Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proo...Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using...Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using VOSviewer and R to quantify research evolution.Intervention modalities,signaling pathways,and mechanisms were innovatively extracted.Results:Quantified analysis revealed a distinct temporal evolution:early research was dominated by TGF-βsignaling,while starting from 2015,the focus of the research turned to podocyte-targeted studies.Traditional Chinese medicine compounds emerged as the predominant intervention,yet standardization deficits persisted across 73 formulas.Despite limited human pathological concordance,Spontaneously hypertensive rats models were utilized in most studies.Critically,only a few podocyte-focused therapeutics advanced to clinical trials,primarily hindered by species-specific Transient receptor potential channel expression divergence and mesenchymal stem cells renal delivery.Conclusion:Podocyte protection and standardized traditional Chinese medicine are potential translational targets,but there is a lack of reliable clinical trials for clinical verification.展开更多
Colorectal cancer(CRC)is the third most common cancer worldwide and the second most common cause of cancer death.Nanotherapies are able to selectively target the delivery of cancer therapeutics,thus improving overall ...Colorectal cancer(CRC)is the third most common cancer worldwide and the second most common cause of cancer death.Nanotherapies are able to selectively target the delivery of cancer therapeutics,thus improving overall antitumor eff-iciency and reducing conventional chemotherapy side effects.Mesoporous silica nanoparticles(MSNs)have attracted the attention of many researchers due to their remarkable advantages and biosafety.We offer insights into the recent advances of MSNs in CRC treatment and their potential clinical application value.展开更多
BACKGROUND Ectopic gallbladder,occurring in 0.1%to 0.7%of the population,is rarely found in the left liver lobe without situs inversus totalis.Functional gallbladder disorder(FGBD),characterized by biliary pain withou...BACKGROUND Ectopic gallbladder,occurring in 0.1%to 0.7%of the population,is rarely found in the left liver lobe without situs inversus totalis.Functional gallbladder disorder(FGBD),characterized by biliary pain without stones or sludge,affects 8%of men and 21%of women.No prior cases of concomitant FGBD and left-sided gallbladder have been reported,posing diagnostic and surgical challenges.CASE SUMMARY A 73-year-old woman with a 20-year history of epigastric pain was diagnosed with a left-sided gallbladder and FGBD based on imaging findings and impaired gallbladder contraction.Laparoscopic cholecystectomy was performed and confirmed the ectopic gallbladder adherent to the left liver lobe.Postoperative pathology revealed no abnormalities,and the patient achieved complete symptom resolution at three-month follow-up.CONCLUSION This is the first reported case of FGBD with a left-sided gallbladder.Preoperative imaging,such as magnetic resonance cholangiopancreatography or computed tomography,is crucial for identifying anatomical variations of the gallbladder.Laparoscopic cholecystectomy is feasible but requires careful planning to avoid complications.展开更多
Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.A...Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.As a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this journal.The patient had no family history of TB or contact with people with TB.Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient.The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.展开更多
Fecal incontinence is a common symptom among patients with rectal prolapse.Pudendal nerve terminal motor latency(PNTML)testing can serve as a reference indicator for predicting the outcomes of rectal prolapse surgery,...Fecal incontinence is a common symptom among patients with rectal prolapse.Pudendal nerve terminal motor latency(PNTML)testing can serve as a reference indicator for predicting the outcomes of rectal prolapse surgery,thereby assisting surgeons in formulating more appropriate surgical plans.The direct correlation between preoperative PNTML testing results and postoperative fecal incontinence in patients with rectal prolapse remains a contentious issue,necessitating further clarification.Thus,we analyze the existing publications from both clinical and statistical perspectives to comprehensively evaluate the accuracy of preoperative PNTML testing in rectal prolapse and provide some feasible statistical solutions.展开更多
文摘Medical Data Mining published an article entitled Mapping the global research trends and hotspots on hypertensive nephropathy:A novel bibliometrics overview on 10 October 2025.The author confirmed this article’s proof on 28 September 2025 without any questions.However,on 13 November 2025,the Editorial Office of Medical Data Mining noticed an inconsistency between the data presented in the main text and Figure 1.Specifically,erroneous Figure 1 states“a total of 56,691 literatures were obtained through database search”,while the main text in the Search results section states“According to the search term,a total of 59,220 publications were retrieved from the database.”The authors acknowledge that the original version of Figure 1 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金funded by National Natural Science Foundation of China,No.811734071The Fundamental Research Funds for the Central Universities(2023-JYB-XJSJJ043)The fifth batch of National TCM Clinical Outstanding Talents Training Program(National TCM Personnel Education Letter[2022]No.1)。
文摘Background:Hypertensive nephropathy remains a leading cause of end-stage renal disease with limited targeted therapies.Methods:We conducted a bibliometric analysis(1992-2024)of 440 basic studies from 7 databases,using VOSviewer and R to quantify research evolution.Intervention modalities,signaling pathways,and mechanisms were innovatively extracted.Results:Quantified analysis revealed a distinct temporal evolution:early research was dominated by TGF-βsignaling,while starting from 2015,the focus of the research turned to podocyte-targeted studies.Traditional Chinese medicine compounds emerged as the predominant intervention,yet standardization deficits persisted across 73 formulas.Despite limited human pathological concordance,Spontaneously hypertensive rats models were utilized in most studies.Critically,only a few podocyte-focused therapeutics advanced to clinical trials,primarily hindered by species-specific Transient receptor potential channel expression divergence and mesenchymal stem cells renal delivery.Conclusion:Podocyte protection and standardized traditional Chinese medicine are potential translational targets,but there is a lack of reliable clinical trials for clinical verification.
