In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out...In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out according to Pharmacopoeia regulations.The plasma concentration of animals with self-made Panax japonicus tablets or ginsenoside Rg3 in single-dose intragastric administration was determined by high-performance liquid chromatography(HPLC).The pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.0 software.The quality inspection of self-made Panax japonicus tablets met the requirements of Chinese Pharmacopoeia(2015 edition),and this preparation had high bioequivalence of ginsenoside Rg3.The preparation of Panax japonicus tablets was reasonable and highly qualified.Moreover,this new Panax japonicus preparation showed better profiles in oral absorption and utilization.This study provided evidence for the industrial production and clinical application of Panax japonicus tablets.展开更多
Despite the recent progress of medical technology in the diagnosis and treatment of tumors,pancreatic carcinoma remains one of the most malignant tumors,with extremely poor prognosis partly due to the difficulty in ea...Despite the recent progress of medical technology in the diagnosis and treatment of tumors,pancreatic carcinoma remains one of the most malignant tumors,with extremely poor prognosis partly due to the difficulty in early and accurate imaging evaluation.This paper focuses on the research progress of magnetic resonance imaging,nuclear medicine molecular imaging and radiomics in the diagnosis of pancreatic carcinoma.We also briefly described the achievements of our team in this field,to facilitate future research and explore new technologies to optimize diagnosis of pancreatic carcinoma.展开更多
The double-sided lapping process is extensively employed in the manufacturing of wafers,optical windows,and seal rings due to its high efficiency and ability to achieve precise flatness.However,limited research has ex...The double-sided lapping process is extensively employed in the manufacturing of wafers,optical windows,and seal rings due to its high efficiency and ability to achieve precise flatness.However,limited research has explored the thickness uniformity among different workpieces after double-sided lapping,and the underlying mechanism remains unclear.To address the demand for higher precision,this paper first analyzed the relative kinematic model between the workpiece and the lapping plate to clarify the causes of thickness variations among workpieces after double-sided lapping.Subsequently,a finite element method(FEM)model was developed to account for the pressure distribution on the workpiece surfaces at the initial stage of the process.The results indicate that the number of workpieces influences the final thickness variation.Then,various sets of thin copper plates with different thicknesses were lapped,and the findings revealed that five copper plates processed simultaneously exhibited more uniform thickness compared to the three plates.The experimental results align well with the theoretical analysis.Ultimately,a thickness variation of less than 6μm was achieved on five copper plates measuringΦ100×2.9 mm.This study presents a comprehensive analysis of the mechanisms influencing thickness uniformity in the double-sided lapping process and provides practical guidelines for optimizing the process to achieve stringent precision standards in industrial applications.展开更多
This paper investigates the frictional adhesive contact of a rigid,electrically/magnetically conductive spherical indenter sliding past a multiferroic coating deposed onto a rigid substrate,based on the hybrid element...This paper investigates the frictional adhesive contact of a rigid,electrically/magnetically conductive spherical indenter sliding past a multiferroic coating deposed onto a rigid substrate,based on the hybrid element method.The adhesion behavior is described based on the Maugis-Dugdale model.The adhesion-driven conjugate gradient method is employed to calculate the distribution of unknown pressures,while the discrete convolution-fast Fourier transform is utilized to compute the deformations,surface electric and magnetic potentials as well as the subsurface stresses,electric displacements,and magnetic inductions.The goal of this study is to investigate the influences of adhesion parameter,friction coefficient,coating thickness,and surface electric and magnetic charge densities on contact behaviors,such as contact area and pressures,electric and magnetic potentials,and subsurface stresses.展开更多
In this study,a cleaner method for separation and recovery of V/W/Na in waste selective catalytic reduction(SCR)catalyst alkaline leaching solution was proposed.The method involved membrane electrolysis followed by io...In this study,a cleaner method for separation and recovery of V/W/Na in waste selective catalytic reduction(SCR)catalyst alkaline leaching solution was proposed.The method involved membrane electrolysis followed by ion morphology pretreatme nt and solvent extraction.An acidic V(Ⅴ)/W(Ⅵ)solution was obtained using the me mbrane electrolysis method without adding any other chemical reagents.In addition,Na was recovered in the form of NaOH by product,avoiding the generation of Na containing wastewater.The electrolysis parameters were investigated,the lowest power consumption of 3063 kW·h·t^(-1)NaOH was obtained at a current density of 125 A·m^(-2)and an initial NaOH concentration of 2 mol·L^(-1).After electrolysis,oxalic acid was added to the acidic V/W containing solution,converting V(Ⅴ)negative ion to V(Ⅳ)positive ion.Since W(Ⅵ)ion state remained in negative form,the generation of heteropolyacid ions(W_(x)V_(y)O_(z)^(n-))was prevented.It was found that under the condition of oxalic acid addition/theoretical consumption 1.2 and reaction temperature 75℃,100%V(Ⅴ)was co nverted to V(Ⅳ4).Using 10%N263+10%noctanol+80%sulfonated kerosene as extractant,the highest W(Ⅵ)/V(Ⅳ)separation coefficient of 7559.76was obtained at pH=1.8,O:A ratio=1:1 and extraction time 15 min.With 2 mol·L^(-1)NaOH as stripping reagent,the W stripping efficiency reached 98.50%at O:A ratio=2:1 after 4-stages of stripping.The enrichment of V remained in the solution was realized using P204 as extractant and 20%(mass)H_(2)SO_(4)as stripping reagent.The parameters of extraction/stripping process were investigated,using 10%P204+10%TBP+80%sulfonated kerosene as extractant,the V extraction efficiency reached 97.50%at O:A ratio=1:2after 4 stages of extraction.Using 20%H_(2)SO_(4)as the stripping reagent,the V stripping efficiency was 98.30%at an O:A ratio of 4:1 after five stage s of stripping.After the entire process,a high-purity VOSO_(4)and Na_(2)WO_(4)product solutions were obtained with V/W recovery efficiency 95.84%/98.50%,separately.This study examined a more effective and cleaner method for separating V/W/Na in Na_(2)WO_(4)/NaVO_(3)solution,which may serve as a reference for the separation and recovery of V/W/Na in waste SCR catalysts.展开更多
