Internal herniation(IH)refers to the movement of intra-abdominal organs or tissues out of their original position through normal or abnormal orifices and fissures in the peritoneum or mesentery and into an anatomic sp...Internal herniation(IH)refers to the movement of intra-abdominal organs or tissues out of their original position through normal or abnormal orifices and fissures in the peritoneum or mesentery and into an anatomic space within the abdominal cavity.Although the incidence of small bowel obstruction(SBO)caused by IH is very low(approximately 0.2%to 0.9%),its incidence may be increased in certain specific populations or in postoperative patients.Recently Kaw et al shared their 13-year experience of managing IHs in a tertiary care hospital in India.This retrospective study analyzed and determined the clinico-demographic profiles,radiological and operative findings and postoperative course of patients with IH and the association with SBO.The results provide valuable insights into early diagnosis and establishment of a timely treatment regimen for this condition and emphasize the importance of combining rapid imaging evaluation with the traditional therapeutic approach of laparoscopic surgery,thus providing a novel perspective on the diagnosis and treatment of SBO caused by IH.展开更多
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,brexanolone,zuranolone)targeting the GABA-A receptor were introduced.The zona incerta(ZI),an inhibitory subthalamic region mainly composed of GABAergic neurons,has been implicated in emotional regulation.Deep brain stimulation of the ZI in humans affects anxiety and depression symptoms,while activation of ZI neurons in mice can either worsen or alleviate anxiety.Currently,there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in rodents.AIM To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in mice.METHODS A chronic restraint stress(CRS)model was utilized to induce depression in mice.Whole-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ZI.Additionally,chemogenetic techniques were employed to modulate ZI GABAergic neurons.The performance of the mice in behavioral tests for depression and anxiety was observed.RESULTS The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in mice.Twenty-eight days after the CRS model was established,depression-like and anxiety-like behaviors were observed in the mice.The excitability of GABAergic neurons in the ZI was reduced.Chemogenetic activation of these neurons alleviated CRS-induced depression-like and anxiety-like behaviors.Conversely,inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in mice.CONCLUSION Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice,suggesting that these neurons could be a potential therapeutic target for treating depression.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have fo...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up^(18)F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas^(18)F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.展开更多
Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangio...Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events.展开更多
Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment process.Psychological distress of FCs is common and often ignored.A simple and effective instrument for screening ps...Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment process.Psychological distress of FCs is common and often ignored.A simple and effective instrument for screening psychological distress would help in selecting those FCs requiring special attention and intervention.Here,the validity of distress thermometer(DT)in FCs of Chinese breast cancer patients receiving postoperative chemotherapy was assessed,and the prevalence of anxiety and depression was evaluated.Methods:We recruited 200 FCs of hospitalized breast cancer patients in this cross-sectional descriptive study.Before the first cycle of adjuvant chemotherapy,the levels of anxiety and depression among FCs were assessed using DT and Hospital Anxiety and Depression Scale(HADS).In total,191 valid cases were analyzed.HADS was used as the diagnostic standard to assess the effectiveness of DT as a screening tool for anxiety and depression as well as to analyze the diagnostic efficiency of DT at various cutoff points.Results:The definitive prevalence of both anxiety and depression was 8.90%.The mean level of anxiety and depression among FCs was 5.64±3.69 and 5.09±3.85,respectively,both of which were significantly higher than corresponding Chinese norms(P<0.01).The areas under receiver operating characteristic curves of DT for the diagnoses of FCs'anxiety and depression were 0.904 and 0.885,respectively.A cutoff value of 5 produced the best diagnostic effects of DT for anxiety and depression.Conclusions:The levels of both anxiety and depression were higher in the FCs of Chinese breast cancer patients receiving postoperative chemotherapy than the national norm.DT might be an effective tool to initially screen psychological distress among FCs.This process could be integrated into the palliative care of breast cancer patients and warrant further research.展开更多
Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic ...Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic landscape.Cross-line CDK4/6i therapy in which another CDK4/6i is continued after progression on a prior CDK4/6i may still offer advantageous therapeutic effects.Cross-line CDK4/6i therapy is an area of active investigation in the ongoing pursuit to improve outcomes for patients with HR+/human epidermal growth factor receptor 2(HER2)–ABC.Methods:This retrospective study enrolled 82 patients with HR+/HER2–ABC who were treated with cross-line CDK4/6is(abemaciclib,palbociclib,ribociclib,and dalpiciclib)after progression with another CDK4/6i.The primary endpoint was progression-free survival(PFS)according to version 1.1 of the Response Evaluation Criteria in Solid Tumors.Secondary endpoints included toxicity,objective response rate,disease control rate,and overall survival.Adverse events(AEs)were graded according to version 5.0 of the Common Terminology Criteria for Adverse Events,as promulgated by the U.S.Department of Health and Human Services.Results:Eighty-two