Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidne...Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidney beans,a subcategory of dry common beans,are highly valued for their rich protein,dietary fiber,low fat content,and various trace elements(Garcia-Cordero et al.,2021).Despite the release of several de novo genome assemblies(Goodstein et al.,2012;Schmutz et al.,2014;Vlasova et al.,2016;Cortinovis et al.,2024),existing common bean genomes remain incomplete,particularly in complex regions such as centromeres and telomeres,limiting a comprehensive understanding of the genomic landscape.展开更多
The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary int...The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary intervention(PCI)significantly improved the patency of the infarct-related artery in patients with STsegment elevation myocardial infarction(STEMI),who were expected to undergo PCI within 120 min.The present study aimed to investigate the one-year clinical outcomes and the effect of the anti-r-SAK antibodies on a second r-SAK thrombolysis in OPTIMA-5 patients.The clinical outcome measured was major adverse cardiovascular events(MACE)within 360 days.Patients'anti-r-SAK antibody levels were determined on day 90(±7 days),day 180(±7 days),and day 360(±14 days)after thrombolysis,and in vitro r-SAK antibody neutralization experiments were performed to explore an optimal interval for a second r-SAK thrombolysis.Results showed that the MACE incidence was numerically lower in the r-SAK group compared with the normal saline(NS)group(14.0%vs.20.0%,hazard ratio[HR]=0.67,95%confidence interval[CI]:0.34–1.32;log-rank P=0.245).The anti-r-SAK antibody levels in the r-SAK group decreased with time,but remained significantly higher than those in the NS group on day 90(±7 days)(2.96±0.68 vs.0.22±0.53,P<0.001),day 180(±7 days)(2.19±0.74 vs.0.44±0.65,P<0.001),and day 360(±14 days)(1.73±0.97 vs.0.37±0.71,P<0.001).The in vitro anti-r-SAK antibody neutralization experiments demonstrated that the thrombolysis rate decreased exponentially as the antibody titer increased from 1.90 to 2.20(67.80%±14.19%vs.44.32%±21.54%,P<0.0001).Therefore,for STEMI patients who are expected to undergo PCI within 120 min,a single bolus of half-dose rSAK before primary PCI may reduce the one-year MACE risk.The anti-r-SAK antibody persists over one year,and a second r-SAK thrombolysis may not be indicated until at least one year after the first administration,if necessary.展开更多
Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controll...Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.展开更多
This paper describes the design and performance of the tender energy spectroscopy beamline(BL16U1),a phase Ⅱ beamline,at the Shanghai Synchrotron Radiation Facility.The beamline,based on an in-vacuum undulator source...This paper describes the design and performance of the tender energy spectroscopy beamline(BL16U1),a phase Ⅱ beamline,at the Shanghai Synchrotron Radiation Facility.The beamline,based on an in-vacuum undulator source with 26 mm period,provides an operable energy range between 2.1 keV and 16 keV,covering the K-edges of P to Rb and L3-edges of Zr to Bi.The principal optical elements of the beamline are a toroidal mirror,a liquid nitrogen-cooled double-crystal monochromator,a high-harmonic-rejection mirror,and two pairs of Kirkpatrick–Baez(KB)mirrors.Three end-stations,including non-focusing,microprobe,and sub-microprobe types,are installed on the beamline.X-ray fluorescence(XRF)and X-ray absorption spectroscopy(XAS),including X-ray absorption near-edge structure(XANES)and extended X-ray absorption fine structure(EXAFS),are performed under vacuum or He atmosphere at the non-focusing end-station(with a beam spot size of∼670μm×710μm).Using two KB mirrors systems,micro-XRF(μXRF)mapping and micro-XANES(μXANES)studies can be performed with a spot size of approximately∼3.3μm×1.3μm at the microprobe end-station and with a smaller spot size of∼0.5μm×0.25μm at the sub-microprobe end-station.The non-focusing end-station was officially opened to users in January 2024.The microprobe and sub-microprobe end-stations will be opened to users in the near future.This paper presents the characteristics,short-term technical developments,and early experimental results of this new beamline.展开更多