In response to the interest in degradable magnesium staples for oral and maxillofacial surgical procedures,high-performance Mg−3Zn−0.2Ca−2Ag alloy wires were reported.The impact of annealing temperature on the mechani...In response to the interest in degradable magnesium staples for oral and maxillofacial surgical procedures,high-performance Mg−3Zn−0.2Ca−2Ag alloy wires were reported.The impact of annealing temperature on the mechanical properties and corrosion behavior of the alloy wires was investigated.Results indicated that an increased annealing temperature led to grain growth,reduced the volume fraction of the second phase,and lowered dislocation density,causing decreased strength.The alloy annealed at 150℃exhibited the highest elongation(19.6%)due to uniform and fine grains,along with lower dislocation density.Microscopic observation,and electrochemical and immersion tests highlighted the significant influence of annealing temperature on corrosion rates.Alloy wires annealed at 150℃demonstrated superior corrosion resistance,which is attributed to small and uniform grains,low stress,and a well-distributed nano-second phase.Finally,the alloy wires annealed at 150℃exhibited enhanced comprehensive properties,making them good candidates for degradable staples.展开更多
Residual stress is one of the main factors affecting the mechanical properties of materials, such as their strength, plasticity and surface integrity. For instance, tensile stress conditions can adversely affect mater...Residual stress is one of the main factors affecting the mechanical properties of materials, such as their strength, plasticity and surface integrity. For instance, tensile stress conditions can adversely affect material performance or component life, while compressive stress conditions can improve material fatigue strength. During the processing of integrated aviation structures, machining deformation caused by residual stress has become one of the most prominent manufacturing problems. Therefore, it is very important to measure and evaluate the stress for real applications.This paper reviews the research of residual stress measurement methods over the past five years by classifying them according to the measurement methods appearing in each stage. The existing problems and difficulties of each measurement technology are summarized, and future trends are forecasted. This paper provides a reference for further in-depth study of residual stress measurement technologies.展开更多
Five new species(Gastrochilus yei,Gastrochilus minimus,Luisia simaoensis,Taeniophyllum xizangense,Tuberolabium subulatum)and two newly recorded species(Cleisostoma tricornutum,Luisia inconspicua)of Vandeae(Orchidaceae...Five new species(Gastrochilus yei,Gastrochilus minimus,Luisia simaoensis,Taeniophyllum xizangense,Tuberolabium subulatum)and two newly recorded species(Cleisostoma tricornutum,Luisia inconspicua)of Vandeae(Orchidaceae)from China are described and illustrated.Gastrochilus yei is similar to G.affinis and G.nepalensis,but differs from them by having an epichile not lobed,the apex of the hypochile not bilobed,and a tine on the apex of the leaf.Gastrochilus minimus is similar to G.acinacifolius,but can be distinguished from the latter by having a flabellate epichile that is densely hirsute on the adaxial surface and an inconspicuous central cushion;in addition,the hypochile of G.minimus has a keel that extends to the apex of the epichile.Taeniophyllum xizangense is similar to T.stella and T.radiatum,but it is distinguished from them by having much bigger flowers,inflorescences densely covered with short-bristly hairs,papillae on the external surface of sepals,and bigger triangular-ovate viscidium.Luisia simaoensis is similar to L magniflora and L ramosii,but can be easily distinguished from them by having lateral sepals longer than dorsal sepals and petals,lip with irregular and waved margins,and lip with bilobed apex.Luisia inconspicua is moved from Gastrochilus to Luisia based on phylogenetic analyses of plastid matK sequence data.Tuberolabium subulatum is similar to T.camosum,but it can be easily distinguished from the latter by having an inflorescence much shorter than the leaves,yellow sepals and petals,and many small papillae outside the lip lobes.展开更多
Primary malignant lymphoma of the prostate is exceedingly rare.Here we report a case of a 65-year-old man who presented with increased urinary frequency,urinary urgency,and urinary incontinence for two years.Benign pr...Primary malignant lymphoma of the prostate is exceedingly rare.Here we report a case of a 65-year-old man who presented with increased urinary frequency,urinary urgency,and urinary incontinence for two years.Benign prostatic hypertrophy was suspected at primary impression.Ultrasound revealed a hypoechoic lesion of the prostate.The total serum prostate-specific antigen was within normal range.Positron emission tomography/computerized tomography(PET/CT)showed a hypermetabolic prostatic lesion.Prostate biopsy was consistent with a non-germinal center diffuse large B cell lymphoma.There was complete remission of the prostatic lesion following six cycles of chemotherapy as shown on the second PET/CT imaging.18F-fluoro-deoxy glucose PET/CT is not only a complement to conventional imaging,but also plays a significant role in the diagnosis and evaluation of treatment response of prostatic lymphoma.展开更多