HR+/HER2–ABC patients who received cross-line CDK4/6i therapy from January 2022 to February 2024 were enrolled.The median age of the patients was 60 years.The median PFS of all patients was 7.6 months(95%CI,5.9-9.2).Cox regression analysis identified lung metastasis and a switch to endocrine therapy following prior CDK4/6i therapy as independent predictive factors for PFS.Notably,patients who previously received abemaciclib and switched to palbociclib upon disease progression had a median PFS of 10.7 months.The strategy of transitioning to chemotherapy after progression on a prior CDK4/6i,then to a subsequent CDK4/6i merits further investigation.Hematologic toxicity was the most common grade≥3 AEs.No instances of fatal safety events were observed.Conclusions:Cross-line CDK4/6i therapy is associated with significant clinical benefits and manageable safety profiles in patients with HR+/HER2–ABC,which underscores cross-line CDK4/6i therapy potential as an effective treatment strategy.展开更多
Objective: The mechanism of acquired gene mutation plays a major role in resistance to endocrine therapy in hormone receptor(HR)-positive advanced breast cancer. Circulating tumor DNA(ctDNA) has been allowed for the a...Objective: The mechanism of acquired gene mutation plays a major role in resistance to endocrine therapy in hormone receptor(HR)-positive advanced breast cancer. Circulating tumor DNA(ctDNA) has been allowed for the assessment of the genomic profiles of patients with advanced cancer. We performed this study to search for molecular markers of endocrine therapy efficacy and to explore the clinical value of ctDNA to guide precise endocrine therapy for HR-positive/human epidermal growth factor receptor-2(HER-2)-negative metastatic breast cancer patients.Methods: In this open-label, multicohort, prospective study, patients were assigned to four parallel cohorts and matched according to mutations identified in ctDNA: 1) activation of the phosphatidylinositol-3-kinase(PI3K)/AKT/mammalian target of rapamycin(mTOR) signaling pathway preferred mTOR inhibitor combined with endocrine therapy;2) estrogen receptor 1(ESR1) mutation preferred fulvestrant;3) HER-2 mutations preferred pyrotinib;and 4) no actionable mutations received treatment according to the clinical situation. In all cohorts, patients were divided into compliance group and violation group. The primary outcome measure was progression-free survival(PFS), and the secondary outcome measure was overall survival(OS).Results: In all cohorts, the combined median PFS was 4.9 months, and median PFS for the compliance and violation groups was 6.0 and 3.0 months, respectively [P=0.022, hazard ratio(HR)=0.57]. Multivariate Cox regression model showed the risk of disease progression was lower in compliance group than in violation group(P=0.023, HR=0.55). Among the patients with HER-2 mutations, the median PFS was 11.1 months in the compliance group and 2.2 months in the violation group(P=0.011, HR=0.20). There was no significant difference in the median PFS between patients who did and did not comply with the treatment protocol in patients with activation of the PI3K/AKT/mTOR or ESR1 mutation.Conclusions: The results suggest that ctDNA may help to guide the optimal endocrine therapy strategy for metastatic breast cancer patients and to achieve a better PFS. Next-generation sequencing(NGS) detection could aid in distinguishing patients with HER-2 mutation and developing new treatment strategies.展开更多
Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is...Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is still poorly understood,especially with respect to unique problem of maintaining force generation and transmission within the confine of an ever-changing cytoskeleton in smooth muscle.Using a cytoskeletal preparation derived from skinned airway smooth muscle,we aimed at separating the contribution of actomyosin interaction and elucidating the cytoskeletal stiffness in smooth muscle.The results indicate that there is a Ca++de-展开更多
Recycling spent lithium-ion batteries(LIBs)is crucial for environmental protection and sustainability.Currently,the main methods for recycling spent LIBs include element extraction and material regeneration.Materials ...Recycling spent lithium-ion batteries(LIBs)is crucial for environmental protection and sustainability.Currently,the main methods for recycling spent LIBs include element extraction and material regeneration.Materials upcycling is a complementary strategy aimed at transforming existing materials into next-generation high-performance materials.This review summarizes recent advancements in upcycling cathode materials from spent LIBs into high-performance cathode.We begin by outlining the development of cathode materials and exploiting how material upcycling can meet the needs of future battery technologies.Next,we introduce the concept and historical evolution of cathode material upcycling and provide a detailed summary of strategies such as doping,coating,and the transformation between different cathode materials.Finally,we discuss the challenges of cathode upcycling and offer guidance for future research directions.展开更多
Based on available experimental results on χ_(cJ)(J = 0,1,2) decays, we investigated the χ_(cJ)-→PP,VV,PV, and PT decays using the SU(3) flavor symmetry/breaking approach, where P, V, and T denote light pseudoscala...Based on available experimental results on χ_(cJ)(J = 0,1,2) decays, we investigated the χ_(cJ)-→PP,VV,PV, and PT decays using the SU(3) flavor symmetry/breaking approach, where P, V, and T denote light pseudoscalar, vector, and tensor mesons, respectively. With the decay amplitude relations determined by SU(3) flavor symmetry/breaking, we present the branching ratios for all χ_(cJ)-PP and χ_(cJ) → VV modes, including those without experimental data. While theoretical considerations strongly suppress or even forbid most χ_(cJ) - PV and PT decays,we also provide quantitative predictions constrained by existing experimental data. Our results are expected to be accessible in future experiments at BESIlI and the planned Super Tau-Charm Facility.展开更多
