Covalent organic frameworks(COFs)are crystalline porous polymeric materials composed of organic monomers connected by strong covalent bonds and offer high stability,good crystallinity,a large specific surface area,and...Covalent organic frameworks(COFs)are crystalline porous polymeric materials composed of organic monomers connected by strong covalent bonds and offer high stability,good crystallinity,a large specific surface area,and controllable structures.COFs are widely used in the fields of adsorption and separation,catalysis,photovoltaics,and drug-delivery.The structural regulation and performance optimization of COFs can be realized through the modification of ligands and the selection of linkage methods.In which,the types of linkage are closely related to the stability and performance of COFs.In this review,nitrogencontaining linkage-bonds(NCLBs)in COFs are divided into N-containing double bonds,N-containing conjugated rings and N-containing unconjugated rings.The association between structure and performance of COFs is elaborated and the synthesis methods of COFs are systematically summarized.Moreover,the structural design,theoretical prediction and machinable application of COFs are prospected.展开更多
Few studies have investigated alterations in the immune cell microenvironment of the dorsal root ganglia following spinal cord injury and whether these modifications facilitate axonal regeneration.In this study,we use...Few studies have investigated alterations in the immune cell microenvironment of the dorsal root ganglia following spinal cord injury and whether these modifications facilitate axonal regeneration.In this study,we used a single-cell RNA sequencing dataset to create a comprehensive profile of the diverse cell types in the dorsal root ganglia and spinal cord of a mid-thoracic contusion injury model in cynomolgus monkeys.Cell communication analysis indicated that specific signaling events among various dorsal root ganglia cell types occur in response to spinal cord injury.Single-cell analysis using dimensionality reduction clustering identified distinct molecular signatures for nine cell types,including macrophage subpopulations,and differential gene expression profiles between dorsal root ganglia cells and spinal cord cells following spinal cord injury.The macrophage subpopulations were categorized into 11 clusters(MC0-MC10)based on differentially expressed genes,with the top 10 genes being ABCA6,RBMS3,EBF1,LAMA4,ANTXR2,LAMA2,SOX5,FOXP2,GHR,and APOD.MC0,MC1,and MC2 constituted the predominant macrophage populations.MC4,MC6,and MC9 were nearly absent in the spinal cord,but exhibited significant increases in the dorsal root ganglia post-spinal cord injury.Notably,these subpopulations possess a strong capacity for regulating axonal regeneration.The developmental progression of dorsal root ganglia macrophages after spinal cord injury was elucidated using cell trajectory and pseudo-time analyses.Genes such as EBF1(MC6 and MC9 marker),RBMS3(MC6 and MC9 marker),and ABCA6(MC6 marker)showed high expression levels in the critical pathways of macrophage function.Through ligand-receptor pair analysis,we determined that the effects of macrophages on microglia are predominantly mediated through interaction pairs(e.g.,SPP1-CD44,LAMC1-CD44,and FN1-CD44),potentially facilitating specific cellular communications within the immune microenvironment.The single-cell RNA sequencing dataset used in this study represents the first comprehensive transcriptional analysis of the dorsal root ganglia after spinal cord injury in cynomolgus monkeys,encompassing nearly all cell types within the dorsal root ganglia region.Using this dataset,we evaluated diverse subtypes of macrophages in the post-spinal cord injury dorsal root ganglia area and examined the signaling pathways that facilitate interactions among immune response-related macrophages in the dorsal root ganglia.Findings from this study provide a theoretical basis for understanding how the immune microenvironment influences the regenerative capacity of dorsal root ganglia neurons after spinal cord injury and offer novel insights into the complex processes underlying the pathobiology of spinal cord injury.展开更多
Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
Single-atom catalysts(SACs)are among the most cutting-edge catalysts in the multiphase catalysis track due to their unique geometrical and electronic properties,the highest atom utilization efficiency,and uniform acti...Single-atom catalysts(SACs)are among the most cutting-edge catalysts in the multiphase catalysis track due to their unique geometrical and electronic properties,the highest atom utilization efficiency,and uniform active sites.SACs have been facing an unresolved problem in practical applications:the opposing contradiction of activity-stability.The successful development of single-atom nano-islands(SANIs)cleverly combines the ultra-high atom utilization efficiency of SACs with the confinement effect and structural stability of nano-island structures,realizing the“moving but not aggregation”of SACs,which fundamentally solves this inherent contradiction.Although research on the precise loading of single atoms on nano-islands continues to advance,existing reviews have not yet established a closed-loop cognitive framework encompassing“models-synthesis-high stability mechanisms-high activity essence-applications.”This work fills this critical gap by systematically integrating the basic conceptual models and cutting-edge synthesis strategies of SANIs,focusing on revealing the underlying mechanisms by which SANIs overcome the stability bottleneck of SACs,elucidating the role of nano-islands and their synergistic mechanisms to clarify the high activity essence,and establishing the structure-activity relationship between atomic confinement effects and macroscopic performance,ultimately achieving breakthrough validation across catalytic systems.This review aims to open new perspectives,drive a paradigm shift in understanding the multi-dimensional advantages of SANIs,and thereby spur breakthrough progress in this frontier field.展开更多
The recovery of gold from waste electronic and electric equipment(WEEE) has gained great attention with the increased number of WEEE,because it can largely alleviate the pressure on the environment and resources.Coval...The recovery of gold from waste electronic and electric equipment(WEEE) has gained great attention with the increased number of WEEE,because it can largely alleviate the pressure on the environment and resources.Covalent organic frameworks(COFs) are ideal adsorbents for gold recovery owing to their large surface area,good stability,easily functionalized ability,periodic structures,and definitive nanopores.Herein,a cyano-functionalized COF(COF-CN) with high crystallinity was large-scale prepared under mild conditions for the recovery of gold.The introduction of cyano groups enable COF-CN to exhibit excellent gold recovery performance,which possesses fast adsorption kinetics,high cycling stability,and adsorption capacity up to 663.67 mg/g.Excitingly,COF-CN showed extremely high selectivity for gold ions,even in the presence of various competing cations and anions.The COF-CN maintained excellent selectivity and removal efficiency in gold recovery experiments from WEEE.The facile synthesis of COF-CN and its outstanding selectivity in actual samples make it an attractive opportunity for practical gold recovery.展开更多
