autonomous sol-gel transitions and the formation of fuel-driven dissipative organo-hydrogel through both chemical and light input.This work represents a new approach to allowing CRNs to communicate with the environment that can be used in the development of materials with lifelike behaviors.展开更多
As a distributed computing platform, Hadoop provides an effective way to handle big data. In Hadoop, the completion time of job will be delayed by a straggler. Although the definitive cause of the straggler is hard to...As a distributed computing platform, Hadoop provides an effective way to handle big data. In Hadoop, the completion time of job will be delayed by a straggler. Although the definitive cause of the straggler is hard to detect, speculative execution is usually used for dealing with this problem, by simply backing up those stragglers on alternative nodes. In this paper, we design a new Speculative Execution algorithm based on C4.5 Decision Tree, SECDT, for Hadoop. In SECDT, we speculate completion time of stragglers and also of backup tasks, based on a kind of decision tree method: C4.5 decision tree. After we speculate the completion time, we compare the completion time of stragglers and of the backup tasks, calculating their differential value, and selecting the straggler with the maximum differential value to start the backup task.Experiment result shows that the SECDT can predict execution time more accurately than other speculative execution methods, hence reduce the job completion time.展开更多
This paper addresses the leader-following consensus problem in multi-agent systems(MASs)with limited communication rates,while also considering sensor and actuator false data injection(FDI)attacks.A distributed event-...This paper addresses the leader-following consensus problem in multi-agent systems(MASs)with limited communication rates,while also considering sensor and actuator false data injection(FDI)attacks.A distributed event-triggered adaptive control protocol is developed to achieve cooperative uniform ultimate boundedness(UUB)in consensus tracking for compromised networked MASs.To implement this protocol,a distributed estimator is first designed to allow followers to estimate the leader's state.Then,adaptive internal controllers are constructed for each follower to mitigate the impact of FDI attack signals.Additionally,an event-triggered transmission logic is introduced to handle the constraints imposed by finite communication rates.Simulation results demonstrate the effectiveness of the proposed approach.展开更多
Time-resolved photoluminescence(TRPL)has been extensively used to measure the carrier lifetime in lead halide perovskites.The TRPL curves of perovskite materials are usually fitted with a multi-exponential function,in...Time-resolved photoluminescence(TRPL)has been extensively used to measure the carrier lifetime in lead halide perovskites.The TRPL curves of perovskite materials are usually fitted with a multi-exponential function,instead of a single exponential one.This was considered to be a result of the surface and the bulk recombination or the additional radiative recombination caused by the high excited carrier density.Here,a new model considering the diffusion and the trap-assisted recombination of carriers is proposed to explain the TRPL curves.The expressions of the TRPL curves and the transient absorption(TA)dynamic curves are theoretically derived,demonstrating that the TRPL curve is an infinite exponential series,regardless of the presence of surface recombination or not.Our newly developed highly sensitive nanosecond TA and TRPL were employed to measure the carrier dynamics of the same sample under low illumination in the linear response region of TA,thereby experimentally verifying our model.These results suggest that the decay of the TRPL is not only a consequence of the carrier recombination but also the carrier diffusion.TRPL cannot provide a direct measurement of the carrier lifetime,whereas TA spectroscopy can.Furthermore,the surface and the bulk recombination can be resolved and the average diffusion coefficient(D)can also be correctly obtained by combining TRPL and TA measurements.We also propose an approximate method for calculating the carrier lifetime and diffusion coefficient of high-quality perovskite films.Our model provides not only a new interpretation of the dynamics of the PL decay but also a deep insight into the carrier dynamics in the nanosecond time scale under working condition of perovskites solar cells.展开更多