This study focuses on Early Cretaceous mudstones from the Shahai and Fuxin formations in the Fuxin continental basin. We analyse chemical weathering, land surface temperatures and palaeoclimates based on chemical weat...This study focuses on Early Cretaceous mudstones from the Shahai and Fuxin formations in the Fuxin continental basin. We analyse chemical weathering, land surface temperatures and palaeoclimates based on chemical weathering indices, and emphasize the implications of continental chemical weathering on nutrient fluxes into lakes and oceans.According to Cr and Ni abundance, Al2O3-TiO2, La/Sc-Th/Co and V-Ni-Th×10 plots, as well as rare earth element(REE)analysis, mudstone samples from the Shahai and Fuxin formations were derived from the same type of provenance comprising mainly felsic igneous rocks. Chemical weathering trends reflected by the Chemical Index of Alteration(CIA),Weathering Index of Parker(WIP) and the Mafic Index of Alteration for Oxidative weathering environments(MIA(O)) are consistent with each other and allow the geological succession to be divided into four stages. Land surface temperatures of the Shahai and Fuxin formations are estimated based on the linear relationship of CIA to temperature,and also can be divided into four stages consistent with those determined from chemical weathering trends. During Stage A(early part of the late Aptian) chemical weathering and land surface temperatures were relatively low and showed characteristic high fluctuations, while Stage B(latest Aptian) represented a transitional period where weathering rates and temperatures increased, and high amplitude fluctuations continued. Conditions changed markedly in Stage C(early Albian) with very high and stable weathering, and warm, humid climates, while in Stage D(middle and late Albian) conditions returned to low chemical weathering and land surface temperatures. These stages of chemical weathering and land surface temperature fluctuations represent responses to global climate fluctuations during the Early Cretaceous, with the early Albian high weathering intensities and warm, humid climates combining to create high nutrient levels that would have flushed through rivers into lakes and ultimately oceans. This correlates stratigraphically with the development of Early Cretaceous black shales during Ocean Anoxic Event 1 b, showing the importance of continental weathering regimes as a causal mechanism for lake and ocean anoxia.展开更多
With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition me...With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition metal phosphides,especially cobalt phosphide(CoP)composites,have become a research hotspot for LIBs anode materials in recent years due to their high theoretical specific capacity,low polarization,and suitable voltage plateau.This review first systematically discusses the lithium storage mechanism and preparation methods of CoP in current research.Subsequently,the applications of CoP anode materials in LIBs are categorically reviewed,including the composites of CoP with various types of carbon materials and heterostructures.Finally,the challenges and future development directions of CoP anode materials are summarized to provide guidance for further improving the lithium storage performance of CoP and its practical applications.展开更多
Over the past 2000 years,a high-resolution pollen record from the Yushenkule Peat(46°45′-46°57′N,90°46′-90°61′E,2374 m a.s.l.)in the south-eastern Altai Mountains of northwestern China has been...Over the past 2000 years,a high-resolution pollen record from the Yushenkule Peat(46°45′-46°57′N,90°46′-90°61′E,2374 m a.s.l.)in the south-eastern Altai Mountains of northwestern China has been used to explore the changes in vegetation and climate.The regional vegetation has been dominated by alpine meadows revealed from pollen diagrams over the past 2000 years.The pollen-based climate was warm and wet during the Roman Warm Period(0-520 AD),cold and wet during the Dark Age Cold Period(520-900 AD),warm and wet during the Medieval Warm Period(900-1300 AD),and cold and dry during the Little Ice Age(1300-1850 AD).Combined with other pollen data from the Altai Mountains,we found that the percentage of arboreal pollen showed a reduced trend along the NW-SE gradient with decreasing moisture and increasing climatic continentality of the Altai Mountains over the past 2000 years;this is consistent with modern distributions of taiga forests.We also found that the taiga(Pinus forest)have spread slightly,while the steppe(Artemisia,Poaceae and Chenopodiaceae)have recovered significantly in the Altai Mountains over the past 2000 years.In addition,the relatively warm-wet climate may promote high grassland productivity and southward expansion of steppe,which favors the formation of Mongol political and military power.展开更多
Background:Breast cancer survivors with psychological problems have higher mortality than those without.Therefore,it is important to monitor and manage their psychological status.This study mainly aimed to dynam-icall...Background:Breast cancer survivors with psychological problems have higher mortality than those without.Therefore,it is important to monitor and manage their psychological status.This study mainly aimed to dynam-ically estimate the prevalence of anxiety and depression and to clarify the factors associated with anxiety and depression of patients undergoing adjuvant chemotherapy.The secondary objective was to investigate the rela-tionship between depression and anxiety and quality of life(QOL)in Chinese early-stage breast cancer patients.Methods:In a prospective observational single-center cohort study with early-stage breast cancer patients(n=290),depression and anxiety severity,QOL,and social support were measured using the Hospital Anxiety and Depression Scale(HADS),the Functional Assessment of Cancer Therapy-Breast Cancer(FACT-B)scale,and the Chinese version of the Social Support Rating Scale(SSRS),respectively.Canonical correlations were applied to identify correlates between anxiety and depression and demographic and clinical variables.One-way repeated measure analysis of covariance(RMANCOVA)was used to analyze dynamic changes in anxiety,depression,and QOL.Relationships between anxiety and depression and QOL were analyzed using two-way RMANCOVA.Results:The overall anxiety and depression prevalence rates were 35.2% and 44.1%,respectively.Age(P=0.042),surgical method(P=0.009),social support(P=0.001),and breast cancer family history(P=0.045)were signifi-cantly associated with depression.The number of children(P=0.048)was significantly associated with anxiety.FACT-B scores differed between anxiety and depression and nonanxiety and depression groups,and patients with higher HADS depression and anxiety scores had lower FACT-B scores during chemotherapy(P<0.001).Conclusions:We observed dynamic changes in anxiety and depression and QOL and associated factors of anxiety and depression.These findings can provide guidance for psychological monitoring and support for breast cancer patients during the postoperative chemotherapy period.展开更多