Objective:To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer(BBC)in China.Methods:Data of 440 patients diagnosed with BBC in 2018 were collected from 33 centers...Objective:To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer(BBC)in China.Methods:Data of 440 patients diagnosed with BBC in 2018 were collected from 33 centers of the Chinese Society of Breast Surgery.Demographic characteristics,bilateral tumor characteristics,and comprehensive treatment data were obtained.Correlations between the clinicopathological characteristics of bilateral tumors were analyzed.Results:The proportion of BBC was 0.22%-3.08%.A total of 33(7.5%)patients had a family history of malignant tumors,304(69.1%)patients had synchronous BBC.Only 1(0.2%)patient was male.More than half of all patients received concurrent or asynchronous endocrine/chemotherapy,32.5%of all human epidermal growth factor receptor 2(HER2)-positive patients received HER2-targeted therapy,and approximately 21.6%of all patients received radiotherapy.The most common pathological cancer type was invasive ductal cancer(>60%).Approximately 70%of all patients had bilateral hormone receptor(HR)-positive tumors and presented with a single breast mass.Significant correlations were found with pathological type,histological grade,locations of tumor,molecular subtype,Ki-67 index,tumor site and size of bilateral tumors.Results of the subgroup analysis showed more clinicopathological characteristics when synchronous BBC was compared with metachronous BBC.Conclusions:In China,the clinicopathological characteristics of bilateral tumors showed significant correlations,and more significant clinicopathological correlations were observed when synchronous BBC was compared with metachronous BBC.展开更多
Dumasia taxonomy and classification have long been problematic.Species within this genus have few morphological differences and plants without flowers or fruits are difficult to accurately identify.In this study,we ev...Dumasia taxonomy and classification have long been problematic.Species within this genus have few morphological differences and plants without flowers or fruits are difficult to accurately identify.In this study,we evaluated the ability of six DNA barcoding sequences,one nuclear(ITS)and five chloroplast regions(trnH-psbA,matK,rbcL,trnL-trnF,psbB-psbF),to efficiently identify Dumasia species.Most single markers or their combinations identify obvious barcoding gaps between intraspecific and interspecific genetic variation.Most combined analyses including ITS showed good species resolution and identification efficiency.We therefore suggest that ITS alone or a combination of ITS with any cpDNA marker are most suitable for DNA barcoding of Dumasia.The phylogenetic analyses clearly indicated that Dumasia yunnanensis is not monophyletic and is separated as two independent branches,which may result from cryptic differentiation.Our results demonstrate that molecular data can deepen the comprehension of taxonomy of Dumasia and provide an efficient approach for identification of the species.展开更多
Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-ye...Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-year-old woman who presented with low-grade fever and weight loss of three months.On CT scanning,a mass was identified which appeared to be a hypoattenuating lesion,on ultrasonographic imaging,the mass was hypoechoic,therefore,liver abscess or hepatic metastasis from a gastrointestinal primary was initially suspected.Tumor markers such as alpha-fetoprotein,carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits.PET/CT demonstrated a large abnormal ring-like hypermetabolic focus in the right liver lobe.The lesion was resected and the histo-pathological findings were consistent with lymphoma.The patient was discharged two weeks after surgery and did not receive any further treatment.After 25 mo follow-up,she is in good health.18F-fluorodeoxyglucose PET/CT is useful in confirming the diagnosis of primary hepatic lymphoma by demonstrating no other foci with high uptake in other parts of the body.展开更多
Background:This study investigated the effect of melatonin(MT)on cell cycle(G1/S/G2/M)of parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II(MII)oocytes and elucidated the potential mechanism of...Background:This study investigated the effect of melatonin(MT)on cell cycle(G1/S/G2/M)of parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II(MII)oocytes and elucidated the potential mechanism of MT action in the first cleavage of embryos.Results:After vitrification and warming,oocytes were parthenogenetically activated(PA)and in vitro cultured(IVC).Then the spindle morphology and chromosome segregation in oocytes,the maternal mRNA levels of genes including Miss,Doc1r,Setd2 and Ythdf2 in activated oocytes,pronuclear formation,the S phase duration in zygotes,mitochondrial function at G1 phase,reactive oxygen species(ROS)level at S phase,DNA damage at G2 phase,early apoptosis in 2-cell embryos,cleavage and blastocyst formation rates were evaluated.The results indicated that the vitrification/warming procedures led to following perturbations 1)spindle abnormalities and chromosome misalignment,alteration of maternal mRNAs and delay in pronucleus formation,2)decreased mitochondrial membrane potential(MMP)and lower adenosine triphosphate(ATP)levels,increased ROS production and DNA damage,G1/S and S/G2 phase transition delay,and delayed first cleavage,and 3)increased early apoptosis and lower levels of cleavage and blastocyst formation.Our results further revealed that such negative impacts of oocyte cryopreservation could be alleviated by supplementation of warming,recovery,PA and IVC media with 10^(−9) mol/L MT before the embryos moved into the 2-cell stage of development.Conclusions:MT might promote cell cycle progression via regulation of MMP,ATP,ROS and maternal mRNA levels,potentially increasing the first cleavage of parthenogenetic zygotes developed from vitrified-warmed mouse oocytes and their subsequent development.展开更多
Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum alb...Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum albumin(HSA)via a bifunctional linker under mild conditions.The semi-syntheticβ-1,2-mannoside–KLH conjugates were evaluated for the immunization of BALB/c mice.The ELISA results revealed that all three conjugates could elicit high levels of specific IgG antibodies and the acquired antisera could effectively identify theβ-1,2-mannan epitope.Furthermore,the immunofluorescence and flow cytometry assays also uncovered that the induced antibodies,especially that obtained from immunization withβ-1,2-mannotriose–KLH conjugate(1b),could bind well to fungi cell.Eventually,the structure–immunogenicity relationship analysis ofβ-mannan showed that the length of oligo-β-mannoses had a big impact on their immunogenicity andβ-1,2-mannotriose showed the strongest immunogenicity.The results suggested the great potential ofβ-1,2-mannotriose–KLH conjugate as an antifungal vaccine candidate.展开更多
Background Previous studies have shown that the vitrification of metaphaseⅡ(MⅡ)oocytes significantly represses their developmental potential.Abnormally increased oxidative stress is the probable factor;however,the u...Background Previous studies have shown that the vitrification of metaphaseⅡ(MⅡ)oocytes significantly represses their developmental potential.Abnormally increased oxidative stress is the probable factor;however,the underlying mechanism remains unclear.The walnut-derived peptide TW-7 was initially isolated and purified from walnut protein hydrolysate.Accumulating evidences implied thatTW-7 was a powerful antioxidant,while its prospective application in oocyte cryopreservation has not been reported.Result Here,we found that parthenogenetic activation(PA)zygotes derived from vitrified MⅡoocytes showed elevated ROS level and delayed progression of pronucleus formation.Addition of 25μmol/LTW-7 in warming,recovery,PA,and embryo culture medium could alleviate oxidative stress in PA zygotes from vitrified mouse MⅡoocytes,furtherly increase proteins related to histone lactylation such as LDHAe LDHB,and EP300 and finally improve histone lactylation in PA zygotes.The elevated histone lactylation facilitated the expression of minor zygotic genome activation(ZGA)genes and preimplantation embryo development.Conclusions Our findings revealed the mechanism of oxidative stress inducing repressed development of PA embryos from vitrified mouse MⅡoocytes and found a potent and easy-obtained short peptide that could significantly rescue the decreased developmental potential of vitrified oocytes,which would potentially contribute to reproductive medicine,animal protection,and breeding.展开更多
Double-sided lapping is an precision machining method capable of obtaining high-precision surface.However,during the lapping process of thin pure copper substrate,the workpiece will be warped due to the influence of r...Double-sided lapping is an precision machining method capable of obtaining high-precision surface.However,during the lapping process of thin pure copper substrate,the workpiece will be warped due to the influence of residual stress,including the machining stress and initial residual stress,which will deteriorate the flatness of the workpiece and ultimately affect the performance of components.In this study,finite element method(FEM)was adopted to study the effect of residual stress-related on the deformation of pure copper substrate during double-sided lapping.Considering the initial residual stress of the workpiece,the stress caused by the lapping and their distribution characteristics,a prediction model was proposed for simulating workpiece machining deformation in lapping process by measuring the material removal rate of the upper and lower surfaces of the workpiece under the corresponding parameters.The results showed that the primary cause of the warping deformation of the workpiece in the doublesided lapping is the redistribution of initial residual stress caused by uneven material removal on the both surfaces.The finite element simulation results were in good agreement with the experimental results.展开更多
基金Postgraduate Research Innovation Program of Yangzhou University(Grant No.XKYCX18_128)
文摘In the present study,we aimed to prepare Panax japonicus tablets and carry out quality inspection.Panax japonicus tablets were prepared by ultrafine pulverization-wet granulation,and quality inspection was carried out according to Pharmacopoeia regulations.The plasma concentration of animals with self-made Panax japonicus tablets or ginsenoside Rg3 in single-dose intragastric administration was determined by high-performance liquid chromatography(HPLC).The pharmacokinetic parameters and relative bioavailability were calculated by DAS 2.0 software.The quality inspection of self-made Panax japonicus tablets met the requirements of Chinese Pharmacopoeia(2015 edition),and this preparation had high bioequivalence of ginsenoside Rg3.The preparation of Panax japonicus tablets was reasonable and highly qualified.Moreover,this new Panax japonicus preparation showed better profiles in oral absorption and utilization.This study provided evidence for the industrial production and clinical application of Panax japonicus tablets.
基金Supported by The Basic and Clinical Cooperative Research Promotion Plan of Anhui Medical University,No.2019xkjT011Anhui Provincial Natural Science Foundation,No.2008085QH406Anhui Medical University Joint Project of Nuclear Medicine and Radiation Medicine,No.2021 Lcxk035.
文摘Despite the recent progress of medical technology in the diagnosis and treatment of tumors,pancreatic carcinoma remains one of the most malignant tumors,with extremely poor prognosis partly due to the difficulty in early and accurate imaging evaluation.This paper focuses on the research progress of magnetic resonance imaging,nuclear medicine molecular imaging and radiomics in the diagnosis of pancreatic carcinoma.We also briefly described the achievements of our team in this field,to facilitate future research and explore new technologies to optimize diagnosis of pancreatic carcinoma.