The interest in dynamic modulation of light by ultra-thin materials exhibiting insulator–metal phase transition,such as VO_(2),has rapidly grown due to the myriad industrial applications,including smart windows and o...The interest in dynamic modulation of light by ultra-thin materials exhibiting insulator–metal phase transition,such as VO_(2),has rapidly grown due to the myriad industrial applications,including smart windows and optical limiters.However,for applications in the telecommunication spectral band,the light modulation through a thin VO_(2) film is low due to the presence of strong material loss.Here,we demonstrate tailored nanostructuring of VO_(2) to dramatically enhance its transmission modulation,reaching a value as high as 0.73,which is 2 times larger than the previous modulation achieved.The resulting designs,including free-topology optimization,demonstrate the fundamental limit in acquiring the desired optical performance,including achieving positive or negative transmission contrast.Our results on nanophotonic management of lossy nanostructured films open new opportunities for applications of VO_(2) metasurfaces.展开更多
Nonlinear feedback shift register(NFSR)is one of the most important cryptographic primitives in lightweight cryptography.At ASIACRYPT 2010,Knellwolf et al.proposed conditional differential attack to perform a cryptana...Nonlinear feedback shift register(NFSR)is one of the most important cryptographic primitives in lightweight cryptography.At ASIACRYPT 2010,Knellwolf et al.proposed conditional differential attack to perform a cryptanalysis on NFSR-based cryptosystems.The main idea of conditional differential attack is to restrain the propagation of the difference and obtain a detectable bias of the difference of the output bit.QUARK is a lightweight hash function family which is designed by Aumasson et al.at CHES 2010.Then the extended version of QUARK was published in Journal of Cryptology 2013.In this paper,we propose an improved conditional differential attack on QUARK.One improvement is that we propose a method to select the input difference.We could obtain a set of good input differences by this method.Another improvement is that we propose an automatic condition imposing algorithm to deal with the complicated conditions efficiently and easily.It is shown that with the improved conditional differential attack on QUARK,we can detect the bias of output difference at a higher round of QUARK.Compared to the current literature,we find a distinguisher of U-QUARK/D-QUARK/S-QUARK/C-QUARK up to 157/171/292/460 rounds with increasing 2/5/33/8 rounds respectively.We have performed the attacks on each instance of QUARK on a 3.30 GHz Intel Core i5 CPU,and all these attacks take practical complexities which have been fully verified by our experiments.As far as we know,all of these results have been the best thus far.展开更多
In this paper,the spherical particles growth during lithium electrodeposition was investigated by directly solving the governing equations based on the Landau transformation method.The basic growth kinetic characteris...In this paper,the spherical particles growth during lithium electrodeposition was investigated by directly solving the governing equations based on the Landau transformation method.The basic growth kinetic characteristics of a spherical particle during electrodeposition was studied.Predicted results show that the dynamic oscillation of the growth velocity occurs during the spherical particle growth.It was found from numerical simulations that applied electrical potential difference,electrolyte concentration,and diffusion coefficient are 3 main factors influencing the spherical growth and the existence of the dynamic oscillation state of the growth velocity during electrodeposition.The increase in both the applied electrical potential difference and the electrolyte concentration can lead to the increase of the growth velocity of the spherical particle,while the growth velocity is independent of the diffusion coefficient.Moreover,it was found that the wavelength and the amplitude of the dynamic oscillation of the growth velocity can be influenced by the applied electrical potential difference,the electrolyte concentration,and the diffusion coefficient.We determined that the dynamic competition between electrochemical reactions and ion transport in the electrodeposition is the reason for the existence of the oscillation of the growth velocity.展开更多