Background:The current standard of care for advanced human epidermal growth factor receptor 2(HER2)‐positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first‐line therapy.However,with the developm...Background:The current standard of care for advanced human epidermal growth factor receptor 2(HER2)‐positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first‐line therapy.However,with the development of newer treatment regimens,there is a lack of evidence regarding which is the optimal treatment strategy.The aim of this network meta‐analysis was to evaluate the efficacy and safety of first‐line regimens for advanced HER2‐positive breast cancer by indirect comparisons.Methods:A systematic review and Bayesian network meta‐analysis were conducted.The PubMed,EMBASE,and Cochrane Library databases were searched for relevant articles published through to December 2023.The hazard ratio(HR)and 95%credible interval(CrI)were used to compare progressionfree survival(PFS)between treatments,and the odds ratio and 95%CrI were used to compare the objective response rate(ORR)and safety.Results:Twenty randomized clinical trials that included 15 regimens and 7094 patients were analyzed.Compared with the traditional trastuzumab and docetaxel regimen,PFS was longer on the pyrotinib and trastuzumab plus docetaxel regimen(HR:0.41,95%CrI:0.22–0.75)and the pertuzumab and trastuzumab plus docetaxel regimen(HR:0.65,95%CrI:0.43–0.98).Consistent with the results for PFS,the ORR was better on the pyrotinib and trastuzumab plus docetaxel regimen and the pertuzumab and trastuzumab plus docetaxel regimen than on the traditional trastuzumab and docetaxel regimen.The surface under the cumulative ranking curve indicated that the pyrotinib and trastuzumab plus docetaxel regimen was most likely to rank first in achieving the best PFS and ORR.Comparable results were found for grade≥3 AE rates of≥10%.Conclusions:Our results suggest that the pyrotinib and trastuzumab plus docetaxel regimen is most likely to be the optimal first‐line therapy for patients with HER2‐positive breast cancer.展开更多
Malignant tumors have become a major threat to human health worldwide.According to incomplete statistics from the World Health Organization,in 112 of 183 countries,malignant tumors are the primary cause of death among...Malignant tumors have become a major threat to human health worldwide.According to incomplete statistics from the World Health Organization,in 112 of 183 countries,malignant tumors are the primary cause of death among people under the age of 70,and cancer morbidity and mortality are increasing year by year[1].Owing to the limits of current medical technology,it is impossible to completely overcome this persistent disease.展开更多
Breast cancer has become the most common malignant tumor worldwide.However,the survival rate of breast cancer patients in China is 8%lower compared to that in European and American countries.Insufficient screen-ing co...Breast cancer has become the most common malignant tumor worldwide.However,the survival rate of breast cancer patients in China is 8%lower compared to that in European and American countries.Insufficient screen-ing coverage and low rate of early detection are key problems.Therefore,it is imperative to develop a set of guidelines for breast cancer screening,early diagnosis,and treatment strategies suitable for Chinese women.The National Health Commission,the National Cancer Center,and the National Cancer Quality Control Center col-lectively organized a committee of specialists with multidisciplinary backgrounds in breast surgery,oncology,radiotherapy,diagnostic imaging,ultrasound,pathology,epidemiology,and health economics.The committee collectively published"China Breast Cancer Screening,Early Diagnosis and Treatment Specification",in which the committee outlined a set of strategies of breast cancer screening,early diagnosis,and treatment suitable for China’s national conditions.The strategies were formulated based on clinical experience in breast cancer preven-tion and treatment,characteristics of breast cancer patients in China,and socioeconomic conditions.The purpose of this article is to provide an interpretation of the above guidelines as a reference for breast cancer screening.展开更多
基金Supported by the Chongqing Fundamental Research Funds,No.jbky20210001Performance Incentive-oriented Project of Chongqing,No.jxjl20220006。
文摘Internal herniation(IH)refers to the movement of intra-abdominal organs or tissues out of their original position through normal or abnormal orifices and fissures in the peritoneum or mesentery and into an anatomic space within the abdominal cavity.Although the incidence of small bowel obstruction(SBO)caused by IH is very low(approximately 0.2%to 0.9%),its incidence may be increased in certain specific populations or in postoperative patients.Recently Kaw et al shared their 13-year experience of managing IHs in a tertiary care hospital in India.This retrospective study analyzed and determined the clinico-demographic profiles,radiological and operative findings and postoperative course of patients with IH and the association with SBO.The results provide valuable insights into early diagnosis and establishment of a timely treatment regimen for this condition and emphasize the importance of combining rapid imaging evaluation with the traditional therapeutic approach of laparoscopic surgery,thus providing a novel perspective on the diagnosis and treatment of SBO caused by IH.
