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In-situ bond-assisted aqueous binder for enhancing sodium storage in ionic conductor-modified black phosphorus/carbon anodes 被引量:1
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作者 bo yan Longfeng Chen +6 位作者 yanping Li Hui Ma Wei Xiao Meihua Zhong Lulu Zhang Xuelin yang Xifei Li 《Journal of Energy Chemistry》 2025年第4期188-199,共12页
Black phosphorus(BP)is recognized as a promising anode for sodium-ion batteries(SIBs)due to its high safety and theoretical capacity.However,traditional ball milling methodologies for fabricating BP composite anodes h... Black phosphorus(BP)is recognized as a promising anode for sodium-ion batteries(SIBs)due to its high safety and theoretical capacity.However,traditional ball milling methodologies for fabricating BP composite anodes have not satisfactorily addressed the challenges of poor rate performance and short cycle life.To fill this scientific gap,we herein pioneer incorporating the sodium fast ionic conductorβ"-Al_(2)O_(3)into ball-milled BP with carbon,which facilitates the formation of three-dimensional mass transfer channels in the resulting composite.To stabilize these channels,we develop a novel and environmentally friendly functional binder that outperforms traditional binders in thermal stability,wettability,and mechanical properties.The newly established binder is capable of remarkably mitigating volume expansion and interfacial side reactions in the BP/β"-Al_(2)O_(3)/C composite anode.Additionally,we identify synergistic effects of the binder interacting with the BP/β"-Al_(2)O_(3)/C composite during cycling,characterized by the in-situ formation of P-O-C bonds,which is the first instance of a strong,durable chemical bond between the binder and the active material to the best of our knowledge.These advancements allow the composite electrode to exhibit exceptional sodium storage,including high initial Coulombic efficiency and long-term cycling stability,which surpasses most previous phosphorus-based anodes fabricated via traditional approaches.Notably,when paired with a Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_7(NFPP)cathode,the full cell exhibits unexpectedly high energy and power densities,highlighting the BP potential in SIBs.The findings presented in the present work contribute to the promotion of economical and efficient applications of phosphorus-based anode materials. 展开更多
关键词 Black phosphorus anodes Fast ionic conductors Aqueous functional binders In-situ chemical bonds Sodium storage properties
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Zircon U-Pb dating of metagabbro masses from the Liwu Group Complex within the Taka dome:Geochronological constraints on the Indosinian-Yanshanian tectonic events in western Sichuan,China
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作者 Hong-chao Zhang Hong-bing Zhou +7 位作者 bo yan Chong-bo Sun Yue-zhong Wang Yun-chuan Zhao Yao Wen Ren-liang Cao yang Qin Hong-qi Tan 《China Geology》 2025年第4期865-868,I0004-I0006,共7页
1.Objective The Songpan-Ganze terrane is a key region for understanding the tectonic evolution of the Tibetan Plateau and the Yangtze Craton.The Songpan-Ganzi complex comprises a thick succession of deformed Ladinian-... 1.Objective The Songpan-Ganze terrane is a key region for understanding the tectonic evolution of the Tibetan Plateau and the Yangtze Craton.The Songpan-Ganzi complex comprises a thick succession of deformed Ladinian-Norian turbidites(ca.230-203 Ma),covering about 200000 km^(2)of the eastern Tibet Plateau with a volume of approximately 2.0×10^(6)km^(3)(Fig.1a).Furthermore,this complex has over 100 Permian-Cenozoic felsic plutons. 展开更多
关键词 u pb dating INDOSINIAN zircon METAGABBRO taka dome YANSHANIAN liwu group complex tectonic events
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采用基因测序鉴定ABO疑难血型12例 被引量:6
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作者 赵媛 薄艳 +1 位作者 冯强 李代红 《中国输血杂志》 CAS 2020年第6期637-639,共3页
目的采用基因测序方法鉴定12例ABO疑难血型。方法 2018年1月—2019年6月收集本院正反定型不符的疑难血型标本12例,采用基因测序方法检测基因型。结果 12例标本基因型分别为2例A201/B01、1例Bx01/O01、1例Bw11/O01、1例A102/Bx14、1例B01... 目的采用基因测序方法鉴定12例ABO疑难血型。方法 2018年1月—2019年6月收集本院正反定型不符的疑难血型标本12例,采用基因测序方法检测基因型。结果 12例标本基因型分别为2例A201/B01、1例Bx01/O01、1例Bw11/O01、1例A102/Bx14、1例B01/O01、1例A102/O01、1例A102/O02、2例在A101/B01基础上分别发生150G>C、240T>C新突变、1例B01/B01发生431G>T新突变、1例O02/O02其FUT1及FUT2分别发生35C>T及357C>T突变。结论基因测序可以辅助血清学鉴定疑难血型,但仍存在一定的局限性。 展开更多
关键词 血型 血清学 基因型 基因测序
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Machine learning combined with the PMF model reveals the sources and driving factors of PAHs and Cl-PAHs in urban runoff
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作者 Li Li Hai Huang +5 位作者 Pei Hua Tao Chen Jin Zhang Peng Deng Zongxi Zhao bo yan 《Journal of Environmental Sciences》 2026年第2期174-184,共11页
