BACKGROUND There are conflicting results on the potential correlation between folic acid and gestational diabetes mellitus(GDM),and the correlation between genetic factors related to folic acid metabolism pathways and...BACKGROUND There are conflicting results on the potential correlation between folic acid and gestational diabetes mellitus(GDM),and the correlation between genetic factors related to folic acid metabolism pathways and GDM remains to be revealed.AIM To examine the association between single-nucleotide polymorphisms(SNPs)of enzyme genes in the folate metabolite pathway as well as that between GDM-related genes and risk for GDM.METHODS A nested case-control study was conducted with GDM cases(n=412)and healthy controls(n=412).DNA was extracted blood samples and SNPs were genotyped using Agena Bioscience’s MassARRAY gene mass spectrometry system.The associations between different SNPs of genes and the risk for GDM were estimated using logistic regression models.The generalized multi-factor dimensionality reduction(GMDR)method was used to analyze gene-gene and gene-environment interactions using the GMDR 0.9 software.RESULTS The variation allele frequency of melatonin receptor 1B(MTNR1B)rs10830963 was higher in the GDM group than in controls(P<0.05).MTNR1B rs10830963 mutant G was associated with risk for GDM[adjusted odds ratio(aOR):1.43;95%confidence interval(95%CI):1.13-1.80]in the additive model.MTNR1B rs10830963 GG+GC was significantly associated with the risk for GDM(aOR:1.65;95%CI:1.23-2.22)in the dominant model.The two-locus model of MTNR1B rs10830963 and CHEMERIN rs4721 was the best model(P<0.05)for gene-gene interactions in the GMDR results.The high-risk rs10830963×rs4721 type of interaction was a risk factor for GDM(aOR:2.09;95%CI:1.49-2.93).CONCLUSION This study does not find an association between SNPs of folate metabolic enzymes and risk for GDM.The G mutant allele of MTNR1B rs10830963 is identified as a risk factor for GDM in the additive model,and there may be gene-gene interactions between MTNR1B rs10830963 and CHEMERIN rs4721.It is conducive to studying the causes of GDM and provides a new perspective for the precise prevention of this disease.展开更多
[Objectives]This study was conducted to evaluate the nutritional value and safety of black soldier flies fed with dead pig meat and bone meal(DPMBM)and to explore the resource utilization of DPMBM.[Methods]The general...[Objectives]This study was conducted to evaluate the nutritional value and safety of black soldier flies fed with dead pig meat and bone meal(DPMBM)and to explore the resource utilization of DPMBM.[Methods]The general nutrient composition,amino acids,fatty acids and mineral elements of black soldier fly meal(BSLM)were detected and analyzed.[Results]The results showed that the contents of moisture,crude protein,crude fat and ash in BSLM were 3.42%,42.31%,34.04%and 5.40%,respectively.The contents of total amino acids(TAA),essential amino acids(∑EAA)and non-essential amino acids(∑NEAA)and umami amino acids(∑DAA),the EAA/TAA value and the EAA/NEAA value were 37.93%,13.08%,24.85%,13.43%,34.47%,52.61%,respectively.A total of eight kinds of saturated fatty acids and seven kinds of unsaturated fatty acids were detected,accounting for 63.65%and 32.67%of the total fatty acids.Among the major mineral elements,the content of Ca was the highest,followed by K,Mg and Na.Among the trace mineral elements,the content of Mn was the highest,followed by Fe,Zn,Cu,Ni,Cr,Cd,As,Pb,Se,Sn,Ti,Sb and Hg.The contents of heavy metal mineral elements in BSLM were far lower than the limits specified in Hygienical Standard for Feeds.[Conclusions]In conclusion,BSLM has high nutritional value and good safety of heavy metals,and thus great potential for development and utilization as a high quality dietary protein,fat and mineral elements source.展开更多
High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V1...High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.展开更多
Low-concentration acetone detection is of great importance for acetone sensor in the fields of environmental protection and noninvasive diagnosis.In this work,mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)n-p heterojunctions were...Low-concentration acetone detection is of great importance for acetone sensor in the fields of environmental protection and noninvasive diagnosis.In this work,mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)n-p heterojunctions were constructed for efficient improvement of low-concentration acetone gas sensing.The gas-sensing results indicated that the mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)composites with a significantly large specific surface area exhibited significantlyenhanced acetone gas-sensitive performance compared to pure Fe_(2)O_(3).The Fe_(2)O_(3)/Cr_(2)O_(3)composites demonstrated a high response,good selectivity and excellent stability over200 days to 10 ppm acetone at 220℃.And the theoretical detection limit was calculated to reach 0.285 ppm acetone.A feasible acetone sensing mechanism was proposed through electronic band structure and density functional theory.The improved low-concentration acetone sensing performance was due to the formed mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)n-p heterojunctions with a large specific surface area.The Fe_(2)O_(3)/Cr_(2)O_(3)composites showed excellent acetone gas-sensitive performance,which could be a promising candidate for developing low-concentration acetone sensing devices at low working temperatures.展开更多
基金Supported by the National Key Research and Development Program of China,No.2021YFC2700700 and No.2021YFC2700704Capital’s Funds for Health Improvement and Research(CFH)in People’s Republic of China,No.2020-1-5112.