基金Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
文摘BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,brexanolone,zuranolone)targeting the GABA-A receptor were introduced.The zona incerta(ZI),an inhibitory subthalamic region mainly composed of GABAergic neurons,has been implicated in emotional regulation.Deep brain stimulation of the ZI in humans affects anxiety and depression symptoms,while activation of ZI neurons in mice can either worsen or alleviate anxiety.Currently,there is no direct evidence linking GABAergic neurons in the ZI to depression-like behaviors in rodents.AIM To explore the relationship between GABAergic neurons in the ZI and depression-like behaviors in mice.METHODS A chronic restraint stress(CRS)model was utilized to induce depression in mice.Whole-cell patch-clamp recordings assessed the excitability changes of GABAergic neurons in the ZI.Additionally,chemogenetic techniques were employed to modulate ZI GABAergic neurons.The performance of the mice in behavioral tests for depression and anxiety was observed.RESULTS The findings indicated that GABAergic neurons in the ZI were closely associated with depression-like behaviors in mice.Twenty-eight days after the CRS model was established,depression-like and anxiety-like behaviors were observed in the mice.The excitability of GABAergic neurons in the ZI was reduced.Chemogenetic activation of these neurons alleviated CRS-induced depression-like and anxiety-like behaviors.Conversely,inhibition of GABAergic neurons in the ZI led to changes in emotion-related behavioral outcomes in mice.CONCLUSION Activity of GABAergic neurons in the ZI was closely associated with depression-like phenotypes in mice,suggesting that these neurons could be a potential therapeutic target for treating depression.
基金Supported by the National Natural Science Foundation of China,No.82160330the Science and Technology Program of the Health Commission of Jiangxi Province,No.2025110045+1 种基金the Ganzhou Science and Technology Planning Project,No.GZ2024YLJ016,No.GZ2024YLJ026,and No.GZ2024ZSF064the Ganzhou Health Commission Scientific Research Planning Project,No.GZWJW202402108.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up^(18)F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas^(18)F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.
基金supported by a grant from CAMS Initiative for Innovative Medicine (Grant No. CAMS-12M-1-010)
文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events.
文摘Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment process.Psychological distress of FCs is common and often ignored.A simple and effective instrument for screening psychological distress would help in selecting those FCs requiring special attention and intervention.Here,the validity of distress thermometer(DT)in FCs of Chinese breast cancer patients receiving postoperative chemotherapy was assessed,and the prevalence of anxiety and depression was evaluated.Methods:We recruited 200 FCs of hospitalized breast cancer patients in this cross-sectional descriptive study.Before the first cycle of adjuvant chemotherapy,the levels of anxiety and depression among FCs were assessed using DT and Hospital Anxiety and Depression Scale(HADS).In total,191 valid cases were analyzed.HADS was used as the diagnostic standard to assess the effectiveness of DT as a screening tool for anxiety and depression as well as to analyze the diagnostic efficiency of DT at various cutoff points.Results:The definitive prevalence of both anxiety and depression was 8.90%.The mean level of anxiety and depression among FCs was 5.64±3.69 and 5.09±3.85,respectively,both of which were significantly higher than corresponding Chinese norms(P<0.01).The areas under receiver operating characteristic curves of DT for the diagnoses of FCs'anxiety and depression were 0.904 and 0.885,respectively.A cutoff value of 5 produced the best diagnostic effects of DT for anxiety and depression.Conclusions:The levels of both anxiety and depression were higher in the FCs of Chinese breast cancer patients receiving postoperative chemotherapy than the national norm.DT might be an effective tool to initially screen psychological distress among FCs.This process could be integrated into the palliative care of breast cancer patients and warrant further research.
基金supported by grants from the CAMS Innovation Fund for Medical Sciences[CIFMS](Grant Nos.2021-I2M-1-014 and 2022-I2M-2-002).
文摘Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic landscape.Cross-line CDK4/6i therapy in which another CDK4/6i is continued after progression on a prior CDK4/6i may still offer advantageous therapeutic effects.Cross-line CDK4/6i therapy is an area of active investigation in the ongoing pursuit to improve outcomes for patients with HR+/human epidermal growth factor receptor 2(HER2)–ABC.Methods:This retrospective study enrolled 82 patients with HR+/HER2–ABC who were treated with cross-line CDK4/6is(abemaciclib,palbociclib,ribociclib,and dalpiciclib)after progression with another CDK4/6i.The primary endpoint was progression-free survival(PFS)according to version 1.1 of the Response Evaluation Criteria in Solid Tumors.Secondary endpoints included toxicity,objective response rate,disease control rate,and overall survival.Adverse events(AEs)were graded according to version 5.0 of the Common Terminology Criteria for Adverse Events,as promulgated by the U.S.Department of Health and Human Services.Results:Eighty-two HR+/HER2–ABC patients who received cross-line CDK4/6i therapy from January 2022 to February 2024 were enrolled.The median age of the patients was 60 years.The median PFS of all patients was 7.6 months(95%CI,5.9-9.2).Cox regression analysis identified lung metastasis and a switch to endocrine therapy following prior CDK4/6i therapy as independent predictive factors for PFS.Notably,patients who previously received abemaciclib and switched to palbociclib upon disease progression had a median PFS of 10.7 months.The strategy of transitioning to chemotherapy after progression on a prior CDK4/6i,then to a subsequent CDK4/6i merits further investigation.Hematologic toxicity was the most common grade≥3 AEs.No instances of fatal safety events were observed.Conclusions:Cross-line CDK4/6i therapy is associated with significant clinical benefits and manageable safety profiles in patients with HR+/HER2–ABC,which underscores cross-line CDK4/6i therapy potential as an effective treatment strategy.