Urban rainwater runoff is an important source of nonpoint source pollution due to its transport of diverse contaminants,including polycyclic aromatic hydrocarbons(PAHs)and chlorinated derivatives.Importantly,these chl... Urban rainwater runoff is an important source of nonpoint source pollution due to its transport of diverse contaminants,including polycyclic aromatic hydrocarbons(PAHs)and chlorinated derivatives.Importantly,these chlorinated polycyclic aromatic hydrocarbons(Cl-PAHs)exhibit elevated toxicological potential compared to their non-halogenated parent compounds.In this study,we proposed an approach that combined multivariate receptor model with integration of SHapley Additive exPlanations and Random Forest model.This method identifies the possible sources and reveals the impact of source apportionment results and environmental driving factors(such as geographical and meteorological data)on pollutant concentrations.Sixteen PAHs and nine ClPAHs were detected in 79 runoff samples from all three sites.TheΣ_(16)PAHs average concentration(2923.93 to 6071.83 ng/L)was significantly higher than theΣ_(9)Cl-PAHs(384.34 to 1314.73 ng/L).The source apportionment was conducted by positive matrix factorization(PMF),and six potential pollution sources for PAHs and three for Cl-PAHs were quantified.PAHs primarily originate from the combustion of fossil fuels such as traffic,industrial emissions and coal tar,while Cl-PAHs are mainly derived from atmospheric deposition and industrial emissions.Meanwhile,the self‑organizing map classified PAHs and Cl-PAHs into 2 and 3 groups,respectively.The k-means algorithm yielded 4 clusters for runoff samples.Among machine learning models,Random Forest(RF)demonstrated optimal predictive performance and integrated with SHapley Additive exPlanations(RF-SHAP)revealed the effects of driving factors on the predicted concentration of PAHs and Cl-PAHs in urban runoff samples. 展开更多
关键词 Machine learning PAHS Cl-PAHs Positive matrix factorization RUNOFF Shapley additive explanations
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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis
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作者 Ze-Xi Jia Meng-Tian Guo +11 位作者 Mei-Mei Li Pan Liao bo yan Wei Zhang Fang-Yuan Cheng Ya-Ru Liu Zi-Han Zhang Cheng Wei Jie Zhou Fang-Lian Chen Ping Lei Xin-Tong Ge 《Military Medical Research》 2026年第1期24-42,共19页
Background:Repetitive mild traumatic brain injury(rmTBI)is a significant risk factor for neurodegeneration,characterized by pathological protein deposition and persistent neuroinflammation.Research has observed increa... Background:Repetitive mild traumatic brain injury(rmTBI)is a significant risk factor for neurodegeneration,characterized by pathological protein deposition and persistent neuroinflammation.Research has observed increased interleukin-33(IL-33)levels in the peripheral blood of patients with rmTBI,suggesting IL-33 may participate in regulating the pathological development of rmTBI.The study aims to elucidate the impact and mechanism of IL-33 in the progression of neuropathology following rmTBI,and to explore its potential as a therapeutic target to improve the neurological outcome.Methods:The study employed an rmTBI mouse model using the wild-type(WT)and IL-33 knockout mice.Cognitive function was assessed via the Y-maze and Barnes tests.The main cell type expressing IL-33 and its receptor,suppression of tumorigenicity 2(ST2),was then investigated in the mouse brain through immunofluorescence colocalization.As the primary neural cell responsible for ST2 expression,microglia were studied in vitro using the BV2 cell line.The effects of lipid droplets(LDs)accumulation and amyloid-beta(Aβ)phagocytosis were measured to elucidate the impact of IL-33 on BV2 cells'phagocytosis.Additionally,HT22 neuronal apoptosis was assessed by flow cytometry.Finally,the cognitive effects of intranasal administration of IL-33 were evaluated in mice.Results:IL-33 KO mice exhibited pronounced cognitive impairment after rmTBI.In the mouse brain,astrocytes were identified as the primary source of IL-33 secretion,while microglia predominantly expressed ST2.Transcriptome sequencing revealed that IL-33 significantly influenced phagocytosis function.IL-33 mitigated LDs accumulation in BV2 cells and enhanced Aβphagocytosis in vitro.In addition,the culture medium of BV2 cells with activated IL-33/ST2 signaling reduced HT22 neuronal apoptosis and axonal damage.Furthermore,intranasal administration of IL-33 was observed to be effective in alleviating neurodegeneration and cognitive outcome of rmTBI mice.Conclusions:Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage.IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI. 展开更多
关键词 Repetitive mild traumatic brain injury(rmTBI) Interleukin-33(IL-33) Microglia Cognition