Ground-based radar is the primary means by which severe storms are monitored and tracked;however, due to limited coverage, important data is often missed over ocean and mountainous areas. On the other hand, geostation...Ground-based radar is the primary means by which severe storms are monitored and tracked;however, due to limited coverage, important data is often missed over ocean and mountainous areas. On the other hand, geostationary(GEO)weather satellites provide continuous observations with seamless coverage with advanced imager, despite their limited capability to penetrate clouds. Combining satellite and ground-radar observations could exploit the advantages of both techniques, providing tracking capability close to that of ground radar while maintaining full spatial coverage. This study presents a novel method called Multi-dimensional satellite Observation information for Radar Estimation(MORE) to reconstruct radar composite reflectivity(CREF). Deep learning techniques are important components of MORE for estimating CREF from China's Fengyun-4B(FY-4B) GEO satellite observations. Two models are developed: an infraredonly(IR-Single) model available for all times, and a visible-infrared(VIS+IR) model for daytime applications. These models incorporate multi-dimensional satellite observation information, including temporal, spatial, spectral, and viewing angle information, to enhance the accuracy of radar echo reconstruction. Results demonstrate that the VIS+IR model outperforms the IR-Single model, and both models achieves a root-mean-square error(RMSE) of less than 6 dBZ and a coefficient of determination(R~2) of greater than 0.7. The models effectively reconstruct radar echoes, including strong echoes exceeding 50 dBZ, and show good agreement with precipitation data in radar-blind areas. This study offers a valuable solution for severe weather monitoring and tracking in regions lacking ground-based radar observations, and provides a potential tool for enhanced data assimilation in numerical weather prediction(NWP) models.展开更多
Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hyperten...Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.展开更多
Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 （PRMT1）/dimethyl...Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 （PRMT1）/dimethylarginine dimethylaminohydrolase （DDAH）/ asymmetrical dimethylarginine （ADMA）/NO synthase （NOS） pathway regulate NO production in the vascular endothelium. Epigallocatechin-3-gallate （EGCG） is one of the most abundant and antioxidative ingredients isolated from green tea. In the present study, 40 Sprague-Dawley rats were randomly distributed into four groups： one young rat group and three aged rat groups treated with daily gavage feedings of EGCG at doses of O, 10 mg kg-1, and 100 mg kg-1 for 12 weeks, respectively. Erectile function was assessed by electrical stimulation of the cavernous nerves with intracavernous pressure （ICP） measurement. After euthanasia, penile tissue was investigated using Western blot and ELISA to assess the PRMTI/DDAH/ADMA/NOS metabolism pathway. Superoxide dismutase （SOD） and malondialdehyde （MDA） levels were detected by colorimetry. We also evaluated smooth muscle contents. The ratio of maximal ICP and mean systemic arterial pressure （MAP） was markedly higher in EGCG-treated aged rats than in untreated aged rats. We found that DDAH 1 and DDAH2 were expressed in cavernosal tissue, and they were downregulated in corpora of aged rats. The administration of EGCG upregulated the expression and activity of DDAH. In contrast, EGCG treatment downregulated the expression of PRMT1 and ADMA content. Moreover, EGCG-treated rats showed an improvement in smooth muscle expression, the ratio of smooth muscle cell/collagen fibril, SOD activity, and MDA levels when compared with untreated aged rats.展开更多
There are vast constraint equations in conventional dynamics analysis of deployable structures,which lead to differential-algebraic equations(DAEs)solved hard.To reduce the difficulty of solving and the amount of equa...There are vast constraint equations in conventional dynamics analysis of deployable structures,which lead to differential-algebraic equations(DAEs)solved hard.To reduce the difficulty of solving and the amount of equations,a new flexible multibody dynamics analysis methodology of deployable structures with scissor-like elements(SLEs)is presented.Firstly,a precise model of a flexible bar of SLE is established by the higher order shear deformable beam element based on the absolute nodal coordinate formulation(ANCF),and the master/slave freedom method is used to obtain the dynamics equations of SLEs without constraint equations.Secondly,according to features of deployable structures,the specification matrix method(SMM)is proposed to eliminate the constraint equations among SLEs in the frame of ANCF.With this method,the inner and the boundary nodal coordinates of element characteristic matrices can be separated simply and efficiently,especially on condition that there are vast nodal coordinates.So the element characteristic matrices can be added end to end circularly.Thus,the dynamic model of deployable structure reduces dimension and can be assembled without any constraint equation.Next,a new iteration procedure for the generalized-a algorithm is presented to solve the ordinary differential equations(ODEs)of deployable structure.Finally,the proposed methodology is used to analyze the flexible multi-body dynamics of a planar linear array deployable structure based on three scissor-like elements.The simulation results show that flexibility has a significant influence on the deployment motion of the deployable structure.The proposed methodology indeed reduce the difficulty of solving and the amount of equations by eliminating redundant degrees of freedom and the constraint equations in scissor-like elements and among scissor-like elements.展开更多
The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea flavors.However,there has been relatively little research on molecular markers related t...The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea flavors.However,there has been relatively little research on molecular markers related to these metabolites.Thus,we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three seasons.The theanine,caffeine,and catechin levels in Population 1 comprising 191 tea plant germplasms were examined,which revealed that their heritability exceeded 0.5 in the analyzed seasons,with the following rank order(highest to lowest heritabilities):(+)-catechin>(−)-gallocatechin gallate>caffeine=(−)-epicatechin>(−)-epigallocatechin-3-gallate>theanine>(−)-epigallocatechin>(−)-epicatechin-3-gallate>catechin gallate>(+)-gallocatechin.The SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven subgroups.An association analysis yielded 307 SNP markers related to theanine,caffeine,and catechins that were common to all three seasons.Some of the markers were pleiotropic.The functional annotation of 180 key genes at the SNP loci revealed that FLS,UGT,MYB,and WD40 domain-containing proteins,as well as ATP-binding cassette transporters,may be important for catechin synthesis.KEGG and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite biosynthesis.Moreover,in Population 2(98 tea plant germplasm resources),30 candidate SNPs were verified,including 17 SNPs that were significantly or extremely significantly associated with specific metabolite levels.These results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties.展开更多