基金supported by grant from the CAMS Innovation Fund for Medical Sciences (CIFMS, No. 2021I2M-1-014)。
文摘Objective: The mechanism of acquired gene mutation plays a major role in resistance to endocrine therapy in hormone receptor(HR)-positive advanced breast cancer. Circulating tumor DNA(ctDNA) has been allowed for the assessment of the genomic profiles of patients with advanced cancer. We performed this study to search for molecular markers of endocrine therapy efficacy and to explore the clinical value of ctDNA to guide precise endocrine therapy for HR-positive/human epidermal growth factor receptor-2(HER-2)-negative metastatic breast cancer patients.Methods: In this open-label, multicohort, prospective study, patients were assigned to four parallel cohorts and matched according to mutations identified in ctDNA: 1) activation of the phosphatidylinositol-3-kinase(PI3K)/AKT/mammalian target of rapamycin(mTOR) signaling pathway preferred mTOR inhibitor combined with endocrine therapy;2) estrogen receptor 1(ESR1) mutation preferred fulvestrant;3) HER-2 mutations preferred pyrotinib;and 4) no actionable mutations received treatment according to the clinical situation. In all cohorts, patients were divided into compliance group and violation group. The primary outcome measure was progression-free survival(PFS), and the secondary outcome measure was overall survival(OS).Results: In all cohorts, the combined median PFS was 4.9 months, and median PFS for the compliance and violation groups was 6.0 and 3.0 months, respectively [P=0.022, hazard ratio(HR)=0.57]. Multivariate Cox regression model showed the risk of disease progression was lower in compliance group than in violation group(P=0.023, HR=0.55). Among the patients with HER-2 mutations, the median PFS was 11.1 months in the compliance group and 2.2 months in the violation group(P=0.011, HR=0.20). There was no significant difference in the median PFS between patients who did and did not comply with the treatment protocol in patients with activation of the PI3K/AKT/mTOR or ESR1 mutation.Conclusions: The results suggest that ctDNA may help to guide the optimal endocrine therapy strategy for metastatic breast cancer patients and to achieve a better PFS. Next-generation sequencing(NGS) detection could aid in distinguishing patients with HER-2 mutation and developing new treatment strategies.
基金supported by National Natural Science Foundation of China(11172340)Training Program for Hundreds of Distinguished Leading Scientists of ChongqingSpecialized Research Fund for the Doctoral Program of Higher Education of China(20120191120032)
文摘Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is still poorly understood,especially with respect to unique problem of maintaining force generation and transmission within the confine of an ever-changing cytoskeleton in smooth muscle.Using a cytoskeletal preparation derived from skinned airway smooth muscle,we aimed at separating the contribution of actomyosin interaction and elucidating the cytoskeletal stiffness in smooth muscle.The results indicate that there is a Ca++de-
基金the Shenzhen Science and Technology Program(KCXST20221021111201003)the National Natural Science Foundation of China(Nos.52261160384 and 52072208)+3 种基金Fundamental Research Project of Shenzhen(No.JCYJ20220818101004009)Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110531)China Postdoctoral Science Foundation(No.2022M721800)the Major Science and Technology Infrastructure Project of Material Genome Big-science Facilities Platform supported by Municipal Development and Reform Commission of Shenzhen.
文摘Recycling spent lithium-ion batteries(LIBs)is crucial for environmental protection and sustainability.Currently,the main methods for recycling spent LIBs include element extraction and material regeneration.Materials upcycling is a complementary strategy aimed at transforming existing materials into next-generation high-performance materials.This review summarizes recent advancements in upcycling cathode materials from spent LIBs into high-performance cathode.We begin by outlining the development of cathode materials and exploiting how material upcycling can meet the needs of future battery technologies.Next,we introduce the concept and historical evolution of cathode material upcycling and provide a detailed summary of strategies such as doping,coating,and the transformation between different cathode materials.Finally,we discuss the challenges of cathode upcycling and offer guidance for future research directions.
基金the National Natural Science Foundation of China(12175088,12305100,12365014)Graduate Innovation Fund Project of Jiangxi ProvincialDepartment of Education(YJS2024091)。
文摘Based on available experimental results on χ_(cJ)(J = 0,1,2) decays, we investigated the χ_(cJ)-→PP,VV,PV, and PT decays using the SU(3) flavor symmetry/breaking approach, where P, V, and T denote light pseudoscalar, vector, and tensor mesons, respectively. With the decay amplitude relations determined by SU(3) flavor symmetry/breaking, we present the branching ratios for all χ_(cJ)-PP and χ_(cJ) → VV modes, including those without experimental data. While theoretical considerations strongly suppress or even forbid most χ_(cJ) - PV and PT decays,we also provide quantitative predictions constrained by existing experimental data. Our results are expected to be accessible in future experiments at BESIlI and the planned Super Tau-Charm Facility.