As China is accelerating into an aging society,the coexistence of multiple diseases,multiple drugs,and the decline of body function are serious problems faced by elderly patients.Therefore,it is imperative to carry ou...As China is accelerating into an aging society,the coexistence of multiple diseases,multiple drugs,and the decline of body function are serious problems faced by elderly patients.Therefore,it is imperative to carry out the comprehensive prevention and control of chronic diseases,strengthen the health guidance and comprehensive intervention of common and chronic diseases of the elderly,and strengthen the health management of elderly patients.Collaborative drug therapy management(CDTM)is a drug treatment management mode that emerged in pharmaceutical services under the situation of new medical reform,aiming to expand the role of pharmacists in the medical team and improve the quality of hospital medical service.Although CDTM has shown some favorable effects in managing chronic diseases in the elderly population,the popularization of CDTM in China is limited by the differences in supporting facilities,management mode,and pharmacist’s abilities in hospitals.By exploring the CDTM mode for elderly patients with chronic diseases,we provided a reference for further promoting the CDTM services and laid a good foundation for displaying pharmacist value and the realization of real pharmaceutical care.展开更多
The Low-Frequency Radio Spectrometer(LFRS)is a scientific payload onboard the Chang’e-4 lunar lander launched in December 2018.The LFRS provides in-situ measurements of the low-frequency radio phenomena on the far-si...The Low-Frequency Radio Spectrometer(LFRS)is a scientific payload onboard the Chang’e-4 lunar lander launched in December 2018.The LFRS provides in-situ measurements of the low-frequency radio phenomena on the far-side of theMoon for the first time in human history.To evaluate the performance of the LFRS,a series of ground experiments are conducted using an engineering model of the LFRS.It is not easy to perform the experiments because the Electro Magnetic Interference(EMI)from the Chang’e-4 lunar lander itself and the environment is very intense.The results after EMI mitigation show that the sensitivity of the LFRS may be 10^(−18)W m^(−2)Hz^(−1).展开更多
Vision-based technologies have been extensively applied for on-street parking space sensing,aiming at providing timely and accurate information for drivers and improving daily travel convenience.However,it faces great...Vision-based technologies have been extensively applied for on-street parking space sensing,aiming at providing timely and accurate information for drivers and improving daily travel convenience.However,it faces great challenges as a partial visualization regularly occurs owing to occlusion from static or dynamic objects or a limited perspective of camera.This paper presents an imagery-based framework to infer parking space status by generating 3D bounding box of the vehicle.A specially designed convolutional neural network based on ResNet and feature pyramid network is proposed to overcome challenges from partial visualization and occlusion.It predicts 3D box candidates on multi-scale feature maps with five different 3D anchors,which generated by clustering diverse scales of ground truth box according to different vehicle templates in the source data set.Subsequently,vehicle distribution map is constructed jointly from the coordinates of vehicle box and artificially segmented parking spaces,where the normative degree of parked vehicle is calculated by computing the intersection over union between vehicle’s box and parking space edge.In space status inference,to further eliminate mutual vehicle interference,three adjacent spaces are combined into one unit and then a multinomial logistic regression model is trained to refine the status of the unit.Experiments on KITTI benchmark and Shanghai road show that the proposed method outperforms most monocular approaches in 3D box regression and achieves satisfactory accuracy in space status inference.展开更多
Traditional carbon layer enwrapping active materials cannot easily realize perfect cladding.Therefore,it still cannot prevent the pulverization of active materials during the course of charging/discharging.In this pap...Traditional carbon layer enwrapping active materials cannot easily realize perfect cladding.Therefore,it still cannot prevent the pulverization of active materials during the course of charging/discharging.In this paper,we utilize natural bacteria to absorb nickel acetate,the active materials Ni3P nanoparticles are well enwrapped,as a natural organisms surviving for billions of years,their cell walls have a perfect carbon structure,and the cell walls become carbon layer through high annealing temperature.Based on this,the yolk-shell Ni3P–carbon@reduced graphene oxides paper is prepared,through a proper annealing temperature,the Ni3P particles disperse in the inner surface or both ends,so the active materials were prevented from dissolving into the electrolyte,so it may keep from invalidity during charging/discharging.The electrochemical performances display that it has stable and high capacities as Li-ion batteries(LIBs)anode.Its capacity can keep 200 cycles without any decrease,and especially its rate performance exhibits an excellent peculiarity,with the current density increasing from 400 to 1000 mA g^(−1) every 200 mA g^(−1),its capacities decrease only 9.8%,2.9%and 6.4%,and its can recover the same capacity when the current density comes back to 200 mA g^(−1).It may be a fine choice for LIBs.展开更多