Thermal stability of HgCl2 has a pivotal importance for the hydrochlorination reaction as the loss of mercuric compounds is toxic and detrimental to environment.Here we report a low-mercury catalyst which has durabili...Thermal stability of HgCl2 has a pivotal importance for the hydrochlorination reaction as the loss of mercuric compounds is toxic and detrimental to environment.Here we report a low-mercury catalyst which has durability over 10000 h for acetylene hydrochlorination under the industrial condition.The stability of the catalyst is carefully analyzed from a combined experimental and density functional theory study.The analysis shows that the extraordinary stability of mercury catalyst is resulted from the synergy effects between surface oxygen groups and defective edge sites.The binding energy of HgCl2 is increased to be higher than 130 kJ/mol when adsorption is at the edge site with a nearby oxygen group.Therefore,the present study revealed that the thermal stability problem of mercury-based catalyst can be solved by simply adjusting the surface chemistry of activated carbon.Furthermore,the reported catalyst has already been successfully applied in the commercialized production of vinyl chloride.展开更多
BACKGROUND Given the shortage of suitable liver grafts for liver transplantation, proper use of hepatitis B core antibody-positive livers might be a possible way to enlarge the donor pool and to save patients with end...BACKGROUND Given the shortage of suitable liver grafts for liver transplantation, proper use of hepatitis B core antibody-positive livers might be a possible way to enlarge the donor pool and to save patients with end-stage liver diseases. However, the safety of hepatitis B virus core antibody positive(HBcAb+) donors has been controversial. Initial studies were mainly conducted overseas with relatively small numbers of HBcAb+ liver recipients, and there are few relevant reports in the population of China's Mainland. We hypothesized that the safety of HBcAb+ liver grafts is not suboptimal.AIM To evaluate the safety of using hepatitis B virus(HBV) core antibody-positive donors for liver transplantation in Chinese patients.METHODS We conducted a retrospective study enrolling 1071 patients who underwent liver transplantation consecutively from 2005 to 2016 at West China Hospital Liver Transplantation Center. Given the imbalance in several baseline variables, propensity score matching was used, and the outcomes of all recipients were reviewed in this study.RESULTS In the whole population, 230 patients received HBcAb+ and 841 patients received HBcAb negative(HBcAb-) liver grafts. The 1-, 3-and 5-year survival rates in patients and grafts between the two groups were similar(patient survival: 85.8% vs 87.2%, 77.4% vs 81.1%, 72.4% vs 76.7%, log-rank test, P = 0.16; graft survival: 83.2% vs 83.6%, 73.8% vs 75.9%, 70.8% vs 74.4%, log-rank test, P = 0.19). After propensity score matching, 210 pairs of patients were generated. The corresponding 1-, 3-and 5-year patient and graft survival rates showed no significant differences. Further studies illustrated that the post-transplant major complication rates and liver function recovery after surgery were also similar. In addition, multivariate regression analysis in the original cohort and propensity score-matched Cox analysis demonstrated that receiving HBcA b+ liver grafts was not a significant risk factor for long-term survival. These findings were consistent in both HBV surface antigen-positive(HBsAg+) and HBsA g negative(HBsAg-) patients.Newly diagnosed HBV infection had a relatively higher incidence in HBsAg-patients with HBcAb+ liver grafts(13.23%), in which HBV naive recipients suffered most(31.82%), although this difference did not affect patient and graft survival(P = 0.50 and P = 0.49, respectively). Recipients with a high HBV surface antibody(anti-HBs) titer(more than 100 IU/L) before transplantation and antiviral prophylaxis with nucleos(t)ide antiviral agents post-operation, such as nucleos(t)ide antiviral agents, had lower de novo HBV infection risks. CONCLUSION HBcA b+ liver grafts do not affect the long-term outcome of the recipients. Combined with proper postoperative antiviral prophylaxis, utilization of HBcAb+ grafts is rational and feasible.展开更多
Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracrani...Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracranial aneurysms were treated with endovascular embolization in our hospital,in which 9 cases of acute TEs occurred during the embolization procedures.The clinical data,radiological findings and treatments of the 9 patients were reviewed and analyzed.Results:The TEs occurred at the aneurysmal neck in 3 patients,at distal part of the parent artery in 3,in the stent in 2,and at the proximal part of the parent artery in 1.Intra-arterial(IA)infusion of tirofiban were performed in 6 patients,mechanical thromboectomy(MT)with a stent in 2 patients,and combined use of the two methods in 1 patients.According to the modified Thrombolysis In Cerebral Infarction(mTICI)score,7 patients had recanalization of 2b/3a,1 patients had recanalization of 1,and 1 patients had recanalization of 0.At discharge,the mRS score was 0 in 3 patients,1 in 3 patients,and 2,3,4 in 1 patient each.6 months after the endovascular treatment,the mRS score was 0 in 5 patients,1 in 2 patients,and 3 in 1 patient.Conclusions:IA tirofiban and MT are effective remedies for the acute TE during endovascular embolization of intracranial aneurysm,reasonable selection of which may improve the prognosis of patients.展开更多
BACKGROUND: Transcatheter arterial chemoembolization(TACE) and TACE in combination with sorafenib(TACEsorafenib) have shown a significant survival benefit for the treatment of unresectable hepatocellular carcinoma(HCC...BACKGROUND: Transcatheter arterial chemoembolization(TACE) and TACE in combination with sorafenib(TACEsorafenib) have shown a significant survival benefit for the treatment of unresectable hepatocellular carcinoma(HCC). Adopting either as a first-line therapy carries major cost and resource implications. The objective of this study was to estimate the relative cost-effectiveness of TACE against TACE-sorafenib for unresectable HCC using a decision analytic model.METHODS: A Markov cohort model was developed to compare TACE and TACE-sorafenib. Transition probabilities and utilities were obtained from systematic literature reviews, and costs were obtained from West China Hospital, Sichuan University, China. Survival benefits were reported in quality-adjusted life-years(QALYs). The incremental cost-effectiveness ratio(ICER) was calculated. Sensitive analysis was performed by varying potentially modifiable parameters of the model.RESULTS: The base-case analysis showed that TACE cost $26 951 and yielded survival of 0.71 QALYs, and TACE-sorafenib cost $44 542 and yielded survival of 1.02 QALYs in the entire treatment. The ICER of TACE-sorafenib versus TACE was $56 745 per QALY gained, which was above threshold for cost-effectiveness in China. Sensitivity analysis revealed that the major driver of ICER was the cost post TACE-sorafenib therapy with stable state.CONCLUSION: TACE is a more cost-effective strategy than TACE-sorafenib for the treatment of unresectable HCC.展开更多