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Compact dual MOT apparatus of K and Rb for optical tweezer experiment
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作者 Kedi Wei yangbo Wei +1 位作者 Shangjin Li bo yan 《Chinese Physics B》 2026年第1期425-430,共6页
The optical tweezer experiment with neutral atoms is widely used for quantum information research.Here,we present a compact dual magneto-optical trap(MOT)setup for a two-species optical tweezer.Rubidium(Rb)atoms are d... The optical tweezer experiment with neutral atoms is widely used for quantum information research.Here,we present a compact dual magneto-optical trap(MOT)setup for a two-species optical tweezer.Rubidium(Rb)atoms are directly captured using a vapor MOT,while potassium(K)atoms are collected via a 2-stage MOT.Both the quadratic and gradient magnetic fields required for the MOT and Zeeman slower are created by permanent magnets.With the help of the Zeeman slower,the K MOT loading efficiency is enhanced by a factor of three.After the MOT stage,we apply D_(1) gray molasses to reduce the temperature of the K atoms to 9μK.Using this apparatus,both Rb and K are loaded into the optical tweezer. 展开更多
关键词 ATOM MOLECULE ion cooling methods atom cooling methods
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Epidemiological and clinical characteristics of COVID-19 patients in Hengyang,Hunan Province,China 被引量:3
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作者 Zhe-Feng Zhong Jia Huang +19 位作者 Xia yang Jin-Ling Peng Xiao-yan Zhang yang Hu Nian Fu Hai-Lian Lin bo Jiang Ya-Ying Tian Hong-Yi Yao Li-Pu Deng Xiao-Qing Tang Jie-Can Zhou Jian Tang Xia Xie Qiong Liu Jing Liu Cheng-Yun Dou Rong-Juan Dai bo yan Xue-Feng yang 《World Journal of Clinical Cases》 SCIE 2020年第12期2554-2565,共12页
BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully repre... BACKGROUND In December 2019,an ongoing outbreak of coronavirus disease 2019(COVID-19)was first identified in Wuhan,China.The characteristics of COVID-19 patients treated in local hospitals in Wuhan are not fully representative of patients outside Wuhan.Therefore,it is highly essential to analyze the epidemiological and clinical characteristics of COVID-19 in areas outside Wuhan or Hubei Province.To date,a limited number of studies have concentrated on the epidemiological and clinical characteristics of COVID-19 patients with different genders,clinical classification,and with or without basic diseases.AIM To study the epidemiological and clinical characteristics of COVID-19 patients in Hengyang(China)and provide a reliable reference for the prevention and control of COVID-19.METHODS From January 16 to March 2,2020,a total of 48 confirmed cases of COVID-19 were reported in Hengyang,and those cases were included in this study.The diagnostic criteria,clinical classification,and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia(Trial Version 7)released by National Health Commission and National Administration of Traditional Chinese Medicine.The presence of SARS-CoV-2 in pharyngeal swab specimens was detected by quantitative reverse transcription polymerase chain reaction.All the data were imported into the excel worksheet and statistically analyzed by using SPSS 25.0 software.RESULTS A total of 48 cases of COVID-19 were collected,of which 1 was mild,38 were moderate,and 9 were severe.It was unveiled that there were 31(64.6%)male patients and 17(35.4%)female patients,with a female-to-male ratio of 1.82:1.The range of age of patients with COVID-19 was dominantly 30-49 years old[25(52.1%)of 48],followed by those aged over 60 years old[11(22.9%)].Besides,29.2%(14 of 48)of patients had basic diseases,and 57.2%(8 of 14)of patients with basic diseases were aged over 60 years old.The occupations of 48 COVID-19 patients were mainly farmers working in agricultural production[15(31.5%)of 48],rural migrant workers from Hengyang to Wuhan[15(31.5%)],and service workers operating in the service sector[8(16.7%)].The mean latent period was 6.86±3.57 d,and the median was 7[interquartile range(IQR):4-9]d.The mean time from onset of symptoms to the first physician visit was 3.38±2.98(95%CI:2.58-9.18)d,with a median of 2(IQR:1-5)d,and the mean time from hospital admission to confirmed diagnosis was 2.29±2.11(95%CI:1.18-6.42)d,with a median of 2(IQR:1-3)d.The main symptoms were fever[43(89.6%)of 48],cough and expectoration[41(85.4%)],fatigue[22(45.8%)],and chills[22(45.8%)].Other symptoms included poor appetite[13(27.1%)],sore throat[9(18.8%)],dyspnea[9(18.8%)],diarrhea[7(14.6%)],dizziness[5(10.4%)],headache[5(10.4%)],muscle pain[5(10.4%)],nausea and vomiting[4(8.3%)],hemoptysis[4(8.3%)],and runny nose[1(2.1%)].The numbers of peripheral blood leukocytes,lymphocytes,and eosinophils were significantly reduced in the majority of the patients.The levels of C-reactive protein,fibrinogen,blood glucose,lactate