In the applications such as food production,the environmental temperature should be measured continuously dur-ing the entire process,which requires an ultra-low-power temperature sensor for long-termly monitoring.Conv...In the applications such as food production,the environmental temperature should be measured continuously dur-ing the entire process,which requires an ultra-low-power temperature sensor for long-termly monitoring.Conventional tempera-ture sensors trade the measurement accuracy with power consumption.In this work,we present a battery-free wireless tempera-ture sensing chip for long-termly monitoring during food production.A calibrated oscillator-based CMOS temperature sensor is proposed instead of the ADC-based power-hungry circuits in conventional works.In addition,the sensor chip can harvest the power transferred by a remote reader to eliminate the use of battery.Meanwhile,the system conducts wireless bidirectional communication between the sensor chip and reader.In this way,the temperature sensor can realize both a high precision and battery-free operation.The temperature sensing chip is fabricated in 55 nm CMOS process,and the reader chip is imple-mented in 65 nm CMOS technology.Experimental results show that the temperature measurement error achieves±1.6℃ from 25 to 50℃,with battery-free readout by a remote reader.展开更多
To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy...To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy storage systems based on measurement feedback is proposed.First,considering the high charge/discharge losses of hydrogen storage and the low energy density of battery storage,an operational optimization objective is established to enable adaptive energy adjustment in the Battery-hydrogen hybrid energy storage system.Next,an online optimization model minimizing the operational cost of the hybrid system is constructed to suppress grid-injected power deviations with satisfying the operational constraints of hydrogen storage and batteries.Finally,utilizing the online measurement of the energy states of hydrogen storage and batteries,an online optimization strategy based on measurement feedback is designed.Case study results show:before and after smoothing the fluctuations in wind power,the time when the power exceeded the upper and lower limits of the grid-injected power accounted for 24.1%and 1.45%of the total time,respectively,the proposed strategy can effectively keep the grid-injected power deviations of wind farms within the allowable range.Hydrogen storage and batteries respectively undertake long-term and short-term charge/discharge tasks,effectively reducing charge/discharge losses of the Battery-hydrogen hybrid energy storage systems and improving its operational efficiency.展开更多
On September 5,2022,at least 10,855 landslides had been triggered by a magnitude Mw 6.7(Ms 6.8)earthquake on the eastern margin of the Tibetan Plateau.Unfortunately,a detailed analysis of the spatial patterns of lands...On September 5,2022,at least 10,855 landslides had been triggered by a magnitude Mw 6.7(Ms 6.8)earthquake on the eastern margin of the Tibetan Plateau.Unfortunately,a detailed analysis of the spatial patterns of landslides in the eastern margin of the Baryan Har block is lacking.The observations show that the highest landslide concentrations are distributed along the seismogenic fault(Moxi fault)and Dadu River valley,coinciding with the effects of the hanging wall and microepicenter.Seismogenic tectonics controlled the regional distribution of new landslides,and the local topography influenced the detailed positions on the slopes.The total landslide mass wasting volume was 223.1×10^(6)m^(3),and the maximum occurred in the Wandong Basin(value of 74×10^(6)m^(3)).Thirty landslide dams were temporarily existing.Although some local collapses occurred at the toe of the Hailuogou glacier,seismic shaking had no obvious influence on the overall stability of the glacier.A post debris flow assessment indicates that some large basins contained much loose material and that some steep small basins had high debris flow susceptibility.On the eastern margin of the Bayan Har block,the landslide-triggering thrust and strike-slip events both follow the distributions of the hanging wall.展开更多
Aiming at the problem of low accuracy of interpolation error calculation of existing NURBS curves, an approximate method for the distance between a point and a NURBS interpolation curve is proposed while satisfying th...Aiming at the problem of low accuracy of interpolation error calculation of existing NURBS curves, an approximate method for the distance between a point and a NURBS interpolation curve is proposed while satisfying the accuracy of the solution. Firstly, the minimum parameter interval of the node vector corresponding to the data point under test in the original data point sequence is determined, and the parameter interval is subdivided according to the corresponding step size, and the corresponding parameter value is obtained. Secondly, the distance from the measured point to the NURBS curve is calculated, and the nearest distance is found out. The node interval is subdivided again on one side of the nearest distance. Finally, the distance between the data point to be measured and each subdivision point is calculated again, and the minimum distance is taken as the interpolation error between the point and the NURBS curve. The simulation results of actual tool position data show that this method can more accurately obtain the error of spatial NURBS interpolation curve.展开更多
