This paper deals with numerical computation and analysis for the initial boundary problems of two dimensional(2D)Sobolev equations with piecewise continuous argument.Firstly,a two-level high-order compact difference m...This paper deals with numerical computation and analysis for the initial boundary problems of two dimensional(2D)Sobolev equations with piecewise continuous argument.Firstly,a two-level high-order compact difference method(HOCDM)with computational accuracy O(τ^(2)+h_(x)^(4)+h_(y)^(4))is suggested,whereτ,h_(x),h_(y) denote the temporal and spatial stepsizes of the method,respectively.In order to improve the temporal computational accuracy of this method,the Richardson extrapolation technique is used and thus a new two-level HOCDMis derived,which is proved to be convergent of order four both in time and space.Although the new two-level HOCDM has the higher computational accuracy in time than the previous one,it will bring a larger computational cost.To overcome this deficiency,a three-level HOCDM with computational accuracy O(τ^(4)+h_(x)^(4)+h_(y)^(4))is constructed.Finally,with a series of numerical experiments,the theoretical accuracy and computational efficiency of the above methods are further verified.展开更多
A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by diff...A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by different feeding modes(O-noant,outdoor without antibiotics;O-ant,outdoor with antibiotics;D-noant,indoor without antibiotics;D-ant,indoor with antibiotics),respectively,to evaluate the effect on liver.The results showed that different feeding modes significantly influenced the growth,liver weight,subcutaneous fat thickness,liver fat and liver free amino acid contents.The outdoor feeding without antibiotic reflected remarkably(P﹤0.05)low liver weight and fat content with normal morphology.While,other groups showed different levels of fat metabolism disorder in the liver.Based on chicken liver healthy,the outdoor feeding without antibiotic was the optimal feeding mode for Gushi chicken.展开更多
Electrical energy is essential for modern society to sustain economic growths.The soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shif...Electrical energy is essential for modern society to sustain economic growths.The soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar energy.However,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban environment.To overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric energy.Current TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar panels.In this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve transparency.Figures of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV technology.Then we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic PVs.The applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and facades.Finally,current challenges and future opportunities in TPV research are pointed out.展开更多
ObjectivesThe PTPRQ gene is essential for preserving the structure and function of stereocilia in inner ear.However,research on splicing mutations within this gene is limited.This study aims to investigate novel splic...ObjectivesThe PTPRQ gene is essential for preserving the structure and function of stereocilia in inner ear.However,research on splicing mutations within this gene is limited.This study aims to investigate novel splicing mutations in PTPRQ,clarify their molecular mechanisms,and provide new insights into the genetic factors associated with hearing loss,ultimately enhancing diagnostic accuracy.MethodClinical data and peripheral blood samples were obtained from members of a family with congenital hearing loss.Variants were identified through high-throughput sequencing and confirmed by Sanger sequencing to ensure genealogical co-segregation.The splicing effects of PTPRQ variants were evaluated using bioinformatics tools and minigene assays.ResultsWe used whole exome sequencing to identify novel double compound heterozygous splice-altering variants(c.5426+1 G>A and c.6603-3 T>G)in the PTPRQ gene with DFNB84A.We molecularly characterized these variants,and they were found to co-segregate with the disease within the family.Minigene assays and Sanger sequencing confirmed that the c.6603-3 T>G variant caused exon 43 skipping,resulting in a frameshift mutation(p.Ser2201ArgfsTer112).Further bioinformatic analysis supported these findings.ConclusionsThis study identifies a novel compound heterozygous splicing variant in the PTPRQ gene in a Chinese family with DFNB84A,expanding the known spectrum of PTPRQ mutations.These findings enhance the understanding of PTPRQ-related hearing loss and may aid in early diagnosis,prevention,and therapeutic strategies.展开更多