基金Supported by The Natural Science Foundation of Liaoning Province,No.2022-MS-435Shenyang Science and Technology Plan Project,No.22-321-33-79.
文摘Colorectal cancer(CRC)is the third most common cancer worldwide and the second most common cause of cancer death.Nanotherapies are able to selectively target the delivery of cancer therapeutics,thus improving overall antitumor eff-iciency and reducing conventional chemotherapy side effects.Mesoporous silica nanoparticles(MSNs)have attracted the attention of many researchers due to their remarkable advantages and biosafety.We offer insights into the recent advances of MSNs in CRC treatment and their potential clinical application value.
文摘BACKGROUND Ectopic gallbladder,occurring in 0.1%to 0.7%of the population,is rarely found in the left liver lobe without situs inversus totalis.Functional gallbladder disorder(FGBD),characterized by biliary pain without stones or sludge,affects 8%of men and 21%of women.No prior cases of concomitant FGBD and left-sided gallbladder have been reported,posing diagnostic and surgical challenges.CASE SUMMARY A 73-year-old woman with a 20-year history of epigastric pain was diagnosed with a left-sided gallbladder and FGBD based on imaging findings and impaired gallbladder contraction.Laparoscopic cholecystectomy was performed and confirmed the ectopic gallbladder adherent to the left liver lobe.Postoperative pathology revealed no abnormalities,and the patient achieved complete symptom resolution at three-month follow-up.CONCLUSION This is the first reported case of FGBD with a left-sided gallbladder.Preoperative imaging,such as magnetic resonance cholangiopancreatography or computed tomography,is crucial for identifying anatomical variations of the gallbladder.Laparoscopic cholecystectomy is feasible but requires careful planning to avoid complications.
基金Supported by Shenyang Science and Technology Plan Project,No.23-408-3-01The Natural Science Foundation of Liaoning Province,No.2022-MS-435.
文摘Gastroduodenal tuberculosis(GD-TB)is exceptionally rare.The clinical manifestations of gastrointestinal TB are diverse and non-specific,which makes diagnosis difficult,leading to delayed diagnosis and high mortality.As a peer-reviewer of World Journal of Clinical Cases,I would like to share my opinion on the article published by this journal.The patient had no family history of TB or contact with people with TB.Primary GD-TB presenting as gastric outlet obstruction and normal findings of thoracic computed tomography increased the difficulty of diagnosis and treatment in this patient.The diagnosis and treatment scheme of this typical case have reference value for the clinical treatment of GD-TB.
基金Supported by The Shenyang Science and Technology Plan Project of 2022,No.22-321-33-79The Shenyang Science and Technology Plan Project of 2023,No.23-408-3-01The Natural Science Foundation of Liaoning Province,No.2022-MS-435.
文摘Fecal incontinence is a common symptom among patients with rectal prolapse.Pudendal nerve terminal motor latency(PNTML)testing can serve as a reference indicator for predicting the outcomes of rectal prolapse surgery,thereby assisting surgeons in formulating more appropriate surgical plans.The direct correlation between preoperative PNTML testing results and postoperative fecal incontinence in patients with rectal prolapse remains a contentious issue,necessitating further clarification.Thus,we analyze the existing publications from both clinical and statistical perspectives to comprehensively evaluate the accuracy of preoperative PNTML testing in rectal prolapse and provide some feasible statistical solutions.