The DNA replication stress(RS)response is crucial for maintaining cellular homeostasis and promoting physiological longevity.However,the mechanisms by which long-lived species,such as bats,regulate RS to maintain geno...The DNA replication stress(RS)response is crucial for maintaining cellular homeostasis and promoting physiological longevity.However,the mechanisms by which long-lived species,such as bats,regulate RS to maintain genomic stability remain unclear.Also,recent studies have uncovered noncanonical roles of ribosome-associated factors in maintaining genomic stability.In this study,somatic skin fibroblasts from the long-lived big-footed bat(Myotis pilosus)were examined,with results showing that bat cells exhibited enhanced RS tolerance compared to mouse cells.Comparative transcriptome analysis under RS conditions revealed pronounced species-specific transcriptional differences,including robust up-regulation of ribosome biogenesis genes in bat cells and a markedly reduced activation of the P53 signaling pathway.These features emphasize a distinct homeostatic strategy in bat cells.Nuclear fragile X mental retardation-interacting protein 1(Nufip1),a ribosome-associated factor highly expressed in bat fibroblasts,was identified as a potential integrator of ribosomal and P53 signaling via its association with ribosomal protein S27-like(Rps27l).These findings provide direct cellular and molecular evidence for a noncanonical RS response in bats,highlighting a deeper understanding of the biological characteristics and genomic maintenance mechanisms of long-lived species.展开更多
A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts ...A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts a numerical investigation of the transverse VIV characteristics of a piggyback pipeline at low Reynolds numbers, as the vortex shedding modes and vibration characteristics can be accurately represented under laminar flow conditions with minimal computational expense. The effects of influential factors, such as the mass ratio, position angle of the small pipe relative to the main pipe, and Reynolds number, on the VIV amplitude, frequency, vibration center, and mean lift coefficient are specifically examined. The results indicate that the mass ratio has a limited effect on the maximum VIV amplitude. However, as the mass ratio decreases, the lock-in region expands, and the vibration center of the piggyback pipeline deviates further from its original position. The VIV amplitude is minimized, and the lock-in region is the narrowest at a position angle of 45°, whereas the vibration center reaches its maximum displacement at a position angle of 135°. As the Reynolds number increases, the VIV amplitude slightly increases, accompanied by convergence of the vibration center toward its initial position. The mean lift coefficient and wake vortices are also analyzed to establish a connection with the vibration characteristics of the piggyback pipeline. The optimal configuration of the piggyback pipeline is also proposed on the basis of the present numerical results.展开更多
基金supported by the National Natural Science Foundation of China(32241045,32241046,32241038)the Major Special Science and Technology Projects in Shanxi Province(202101140601027)+3 种基金Shanxi Provincial Agricultural Key Technologies Breakthrough Project(NYGG01)Doctoral Research Starting Project at Shanxi Agricultural University(2024BQ77)the National Key Research and Development Program of China(2023YFD1202705/2023YFD120270503,2023YFD1202703/2023YFD1202703-4)Shanxi HouJi Laboratory Self-proposed Research Project(202304010930003/202304010930003-03).
文摘Common bean(Phaseolus vulgaris L.)is a vital source of protein and essential nutrients for human consumption and plays a key role in sustainable agriculture due to its nitrogen-fixing ability(Nadeem et al.,2021).Kidney beans,a subcategory of dry common beans,are highly valued for their rich protein,dietary fiber,low fat content,and various trace elements(Garcia-Cordero et al.,2021).Despite the release of several de novo genome assemblies(Goodstein et al.,2012;Schmutz et al.,2014;Vlasova et al.,2016;Cortinovis et al.,2024),existing common bean genomes remain incomplete,particularly in complex regions such as centromeres and telomeres,limiting a comprehensive understanding of the genomic landscape.