Angle deviations between the two substrates during transient liquid phase （TLP） bonding single crystal superalloys cannot be avoided. In the present work, specimens have been prepared to investigate the influences o...Angle deviations between the two substrates during transient liquid phase （TLP） bonding single crystal superalloys cannot be avoided. In the present work, specimens have been prepared to investigate the influences of the various substrate orientations. It is found that the width of the non-isothermal solidification zone （NSZ） is linear with the square root of the isothermal solidification time. This suggests that the isothermal solidification process is B-diffusion controlled in different substrate orientation deviations. And also the width of the NSZ increases with increasing angle deviation, indicating that the isothermal solidification time needed in the TLP bonding increases with increasing orientation deviation between the two substrates.展开更多
AIM: To study the mechanism underlying carbon tetrachloride (CCl4)-induced alterations of protein synthesis in liver. METHODS: Male Sprague-Dawley rats were given CCl4 (1 mL/100 g body weight) and 3H-leucine incorpora...AIM: To study the mechanism underlying carbon tetrachloride (CCl4)-induced alterations of protein synthesis in liver. METHODS: Male Sprague-Dawley rats were given CCl4 (1 mL/100 g body weight) and 3H-leucine incorporation. Malondialdehyde (MDA) level in the liver, in vitro response of hepatocyte nuclei nucleotide triphosphatase (NTPase) to free radicals, and nuclear export of total mRNA with 3'-poly A+ were measured respectively. Survival response of HepG2 cells to CCl4 treatment was assessed by methyl thiazolyl tetrazolium. Km and Vmax values of nuclear envelope NTPase activity in liver of rats treated with CCl4 were assayed by a double-reciprocal plot. RESULTS: The protein synthesis was inhibited while the MDA level was signif icantly increased in liver of rats treated with CCl4. In addition, CCl4 decreased the NTPase binding capacity of nuclear envelope (Km value) in cultured HepG2 cells. Moreover, in vitro ferrous radicals from Fenton's system suppressed the NTPase activity of liver nuclear envelope in a dose-dependent manner. Down-regulation of the nuclear envelope NTPase activity indicated a lower energy provision for nucleocytoplasmic transport of mRNA molecules, an evidence in CCl4-treated HepG2 cells correspondingly supported by the nuclear sequestration of poly (A)+ mRNA molecules in morphological hybridization research. CONCLUSION: Inhibition of mRNA transport, suggestive of decreased NTPase activity of the nuclear envelope, may be involved in carbon tetrachloride-inhibited protein synthesis in liver.展开更多
Self-assembled nanostructure arrays integrating the advantages of the intrinsic characters of nanostructure as well as the array stability are appealing in advanced materials.However,the precise bottom-up synthesis of...Self-assembled nanostructure arrays integrating the advantages of the intrinsic characters of nanostructure as well as the array stability are appealing in advanced materials.However,the precise bottom-up synthesis of nanostructure arrays without templates or substrates is quite challenging because of the general occurrence of homogeneous nucleation and the difficult manipulation of noncovalent interactions.Herein,we first report the precisely manipulated synthesis of well-defined louver-like P-doped carbon nitride nanowire arrays(L-PCN)via a supramolecular self-assembly method by regulating the noncovalent interactions through hydrogen bond.With this strategy,CN nanowires align in the outer frame with the separation and spatial location achieving ultrastability and outstanding photoelectricity properties.Significantly,this self-assembly L-PCN exhibits a superior visible light-driven hydrogen evolution activity of 1872.9μmol h^−1 g^−1,rendering a^25.6-fold enhancement compared to bulk CN,and high photostability.Moreover,an apparent quantum efficiency of 6.93%is achieved for hydrogen evolution at 420±15 nm.The experimental results and first-principles calculations demonstrate that the remarkable enhancement of photocatalytic activity of L-PCN can be attributed to the synergetic effect of structural topology and dopant.These findings suggest that we are able to design particular hierarchical nanostructures with desirable performance using hydrogen-bond engineering.展开更多
Owing to their remarkable flexibility and favorable cost-effectiveness,industrial robots have found extensive applications to cutting of materials across sophisticated manufacturing fields.However,the structurally low...Owing to their remarkable flexibility and favorable cost-effectiveness,industrial robots have found extensive applications to cutting of materials across sophisticated manufacturing fields.However,the structurally low rigidity of these robots renders the tool tip prone to substantial oscillations during machining processes,significantly impacting product fabrication quality.The objective of this study is to present a novel methodology employing magnetorheological dampers for mitigating vibrations during robotic milling operations.Specifically,a new type of ring nested Magneto-Rheological Foam Damper(MRFD)working in the squeeze mode is developed.Firstly,the MRFD’s structure is designed considering the vibrational characteristics of robotic milling.Subsequently,a damping force model of the MRFD is derived.The feasibility of the MRFD’s structural design is validated by the finite element analyses,which is instrumental in comprehending the influence of structural parameters on the electromagnetic characteristics of the MRFD.Next,a prototype of the MRFD is fabricated selecting appropriate parameters.Finally,a series of excitation and milling experiments are conducted on a KUKA KR500 robot.The outcomes demonstrate a substantial reduction(37%-69%)in radial vibration amplitude at the tool tip during robotic milling,highlighting the effectiveness of the developed MRFD.This research endeavor has introduced a pioneering avenue and framework for vibration control in robotic milling,offering a novel paradigm for enhancing the precision of robotic machining.展开更多
基金supported by the National Key Research and Development Program of China(Nos.2022YFD1700800 and 2023YFC3905903)the Science and Technology Project of Education Department of Jiangxi Province(No.GJJ2201103)+2 种基金the Fund of Nanchang Hangkong University(Nos.EA202201110 and EA202201065)National Undergraduate Innovation and Entrepreneurship Training Program(No.202310406023)the National Natural Science Foundation of China(No.52470149)。
文摘Covalent organic frameworks(COFs)are crystalline porous polymeric materials composed of organic monomers connected by strong covalent bonds and offer high stability,good crystallinity,a large specific surface area,and controllable structures.COFs are widely used in the fields of adsorption and separation,catalysis,photovoltaics,and drug-delivery.The structural regulation and performance optimization of COFs can be realized through the modification of ligands and the selection of linkage methods.In which,the types of linkage are closely related to the stability and performance of COFs.In this review,nitrogencontaining linkage-bonds(NCLBs)in COFs are divided into N-containing double bonds,N-containing conjugated rings and N-containing unconjugated rings.The association between structure and performance of COFs is elaborated and the synthesis methods of COFs are systematically summarized.Moreover,the structural design,theoretical prediction and machinable application of COFs are prospected.