基金supported by the Yue Qi Scholar Fund of China University of Mining and Technology (Beijing)the National Natural Science Foundation of China (41572090)Shandong Key Laboratory of Depositional Mineralization & Sedimentary Mineral, Shandong University of Science and Technology (DMSM20190015)。
文摘This study focuses on Early Cretaceous mudstones from the Shahai and Fuxin formations in the Fuxin continental basin. We analyse chemical weathering, land surface temperatures and palaeoclimates based on chemical weathering indices, and emphasize the implications of continental chemical weathering on nutrient fluxes into lakes and oceans.According to Cr and Ni abundance, Al2O3-TiO2, La/Sc-Th/Co and V-Ni-Th×10 plots, as well as rare earth element(REE)analysis, mudstone samples from the Shahai and Fuxin formations were derived from the same type of provenance comprising mainly felsic igneous rocks. Chemical weathering trends reflected by the Chemical Index of Alteration(CIA),Weathering Index of Parker(WIP) and the Mafic Index of Alteration for Oxidative weathering environments(MIA(O)) are consistent with each other and allow the geological succession to be divided into four stages. Land surface temperatures of the Shahai and Fuxin formations are estimated based on the linear relationship of CIA to temperature,and also can be divided into four stages consistent with those determined from chemical weathering trends. During Stage A(early part of the late Aptian) chemical weathering and land surface temperatures were relatively low and showed characteristic high fluctuations, while Stage B(latest Aptian) represented a transitional period where weathering rates and temperatures increased, and high amplitude fluctuations continued. Conditions changed markedly in Stage C(early Albian) with very high and stable weathering, and warm, humid climates, while in Stage D(middle and late Albian) conditions returned to low chemical weathering and land surface temperatures. These stages of chemical weathering and land surface temperature fluctuations represent responses to global climate fluctuations during the Early Cretaceous, with the early Albian high weathering intensities and warm, humid climates combining to create high nutrient levels that would have flushed through rivers into lakes and ultimately oceans. This correlates stratigraphically with the development of Early Cretaceous black shales during Ocean Anoxic Event 1 b, showing the importance of continental weathering regimes as a causal mechanism for lake and ocean anoxia.
基金supported by the China Postdoctoral Science Foundation(grant Nos.2019M662405,2019M650612)Natural Science Foundation of Shandong Province(grant Nos.ZR2019BF047,ZR2020KE059)+1 种基金School city integration in Zibo(grant No.2019ZBXC299)Financially Sponsored by Heilongjiang Touyan Team Program,Fundamental Research Funds for the Central Universities(grant No.HIT.OCEF.2021003).
文摘With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition metal phosphides,especially cobalt phosphide(CoP)composites,have become a research hotspot for LIBs anode materials in recent years due to their high theoretical specific capacity,low polarization,and suitable voltage plateau.This review first systematically discusses the lithium storage mechanism and preparation methods of CoP in current research.Subsequently,the applications of CoP anode materials in LIBs are categorically reviewed,including the composites of CoP with various types of carbon materials and heterostructures.Finally,the challenges and future development directions of CoP anode materials are summarized to provide guidance for further improving the lithium storage performance of CoP and its practical applications.
基金This research was financially supported by Western Young Scholar Program-B of Chinese Academy of Sciences(No.2018-XBQNXZ-B-020)National Natural Science Foundation of China(Grant Nos.41771234 and 41803024)Open Fund of State Key Laboratory of Loess and Quaternary Geology(No.SKLLQG2011).
文摘Over the past 2000 years,a high-resolution pollen record from the Yushenkule Peat(46°45′-46°57′N,90°46′-90°61′E,2374 m a.s.l.)in the south-eastern Altai Mountains of northwestern China has been used to explore the changes in vegetation and climate.The regional vegetation has been dominated by alpine meadows revealed from pollen diagrams over the past 2000 years.The pollen-based climate was warm and wet during the Roman Warm Period(0-520 AD),cold and wet during the Dark Age Cold Period(520-900 AD),warm and wet during the Medieval Warm Period(900-1300 AD),and cold and dry during the Little Ice Age(1300-1850 AD).Combined with other pollen data from the Altai Mountains,we found that the percentage of arboreal pollen showed a reduced trend along the NW-SE gradient with decreasing moisture and increasing climatic continentality of the Altai Mountains over the past 2000 years;this is consistent with modern distributions of taiga forests.We also found that the taiga(Pinus forest)have spread slightly,while the steppe(Artemisia,Poaceae and Chenopodiaceae)have recovered significantly in the Altai Mountains over the past 2000 years.In addition,the relatively warm-wet climate may promote high grassland productivity and southward expansion of steppe,which favors the formation of Mongol political and military power.