Construction of lead halide perovskite nanocrystals(LHP NCs)heterostructures is essential to obtain highly stable photoluminescence and expand their applications.Herein,a novel self-assembly strategy combining with a ...Construction of lead halide perovskite nanocrystals(LHP NCs)heterostructures is essential to obtain highly stable photoluminescence and expand their applications.Herein,a novel self-assembly strategy combining with a solvent-free thermal-assisted synthesis and a water-triggered reaction is developed to subsequently grow BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures at low nucleation temperature with high crystallinity.The as-obtained ternary BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures exhibit remarkably enhanced panchromatic emission and ultrastable luminescence ascribing to the low-defect growth based on lattice matching.Stable white light-emitting diodes(WLEDs)have been constructed with a high correlated color temperature(CCT)of 7225 K and luminous efficiency of 74.4 lm·W-1.Ln^(3+)-doped BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(Ln^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Sm^(3+),Yb^(3+)/Er^(3+))nanocomposites are further designed with excitation-dependent photoluminescence and thermochromic properties,making them excellent candidates for high-level anti-counterfeiting and encryption.This work offers a green and universal approach in assembling CsPbX_(3)(X=Cl,Br,I)on lattice-matched tungstate with adjustable panchromatic emission for versatile optical applications.展开更多
The circadian clock is crucial for the progression of cardiovascular diseases.Our previous studies showed that acrolein,an environmental pollutant,exacerbated atherosclerosis by reducing CLOCK/BMAL1 levels and disrupt...The circadian clock is crucial for the progression of cardiovascular diseases.Our previous studies showed that acrolein,an environmental pollutant,exacerbated atherosclerosis by reducing CLOCK/BMAL1 levels and disrupting circadian rhythm;in contrast,intermittent fasting(IF),a dietary regimen,ameliorated acrolein-induced atherosclerosis.In the current study,mice were administered acrolein at a dose of 3 mg/(kg·day)via drinking water and subjected to IF for 18 h(from 0:00 to 18:00).We observed that IF reduced the formation of aortic lesions accelerated by acrolein in Apo E-/-mice.Upon exposure to acrolein,the expression of Rel A,Il1b,and Tnf increased in the liver and heart tissues,but these changes were reversed by IF treatment.Notably,IF treatment upregulated the expression of adenosine monophosphate(AMP)-activated protein kinase catalytic subunit alpha-1(AMPKα1),p-AMPKα1,and sirtuin 1(SIRT1),while inhibiting acrolein-induced mitogen-activated protein kinase(MAPK)activation.Additionally,the expression of circadian genes Clock/Bmal1 was suppressed and disrupted by acrolein,whereas IF restored their expression.Moreover,consistent with the in vivo findings,shortterm starvation in vitro,as a fasting cell model,alleviated the dysregulation of CLOCK/BMAL1 and upregulated SIRT1 expression by modulating the AMPK and reactive oxygen species(ROS)-MAPK pathways activated by acrolein.In summary,we demonstrated that IF suppressed the ROS-MAPK pathway but activated the AMPK pathway to enhance the expression of circadian clock genes,thereby ameliorating acrolein-induced atherogenesis,which may shed light on strategies for preventing cardiovascular diseases.展开更多
Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway ...Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.展开更多
基金supported by National Natural Science Foundation of China(No.22171040)Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC230784)+1 种基金Guangdong Basic and Applied Basic Research Foundation(No.2023A1515140011)Fundamental Research Funds for the Central Universities,China(No.N2305017)。
文摘Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict their practical application.Herein,the CsPbBr_(3)/CsPb_(2)Br_(5)heteronanocrystals(HNCs)were successfully encapsulated into ZIF-8 through a thermal injection method via controlling the molar ratio of Cs^(+)/Pb2^(+).The surface of ZIF-8 was then modified with hydrophobic copolymer of poly(methyl methacrylate)(PMMA)to improve the water stability.Benefiting from the intimate interfacial interaction and staggered energy band structure,the type-II heterojunction of CsPb Br_(3)/CsPb_(2)Br_(5)guarantees efficient separation and migration of photogenerated electron/hole pairs.Meanwhile,the formation of Z-scheme heterojunction between ZIF-8 and CsPbBr_(3)/CsPb_(2)Br_(5)HNCs contributes to the adsorption and enrichment of pollutants,further accelerates the photocatalytic antibiotic degradation efficiency towards tetracycline hydrochloride(TCH)in aqueous solution.Nearly 87%of TCH(40 mg/L,50 mL)was degraded by 40 mg catalyst within 100 min.This work offers a feasible approach in assembling high-performance MHP NCsbased efficient photocatalyst with expanding application in aqueous solution.
基金supported by a grant of the Korea Healthcare Technology R&D Project,Ministry for Health,Welfare & Family Affairs,Republic of Korea,No.A101578
文摘Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.