dehydrogenase,Ddimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transferase(γ-GT),myoglobin(MB),and creatine kinase(CK)were increased in 64.6%,44.7%,43.2%,37.0%,29.5%,22.9%,20.8%,21.6%,13.6%,and 12.8%of patients,respectively.The incidence of ALT elevation in male patients was remarkably higher than that in females(P<0.01),while the incidences of AST,CK,and blood glucose elevations in severe patients were remarkably higher than those in moderate patients(P<0.05,respectively).Except for the mild patients,chest computed tomography showed characteristic pulmonary lesions.All the patients received antiviral drugs,38(79.2%)accepted traditional Chinese medicine,and 2(4.2%)received treatment of human umbilical-cord mesenchymal stem cells.On March 2,2020,48 patients with COVID-19 were all cured and discharged.CONCLUSION Based on our results,patients with COVID-19 often have multiple organ dysfunction or damage.The incidences of ALT elevation in males,and AST,CK,and blood glucose elevations in severe patients are remarkably higher. 展开更多
关键词 Novel coronavirus pneumonia COVID-19 SARS-CoV-2 EPIDEMIOLOGY Hengyang Coronavirus disease 2019
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Differences in hydrocarbon accumulation and controlling factors of slope belt in graben basin: A case study of Pinghu Slope Belt in the Xihu sag of the east China Sea Shelf basin(ECSSB) 被引量:2
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作者 bo yan Hong-Qi Yuan +5 位作者 Ning Li Wei Zou Peng Sun Meng Li Yue-Yun Zhao Qian Zhao 《Petroleum Science》 SCIE EI CAS CSCD 2024年第5期2901-2926,共26页
The Pinghu slope belt in the Xihu sag of the East China Sea Shelf Basin(ECSSB) is a crucial hydrocarbon production area in eastern China. However, due to the complex geological conditions, publications have lacked com... The Pinghu slope belt in the Xihu sag of the East China Sea Shelf Basin(ECSSB) is a crucial hydrocarbon production area in eastern China. However, due to the complex geological conditions, publications have lacked comprehensive research on the spatial-temporal coupling relationships of primary factors that impact hydrocarbon accumulation in the Pinghu slope belt. Furthermore, the hydrocarbon distribution patterns and the controlling factors across different study areas within the same slope belt are not yet fully understood. This study extensively utilized three-dimensional seismic data, well logging data,geochemical analysis, fluorescence analysis, and oil testing and production data to address these issues.Following a “stratification and differentiation” approach, the study identified seven distinct hydrocarbon migration and accumulation units(HMAU) in the Pinghu slope area based on the structural morphology characteristics, hydrocarbon source-reservoir-cap rock patterns, hydrocarbon migration pathways, and hydrocarbon supply range. Detailed analysis was conducted to examine the hydrocarbon distribution patterns and controlling factors within each migration and accumulation unit across different structural units, including high, medium, and low structural components. All data sources support a “southern-northern sub-area division, eastern-western sub-belt division, and variations in hydrocarbon accumulation” pattern in the Pinghu slope belt. The degree of hydrocarbon accumulation is controlled by the factors of structural morphology, hydrocarbon generation potential of source rocks, the spatial position of source slopes, fault sealing capacity, and sand body distribution. Furthermore, different coupling patterns of faults and sand bodies play a pivotal role in governing hydrocarbon enrichment systems across various migration and accumulation units. These observations indicate that three hydrocarbon accumulation patterns have been established within the slope belt, including near-source to far-source gentle slope with multiple hydrocarbon kitchens in the XP1-XP4 zones, near-source to middle-source gentle slope with dual-hydrocarbon kitchens in the XP5 zone, and near-source steep slope with a single hydrocarbon kitchen in the XP6-XP7 zones. These findings contribute to enhancing the theoretical system of hydrocarbon accumulation in the slope belt. 展开更多
关键词 East China Sea Shelf Basin(ECSSB) Pinghu slope belt Variation in hydrocarbon accumulation Controlling factors of hydrocarbon accumulation Hydrocarbon accumulation pattern
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角色创新与角色协调:中国在全球气候变化治理中的角色成长逻辑 被引量:1
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作者 薄燕 马延滨 《太平洋学报》 北大核心 2025年第7期1-16,共16页
中国在全球气候变化治理中一直是关键的参与者,但中国的角色概念和角色行为在过去三十多年里发生了巨大的变化。这种变化成为很多学者的研究议题。本文试图从新的角度描述和解释这种变化。在与角色理论对话的基础上,本文首先提出角色成... 中国在全球气候变化治理中一直是关键的参与者,但中国的角色概念和角色行为在过去三十多年里发生了巨大的变化。这种变化成为很多学者的研究议题。本文试图从新的角度描述和解释这种变化。在与角色理论对话的基础上,本文首先提出角色成长的概念,强调国家角色成长作为角色变化方式的持续性、方向性和建设性,并提出角色创新和角色协调是实现角色成长的重要路径和逻辑。其次分析了中国在全球气候变化治理中角色成长的实际表现,接着从角色创新和角色协调两个方面探讨中国如何在全球气候变化治理中实现角色成长。中国正是基于内生性的理念创新和实践创新,主动统筹经济发展、国内环境治理和气候变化治理,并通过与全球南方国家和发达国家的积极对话合作,协调国际规则和国内规则,成长为全球气候变化治理中更具雄心的贡献者和引领者。这对广大的全球南方国家而言具有一定的借鉴意义。 展开更多