基金Supported by the Liaoning Provincial Natural Science Foundation(Grant No.2023-MSBA-008)Unveiling and Commanding Program of Liaoning Province(Grant No.2022JH1/10800080)the Fundamental Research Funds for the Central Universities(Grant No.DUT24MS008).
文摘The double-sided lapping process is extensively employed in the manufacturing of wafers,optical windows,and seal rings due to its high efficiency and ability to achieve precise flatness.However,limited research has explored the thickness uniformity among different workpieces after double-sided lapping,and the underlying mechanism remains unclear.To address the demand for higher precision,this paper first analyzed the relative kinematic model between the workpiece and the lapping plate to clarify the causes of thickness variations among workpieces after double-sided lapping.Subsequently,a finite element method(FEM)model was developed to account for the pressure distribution on the workpiece surfaces at the initial stage of the process.The results indicate that the number of workpieces influences the final thickness variation.Then,various sets of thin copper plates with different thicknesses were lapped,and the findings revealed that five copper plates processed simultaneously exhibited more uniform thickness compared to the three plates.The experimental results align well with the theoretical analysis.Ultimately,a thickness variation of less than 6μm was achieved on five copper plates measuringΦ100×2.9 mm.This study presents a comprehensive analysis of the mechanisms influencing thickness uniformity in the double-sided lapping process and provides practical guidelines for optimizing the process to achieve stringent precision standards in industrial applications.
基金support from the National Natural Science Foundation of China(12102085)the Postdoctoral Science Foundation of China(2023M730504)+2 种基金the Sichuan Province Regional Innovation and Cooperation Project(2024YFHZ0210)supported by the European Union-NextGenerationEU through the Italian Ministry of University and Research under the following programs:(NM)PRIN2022(Projects of Relevant National Interest)grant no.2022SJ8HTC-Electroactive Gripper for Micro-Object Manipulation(ELFIN)(NM)PRIN2022 PNRR(Projects of Relevant National Interest)grant no.P2022MAZHX-Tribological Modeling for Sustainable Design of Industrial Frictional Interfaces(TRIBOSCORE).
文摘This paper investigates the frictional adhesive contact of a rigid,electrically/magnetically conductive spherical indenter sliding past a multiferroic coating deposed onto a rigid substrate,based on the hybrid element method.The adhesion behavior is described based on the Maugis-Dugdale model.The adhesion-driven conjugate gradient method is employed to calculate the distribution of unknown pressures,while the discrete convolution-fast Fourier transform is utilized to compute the deformations,surface electric and magnetic potentials as well as the subsurface stresses,electric displacements,and magnetic inductions.The goal of this study is to investigate the influences of adhesion parameter,friction coefficient,coating thickness,and surface electric and magnetic charge densities on contact behaviors,such as contact area and pressures,electric and magnetic potentials,and subsurface stresses.
基金the support the National Natural Science Foundation of China(5210440)S&T Program of Hebei(23311501D)Program of HBIS Group under HG2023222。
文摘In this study,a cleaner method for separation and recovery of V/W/Na in waste selective catalytic reduction(SCR)catalyst alkaline leaching solution was proposed.The method involved membrane electrolysis followed by ion morphology pretreatme nt and solvent extraction.An acidic V(Ⅴ)/W(Ⅵ)solution was obtained using the me mbrane electrolysis method without adding any other chemical reagents.In addition,Na was recovered in the form of NaOH by product,avoiding the generation of Na containing wastewater.The electrolysis parameters were investigated,the lowest power consumption of 3063 kW·h·t^(-1)NaOH was obtained at a current density of 125 A·m^(-2)and an initial NaOH concentration of 2 mol·L^(-1).After electrolysis,oxalic acid was added to the acidic V/W containing solution,converting V(Ⅴ)negative ion to V(Ⅳ)positive ion.Since W(Ⅵ)ion state remained in negative form,the generation of heteropolyacid ions(W_(x)V_(y)O_(z)^(n-))was prevented.It was found that under the condition of oxalic acid addition/theoretical consumption 1.2 and reaction temperature 75℃,100%V(Ⅴ)was co nverted to V(Ⅳ4).Using 10%N263+10%noctanol+80%sulfonated kerosene as extractant,the highest W(Ⅵ)/V(Ⅳ)separation coefficient of 7559.76was obtained at pH=1.8,O:A ratio=1:1 and extraction time 15 min.With 2 mol·L^(-1)NaOH as stripping reagent,the W stripping efficiency reached 98.50%at O:A ratio=2:1 after 4-stages of stripping.The enrichment of V remained in the solution was realized using P204 as extractant and 20%(mass)H_(2)SO_(4)as stripping reagent.The parameters of extraction/stripping process were investigated,using 10%P204+10%TBP+80%sulfonated kerosene as extractant,the V extraction efficiency reached 97.50%at O:A ratio=1:2after 4 stages of extraction.Using 20%H_(2)SO_(4)as the stripping reagent,the V stripping efficiency was 98.30%at an O:A ratio of 4:1 after five stage s of stripping.After the entire process,a high-purity VOSO_(4)and Na_(2)WO_(4)product solutions were obtained with V/W recovery efficiency 95.84%/98.50%,separately.This study examined a more effective and cleaner method for separating V/W/Na in Na_(2)WO_(4)/NaVO_(3)solution,which may serve as a reference for the separation and recovery of V/W/Na in waste SCR catalysts.