基金supported by the National Natural Science Funding of China(Grant No.82170351)the Special Fund for Key R&D Plans(Social Development)of Jiangsu Province(Grant No.BE2019754)Kanion Pharmaceutical Group,Lianyungang,Jiangsu,China。
文摘The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary intervention(PCI)significantly improved the patency of the infarct-related artery in patients with STsegment elevation myocardial infarction(STEMI),who were expected to undergo PCI within 120 min.The present study aimed to investigate the one-year clinical outcomes and the effect of the anti-r-SAK antibodies on a second r-SAK thrombolysis in OPTIMA-5 patients.The clinical outcome measured was major adverse cardiovascular events(MACE)within 360 days.Patients'anti-r-SAK antibody levels were determined on day 90(±7 days),day 180(±7 days),and day 360(±14 days)after thrombolysis,and in vitro r-SAK antibody neutralization experiments were performed to explore an optimal interval for a second r-SAK thrombolysis.Results showed that the MACE incidence was numerically lower in the r-SAK group compared with the normal saline(NS)group(14.0%vs.20.0%,hazard ratio[HR]=0.67,95%confidence interval[CI]:0.34–1.32;log-rank P=0.245).The anti-r-SAK antibody levels in the r-SAK group decreased with time,but remained significantly higher than those in the NS group on day 90(±7 days)(2.96±0.68 vs.0.22±0.53,P<0.001),day 180(±7 days)(2.19±0.74 vs.0.44±0.65,P<0.001),and day 360(±14 days)(1.73±0.97 vs.0.37±0.71,P<0.001).The in vitro anti-r-SAK antibody neutralization experiments demonstrated that the thrombolysis rate decreased exponentially as the antibody titer increased from 1.90 to 2.20(67.80%±14.19%vs.44.32%±21.54%,P<0.0001).Therefore,for STEMI patients who are expected to undergo PCI within 120 min,a single bolus of half-dose rSAK before primary PCI may reduce the one-year MACE risk.The anti-r-SAK antibody persists over one year,and a second r-SAK thrombolysis may not be indicated until at least one year after the first administration,if necessary.
基金supported by the National Natural Science Foundation of China,No.81671891
文摘Dexmedetomidine has sedative, anxiolytic, analgesic, anti-sympathetic, and anti-shivering effects. Dexmedetomidine might be effective in combination with sevoflurane for anesthesia, but prospective randomized controlled clinical trials with which to verify this hypothesis are lacking. In total, 120 patients who underwent embolization of an intracranial aneurysm were recruited from Anhui Provincial Hospital and Renmin Hospital of Wuhan University of China and randomly allocated to two groups. After intraoperative administration of 2% to 3% sevoflurane inhalation, one group of patients received pump-controlled intravenous injection of 1.0 ~tg/kg dexmedetomidine for 15 minutes followed by maintenance with 0.3 ~tg/kg/h until the end of surgery; the other group of patients only underwent pump-controlled infusion of saline. Bispectral index monitoring revealed that dexmedetomidine-assisted anesthesia can shorten the recovery time of spon- taneous breathing, time to eye opening, and time to laryngeal mask removal. Before anesthetic induction and immediately after laryngeal mask airway removal, the glucose and lactate levels were low, the S100~ and neuron-specific enolase levels were low, the perioperative blood pressure and heart rate were stable, and postoperative delirium was minimal. These findings indicate that dexmedetomidine can effectively assist sevoflurane for anesthesia during surgical embolization of intracranial aneurysms, shorten the time to consciousness and extubation, reduce the stress response and energy metabolism, stabilize hemodynamic parameters, and reduce adverse reactions, thereby reducing the damage to the central nervous system. This trial was registered at the Chinese Clinical Trial Registry （http：//www.chictr.org. cn/） （registration number： ChiCTR-IPR- 16008113）.
基金supported by the National Key R&D Program of China(No.2021YFA1601003)the financial support of the SSRF PhaseⅡproject.