关键词 全球气候变化治理 角色成长 角色创新 角色协调
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Quantum interference of multi-orbital effects in high-harmonic spectra from aligned carbon dioxide and nitrous oxide
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作者 Hong-Jing Liang Xin Fan +5 位作者 Shuang Feng Li-Yu Shan Qing-Hua Gao bo yan Ri Ma Hai-Feng Xu 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第9期27-31,共5页
We investigate experimentally multi-orbital effects in high-order harmonic generation(HHG) from aligned CO2 and N2O molecules by intense femtosecond laser fields with linear and elliptical polarizations.For either of ... We investigate experimentally multi-orbital effects in high-order harmonic generation(HHG) from aligned CO2 and N2O molecules by intense femtosecond laser fields with linear and elliptical polarizations.For either of the aligned molecules, a minimum in the harmonic spectrum is observed, the position of which shifts to lower-order harmonics when decreasing the intensity or increasing the ellipticity of the driving laser.This indicates that the minimum originates from the dynamic interference of different channels, of which the tunneling ionization and recombination are contributed via different molecular orbitals.The results show that both the highest occupied molecular orbital(HOMO) and low-lying HOMO-2 in CO2(or HOMO-1 in N2O) contribute to the molecular HHG in both linearly and elliptically polarized strong laser fields.Our study would pave a way for understanding multi-electron dynamics from polyatomic molecules irradiated by strong laser fields. 展开更多
关键词 high-order HARMONIC generation ALIGNED molecule multi-orbital effect dynamic interference
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Absorption and recovery of n-hexane in aqueous solutions of fluorocarbon surfactants
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作者 Xiao Xiao bo yan +1 位作者 Jiamo Fu Xianming Xiao 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2015年第11期163-171,共9页
n-Hexane is widely used in industrial production as an organic solvent. As an industrial exhaust gas, the contribution of n-hexane to air pollution and damage to human health are attracting increasing attention. In th... n-Hexane is widely used in industrial production as an organic solvent. As an industrial exhaust gas, the contribution of n-hexane to air pollution and damage to human health are attracting increasing attention. In the present study, aqueous solutions of two fluorocarbon surfactants(FSN100 and FSO100) were investigated for their properties of solubilization and dynamic absorption of n-hexane, as well as their capacity for regeneration and n-hexane recovery by thermal distillation. The results show that the two fluorocarbon surfactants enhance dissolution and absorption of n-hexane, and their effectiveness is closely related to their concentrations in solution. For low concentration solutions(0.01%–0.30%), the partition coefficient decreases dramatically and the saturation capacity increases significantly with increasing concentration, but the changes for both are more modest when the concentration is over 0.30%. The FSO100 solution presents a smaller partition coefficient and a greater saturation capacity than the FSN100 solution at the same concentration,indicating a stronger solubilization for n-hexane. Thermal distillation is a feasible method to recover n-hexane from these absorption solutions, and to regenerate them. With 90 sec heating at 80–85°C, the recovery of n-hexane ranges between 81% and 85%, and the regenerated absorption solution maintains its original performance during reuse. This study provides basic information on two fluorocarbon surfactants for application in the treatment of industrial n-hexane waste gases. 展开更多
关键词 Fluorocarbon surfactant n-Hexane Absorption Recovery Regeneration
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全球气候治理制度建设的中国贡献、现实挑战与提升路径
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作者 薄燕 《当代世界》 2025年第12期18-24,共7页
作为全球气候治理的全方位参与者,中国坚定维护联合国多边气候谈判进程的连续性和权威性,推动确立和维护共同但有区别的责任和各自能力原则,推进“一带一路”绿色发展制度化建设,加强双边气候合作,构建和完善国家气候治理制度,为促进全... 作为全球气候治理的全方位参与者,中国坚定维护联合国多边气候谈判进程的连续性和权威性,推动确立和维护共同但有区别的责任和各自能力原则,推进“一带一路”绿色发展制度化建设,加强双边气候合作,构建和完善国家气候治理制度,为促进全球气候治理制度建设作出巨大贡献。在大国战略竞争加剧的时代背景下,全球气候治理制度所面临的普遍性受冲击、有效性不足、融资目标难以实现、碎片化日渐明显等现实挑战更加凸显。全球南方是推动全球气候治理制度增量和增效建设的重要依托,未来需要进一步推动金砖机制和上海合作组织框架下的气候治理合作,提升新兴多边开发银行气候融资能力,加强国际规则和标准的协调衔接,使全球气候治理制度建设朝着更加公平合理的方向发展。 展开更多
关键词 全球气候治理 制度建设 中国贡献
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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis 被引量:5