基金The National Natural Science Foundation of China(Nos.51971020,52171097)the Major State Research and Development Program of China(No.2021YFB3701100)+1 种基金Key Scientific Research Project in Shanxi Province,China(No.202102050201003)the Opening Research Fund of State Key Laboratory for Advanced Metals and Materials,China(No.2023-Z03).
文摘In response to the interest in degradable magnesium staples for oral and maxillofacial surgical procedures,high-performance Mg−3Zn−0.2Ca−2Ag alloy wires were reported.The impact of annealing temperature on the mechanical properties and corrosion behavior of the alloy wires was investigated.Results indicated that an increased annealing temperature led to grain growth,reduced the volume fraction of the second phase,and lowered dislocation density,causing decreased strength.The alloy annealed at 150℃exhibited the highest elongation(19.6%)due to uniform and fine grains,along with lower dislocation density.Microscopic observation,and electrochemical and immersion tests highlighted the significant influence of annealing temperature on corrosion rates.Alloy wires annealed at 150℃demonstrated superior corrosion resistance,which is attributed to small and uniform grains,low stress,and a well-distributed nano-second phase.Finally,the alloy wires annealed at 150℃exhibited enhanced comprehensive properties,making them good candidates for degradable staples.
基金the financial support from Science Challenge Project of China (No. TZ2016006-0103 and No.TZ2016006-0107-02)Liao Ning Revitalization Talents Program of China (No. XLYC1807230)+2 种基金Science Fund for Creative Research Groups of NSFC (No. 51621064)the Fundamental Research Funds for the Central Universities of China (No. DUT17RC(3)105)National Natural Science Foundation of China (No. 51975096)。
文摘Residual stress is one of the main factors affecting the mechanical properties of materials, such as their strength, plasticity and surface integrity. For instance, tensile stress conditions can adversely affect material performance or component life, while compressive stress conditions can improve material fatigue strength. During the processing of integrated aviation structures, machining deformation caused by residual stress has become one of the most prominent manufacturing problems. Therefore, it is very important to measure and evaluate the stress for real applications.This paper reviews the research of residual stress measurement methods over the past five years by classifying them according to the measurement methods appearing in each stage. The existing problems and difficulties of each measurement technology are summarized, and future trends are forecasted. This paper provides a reference for further in-depth study of residual stress measurement technologies.
基金supported by Grant from National Forestry and Grassland Administration(No.2019073018,2019073019,2019073002,2019073003)Science and Technology Basic Resources Investigation Program of China"Survey and Germplasm Conservation of Plant Species with Extremely Small Populations in South-west China"(Grant No.2017FY100100)+3 种基金National Natural Science Foundation of China(No.31870195)Strategic Biological Resources Capacity Building Project from the Chinese Academy of Sciences"Seed Plants Research in Xishuangbanna Karst Region"(Grant No.KFJ-BRP-017-36)the Large-scale Scientific Facilities of the Chinese Academy of Sciences(Grant No.2017-LSFGBOWS-02)the National Wild Plant Germplasm Resource Center,National Science&Technology Infrastructure。
文摘Five new species(Gastrochilus yei,Gastrochilus minimus,Luisia simaoensis,Taeniophyllum xizangense,Tuberolabium subulatum)and two newly recorded species(Cleisostoma tricornutum,Luisia inconspicua)of Vandeae(Orchidaceae)from China are described and illustrated.Gastrochilus yei is similar to G.affinis and G.nepalensis,but differs from them by having an epichile not lobed,the apex of the hypochile not bilobed,and a tine on the apex of the leaf.Gastrochilus minimus is similar to G.acinacifolius,but can be distinguished from the latter by having a flabellate epichile that is densely hirsute on the adaxial surface and an inconspicuous central cushion;in addition,the hypochile of G.minimus has a keel that extends to the apex of the epichile.Taeniophyllum xizangense is similar to T.stella and T.radiatum,but it is distinguished from them by having much bigger flowers,inflorescences densely covered with short-bristly hairs,papillae on the external surface of sepals,and bigger triangular-ovate viscidium.Luisia simaoensis is similar to L magniflora and L ramosii,but can be easily distinguished from them by having lateral sepals longer than dorsal sepals and petals,lip with irregular and waved margins,and lip with bilobed apex.Luisia inconspicua is moved from Gastrochilus to Luisia based on phylogenetic analyses of plastid matK sequence data.Tuberolabium subulatum is similar to T.camosum,but it can be easily distinguished from the latter by having an inflorescence much shorter than the leaves,yellow sepals and petals,and many small papillae outside the lip lobes.
文摘Primary malignant lymphoma of the prostate is exceedingly rare.Here we report a case of a 65-year-old man who presented with increased urinary frequency,urinary urgency,and urinary incontinence for two years.Benign prostatic hypertrophy was suspected at primary impression.Ultrasound revealed a hypoechoic lesion of the prostate.The total serum prostate-specific antigen was within normal range.Positron emission tomography/computerized tomography(PET/CT)showed a hypermetabolic prostatic lesion.Prostate biopsy was consistent with a non-germinal center diffuse large B cell lymphoma.There was complete remission of the prostatic lesion following six cycles of chemotherapy as shown on the second PET/CT imaging.18F-fluoro-deoxy glucose PET/CT is not only a complement to conventional imaging,but also plays a significant role in the diagnosis and evaluation of treatment response of prostatic lymphoma.