基金supported by the Tianjin Key Medical Discipline(Specialty)Construct Project,No.TJYXZDXK-027A(to SF)the National Key Research andDevelopment Project of Stem Cell and Transformation Research,No.2019YFA0112100(to SF)+2 种基金Tianjin Natural Science Foundation’s Youth Project for DiverseInvestments,No.21JCQNJC01300(to BF)the National Natural Science Foundation of China(Youth Program),No.82102563(to BF)Tianjin Major Science andTechnology Special Projects and Engineering Projects,No.21ZXJBSY00080(to YR).
文摘Few studies have investigated alterations in the immune cell microenvironment of the dorsal root ganglia following spinal cord injury and whether these modifications facilitate axonal regeneration.In this study,we used a single-cell RNA sequencing dataset to create a comprehensive profile of the diverse cell types in the dorsal root ganglia and spinal cord of a mid-thoracic contusion injury model in cynomolgus monkeys.Cell communication analysis indicated that specific signaling events among various dorsal root ganglia cell types occur in response to spinal cord injury.Single-cell analysis using dimensionality reduction clustering identified distinct molecular signatures for nine cell types,including macrophage subpopulations,and differential gene expression profiles between dorsal root ganglia cells and spinal cord cells following spinal cord injury.The macrophage subpopulations were categorized into 11 clusters(MC0-MC10)based on differentially expressed genes,with the top 10 genes being ABCA6,RBMS3,EBF1,LAMA4,ANTXR2,LAMA2,SOX5,FOXP2,GHR,and APOD.MC0,MC1,and MC2 constituted the predominant macrophage populations.MC4,MC6,and MC9 were nearly absent in the spinal cord,but exhibited significant increases in the dorsal root ganglia post-spinal cord injury.Notably,these subpopulations possess a strong capacity for regulating axonal regeneration.The developmental progression of dorsal root ganglia macrophages after spinal cord injury was elucidated using cell trajectory and pseudo-time analyses.Genes such as EBF1(MC6 and MC9 marker),RBMS3(MC6 and MC9 marker),and ABCA6(MC6 marker)showed high expression levels in the critical pathways of macrophage function.Through ligand-receptor pair analysis,we determined that the effects of macrophages on microglia are predominantly mediated through interaction pairs(e.g.,SPP1-CD44,LAMC1-CD44,and FN1-CD44),potentially facilitating specific cellular communications within the immune microenvironment.The single-cell RNA sequencing dataset used in this study represents the first comprehensive transcriptional analysis of the dorsal root ganglia after spinal cord injury in cynomolgus monkeys,encompassing nearly all cell types within the dorsal root ganglia region.Using this dataset,we evaluated diverse subtypes of macrophages in the post-spinal cord injury dorsal root ganglia area and examined the signaling pathways that facilitate interactions among immune response-related macrophages in the dorsal root ganglia.Findings from this study provide a theoretical basis for understanding how the immune microenvironment influences the regenerative capacity of dorsal root ganglia neurons after spinal cord injury and offer novel insights into the complex processes underlying the pathobiology of spinal cord injury.
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
基金supported by the National Key Research and Development Program of China(No.2022YFD1700801-3)Key Laboratory of Jiangxi Province for Persistent Pollutants Prevention Control and Resource Reuse(No.2023SSY02061)support of the projects and research platform support provided by the laboratory.
文摘Single-atom catalysts(SACs)are among the most cutting-edge catalysts in the multiphase catalysis track due to their unique geometrical and electronic properties,the highest atom utilization efficiency,and uniform active sites.SACs have been facing an unresolved problem in practical applications:the opposing contradiction of activity-stability.The successful development of single-atom nano-islands(SANIs)cleverly combines the ultra-high atom utilization efficiency of SACs with the confinement effect and structural stability of nano-island structures,realizing the“moving but not aggregation”of SACs,which fundamentally solves this inherent contradiction.Although research on the precise loading of single atoms on nano-islands continues to advance,existing reviews have not yet established a closed-loop cognitive framework encompassing“models-synthesis-high stability mechanisms-high activity essence-applications.”This work fills this critical gap by systematically integrating the basic conceptual models and cutting-edge synthesis strategies of SANIs,focusing on revealing the underlying mechanisms by which SANIs overcome the stability bottleneck of SACs,elucidating the role of nano-islands and their synergistic mechanisms to clarify the high activity essence,and establishing the structure-activity relationship between atomic confinement effects and macroscopic performance,ultimately achieving breakthrough validation across catalytic systems.This review aims to open new perspectives,drive a paradigm shift in understanding the multi-dimensional advantages of SANIs,and thereby spur breakthrough progress in this frontier field.
基金financially supported by the National Natural Science Foundation of China (No.51972302)。
文摘The recovery of gold from waste electronic and electric equipment(WEEE) has gained great attention with the increased number of WEEE,because it can largely alleviate the pressure on the environment and resources.Covalent organic frameworks(COFs) are ideal adsorbents for gold recovery owing to their large surface area,good stability,easily functionalized ability,periodic structures,and definitive nanopores.Herein,a cyano-functionalized COF(COF-CN) with high crystallinity was large-scale prepared under mild conditions for the recovery of gold.The introduction of cyano groups enable COF-CN to exhibit excellent gold recovery performance,which possesses fast adsorption kinetics,high cycling stability,and adsorption capacity up to 663.67 mg/g.Excitingly,COF-CN showed extremely high selectivity for gold ions,even in the presence of various competing cations and anions.The COF-CN maintained excellent selectivity and removal efficiency in gold recovery experiments from WEEE.The facile synthesis of COF-CN and its outstanding selectivity in actual samples make it an attractive opportunity for practical gold recovery.