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作者 Conglin Wang Fangyuan Cheng +9 位作者 Zhaoli Han bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei 《Neural Regeneration Research》 SCIE CAS 2025年第2期518-532,共15页
Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)... Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system diseases.In this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying mechanism.Our results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral hemorrhage.Additionally,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory microenvironment.RNA sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier integrity.Treatment with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these effects.In summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes. 展开更多
关键词 AKT ASTROCYTE blood-brain barrier cerebral edema EXOSOMES human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells NEUROINFLAMMATION PI3K
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基于POE的医养结合机构医疗康复空间优化设计——以呼和浩特市福康老年公寓为例
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作者 博彦 方旭艳 《中外建筑》 2025年第7期21-26,共6页
基于POE使用后评价理论,以呼和浩特市医养结合机构为研究对象,对其医疗康复空间进行系统化评估与优化设计。通过实地调研、问卷调查和深度访谈等方法,构建了包含物理环境、功能性能和行为环境三个维度的评价体系,识别了当前医疗康复空... 基于POE使用后评价理论,以呼和浩特市医养结合机构为研究对象,对其医疗康复空间进行系统化评估与优化设计。通过实地调研、问卷调查和深度访谈等方法,构建了包含物理环境、功能性能和行为环境三个维度的评价体系,识别了当前医疗康复空间在功能布局、设施配置和环境品质等方面存在的主要问题。研究从空间布局优化、功能配置完善和环境品质提升三个层面提出针对性的优化策略,并在选取机构进行优化设计。希望优化后的医疗康复空间在使用效率、环境满意度等方面得到显著提升,为呼和浩特市医养结合机构的空间优化提供参考。 展开更多
关键词 POE 呼和浩特市 医养结合 医疗康复空间 优化设计
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Achieving precise graphenization of diamond coatings below the interfacial thermal stress threshold 被引量:1
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作者 bo yan Ning He +7 位作者 Ni Chen Matthias Weigold Huiwen Chen Shuchen Sun yang Wu Shiyang Fu Liang Li Eberhard Abele 《International Journal of Extreme Manufacturing》 2025年第1期504-520,共17页
Diamond coatings possess numerous excellent properties,making them desirable materials for high-performance surface applications.However,without a revolutionary surface modification method,the surface roughness and fr... Diamond coatings possess numerous excellent properties,making them desirable materials for high-performance surface applications.However,without a revolutionary surface modification method,the surface roughness and friction behavior of diamond coatings can impede their ability to meet the demanding requirements of advanced engineering surfaces.This study proposed the thermal stress control at coating interfaces and demonstrated a novel process of precise graphenization on conventional diamond coatings surface through laser induction and mechanical cleavage,without causing damage to the metal substrate.Through experiments and simulations,the influence mechanism of surface graphitization and interfacial thermal stress was elucidated,ultimately enabling rapid conversion of the diamond coating surface to graphene while controlling the coating’s thickness and roughness.Compared to the original diamond coatings,the obtained surfaces exhibited a 63%-72%reduction in friction coefficients,all of which were below 0.1,with a minimum of 0.06,and a 59%-67%decrease in specific wear rates.Moreover,adhesive wear in the friction counterpart was significantly inhibited,resulting in a reduction in wear by 49%-83%.This demonstrated a significant improvement in lubrication and inhibition of mechanochemical wear properties.This study provides an effective and cost-efficient avenue to overcome the application bottleneck of engineered diamond surfaces,with the potential to significantly enhance the performance and expand the application range of diamond-coated components. 展开更多
关键词 diamond coating GRAPHENE laser thermal stress lubrication and anti-wear
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Soot volume fraction measurements in aero-engine model combustor outlet using two-color laser-induced incandescence
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作者 Linsen WANG Pengji DING +11 位作者 Sijie yan Jie LI Jingwei Zhang Chaozong WANG Zhibo CAO Quan ZHOU Jinhe MU Gang Meng Wenyan SONG Zhenyu XU bo yan Shuang CHEN 《Chinese Journal of Aeronautics》 2025年第3期249-261,共13页