基金the Korea Healthcare Technol-ogy R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea, No. A101578
文摘Previous research has demonstrated that cotransplantation of umbilical cord mesenchymal stem cells （UCMSCs） and Schwann cells （SCs） can repair spinal nerve injury, but few studies have investigated their use in peripheral nerve regeneration. In the present study, we cotransplanted UCMSCs and SCs to repair 5-mm left sciatic nerve defects in rats, and compared the effects of UCMSCs ＋ SCs transplantation with UCMSCs or SCs transplantation alone. After UCMSCs ＋ SCs transplantation, nerve conduction velocity of the left sciatic nerve and gait were both improved. Retrograde tracing analysis demonstrated that the mean count of fluorogold-labeled neurons, as well as the mean axon count and axon density, were significantly greater in the left sciatic nerve after UCMSCs ＋ SCs transplantation, compared with UCMSCs or SCs transplantation alone. Improvements in conduction velocity and increased sheath thickness in the left sciatic nerve were similar after UCMSCs transplantation and UCMSCs ＋ SCs transplantation. These findings suggest that UCMSCs transplantation can promote the repair of sciatic nerve defects to some extent, but that combined UCMSCs ＋ SCs transplantation has a significantly greater regenerative effect.
基金the Korea Health R&D Project,No.A080863,Granted by Ministry of Health and Welfare,Republic of Korea
文摘Enhancing Schwann cell proliferation may be beneficial for peripheral nerve repair and nerve regeneration. A traditional herbal formula composed of Fuling （poria cocos）, Baizhu （Atractylodes macrocephala）, and Danggui （Angelica sinensis） （FBD） improves neuronal survival and growth, and FBD may promote the secretion of brain-derived neurotrophic factor. However, the mechanism underlying Schwann cell proliferation remains unclear. We tested whether FBD enhanced the proliferation of human Schwann cells. FBD （20 ug/mL） increased Schwann cell viability and survival and increased the number of cells at G2/M and S phases. FBD also increased nerve growth factor and brain-derived neurotrophic factor expression in Schwann cells, with maximum efficacy at 20 ug/mL.
基金support provided by the National Natural Science Foundation Founda-tion of China(Grant Nos.52172047,52202040)Inner Mongolia Autonomous Region Major Science and Technology project(Grant No.2020ZD0024).
文摘Transition metal sulfides(TMSs)are widely recognized for their potential as anode materials in the develop-ment of flexible lithium-ion capacitors(FLICs)owing to their high theoretical capacity.However,their practical application has been significantly limited by rapid capacity decay and sluggish kinetics associated with TMS volume variation.In response to these challenges,we have prepared ZnS/CuS nanoparticles embedded in continuous and multichannel carbon fibers(CFs).This was achieved through a process involving blow-spin-ning and subsequent sulfidation.Notably,the electrochemical performance of these materials was largely improved,owing to the synergistic effect of bimetallic sulfides.The ZnS/CuS-CF anode material demon-strated a high specific capacity of over 900 mAh g^(−1)at a current density of 0.2 A g^(−1).Furthermore,it exhibited superior rate capacity(300 mAh g^(−1)at 20 A g^(−1))and excellent cyclic stability,maintaining its performance over 1000 cycles at 10 A g^(−1).We also prepared lithium-ion capacitors(LICs)using the same method.These LICs exhibited a maximum energy density of 136 Wh kg^(−1),a high power density of 43.5 kW kg^(−1),and an impres-sive cyclic stability over 4000 cycles.In addition,the FLICs,when configured in the form of a pouch cell,demonstrated significant potential for the development of smart,flexible electronic devices.
基金Shanghai High-level Local University Innovation Team(Maritime Safety&Technical Support)the National Natural Science Foundation of China (Grant No. 42176217)
文摘Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs),which have widely interested scholars in the shipping industry due to their safety,high efficiency,and energy-saving qualities.Considering the current development of USVs,the types of USVs and applications domestically and internationally are being investigated.USVs emerged with technological developments and their characteristics show some differences from traditional vessels,which brings some problems and advantages for their application.Certain maritime regulations are not applicable to USVs and must be changed.The key technologies in the current development of USVs are being investigated.While the level of intelligence is improving,the protection of cargo cannot be neglected.An innovative approach to the internal structure of USVs is proposed,where the inner hull can automatically recover its original state in case of outer hull tilting.Finally,we summarize the development status of USVs,which are an inevitable direction of development in the marine field.