基金Project supported by the National Natural Science Foundation of China(Nos.41303093,41222025,and 41273138)the Program for New Century Excellent Talents in University of Ministry of Education of Chinathe Recruitment Program of HighlyQualified Scholars in Yunnan Province(No.2010CI109),China
基金supported by the National Natural Science Foundation of China(No.81673762)Provincial Foundation of Liaoning(No.2019-BS-072,No.2019-ZD0780)Innovation Foundation of Dalian(No.2018J11CY026)。
文摘Objective:To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer(BBC)in China.Methods:Data of 440 patients diagnosed with BBC in 2018 were collected from 33 centers of the Chinese Society of Breast Surgery.Demographic characteristics,bilateral tumor characteristics,and comprehensive treatment data were obtained.Correlations between the clinicopathological characteristics of bilateral tumors were analyzed.Results:The proportion of BBC was 0.22%-3.08%.A total of 33(7.5%)patients had a family history of malignant tumors,304(69.1%)patients had synchronous BBC.Only 1(0.2%)patient was male.More than half of all patients received concurrent or asynchronous endocrine/chemotherapy,32.5%of all human epidermal growth factor receptor 2(HER2)-positive patients received HER2-targeted therapy,and approximately 21.6%of all patients received radiotherapy.The most common pathological cancer type was invasive ductal cancer(>60%).Approximately 70%of all patients had bilateral hormone receptor(HR)-positive tumors and presented with a single breast mass.Significant correlations were found with pathological type,histological grade,locations of tumor,molecular subtype,Ki-67 index,tumor site and size of bilateral tumors.Results of the subgroup analysis showed more clinicopathological characteristics when synchronous BBC was compared with metachronous BBC.Conclusions:In China,the clinicopathological characteristics of bilateral tumors showed significant correlations,and more significant clinicopathological correlations were observed when synchronous BBC was compared with metachronous BBC.
基金We thank Dr.Zhi-qiang Lu and Mr.Yi Fu for help during the field survey.We are grateful to Dr.Ovidiu Paun for very helpful comments on earlier drafts of this manuscript.We thank Dr.Shu-feng Li for the distributional map,as well as Dr.Bing Liu,Dr.Ren-bin Zhu,and Mr.Yi Fu for their photos of some Dumasia species.The first author thanks Dr.Wen-bin Yu,Dr.Pei-liang Liu,Dr.Xue-li Zhao,and Dr.Zhu-qiu Song for their help during the writing process.Additional thanks go to Dr.Richard T.Corlett,Raymond Porter and Mr Yuan-qiong Zhang for polishing this work.The authors would also like to express gratitude to two anonymous reviewers for their valuable comments on the manuscript.This work was financially supported by the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)National Natural Science Foundation of China(NSFC 41861008)the 135 Karst‘breakthrough’project Grant 2017XTBG-T03.
文摘Dumasia taxonomy and classification have long been problematic.Species within this genus have few morphological differences and plants without flowers or fruits are difficult to accurately identify.In this study,we evaluated the ability of six DNA barcoding sequences,one nuclear(ITS)and five chloroplast regions(trnH-psbA,matK,rbcL,trnL-trnF,psbB-psbF),to efficiently identify Dumasia species.Most single markers or their combinations identify obvious barcoding gaps between intraspecific and interspecific genetic variation.Most combined analyses including ITS showed good species resolution and identification efficiency.We therefore suggest that ITS alone or a combination of ITS with any cpDNA marker are most suitable for DNA barcoding of Dumasia.The phylogenetic analyses clearly indicated that Dumasia yunnanensis is not monophyletic and is separated as two independent branches,which may result from cryptic differentiation.Our results demonstrate that molecular data can deepen the comprehension of taxonomy of Dumasia and provide an efficient approach for identification of the species.
文摘Primary hepatic lymphoma is extremely rare,and only a few cases have been described on positron emission tomography(PET) or PET/computed tomography(PET/CT) imaging in the English literature.We report a case of a 55-year-old woman who presented with low-grade fever and weight loss of three months.On CT scanning,a mass was identified which appeared to be a hypoattenuating lesion,on ultrasonographic imaging,the mass was hypoechoic,therefore,liver abscess or hepatic metastasis from a gastrointestinal primary was initially suspected.Tumor markers such as alpha-fetoprotein,carcinoembryonic antigen and carbohydrate antigen 19-9 were within normal limits.PET/CT demonstrated a large abnormal ring-like hypermetabolic focus in the right liver lobe.The lesion was resected and the histo-pathological findings were consistent with lymphoma.The patient was discharged two weeks after surgery and did not receive any further treatment.After 25 mo follow-up,she is in good health.18F-fluorodeoxyglucose PET/CT is useful in confirming the diagnosis of primary hepatic lymphoma by demonstrating no other foci with high uptake in other parts of the body.
基金supported by the National Natural Science Foundation of China(grant no.32072735,31572398)the Natural Science Fund of Qinghai Province(2020-ZJ-902)by the China Agriculture Research System(grant no.CARS-36).