文摘This paper describes the design and performance of the tender energy spectroscopy beamline(BL16U1),a phase Ⅱ beamline,at the Shanghai Synchrotron Radiation Facility.The beamline,based on an in-vacuum undulator source with 26 mm period,provides an operable energy range between 2.1 keV and 16 keV,covering the K-edges of P to Rb and L3-edges of Zr to Bi.The principal optical elements of the beamline are a toroidal mirror,a liquid nitrogen-cooled double-crystal monochromator,a high-harmonic-rejection mirror,and two pairs of Kirkpatrick–Baez(KB)mirrors.Three end-stations,including non-focusing,microprobe,and sub-microprobe types,are installed on the beamline.X-ray fluorescence(XRF)and X-ray absorption spectroscopy(XAS),including X-ray absorption near-edge structure(XANES)and extended X-ray absorption fine structure(EXAFS),are performed under vacuum or He atmosphere at the non-focusing end-station(with a beam spot size of∼670μm×710μm).Using two KB mirrors systems,micro-XRF(μXRF)mapping and micro-XANES(μXANES)studies can be performed with a spot size of approximately∼3.3μm×1.3μm at the microprobe end-station and with a smaller spot size of∼0.5μm×0.25μm at the sub-microprobe end-station.The non-focusing end-station was officially opened to users in January 2024.The microprobe and sub-microprobe end-stations will be opened to users in the near future.This paper presents the characteristics,short-term technical developments,and early experimental results of this new beamline.
文摘As China is accelerating into an aging society,the coexistence of multiple diseases,multiple drugs,and the decline of body function are serious problems faced by elderly patients.Therefore,it is imperative to carry out the comprehensive prevention and control of chronic diseases,strengthen the health guidance and comprehensive intervention of common and chronic diseases of the elderly,and strengthen the health management of elderly patients.Collaborative drug therapy management(CDTM)is a drug treatment management mode that emerged in pharmaceutical services under the situation of new medical reform,aiming to expand the role of pharmacists in the medical team and improve the quality of hospital medical service.Although CDTM has shown some favorable effects in managing chronic diseases in the elderly population,the popularization of CDTM in China is limited by the differences in supporting facilities,management mode,and pharmacist’s abilities in hospitals.By exploring the CDTM mode for elderly patients with chronic diseases,we provided a reference for further promoting the CDTM services and laid a good foundation for displaying pharmacist value and the realization of real pharmaceutical care.
基金This work was funded by the Youth Innovation Promotion Association of Chinese Academy of Sciences(CAS)(Grant No.2015334)' the National Natural Science Foundation of China(Grant No.11941002)。
文摘The Low-Frequency Radio Spectrometer(LFRS)is a scientific payload onboard the Chang’e-4 lunar lander launched in December 2018.The LFRS provides in-situ measurements of the low-frequency radio phenomena on the far-side of theMoon for the first time in human history.To evaluate the performance of the LFRS,a series of ground experiments are conducted using an engineering model of the LFRS.It is not easy to perform the experiments because the Electro Magnetic Interference(EMI)from the Chang’e-4 lunar lander itself and the environment is very intense.The results after EMI mitigation show that the sensitivity of the LFRS may be 10^(−18)W m^(−2)Hz^(−1).
基金This work was supported in part by National Natural Science Foundation of China(No.51805312)in part by Shanghai Sailing Program(No.18YF1409400)+2 种基金in part by Training and Funding Program of Shanghai College young teachers(No.ZZGCD15102)in part by Scientific Research Project of Shanghai University of Engineering Science(No.2016-19)in part by the Shanghai University of Engineering Science Innovation Fund for Graduate Students(No.18KY0613).
文摘Vision-based technologies have been extensively applied for on-street parking space sensing,aiming at providing timely and accurate information for drivers and improving daily travel convenience.However,it faces great challenges as a partial visualization regularly occurs owing to occlusion from static or dynamic objects or a limited perspective of camera.This paper presents an imagery-based framework to infer parking space status by generating 3D bounding box of the vehicle.A specially designed convolutional neural network based on ResNet and feature pyramid network is proposed to overcome challenges from partial visualization and occlusion.It predicts 3D box candidates on multi-scale feature maps with five different 3D anchors,which generated by clustering diverse scales of ground truth box according to different vehicle templates in the source data set.Subsequently,vehicle distribution map is constructed jointly from the coordinates of vehicle box and artificially segmented parking spaces,where the normative degree of parked vehicle is calculated by computing the intersection over union between vehicle’s box and parking space edge.In space status inference,to further eliminate mutual vehicle interference,three adjacent spaces are combined into one unit and then a multinomial logistic regression model is trained to refine the status of the unit.Experiments on KITTI benchmark and Shanghai road show that the proposed method outperforms most monocular approaches in 3D box regression and achieves satisfactory accuracy in space status inference.