Quantitative measurement of Soot Volume Fraction (SVF) is an essential prerequisite for controlling soot particle emissions from aero-engine combustors. As an in-situ and non-intrusive optical diagnostic technique, La... Quantitative measurement of Soot Volume Fraction (SVF) is an essential prerequisite for controlling soot particle emissions from aero-engine combustors. As an in-situ and non-intrusive optical diagnostic technique, Laser-Induced Incandescence (LII) has been increasingly applied for soot concentration quantification in various combustion environments such as laminar flame, vehicle exhaust, internal combustion chamber as well as aero-engine combustor. In this work, we experimentally measured the spatial and temporal distribution of SVF using two-color LII technique at the outlet of a single-sector dual-swirl aero-engine model combustor. The effect of inlet pressure and air preheat temperature on the SVF distribution was separately investigated within a pressure range of 241–425 kPa and a temperature range of 292–500 K. The results show that soot production increases with the inlet pressure but generally decreases with the air preheat temperature. Qualitative analysis was provided to explain the above results of parametric studies. The LII experiments were also conducted under 3 designed conditions to evaluate soot emission under practical operations. Particularly, weak soot emission was detected at the outlet under the idle condition. Our experimental results provide a valuable benchmark for evaluating soot emission in the exhaust plume of this aero-engine combustor during practical operations. 展开更多
关键词 Aero-engine combustor Combustion diagnostics Soot Volume Fraction(SVF) Laser-Induced Incandescence(II) Inlet pressure Air preheat temperature
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Development of 2C-Scheimpflug planar laser-induced incandescence system for soot concentration measurement at exhaust of aero-engine model combustor
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作者 Sijie yan Pengji DING +8 位作者 Linsen WANG Jie LI Chaozong WANG Quan ZHOU Jinhe MU Wenyan SONG Zhenyu XU bo yan Shuang CHEN 《Chinese Journal of Aeronautics》 2025年第12期122-133,共12页
Precise and quantitative measurement of soot particle emission plays an essential role in accurately assessing the combustion performance of aero-engine combustors and infrared signature levels in aircraft exhausts.Am... Precise and quantitative measurement of soot particle emission plays an essential role in accurately assessing the combustion performance of aero-engine combustors and infrared signature levels in aircraft exhausts.Among various intrusive or non-intrusive approaches for soot diagnostics,Laser-Induced Incandescence(LⅡ)technique has been increasingly applied for soot concentration measurement in various combustion environments such as laminar flames and internal combustion engines due to its high spatial resolution and sensitivity.As for LⅡmeasurement in aero-engine combustors,however,it normally suffers from very limited optical accesses and often faces mandatory requirements of oblique imaging from a small backward angle.In this work,we demonstrate a Two-Color(2C)LⅡsystem that simultaneously captures LⅡsignal images at two distinct wavelengths using a Scheimpflug imaging configuration.A projective transformation algorithm and image overlapping procedures were employed to spatially correct the raw Scheimpflug LⅡimages.Performance validation of the developed 2C-Scheimpflug LⅡsystem was first conducted under specified conditions in a laminar C_(2)H_(4)/air McKenna flame.The obtained Soot Volume Fraction(SVF)level and its spatial distribution are in consistent with previous studies under identical flame conditions reported by other research groups.Finally,as a demonstration of engineering benchmark application,we applied the developed 2C-Scheimpflug LⅡsystem to measure SVF distribution in the cross-section plane perpendicular to the direction of flame propagation at the exhaust of a single-sector dual-swirl aero-engine model combustor.Transient soot production events were observed and characteristics of the SVF distribution were investigated.These experimental results suggest the feasibility of the 2C-Scheimpflug LⅡtechnique developed in this work for precise and quantitative measurements of soot concentration in practical environments. 展开更多
关键词 Aero-engine combustor 2C-Scheimpflug LⅡ Combustion diagnostics Soot diagnostics Soot volume fraction
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NEA Detection Method with Neural Network in Sidereal Tracking
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作者 Yijun Tang Yunxiao Jiang +9 位作者 Zhen Zhang Chenchen Ying Songqi Zhang Liangcheng Liao Junjie Ma bo yan Chunhai Bai Guojie Feng Xiaoming Zhang Xiaojun Jiang 《Research in Astronomy and Astrophysics》 2025年第9期35-49,共15页