文摘BACKGROUND There are conflicting results on the potential correlation between folic acid and gestational diabetes mellitus(GDM),and the correlation between genetic factors related to folic acid metabolism pathways and GDM remains to be revealed.AIM To examine the association between single-nucleotide polymorphisms(SNPs)of enzyme genes in the folate metabolite pathway as well as that between GDM-related genes and risk for GDM.METHODS A nested case-control study was conducted with GDM cases(n=412)and healthy controls(n=412).DNA was extracted blood samples and SNPs were genotyped using Agena Bioscience’s MassARRAY gene mass spectrometry system.The associations between different SNPs of genes and the risk for GDM were estimated using logistic regression models.The generalized multi-factor dimensionality reduction(GMDR)method was used to analyze gene-gene and gene-environment interactions using the GMDR 0.9 software.RESULTS The variation allele frequency of melatonin receptor 1B(MTNR1B)rs10830963 was higher in the GDM group than in controls(P<0.05).MTNR1B rs10830963 mutant G was associated with risk for GDM[adjusted odds ratio(aOR):1.43;95%confidence interval(95%CI):1.13-1.80]in the additive model.MTNR1B rs10830963 GG+GC was significantly associated with the risk for GDM(aOR:1.65;95%CI:1.23-2.22)in the dominant model.The two-locus model of MTNR1B rs10830963 and CHEMERIN rs4721 was the best model(P<0.05)for gene-gene interactions in the GMDR results.The high-risk rs10830963×rs4721 type of interaction was a risk factor for GDM(aOR:2.09;95%CI:1.49-2.93).CONCLUSION This study does not find an association between SNPs of folate metabolic enzymes and risk for GDM.The G mutant allele of MTNR1B rs10830963 is identified as a risk factor for GDM in the additive model,and there may be gene-gene interactions between MTNR1B rs10830963 and CHEMERIN rs4721.It is conducive to studying the causes of GDM and provides a new perspective for the precise prevention of this disease.
基金Supported by Modern Agricultural Industry Technology System(CARS-45)Science and Technology Major Project of Hunan Province(2017NK1030).
文摘[Objectives]This study was conducted to evaluate the nutritional value and safety of black soldier flies fed with dead pig meat and bone meal(DPMBM)and to explore the resource utilization of DPMBM.[Methods]The general nutrient composition,amino acids,fatty acids and mineral elements of black soldier fly meal(BSLM)were detected and analyzed.[Results]The results showed that the contents of moisture,crude protein,crude fat and ash in BSLM were 3.42%,42.31%,34.04%and 5.40%,respectively.The contents of total amino acids(TAA),essential amino acids(∑EAA)and non-essential amino acids(∑NEAA)and umami amino acids(∑DAA),the EAA/TAA value and the EAA/NEAA value were 37.93%,13.08%,24.85%,13.43%,34.47%,52.61%,respectively.A total of eight kinds of saturated fatty acids and seven kinds of unsaturated fatty acids were detected,accounting for 63.65%and 32.67%of the total fatty acids.Among the major mineral elements,the content of Ca was the highest,followed by K,Mg and Na.Among the trace mineral elements,the content of Mn was the highest,followed by Fe,Zn,Cu,Ni,Cr,Cd,As,Pb,Se,Sn,Ti,Sb and Hg.The contents of heavy metal mineral elements in BSLM were far lower than the limits specified in Hygienical Standard for Feeds.[Conclusions]In conclusion,BSLM has high nutritional value and good safety of heavy metals,and thus great potential for development and utilization as a high quality dietary protein,fat and mineral elements source.
基金supported by the National Key Research and Development Program of China(2023YFD2303302,2022YFD2300803)the National Natural Science Foundation of China(32160445)the China Agriculture Research System of MOF and MARA(CARS-02-16).
文摘High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.
基金financially supported by the National Natural Science Foundation of China(Nos.62374154 and12374128)the National Key R&D Program of China(Nos.2022YFB3903200 and 2022YFB3903203)
文摘Low-concentration acetone detection is of great importance for acetone sensor in the fields of environmental protection and noninvasive diagnosis.In this work,mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)n-p heterojunctions were constructed for efficient improvement of low-concentration acetone gas sensing.The gas-sensing results indicated that the mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)composites with a significantly large specific surface area exhibited significantlyenhanced acetone gas-sensitive performance compared to pure Fe_(2)O_(3).The Fe_(2)O_(3)/Cr_(2)O_(3)composites demonstrated a high response,good selectivity and excellent stability over200 days to 10 ppm acetone at 220℃.And the theoretical detection limit was calculated to reach 0.285 ppm acetone.A feasible acetone sensing mechanism was proposed through electronic band structure and density functional theory.The improved low-concentration acetone sensing performance was due to the formed mesoporous Fe_(2)O_(3)/Cr_(2)O_(3)n-p heterojunctions with a large specific surface area.The Fe_(2)O_(3)/Cr_(2)O_(3)composites showed excellent acetone gas-sensitive performance,which could be a promising candidate for developing low-concentration acetone sensing devices at low working temperatures.