基金This work was financially supported by Jiangxi Provincial Natural Science Foundation(No.20202BABL204049)Education Department of Jiangxi Province(No.GJJ170898)+3 种基金Science and technology project of Yichun University(No.2017DF001)Doctor yang received his funding from Jiangxi Provincial Natural Science Foundation(No.20202BABL204049)Doctor Jun Zhou received his funding from Education Department of Jiangxi Province(No.GJJ170898)Science and technology project of Yichun University(No.2017DF001).
文摘Traditional carbon layer enwrapping active materials cannot easily realize perfect cladding.Therefore,it still cannot prevent the pulverization of active materials during the course of charging/discharging.In this paper,we utilize natural bacteria to absorb nickel acetate,the active materials Ni3P nanoparticles are well enwrapped,as a natural organisms surviving for billions of years,their cell walls have a perfect carbon structure,and the cell walls become carbon layer through high annealing temperature.Based on this,the yolk-shell Ni3P–carbon@reduced graphene oxides paper is prepared,through a proper annealing temperature,the Ni3P particles disperse in the inner surface or both ends,so the active materials were prevented from dissolving into the electrolyte,so it may keep from invalidity during charging/discharging.The electrochemical performances display that it has stable and high capacities as Li-ion batteries(LIBs)anode.Its capacity can keep 200 cycles without any decrease,and especially its rate performance exhibits an excellent peculiarity,with the current density increasing from 400 to 1000 mA g^(−1) every 200 mA g^(−1),its capacities decrease only 9.8%,2.9%and 6.4%,and its can recover the same capacity when the current density comes back to 200 mA g^(−1).It may be a fine choice for LIBs.
基金supported by the National Key R&D Program of China under Grant 2024YFE0203500Xiaomi Young Talents Program。
文摘In the applications such as food production,the environmental temperature should be measured continuously dur-ing the entire process,which requires an ultra-low-power temperature sensor for long-termly monitoring.Conventional tempera-ture sensors trade the measurement accuracy with power consumption.In this work,we present a battery-free wireless tempera-ture sensing chip for long-termly monitoring during food production.A calibrated oscillator-based CMOS temperature sensor is proposed instead of the ADC-based power-hungry circuits in conventional works.In addition,the sensor chip can harvest the power transferred by a remote reader to eliminate the use of battery.Meanwhile,the system conducts wireless bidirectional communication between the sensor chip and reader.In this way,the temperature sensor can realize both a high precision and battery-free operation.The temperature sensing chip is fabricated in 55 nm CMOS process,and the reader chip is imple-mented in 65 nm CMOS technology.Experimental results show that the temperature measurement error achieves±1.6℃ from 25 to 50℃,with battery-free readout by a remote reader.
基金Supported by State Grid Zhejiang Electric Power Co.,Ltd.Science and Technology Project Funding(No.B311DS230005).
文摘To address the issue of coordinated control of multiple hydrogen and battery storage units to suppress the grid-injected power deviation of wind farms,an online optimization strategy for Battery-hydrogen hybrid energy storage systems based on measurement feedback is proposed.First,considering the high charge/discharge losses of hydrogen storage and the low energy density of battery storage,an operational optimization objective is established to enable adaptive energy adjustment in the Battery-hydrogen hybrid energy storage system.Next,an online optimization model minimizing the operational cost of the hybrid system is constructed to suppress grid-injected power deviations with satisfying the operational constraints of hydrogen storage and batteries.Finally,utilizing the online measurement of the energy states of hydrogen storage and batteries,an online optimization strategy based on measurement feedback is designed.Case study results show:before and after smoothing the fluctuations in wind power,the time when the power exceeded the upper and lower limits of the grid-injected power accounted for 24.1%and 1.45%of the total time,respectively,the proposed strategy can effectively keep the grid-injected power deviations of wind farms within the allowable range.Hydrogen storage and batteries respectively undertake long-term and short-term charge/discharge tasks,effectively reducing charge/discharge losses of the Battery-hydrogen hybrid energy storage systems and improving its operational efficiency.
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20603 and U21A2008)the Science Technology Research Program of the Institute of Mountain Hazards and Environment,Chinese Academy of Sciences(Grant No.IMHE-ZYTS-03).