基金This work is supported by National Natural Science Foundation of China(61402225,61728204)Innovation Funding(NJ20160028,NT2018028,NS2018057)+1 种基金Aeronautical Science Foundation of China(2016551500)State Key Laboratory for smart grid protection and operation control Foundation,and the Science and Technology Funds from National State Grid Ltd.,China degree and Graduate Education Fund.
文摘Active learning has been widely utilized to reduce the labeling cost of supervised learning.By selecting specific instances to train the model,the performance of the model was improved within limited steps.However,rare work paid attention to the effectiveness of active learning on it.In this paper,we proposed a deep active learning model with bidirectional encoder representations from transformers(BERT)for text classification.BERT takes advantage of the self-attention mechanism to integrate contextual information,which is beneficial to accelerate the convergence of training.As for the process of active learning,we design an instance selection strategy based on posterior probabilities Margin,Intra-correlation and Inter-correlation(MII).Selected instances are characterized by small margin,low intra-cohesion and high inter-cohesion.We conduct extensive experiments and analytics with our methods.The effect of learner is compared while the effect of sampling strategy and text classification is assessed from three real datasets.The results show that our method outperforms the baselines in terms of accuracy.
基金supported by the National Natural Science Foundation of China(Nos.81960404,81960401 and 82060308)Guizhou Province Science and Technology Project(No.[2019]1429)Guizhou Provincial high-level innovative talents of Science and Technology Department(No.GCC[2022]037–1)。
文摘As the main target cells of immune regulation,macrophages play an important role in the bone regeneration process.Macrophages can be polarized into the M1 and M2 types under the stimulation of different factors.They have proinflammatory and anti-inflammatory effects,respectively,and play key roles in different stages of bone regeneration.The ratio of M1 to M2 macrophages can be regulated by immunomodulatory biomaterials to promote bone repair and regeneration.In this paper,we review the recent literature on the chemical,physical and biological properties of biomaterials and the regulation of macrophage polarization under the influence of other factors.We also cover new methods for preparing immunomodulatory biomaterials for bone regeneration.This paper will provide new design ideas for the development of biomaterials with immunological properties and will support the clinical translation of bone-related medical biomaterials.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant No.62001057by Beijing University of Posts and Telecommunications Basic Research Fund,2021RC26by the National Natural Science Foundation of China(NSFC)under Grant Nos.61871048 and 61872253.
文摘Image Super-Resolution(SR)research has achieved great success with powerful neural networks.The deeper networks with more parameters improve the restoration quality but add the computation complexity,which means more inference time would be cost,hindering image SR from practical usage.Noting the spatial distribution of the objects or things in images,a twostage local objects SR system is proposed,which consists of two modules,the object detection module and the SR module.Firstly,You Only Look Once(YOLO),which is efficient in generic object detection tasks,is selected to detect the input images for obtaining objects of interest,then put them into the SR module and output corresponding High-Resolution(HR)subimages.The computational power consumption of image SR is optimized by reducing the resolution of input images.In addition,we establish a dataset,TrafficSign500,for our experiment.Finally,the performance of the proposed system is evaluated under several State-Of-The-Art(SOTA)YOLOv5 and SISR models.Results show that our system can achieve a tremendous computation improvement in image SR.
基金This work is supported in part by National Natural Science Foundation of China(61728204)Innovation Funding(NJ20160028,NT2018027,NT2018028,NS2018057)+1 种基金Aeronautical Science Foundation of China(2016551500)State Key Laboratory for smart grid protection and operation control Foundation,Association of Chinese Graduate Education(ACGE).