文摘Background:This study investigated the effect of melatonin(MT)on cell cycle(G1/S/G2/M)of parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II(MII)oocytes and elucidated the potential mechanism of MT action in the first cleavage of embryos.Results:After vitrification and warming,oocytes were parthenogenetically activated(PA)and in vitro cultured(IVC).Then the spindle morphology and chromosome segregation in oocytes,the maternal mRNA levels of genes including Miss,Doc1r,Setd2 and Ythdf2 in activated oocytes,pronuclear formation,the S phase duration in zygotes,mitochondrial function at G1 phase,reactive oxygen species(ROS)level at S phase,DNA damage at G2 phase,early apoptosis in 2-cell embryos,cleavage and blastocyst formation rates were evaluated.The results indicated that the vitrification/warming procedures led to following perturbations 1)spindle abnormalities and chromosome misalignment,alteration of maternal mRNAs and delay in pronucleus formation,2)decreased mitochondrial membrane potential(MMP)and lower adenosine triphosphate(ATP)levels,increased ROS production and DNA damage,G1/S and S/G2 phase transition delay,and delayed first cleavage,and 3)increased early apoptosis and lower levels of cleavage and blastocyst formation.Our results further revealed that such negative impacts of oocyte cryopreservation could be alleviated by supplementation of warming,recovery,PA and IVC media with 10^(−9) mol/L MT before the embryos moved into the 2-cell stage of development.Conclusions:MT might promote cell cycle progression via regulation of MMP,ATP,ROS and maternal mRNA levels,potentially increasing the first cleavage of parthenogenetic zygotes developed from vitrified-warmed mouse oocytes and their subsequent development.
基金financially supported by the Natural Science Foundation of China (Nos. 21502223, 81773580)
文摘Phosphorylated di-,tri-and tetra-saccharides ofβ-1,2-mannan antigen derived from Candida albicans(C.albicans)cell wall were synthesized and covalently conjugated with keyhole limpet hemocyanin(KLH)and human serum albumin(HSA)via a bifunctional linker under mild conditions.The semi-syntheticβ-1,2-mannoside–KLH conjugates were evaluated for the immunization of BALB/c mice.The ELISA results revealed that all three conjugates could elicit high levels of specific IgG antibodies and the acquired antisera could effectively identify theβ-1,2-mannan epitope.Furthermore,the immunofluorescence and flow cytometry assays also uncovered that the induced antibodies,especially that obtained from immunization withβ-1,2-mannotriose–KLH conjugate(1b),could bind well to fungi cell.Eventually,the structure–immunogenicity relationship analysis ofβ-mannan showed that the length of oligo-β-mannoses had a big impact on their immunogenicity andβ-1,2-mannotriose showed the strongest immunogenicity.The results suggested the great potential ofβ-1,2-mannotriose–KLH conjugate as an antifungal vaccine candidate.
基金supported by the National Key Research and Development Program of China(No.2021YFD1200403)the National Natural Science Foundation of China(No.32072735)Xigaze City regional Science and technology Collaborative innovation project-Genetic resources of rescue protection for Zhangmu goat(No.QYXTZX-RKZ2023-06)。
文摘Background Previous studies have shown that the vitrification of metaphaseⅡ(MⅡ)oocytes significantly represses their developmental potential.Abnormally increased oxidative stress is the probable factor;however,the underlying mechanism remains unclear.The walnut-derived peptide TW-7 was initially isolated and purified from walnut protein hydrolysate.Accumulating evidences implied thatTW-7 was a powerful antioxidant,while its prospective application in oocyte cryopreservation has not been reported.Result Here,we found that parthenogenetic activation(PA)zygotes derived from vitrified MⅡoocytes showed elevated ROS level and delayed progression of pronucleus formation.Addition of 25μmol/LTW-7 in warming,recovery,PA,and embryo culture medium could alleviate oxidative stress in PA zygotes from vitrified mouse MⅡoocytes,furtherly increase proteins related to histone lactylation such as LDHAe LDHB,and EP300 and finally improve histone lactylation in PA zygotes.The elevated histone lactylation facilitated the expression of minor zygotic genome activation(ZGA)genes and preimplantation embryo development.Conclusions Our findings revealed the mechanism of oxidative stress inducing repressed development of PA embryos from vitrified mouse MⅡoocytes and found a potent and easy-obtained short peptide that could significantly rescue the decreased developmental potential of vitrified oocytes,which would potentially contribute to reproductive medicine,animal protection,and breeding.
基金National Key Research and Development Program of China(Grant No.2018YFA0702900)Science Challenge Project of China(Grant No.TZ2016006)National Natural Science Foundation of China(Grant No.51975096)。
文摘Double-sided lapping is an precision machining method capable of obtaining high-precision surface.However,during the lapping process of thin pure copper substrate,the workpiece will be warped due to the influence of residual stress,including the machining stress and initial residual stress,which will deteriorate the flatness of the workpiece and ultimately affect the performance of components.In this study,finite element method(FEM)was adopted to study the effect of residual stress-related on the deformation of pure copper substrate during double-sided lapping.Considering the initial residual stress of the workpiece,the stress caused by the lapping and their distribution characteristics,a prediction model was proposed for simulating workpiece machining deformation in lapping process by measuring the material removal rate of the upper and lower surfaces of the workpiece under the corresponding parameters.The results showed that the primary cause of the warping deformation of the workpiece in the doublesided lapping is the redistribution of initial residual stress caused by uneven material removal on the both surfaces.The finite element simulation results were in good agreement with the experimental results.