文摘On September 5,2022,at least 10,855 landslides had been triggered by a magnitude Mw 6.7(Ms 6.8)earthquake on the eastern margin of the Tibetan Plateau.Unfortunately,a detailed analysis of the spatial patterns of landslides in the eastern margin of the Baryan Har block is lacking.The observations show that the highest landslide concentrations are distributed along the seismogenic fault(Moxi fault)and Dadu River valley,coinciding with the effects of the hanging wall and microepicenter.Seismogenic tectonics controlled the regional distribution of new landslides,and the local topography influenced the detailed positions on the slopes.The total landslide mass wasting volume was 223.1×10^(6)m^(3),and the maximum occurred in the Wandong Basin(value of 74×10^(6)m^(3)).Thirty landslide dams were temporarily existing.Although some local collapses occurred at the toe of the Hailuogou glacier,seismic shaking had no obvious influence on the overall stability of the glacier.A post debris flow assessment indicates that some large basins contained much loose material and that some steep small basins had high debris flow susceptibility.On the eastern margin of the Bayan Har block,the landslide-triggering thrust and strike-slip events both follow the distributions of the hanging wall.
文摘Aiming at the problem of low accuracy of interpolation error calculation of existing NURBS curves, an approximate method for the distance between a point and a NURBS interpolation curve is proposed while satisfying the accuracy of the solution. Firstly, the minimum parameter interval of the node vector corresponding to the data point under test in the original data point sequence is determined, and the parameter interval is subdivided according to the corresponding step size, and the corresponding parameter value is obtained. Secondly, the distance from the measured point to the NURBS curve is calculated, and the nearest distance is found out. The node interval is subdivided again on one side of the nearest distance. Finally, the distance between the data point to be measured and each subdivision point is calculated again, and the minimum distance is taken as the interpolation error between the point and the NURBS curve. The simulation results of actual tool position data show that this method can more accurately obtain the error of spatial NURBS interpolation curve.
基金supported by the Applied Basic Research Programs of Science and Technology Commission Foundation of Yunnan Province(202401AT070186 to K.Q.L.,202201AS070044 to B.Z.)Yunnan Province(202305AH340006 to B.Z.)Kunming Science and Technology Bureau(2022SCP007 to B.Z.)。
文摘The DNA replication stress(RS)response is crucial for maintaining cellular homeostasis and promoting physiological longevity.However,the mechanisms by which long-lived species,such as bats,regulate RS to maintain genomic stability remain unclear.Also,recent studies have uncovered noncanonical roles of ribosome-associated factors in maintaining genomic stability.In this study,somatic skin fibroblasts from the long-lived big-footed bat(Myotis pilosus)were examined,with results showing that bat cells exhibited enhanced RS tolerance compared to mouse cells.Comparative transcriptome analysis under RS conditions revealed pronounced species-specific transcriptional differences,including robust up-regulation of ribosome biogenesis genes in bat cells and a markedly reduced activation of the P53 signaling pathway.These features emphasize a distinct homeostatic strategy in bat cells.Nuclear fragile X mental retardation-interacting protein 1(Nufip1),a ribosome-associated factor highly expressed in bat fibroblasts,was identified as a potential integrator of ribosomal and P53 signaling via its association with ribosomal protein S27-like(Rps27l).These findings provide direct cellular and molecular evidence for a noncanonical RS response in bats,highlighting a deeper understanding of the biological characteristics and genomic maintenance mechanisms of long-lived species.
基金financially supported by the National Natural Science Foundation of China (Grant Nos. 52371289 and 51979192)。
文摘A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts a numerical investigation of the transverse VIV characteristics of a piggyback pipeline at low Reynolds numbers, as the vortex shedding modes and vibration characteristics can be accurately represented under laminar flow conditions with minimal computational expense. The effects of influential factors, such as the mass ratio, position angle of the small pipe relative to the main pipe, and Reynolds number, on the VIV amplitude, frequency, vibration center, and mean lift coefficient are specifically examined. The results indicate that the mass ratio has a limited effect on the maximum VIV amplitude. However, as the mass ratio decreases, the lock-in region expands, and the vibration center of the piggyback pipeline deviates further from its original position. The VIV amplitude is minimized, and the lock-in region is the narrowest at a position angle of 45°, whereas the vibration center reaches its maximum displacement at a position angle of 135°. As the Reynolds number increases, the VIV amplitude slightly increases, accompanied by convergence of the vibration center toward its initial position. The mean lift coefficient and wake vortices are also analyzed to establish a connection with the vibration characteristics of the piggyback pipeline. The optimal configuration of the piggyback pipeline is also proposed on the basis of the present numerical results.