文摘The rigid structure of the traditional relational database leads to data redundancy,which seriously affects the efficiency of the data query and cannot effectively manage massive data.To solve this problem,we use distributed storage and parallel computing technology to query RDF data.In order to achieve efficient storage and retrieval of large-scale RDF data,we combine the respective advantage of the storage model of the relational database and the distributed query.To overcome the disadvantages of storing and querying RDF data,we design and implement a breadth-first path search algorithm based on the keyword query on a distributed platform.We conduct the LUBM query statements respectively with the selected data sets.In experiments,we compare query response time in different conditions to evaluate the feasibility and correctness of our approaches.The results show that the proposed scheme can reduce the storage cost and improve query efficiency.
基金supported by the National Natural Science Foundation of China(grant no.52073175)National Natural Science Foundation of Shanghai(grant no.23ZR1442700)。
文摘Pathway selection in a complex chemical reaction network(CRN)enables organisms to adapt,evolve,and even learn in response to changing environments.Inspired by this,herein we report an artificial system,where light signal was used to manipulate the reaction pathways in a disulfide-based nonequilibrium CRN.By changing the photon energy and irradiation window,the anion or new radical-mediated pathways were selectively triggered,resulting in a user-defined evolution pathway.Additional photodissipative cycles were achieved by UV(365 nm)irradiation,increasing the total number of reactions from 3 to 7.The emerging pathway selection of the CRN is accurately predictable and controllable even in complex organo-hydrogel materials.We demonstrate up to five-state autonomous sol-gel transitions and the formation of fuel-driven dissipative organo-hydrogel through both chemical and light input.This work represents a new approach to allowing CRNs to communicate with the environment that can be used in the development of materials with lifelike behaviors.
文摘As a distributed computing platform, Hadoop provides an effective way to handle big data. In Hadoop, the completion time of job will be delayed by a straggler. Although the definitive cause of the straggler is hard to detect, speculative execution is usually used for dealing with this problem, by simply backing up those stragglers on alternative nodes. In this paper, we design a new Speculative Execution algorithm based on C4.5 Decision Tree, SECDT, for Hadoop. In SECDT, we speculate completion time of stragglers and also of backup tasks, based on a kind of decision tree method: C4.5 decision tree. After we speculate the completion time, we compare the completion time of stragglers and of the backup tasks, calculating their differential value, and selecting the straggler with the maximum differential value to start the backup task.Experiment result shows that the SECDT can predict execution time more accurately than other speculative execution methods, hence reduce the job completion time.
文摘This paper addresses the leader-following consensus problem in multi-agent systems(MASs)with limited communication rates,while also considering sensor and actuator false data injection(FDI)attacks.A distributed event-triggered adaptive control protocol is developed to achieve cooperative uniform ultimate boundedness(UUB)in consensus tracking for compromised networked MASs.To implement this protocol,a distributed estimator is first designed to allow followers to estimate the leader's state.Then,adaptive internal controllers are constructed for each follower to mitigate the impact of FDI attack signals.Additionally,an event-triggered transmission logic is introduced to handle the constraints imposed by finite communication rates.Simulation results demonstrate the effectiveness of the proposed approach.
基金supported by the National Natural Science Foundation of China(Grant No.11888101)National Key Research and Development Program of China(Grant No.2022YFA1403901)+1 种基金Sichuan Science and Technology Program(Grant Nos.2021JDTD0021,and 2022ZYD0015)Innovation Funds from China Academy of Engineering Physics(Grant No.CX20210037)。
文摘Time-resolved photoluminescence(TRPL)has been extensively used to measure the carrier lifetime in lead halide perovskites.The TRPL curves of perovskite materials are usually fitted with a multi-exponential function,instead of a single exponential one.This was considered to be a result of the surface and the bulk recombination or the additional radiative recombination caused by the high excited carrier density.Here,a new model considering the diffusion and the trap-assisted recombination of carriers is proposed to explain the TRPL curves.The expressions of the TRPL curves and the transient absorption(TA)dynamic curves are theoretically derived,demonstrating that the TRPL curve is an infinite exponential series,regardless of the presence of surface recombination or not.Our newly developed highly sensitive nanosecond TA and TRPL were employed to measure the carrier dynamics of the same sample under low illumination in the linear response region of TA,thereby experimentally verifying our model.These results suggest that the decay of the TRPL is not only a consequence of the carrier recombination but also the carrier diffusion.TRPL cannot provide a direct measurement of the carrier lifetime,whereas TA spectroscopy can.Furthermore,the surface and the bulk recombination can be resolved and the average diffusion coefficient(D)can also be correctly obtained by combining TRPL and TA measurements.We also propose an approximate method for calculating the carrier lifetime and diffusion coefficient of high-quality perovskite films.Our model provides not only a new interpretation of the dynamics of the PL decay but also a deep insight into the carrier dynamics in the nanosecond time scale under working condition of perovskites solar cells.