Near-Earth Asteroids posed a threat to human civilization,making their monitoring crucial.As the demand for asteroid detection technology increased,precise detection of these celestial bodies became an urgent task to ... Near-Earth Asteroids posed a threat to human civilization,making their monitoring crucial.As the demand for asteroid detection technology increased,precise detection of these celestial bodies became an urgent task to understand their characteristics and assess potential impact risks.To improve asteroid detection accuracy and efficiency,we proposed an advanced image processing method and a deep learning network for automatic asteroid detection.Specifically,we aligned star clusters and overlaid images to exploit asteroid motion rates,transforming them into object-like trajectories and improving the signal-to-noise ratio.This approach created the Asteroid Trajectory Image Data set under various conditions.We modified CenterNet2 network to develop AstroCenterNet by integrating Multi-channel Histogram Truncation for feature enhancement,using the SimAM attention mechanism to expand contextual information and suppress noise,and refining Feature Pyramid Network to improve low-level feature detection.Our results demonstrated a detection accuracy of 98.4%,a recall of 97.6%,a mean Average Precision of 94.01%,a false alarm rate of 1.6%,and a processing speed of approximately 17.86 frames per second,indicating that our method achieves high precision and efficiency. 展开更多
关键词 methods data analysis-techniques image processing-minor planets asteroids general-planets and satellites detection
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Engineering Bipolar Doping in a Janus Dual‑Atom Catalyst for Photo‑Enhanced Rechargeable Zn‑Air Battery
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作者 Ning Liu Yinwu Li +10 位作者 Wencai Liu Zhanhao Liang Bin Liao Fang yang Ming Zhao bo yan Xuchun Gui Hong Bin yang Dingshan Yu Zhiping Zeng Guowei yang 《Nano-Micro Letters》 2025年第9期29-44,共16页
Harnessing solar energy to enhance the rechargeable zinc-air batteries(RZABs)performance is a promising avenue toward sustainable energy storage and conversion.Simultaneously enhancing light-absorption capacity and ca... Harnessing solar energy to enhance the rechargeable zinc-air batteries(RZABs)performance is a promising avenue toward sustainable energy storage and conversion.Simultaneously enhancing light-absorption capacity and carrier separation efficiency in nanomaterials,as well as improving electrical conductivity and configuration for electrocatalysis,presents a formidable challenge due to inherent trade-offs and interdependencies.Here,we have developed a Janus dual-atom catalyst(JDAC)with bifunctional centers for efficient charge separation and electrocatalytic performance through a bipolar doping strategy.The in situ X-ray absorption near-edge structure and Raman spectroscopy analyses demonstrated that the Ni and Fe centers in JDAC not only function as effective sites for oxygen evolution reaction and oxygen reduction reaction,respectively,but also serve as efficient hole and electron enrichment sites,effectively suppressing photoelectron recombination while enhancing photocurrent generation.As a result,the assembled JDAC-based lightassisted RZABs exhibited extraordinary stability at large current densities.This work delivers pivotal insight to design Janus dual-atom catalysts that efficiently convert solar energy into electric and chemical energy. 展开更多
关键词 Janus dual-atom catalyst Bifunctional center Bipolar doping Oxygen redox reaction Fuel cell
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Neural Network Adaptive Hierarchical Sliding Mode Control for the Trajectory Tracking of a Tendon-Driven Manipulator
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作者 Yudong Zhang Leiying He +2 位作者 Jianneng Chen bo yan Chuanyu Wu 《Chinese Journal of Mechanical Engineering》 2025年第2期295-314,共20页
Tracking control of tendon-driven manipulators has become a prevalent research area.However,the existence of flexible elastic tendons generates substantial residual vibrations,resulting in difficulties for trajectory ... Tracking control of tendon-driven manipulators has become a prevalent research area.However,the existence of flexible elastic tendons generates substantial residual vibrations,resulting in difficulties for trajectory tracking control of the manipulator.This paper proposes the radial basis function neural network adaptive hierarchical sliding mode control(RBFNNA-HSMC)method,which combines the dynamic model of the elastic tendon-driven manipulator(ETDM)with radial basis neural network adaptive control and hierarchical sliding mode control technology.The aim is to achieve trajectory tracking control of ETDM even under conditions of model inaccuracy and disturbance.The Lyapunov stability theory demonstrates the stability of the proposed RBFNNA-HSM controller.In order to assess the effectiveness and adaptability of the proposed control method,simulations and experiments were performed on a two-DOF ETDM.The RBFNNA-HSM method shows superior tracking accuracy compared to traditional modelbased HSM control.The experiment shows that the maximum tracking error for ETDM double-joint trajectory tracking is below 2.593×10-3rad and 1.624×10-3rad,respectively. 展开更多
关键词 Elastic tendon-driven manipulator Flexible joint Hierarchical sliding mode control Neural network adaptive control Tracking control
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