基金supported by the National Natural Science Foundation of China (NSFC) (Grant No.42205044)Feng Yun Application Pioneering Project (FY-APP) Innovation Center for Feng Yun Meteorological Satellite (FYSIC) Special Project (FY-APP-XC-2023.04)the Wuxi University Research Start-up Fund for Recruited Talent。
文摘Ground-based radar is the primary means by which severe storms are monitored and tracked;however, due to limited coverage, important data is often missed over ocean and mountainous areas. On the other hand, geostationary(GEO)weather satellites provide continuous observations with seamless coverage with advanced imager, despite their limited capability to penetrate clouds. Combining satellite and ground-radar observations could exploit the advantages of both techniques, providing tracking capability close to that of ground radar while maintaining full spatial coverage. This study presents a novel method called Multi-dimensional satellite Observation information for Radar Estimation(MORE) to reconstruct radar composite reflectivity(CREF). Deep learning techniques are important components of MORE for estimating CREF from China's Fengyun-4B(FY-4B) GEO satellite observations. Two models are developed: an infraredonly(IR-Single) model available for all times, and a visible-infrared(VIS+IR) model for daytime applications. These models incorporate multi-dimensional satellite observation information, including temporal, spatial, spectral, and viewing angle information, to enhance the accuracy of radar echo reconstruction. Results demonstrate that the VIS+IR model outperforms the IR-Single model, and both models achieves a root-mean-square error(RMSE) of less than 6 dBZ and a coefficient of determination(R~2) of greater than 0.7. The models effectively reconstruct radar echoes, including strong echoes exceeding 50 dBZ, and show good agreement with precipitation data in radar-blind areas. This study offers a valuable solution for severe weather monitoring and tracking in regions lacking ground-based radar observations, and provides a potential tool for enhanced data assimilation in numerical weather prediction(NWP) models.
基金supported by grants from the Sichuan Science and Technology Program(2023YFQ0094)the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(25HXJS028).
文摘Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.
文摘Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 （PRMT1）/dimethylarginine dimethylaminohydrolase （DDAH）/ asymmetrical dimethylarginine （ADMA）/NO synthase （NOS） pathway regulate NO production in the vascular endothelium. Epigallocatechin-3-gallate （EGCG） is one of the most abundant and antioxidative ingredients isolated from green tea. In the present study, 40 Sprague-Dawley rats were randomly distributed into four groups： one young rat group and three aged rat groups treated with daily gavage feedings of EGCG at doses of O, 10 mg kg-1, and 100 mg kg-1 for 12 weeks, respectively. Erectile function was assessed by electrical stimulation of the cavernous nerves with intracavernous pressure （ICP） measurement. After euthanasia, penile tissue was investigated using Western blot and ELISA to assess the PRMTI/DDAH/ADMA/NOS metabolism pathway. Superoxide dismutase （SOD） and malondialdehyde （MDA） levels were detected by colorimetry. We also evaluated smooth muscle contents. The ratio of maximal ICP and mean systemic arterial pressure （MAP） was markedly higher in EGCG-treated aged rats than in untreated aged rats. We found that DDAH 1 and DDAH2 were expressed in cavernosal tissue, and they were downregulated in corpora of aged rats. The administration of EGCG upregulated the expression and activity of DDAH. In contrast, EGCG treatment downregulated the expression of PRMT1 and ADMA content. Moreover, EGCG-treated rats showed an improvement in smooth muscle expression, the ratio of smooth muscle cell/collagen fibril, SOD activity, and MDA levels when compared with untreated aged rats.
基金Supported by National Natural Science Foundation of China(Grant No.51175422)
文摘There are vast constraint equations in conventional dynamics analysis of deployable structures,which lead to differential-algebraic equations(DAEs)solved hard.To reduce the difficulty of solving and the amount of equations,a new flexible multibody dynamics analysis methodology of deployable structures with scissor-like elements(SLEs)is presented.Firstly,a precise model of a flexible bar of SLE is established by the higher order shear deformable beam element based on the absolute nodal coordinate formulation(ANCF),and the master/slave freedom method is used to obtain the dynamics equations of SLEs without constraint equations.Secondly,according to features of deployable structures,the specification matrix method(SMM)is proposed to eliminate the constraint equations among SLEs in the frame of ANCF.With this method,the inner and the boundary nodal coordinates of element characteristic matrices can be separated simply and efficiently,especially on condition that there are vast nodal coordinates.So the element characteristic matrices can be added end to end circularly.Thus,the dynamic model of deployable structure reduces dimension and can be assembled without any constraint equation.Next,a new iteration procedure for the generalized-a algorithm is presented to solve the ordinary differential equations(ODEs)of deployable structure.Finally,the proposed methodology is used to analyze the flexible multi-body dynamics of a planar linear array deployable structure based on three scissor-like elements.The simulation results show that flexibility has a significant influence on the deployment motion of the deployable structure.The proposed methodology indeed reduce the difficulty of solving and the amount of equations by eliminating redundant degrees of freedom and the constraint equations in scissor-like elements and among scissor-like elements.
基金This work was supported by Key-Area Research and Development Program of Guangdong Province[2020B020220004]the earmarked fund for the National Modern Agro-industry Technology Research System(CARS-19)+5 种基金the National Natural Science Foundation of China(31600550)Science and Technology program of Guangdong Province(2016A030303032 and 2019B030316026)Discipline team building projects of Guangdong Academy of Agricultural Sciences in the 13th Five-Year Period(201619TD)Special funds for scientific innovation strategy-construction of high level Academy of Agriculture Science(R2017PY-QY009)Integrated demonstration of key techniques for the industrial development of featured crops in rocky desertification areas of Yunnan-Guangxi-Guizhou provinces(SMH2019-2021)the Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences(1630052019022).