基金Centre of Excellence for Transformative Meta Optical Systems(TMOS)Australian Research Council(CE20010001)+2 种基金North Atlantic Treaty Organization(G5850–OPTIMIST)Ministero dellaposUniversitàe della Ricerca(2020EY2LJT_002)。
文摘The interest in dynamic modulation of light by ultra-thin materials exhibiting insulator–metal phase transition,such as VO_(2),has rapidly grown due to the myriad industrial applications,including smart windows and optical limiters.However,for applications in the telecommunication spectral band,the light modulation through a thin VO_(2) film is low due to the presence of strong material loss.Here,we demonstrate tailored nanostructuring of VO_(2) to dramatically enhance its transmission modulation,reaching a value as high as 0.73,which is 2 times larger than the previous modulation achieved.The resulting designs,including free-topology optimization,demonstrate the fundamental limit in acquiring the desired optical performance,including achieving positive or negative transmission contrast.Our results on nanophotonic management of lossy nanostructured films open new opportunities for applications of VO_(2) metasurfaces.
基金This work was supported by the National Natural Science Foundation of China(Grant No.61872359,62122085 and 61936008)the National Key R&D Program of China(Grant No.2020YFB1805402),and the Youth Innovation Promotion Association of Chinese Academy of Sciences.
文摘Nonlinear feedback shift register(NFSR)is one of the most important cryptographic primitives in lightweight cryptography.At ASIACRYPT 2010,Knellwolf et al.proposed conditional differential attack to perform a cryptanalysis on NFSR-based cryptosystems.The main idea of conditional differential attack is to restrain the propagation of the difference and obtain a detectable bias of the difference of the output bit.QUARK is a lightweight hash function family which is designed by Aumasson et al.at CHES 2010.Then the extended version of QUARK was published in Journal of Cryptology 2013.In this paper,we propose an improved conditional differential attack on QUARK.One improvement is that we propose a method to select the input difference.We could obtain a set of good input differences by this method.Another improvement is that we propose an automatic condition imposing algorithm to deal with the complicated conditions efficiently and easily.It is shown that with the improved conditional differential attack on QUARK,we can detect the bias of output difference at a higher round of QUARK.Compared to the current literature,we find a distinguisher of U-QUARK/D-QUARK/S-QUARK/C-QUARK up to 157/171/292/460 rounds with increasing 2/5/33/8 rounds respectively.We have performed the attacks on each instance of QUARK on a 3.30 GHz Intel Core i5 CPU,and all these attacks take practical complexities which have been fully verified by our experiments.As far as we know,all of these results have been the best thus far.
基金National Natural Science Foundation of China(Nos.21978298 and 51871186)and Shaanxi Basic Discipline(Liquid Physics)Research Center.
文摘In this paper,the spherical particles growth during lithium electrodeposition was investigated by directly solving the governing equations based on the Landau transformation method.The basic growth kinetic characteristics of a spherical particle during electrodeposition was studied.Predicted results show that the dynamic oscillation of the growth velocity occurs during the spherical particle growth.It was found from numerical simulations that applied electrical potential difference,electrolyte concentration,and diffusion coefficient are 3 main factors influencing the spherical growth and the existence of the dynamic oscillation state of the growth velocity during electrodeposition.The increase in both the applied electrical potential difference and the electrolyte concentration can lead to the increase of the growth velocity of the spherical particle,while the growth velocity is independent of the diffusion coefficient.Moreover,it was found that the wavelength and the amplitude of the dynamic oscillation of the growth velocity can be influenced by the applied electrical potential difference,the electrolyte concentration,and the diffusion coefficient.We determined that the dynamic competition between electrochemical reactions and ion transport in the electrodeposition is the reason for the existence of the oscillation of the growth velocity.