基金supported by the Nonprofit Central Research In-stitute Fund of the Chinese Academy of Medical Sciences(grant num-ber 2019XK320069)the Sanming Project of Medicine in Shenzhen(grant number SZSM201612085).
文摘Background:Breast cancer survivors with psychological problems have higher mortality than those without.Therefore,it is important to monitor and manage their psychological status.This study mainly aimed to dynam-ically estimate the prevalence of anxiety and depression and to clarify the factors associated with anxiety and depression of patients undergoing adjuvant chemotherapy.The secondary objective was to investigate the rela-tionship between depression and anxiety and quality of life(QOL)in Chinese early-stage breast cancer patients.Methods:In a prospective observational single-center cohort study with early-stage breast cancer patients(n=290),depression and anxiety severity,QOL,and social support were measured using the Hospital Anxiety and Depression Scale(HADS),the Functional Assessment of Cancer Therapy-Breast Cancer(FACT-B)scale,and the Chinese version of the Social Support Rating Scale(SSRS),respectively.Canonical correlations were applied to identify correlates between anxiety and depression and demographic and clinical variables.One-way repeated measure analysis of covariance(RMANCOVA)was used to analyze dynamic changes in anxiety,depression,and QOL.Relationships between anxiety and depression and QOL were analyzed using two-way RMANCOVA.Results:The overall anxiety and depression prevalence rates were 35.2% and 44.1%,respectively.Age(P=0.042),surgical method(P=0.009),social support(P=0.001),and breast cancer family history(P=0.045)were signifi-cantly associated with depression.The number of children(P=0.048)was significantly associated with anxiety.FACT-B scores differed between anxiety and depression and nonanxiety and depression groups,and patients with higher HADS depression and anxiety scores had lower FACT-B scores during chemotherapy(P<0.001).Conclusions:We observed dynamic changes in anxiety and depression and QOL and associated factors of anxiety and depression.These findings can provide guidance for psychological monitoring and support for breast cancer patients during the postoperative chemotherapy period.
基金National Key Research and Development Program of China,Grant/Award Number:2021YFF1201300National Natural Science Foundation of China,Grant/Award Number:82230058。
文摘Background:The current standard of care for advanced human epidermal growth factor receptor 2(HER2)‐positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first‐line therapy.However,with the development of newer treatment regimens,there is a lack of evidence regarding which is the optimal treatment strategy.The aim of this network meta‐analysis was to evaluate the efficacy and safety of first‐line regimens for advanced HER2‐positive breast cancer by indirect comparisons.Methods:A systematic review and Bayesian network meta‐analysis were conducted.The PubMed,EMBASE,and Cochrane Library databases were searched for relevant articles published through to December 2023.The hazard ratio(HR)and 95%credible interval(CrI)were used to compare progressionfree survival(PFS)between treatments,and the odds ratio and 95%CrI were used to compare the objective response rate(ORR)and safety.Results:Twenty randomized clinical trials that included 15 regimens and 7094 patients were analyzed.Compared with the traditional trastuzumab and docetaxel regimen,PFS was longer on the pyrotinib and trastuzumab plus docetaxel regimen(HR:0.41,95%CrI:0.22–0.75)and the pertuzumab and trastuzumab plus docetaxel regimen(HR:0.65,95%CrI:0.43–0.98).Consistent with the results for PFS,the ORR was better on the pyrotinib and trastuzumab plus docetaxel regimen and the pertuzumab and trastuzumab plus docetaxel regimen than on the traditional trastuzumab and docetaxel regimen.The surface under the cumulative ranking curve indicated that the pyrotinib and trastuzumab plus docetaxel regimen was most likely to rank first in achieving the best PFS and ORR.Comparable results were found for grade≥3 AE rates of≥10%.Conclusions:Our results suggest that the pyrotinib and trastuzumab plus docetaxel regimen is most likely to be the optimal first‐line therapy for patients with HER2‐positive breast cancer.
文摘Malignant tumors have become a major threat to human health worldwide.According to incomplete statistics from the World Health Organization,in 112 of 183 countries,malignant tumors are the primary cause of death among people under the age of 70,and cancer morbidity and mortality are increasing year by year[1].Owing to the limits of current medical technology,it is impossible to completely overcome this persistent disease.
文摘Breast cancer has become the most common malignant tumor worldwide.However,the survival rate of breast cancer patients in China is 8%lower compared to that in European and American countries.Insufficient screen-ing coverage and low rate of early detection are key problems.Therefore,it is imperative to develop a set of guidelines for breast cancer screening,early diagnosis,and treatment strategies suitable for Chinese women.The National Health Commission,the National Cancer Center,and the National Cancer Quality Control Center col-lectively organized a committee of specialists with multidisciplinary backgrounds in breast surgery,oncology,radiotherapy,diagnostic imaging,ultrasound,pathology,epidemiology,and health economics.The committee collectively published"China Breast Cancer Screening,Early Diagnosis and Treatment Specification",in which the committee outlined a set of strategies of breast cancer screening,early diagnosis,and treatment suitable for China’s national conditions.The strategies were formulated based on clinical experience in breast cancer preven-tion and treatment,characteristics of breast cancer patients in China,and socioeconomic conditions.The purpose of this article is to provide an interpretation of the above guidelines as a reference for breast cancer screening.