文摘The characteristic secondary metabolites in tea(theanine,caffeine,and catechins)are important factors contributing to unique tea flavors.However,there has been relatively little research on molecular markers related to these metabolites.Thus,we conducted a genome-wide association analysis of the levels of these tea flavor-related metabolites in three seasons.The theanine,caffeine,and catechin levels in Population 1 comprising 191 tea plant germplasms were examined,which revealed that their heritability exceeded 0.5 in the analyzed seasons,with the following rank order(highest to lowest heritabilities):(+)-catechin>(−)-gallocatechin gallate>caffeine=(−)-epicatechin>(−)-epigallocatechin-3-gallate>theanine>(−)-epigallocatechin>(−)-epicatechin-3-gallate>catechin gallate>(+)-gallocatechin.The SNPs detected by amplified-fragment SNP and methylation sequencing divided Population 1 into three groups and seven subgroups.An association analysis yielded 307 SNP markers related to theanine,caffeine,and catechins that were common to all three seasons.Some of the markers were pleiotropic.The functional annotation of 180 key genes at the SNP loci revealed that FLS,UGT,MYB,and WD40 domain-containing proteins,as well as ATP-binding cassette transporters,may be important for catechin synthesis.KEGG and GO analyses indicated that these genes are associated with metabolic pathways and secondary metabolite biosynthesis.Moreover,in Population 2(98 tea plant germplasm resources),30 candidate SNPs were verified,including 17 SNPs that were significantly or extremely significantly associated with specific metabolite levels.These results will provide a foundation for future research on important flavor-related metabolites and may help accelerate the breeding of new tea varieties.
文摘Thermal stability of HgCl2 has a pivotal importance for the hydrochlorination reaction as the loss of mercuric compounds is toxic and detrimental to environment.Here we report a low-mercury catalyst which has durability over 10000 h for acetylene hydrochlorination under the industrial condition.The stability of the catalyst is carefully analyzed from a combined experimental and density functional theory study.The analysis shows that the extraordinary stability of mercury catalyst is resulted from the synergy effects between surface oxygen groups and defective edge sites.The binding energy of HgCl2 is increased to be higher than 130 kJ/mol when adsorption is at the edge site with a nearby oxygen group.Therefore,the present study revealed that the thermal stability problem of mercury-based catalyst can be solved by simply adjusting the surface chemistry of activated carbon.Furthermore,the reported catalyst has already been successfully applied in the commercialized production of vinyl chloride.
文摘BACKGROUND Given the shortage of suitable liver grafts for liver transplantation, proper use of hepatitis B core antibody-positive livers might be a possible way to enlarge the donor pool and to save patients with end-stage liver diseases. However, the safety of hepatitis B virus core antibody positive(HBcAb+) donors has been controversial. Initial studies were mainly conducted overseas with relatively small numbers of HBcAb+ liver recipients, and there are few relevant reports in the population of China's Mainland. We hypothesized that the safety of HBcAb+ liver grafts is not suboptimal.AIM To evaluate the safety of using hepatitis B virus(HBV) core antibody-positive donors for liver transplantation in Chinese patients.METHODS We conducted a retrospective study enrolling 1071 patients who underwent liver transplantation consecutively from 2005 to 2016 at West China Hospital Liver Transplantation Center. Given the imbalance in several baseline variables, propensity score matching was used, and the outcomes of all recipients were reviewed in this study.RESULTS In the whole population, 230 patients received HBcAb+ and 841 patients received HBcAb negative(HBcAb-) liver grafts. The 1-, 3-and 5-year survival rates in patients and grafts between the two groups were similar(patient survival: 85.8% vs 87.2%, 77.4% vs 81.1%, 72.4% vs 76.7%, log-rank test, P = 0.16; graft survival: 83.2% vs 83.6%, 73.8% vs 75.9%, 70.8% vs 74.4%, log-rank test, P = 0.19). After propensity score matching, 210 pairs of patients were generated. The corresponding 1-, 3-and 5-year patient and graft survival rates showed no significant differences. Further studies illustrated that the post-transplant major complication rates and liver function recovery after surgery were also similar. In addition, multivariate regression analysis in the original cohort and propensity score-matched Cox analysis demonstrated that receiving HBcA b+ liver grafts was not a significant risk factor for long-term survival. These findings were consistent in both HBV surface antigen-positive(HBsAg+) and HBsA g negative(HBsAg-) patients.Newly diagnosed HBV infection had a relatively higher incidence in HBsAg-patients with HBcAb+ liver grafts(13.23%), in which HBV naive recipients suffered most(31.82%), although this difference did not affect patient and graft survival(P = 0.50 and P = 0.49, respectively). Recipients with a high HBV surface antibody(anti-HBs) titer(more than 100 IU/L) before transplantation and antiviral prophylaxis with nucleos(t)ide antiviral agents post-operation, such as nucleos(t)ide antiviral agents, had lower de novo HBV infection risks. CONCLUSION HBcA b+ liver grafts do not affect the long-term outcome of the recipients. Combined with proper postoperative antiviral prophylaxis, utilization of HBcAb+ grafts is rational and feasible.
文摘Objective:The study aimed to discuss the treatment of acute thromboembolic event(TE)during endovascular embolization of intracranial aneurysms.Methods:Between April 2013 and April 2019,158 patients with 167 intracranial aneurysms were treated with endovascular embolization in our hospital,in which 9 cases of acute TEs occurred during the embolization procedures.The clinical data,radiological findings and treatments of the 9 patients were reviewed and analyzed.Results:The TEs occurred at the aneurysmal neck in 3 patients,at distal part of the parent artery in 3,in the stent in 2,and at the proximal part of the parent artery in 1.Intra-arterial(IA)infusion of tirofiban were performed in 6 patients,mechanical thromboectomy(MT)with a stent in 2 patients,and combined use of the two methods in 1 patients.According to the modified Thrombolysis In Cerebral Infarction(mTICI)score,7 patients had recanalization of 2b/3a,1 patients had recanalization of 1,and 1 patients had recanalization of 0.At discharge,the mRS score was 0 in 3 patients,1 in 3 patients,and 2,3,4 in 1 patient each.6 months after the endovascular treatment,the mRS score was 0 in 5 patients,1 in 2 patients,and 3 in 1 patient.Conclusions:IA tirofiban and MT are effective remedies for the acute TE during endovascular embolization of intracranial aneurysm,reasonable selection of which may improve the prognosis of patients.