基金supported by the National Natural Science Foundation of China(Nos.22171040,51932009 and 52172166)the Fundamental Research Funds for the Central Universities,China(No.N2105006).
文摘Construction of lead halide perovskite nanocrystals(LHP NCs)heterostructures is essential to obtain highly stable photoluminescence and expand their applications.Herein,a novel self-assembly strategy combining with a solvent-free thermal-assisted synthesis and a water-triggered reaction is developed to subsequently grow BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures at low nucleation temperature with high crystallinity.The as-obtained ternary BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures exhibit remarkably enhanced panchromatic emission and ultrastable luminescence ascribing to the low-defect growth based on lattice matching.Stable white light-emitting diodes(WLEDs)have been constructed with a high correlated color temperature(CCT)of 7225 K and luminous efficiency of 74.4 lm·W-1.Ln^(3+)-doped BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(Ln^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Sm^(3+),Yb^(3+)/Er^(3+))nanocomposites are further designed with excitation-dependent photoluminescence and thermochromic properties,making them excellent candidates for high-level anti-counterfeiting and encryption.This work offers a green and universal approach in assembling CsPbX_(3)(X=Cl,Br,I)on lattice-matched tungstate with adjustable panchromatic emission for versatile optical applications.
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and the Key Project of Jiangsu Commission of Health(Grant No.ZD2022012)。
文摘The circadian clock is crucial for the progression of cardiovascular diseases.Our previous studies showed that acrolein,an environmental pollutant,exacerbated atherosclerosis by reducing CLOCK/BMAL1 levels and disrupting circadian rhythm;in contrast,intermittent fasting(IF),a dietary regimen,ameliorated acrolein-induced atherosclerosis.In the current study,mice were administered acrolein at a dose of 3 mg/(kg·day)via drinking water and subjected to IF for 18 h(from 0:00 to 18:00).We observed that IF reduced the formation of aortic lesions accelerated by acrolein in Apo E-/-mice.Upon exposure to acrolein,the expression of Rel A,Il1b,and Tnf increased in the liver and heart tissues,but these changes were reversed by IF treatment.Notably,IF treatment upregulated the expression of adenosine monophosphate(AMP)-activated protein kinase catalytic subunit alpha-1(AMPKα1),p-AMPKα1,and sirtuin 1(SIRT1),while inhibiting acrolein-induced mitogen-activated protein kinase(MAPK)activation.Additionally,the expression of circadian genes Clock/Bmal1 was suppressed and disrupted by acrolein,whereas IF restored their expression.Moreover,consistent with the in vivo findings,shortterm starvation in vitro,as a fasting cell model,alleviated the dysregulation of CLOCK/BMAL1 and upregulated SIRT1 expression by modulating the AMPK and reactive oxygen species(ROS)-MAPK pathways activated by acrolein.In summary,we demonstrated that IF suppressed the ROS-MAPK pathway but activated the AMPK pathway to enhance the expression of circadian clock genes,thereby ameliorating acrolein-induced atherogenesis,which may shed light on strategies for preventing cardiovascular diseases.
基金the National Natural Science Foundation of China(NSFC Grant No.81872021,32200462)Beijing Jiaotong University undergraduate innovation and entrepreneurship training project(No.220171097,220171072,220171037,220171088,220171104)+3 种基金R&D Program of Beijing Municipal Education Commission(Grant No.KM202110025004)Beijing Hospitals Authority Youth Programme(grant No.QML20231602)JH,KC and JMW were also funded in part by Federal funds from the National Cancer Institute,National Institutes of Health(under Contract No.HHSN261200800001E)the Intramural Research Programs of the NCI,CCR,and NIH.
文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.