文摘BACKGROUND: Transcatheter arterial chemoembolization(TACE) and TACE in combination with sorafenib(TACEsorafenib) have shown a significant survival benefit for the treatment of unresectable hepatocellular carcinoma(HCC). Adopting either as a first-line therapy carries major cost and resource implications. The objective of this study was to estimate the relative cost-effectiveness of TACE against TACE-sorafenib for unresectable HCC using a decision analytic model.METHODS: A Markov cohort model was developed to compare TACE and TACE-sorafenib. Transition probabilities and utilities were obtained from systematic literature reviews, and costs were obtained from West China Hospital, Sichuan University, China. Survival benefits were reported in quality-adjusted life-years(QALYs). The incremental cost-effectiveness ratio(ICER) was calculated. Sensitive analysis was performed by varying potentially modifiable parameters of the model.RESULTS: The base-case analysis showed that TACE cost $26 951 and yielded survival of 0.71 QALYs, and TACE-sorafenib cost $44 542 and yielded survival of 1.02 QALYs in the entire treatment. The ICER of TACE-sorafenib versus TACE was $56 745 per QALY gained, which was above threshold for cost-effectiveness in China. Sensitivity analysis revealed that the major driver of ICER was the cost post TACE-sorafenib therapy with stable state.CONCLUSION: TACE is a more cost-effective strategy than TACE-sorafenib for the treatment of unresectable HCC.
基金financially supported by the National Basic Research Program (973 Program) of China under Grant Nos. 2010CB631200 and 2010CB631206the National Natural Science Foundation of China (NSFC) under Grant Nos. 50971124, 50904059, 51071165 and 51204156
文摘Angle deviations between the two substrates during transient liquid phase （TLP） bonding single crystal superalloys cannot be avoided. In the present work, specimens have been prepared to investigate the influences of the various substrate orientations. It is found that the width of the non-isothermal solidification zone （NSZ） is linear with the square root of the isothermal solidification time. This suggests that the isothermal solidification process is B-diffusion controlled in different substrate orientation deviations. And also the width of the NSZ increases with increasing angle deviation, indicating that the isothermal solidification time needed in the TLP bonding increases with increasing orientation deviation between the two substrates.
基金Supported by The National Natural Science Foundation of China,No.30470846
文摘AIM: To study the mechanism underlying carbon tetrachloride (CCl4)-induced alterations of protein synthesis in liver. METHODS: Male Sprague-Dawley rats were given CCl4 (1 mL/100 g body weight) and 3H-leucine incorporation. Malondialdehyde (MDA) level in the liver, in vitro response of hepatocyte nuclei nucleotide triphosphatase (NTPase) to free radicals, and nuclear export of total mRNA with 3'-poly A+ were measured respectively. Survival response of HepG2 cells to CCl4 treatment was assessed by methyl thiazolyl tetrazolium. Km and Vmax values of nuclear envelope NTPase activity in liver of rats treated with CCl4 were assayed by a double-reciprocal plot. RESULTS: The protein synthesis was inhibited while the MDA level was signif icantly increased in liver of rats treated with CCl4. In addition, CCl4 decreased the NTPase binding capacity of nuclear envelope (Km value) in cultured HepG2 cells. Moreover, in vitro ferrous radicals from Fenton's system suppressed the NTPase activity of liver nuclear envelope in a dose-dependent manner. Down-regulation of the nuclear envelope NTPase activity indicated a lower energy provision for nucleocytoplasmic transport of mRNA molecules, an evidence in CCl4-treated HepG2 cells correspondingly supported by the nuclear sequestration of poly (A)+ mRNA molecules in morphological hybridization research. CONCLUSION: Inhibition of mRNA transport, suggestive of decreased NTPase activity of the nuclear envelope, may be involved in carbon tetrachloride-inhibited protein synthesis in liver.
基金the National Natural Science Foundation of China(Nos.51772085 and U1830138)Hunan Provincial Innovation Foundation for Postgraduate(No.CX20190311)
文摘Self-assembled nanostructure arrays integrating the advantages of the intrinsic characters of nanostructure as well as the array stability are appealing in advanced materials.However,the precise bottom-up synthesis of nanostructure arrays without templates or substrates is quite challenging because of the general occurrence of homogeneous nucleation and the difficult manipulation of noncovalent interactions.Herein,we first report the precisely manipulated synthesis of well-defined louver-like P-doped carbon nitride nanowire arrays(L-PCN)via a supramolecular self-assembly method by regulating the noncovalent interactions through hydrogen bond.With this strategy,CN nanowires align in the outer frame with the separation and spatial location achieving ultrastability and outstanding photoelectricity properties.Significantly,this self-assembly L-PCN exhibits a superior visible light-driven hydrogen evolution activity of 1872.9μmol h^−1 g^−1,rendering a^25.6-fold enhancement compared to bulk CN,and high photostability.Moreover,an apparent quantum efficiency of 6.93%is achieved for hydrogen evolution at 420±15 nm.The experimental results and first-principles calculations demonstrate that the remarkable enhancement of photocatalytic activity of L-PCN can be attributed to the synergetic effect of structural topology and dopant.These findings suggest that we are able to design particular hierarchical nanostructures with desirable performance using hydrogen-bond engineering.
基金co-supported by the Natural Science Foundation of Jiangsu Province(No.BK20230092)by the National Natural Science Foundation of China(Nos.52375500,52075256,and U22A20204).
文摘Owing to their remarkable flexibility and favorable cost-effectiveness,industrial robots have found extensive applications to cutting of materials across sophisticated manufacturing fields.However,the structurally low rigidity of these robots renders the tool tip prone to substantial oscillations during machining processes,significantly impacting product fabrication quality.The objective of this study is to present a novel methodology employing magnetorheological dampers for mitigating vibrations during robotic milling operations.Specifically,a new type of ring nested Magneto-Rheological Foam Damper(MRFD)working in the squeeze mode is developed.Firstly,the MRFD’s structure is designed considering the vibrational characteristics of robotic milling.Subsequently,a damping force model of the MRFD is derived.The feasibility of the MRFD’s structural design is validated by the finite element analyses,which is instrumental in comprehending the influence of structural parameters on the electromagnetic characteristics of the MRFD.Next,a prototype of the MRFD is fabricated selecting appropriate parameters.Finally,a series of excitation and milling experiments are conducted on a KUKA KR500 robot.The outcomes demonstrate a substantial reduction(37%-69%)in radial vibration amplitude at the tool tip during robotic milling,highlighting the effectiveness of the developed MRFD.This research endeavor has introduced a pioneering avenue and framework for vibration control in robotic milling,offering a novel paradigm for enhancing the precision of robotic machining.