Improving the plasticity of TiAl alloys at room temperature has been a longstanding challenge for the de-velopment of next-generation aerospace engines.By adopting the nacre-like architecture design strategy,we have o...Improving the plasticity of TiAl alloys at room temperature has been a longstanding challenge for the de-velopment of next-generation aerospace engines.By adopting the nacre-like architecture design strategy,we have obtained a novel heterogeneous lamellar Ti_(2)AlC/TiAl composite with superior strength-plasticity synergy,i.e.,compressive strength of∼2065 MPa and fracture strain of∼27%.A combination of micropil-lar compression and large-scale atomistic simulation has revealed that the superior strength-plasticity synergy is attributed to the collaboration of Ti_(2)AlC reinforcement,lamellar architecture and heteroge-neous interface.More specifically,multiple deformation modes in Ti_(2)AlC,i.e.,basal-plane dislocations,atomic-scale ripples and kink bands,could be activated during the compression,thus promoting the plas-tic deformation capability of composite.Meanwhile,the lamellar architecture could not only induce sig-nificant stress redistribution and crack deflection between Ti_(2)AlC and TiAl,but also generate high-density SFs and DTs interactions in TiAl,leading to an improved strength and strain hardening ability.In addi-tion,profuse unique Ti_(2)AlC(1¯10¯3)/TiAl(111)interfaces in the composite could dramatically contribute to the strength and plasticity due to the interface-mediated dislocation nucleation and obstruction mecha-nisms.These findings offer a promising paradigm for tailoring microstructure of TiAl matrix composites with extraordinary strength and plasticity at ambient temperature.展开更多
This paper investigates limited-budget consensus design and analysis problems of general high-order multiagent systems with intermittent communications and switching topologies.The main contribution of this paper is t...This paper investigates limited-budget consensus design and analysis problems of general high-order multiagent systems with intermittent communications and switching topologies.The main contribution of this paper is that the tradeoff design between the energy consumption and the consensus performance can be realized while achieving leaderless or leaderfollowing consensus,under constraints of limited budgets and intermittent communications.Firstly,a new intermittent limitedbudget consensus control protocol with a practical trade-off design index is proposed,where the total budget of the whole multiagent system is limited.Then,leaderless limited-budget consensus design and analysis criteria are derived,in which the matrix variables of linear matrix inequalities are determined according to the total budget and the practical trade-off design parameters.Meanwhile,an explicit formulation of the consensus function is derived to describe the consensus state trajectory of the whole system.Moreover,a new two-stage transformation strategy is utilized for leader-following cases,by which the dynamics decomposition of leaderless and leader-following cases can be converted into a unified framework,and sufficient conditions of the leader-following limited-budget consensus design and analysis are determined via those of the leaderless cases.Finally,numerical simulations are given to illustrate theoretical results.展开更多
BACKGROUND The early diagnosis of basal ganglia and thalamus germinomas is often difficult due to the absence of elevated tumor markers,and atypical clinical symptoms and neuroimaging features.CASE SUMMARY Four male c...BACKGROUND The early diagnosis of basal ganglia and thalamus germinomas is often difficult due to the absence of elevated tumor markers,and atypical clinical symptoms and neuroimaging features.CASE SUMMARY Four male children aged 8 to 15 years were diagnosed with germinomas in the basal ganglia and thalamus by stereotactic biopsy from 2017 to 2019.All patients developed hemiplegia except patient 4 who also had cognitive decline,speech disturbance,nocturnal enuresis,polydipsia,polyuria,precocious puberty and abnormalities of thermoregulation.All four cases were alpha-fetoprotein and beta-human chorionic gonadotrophin(p-HCG)negative except patient 3 who had slightly elevated p-HCG in cerebrospinal fluid(CSF).No malignant cells were detected in the patients'CSF.Brain magnetic resonance imaging findings were diverse in these patients with the exception of the unique and common characteristics of ipsilateral hemisphere atrophy,especially in the cerebral peduncle.All patients were diagnosed with germinomas of the basal ganglia and thalamus by stereotactic brain biopsy.CONCLUSION Stereotactic brain biopsy is necessary to confirm the diagnosis of ectopic germinomas.Serial neuroimaging studies can not only differentiate disease but also determine the biopsy site.展开更多
Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline H...Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline HER kinetics.Here,we design ternary transition metals-based nickel telluride(Mo WNi Te)catalysts consisting of high valence non-3d Mo and W metals and oxophilic Te as a first demonstration of non-precious heterogeneous electrocatalysts following the bifunctional mechanism.The Mo WNi Te showed excellent HER catalytic performance with overpotentials of 72,125,and 182 mV to reach the current densities of 10,100,and 1000 mA cm^(-2),respectively,and the corresponding Tafel slope of 47,52,and 58 mV dec-1in alkaline media,which is much superior to commercial Pt/C.Additionally,the HER performance of Mo WNi Te is well maintained up to 3000 h at the current density of 100 mA cm^(-2).It is further demonstrated that the Mo WNi Te exhibits remarkable HER activities with an overpotential of 45 mV(31 mV)and Tafel slope of 60 mV dec-1(34 mV dec-1)at 10 mA cm^(-2)in neutral(acid)media.The superior HER performance of Mo WNi Te is attributed to the electronic structure modulation,inducing highly active low valence states by the incorporation of high valence non-3d transition metals.It is also attributed to the oxophilic effect of Te,accelerating water dissociation kinetics through a bifunctional catalytic mechanism in alkaline media.Density functional theory calculations further reveal that such synergistic effects lead to reduced free energy for an efficient water dissociation process,resulting in remarkable HER catalytic performances within universal pH environments.展开更多
Lanthanum-based oxides are promising candidates for low-temperature oxidative coupling of methane(OCM).To further lower the OCM reaction temperature,the Ce doped flower-like La_(2)O_(2)CO_(3)microsphere catalysts were...Lanthanum-based oxides are promising candidates for low-temperature oxidative coupling of methane(OCM).To further lower the OCM reaction temperature,the Ce doped flower-like La_(2)O_(2)CO_(3)microsphere catalysts were synthesized,achieving a significantly low reaction temperature (375℃) while maintaining high C_(2) hydrocarbon selectivity (43.0%).Doping Ce into the lattice of La_(2)O_(2)CO_(3)created more surface oxygen vacancies and bulk lattice defects,which was in favor of the transformation and migration of oxygen species at 350–400℃.The designed H_(2) temperature-programmed reduction (H_(2)-TPR) experiments provided strong evidence that the low reaction temperature of La_(x)Ce_(1-x)O_(1.5+δ)can be attributed to the transformation and migration of oxygen species,which dynamically generated surface oxygen vacancies for continuous oxygen activation to selectively convert methane.Moreover,designed temperatureprogrammed surface reaction (TPSR) clarified that two kinds of surface oxygen species in La_(x)Ce_(1-x)O_(1.5+δ)catalysts were concerned with catalytic performance,that is,the surface chemisorbed oxygen species for the activation of CH_(2)and the formation of CH_(2)·intermediates,surface La-Ce-O lattice oxygen species that caused the excessive oxidation of CH_(2)·intermediates.Finally,the factors affecting the transformation and migration of oxygen species were explored.展开更多
Molybdenum disulfide(MoS_(2))has shown significant promise as an economic hydrogen evolution reaction(HER)catalyst for hydrogen generation,but its catalytic performance is still lower than noble metalbased catalysists...Molybdenum disulfide(MoS_(2))has shown significant promise as an economic hydrogen evolution reaction(HER)catalyst for hydrogen generation,but its catalytic performance is still lower than noble metalbased catalysists.Herein,a silver nanoparticles(Ag NPs)-decorated 1T/2H phase layered MoS_(2) electrocatalyst grown on titanium dioxide nanorod arrays(Ag NPs/1T(2H)MoS_(2)/TNRs)was prepared through acid-tunable ammonium ion intercalation.Taking advantage of MoS_(2) layered structure and crystal phase controllability,as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs exhibited ultrahigh HER activity.As-proposed strategy combines facile hydrogen desorption(Ag NPs)with efficient hydrogen adsorption(1T/2H MoS_(2))effectively circumventes the kinetic limitation of hydrogen desorption by 1T/2H MoS_(2).The as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs electrocatalyst exhibited excellent HER activity in 0.5 mol/L H2SO4 with low overpotential(118 mV vs.reversible hydrogen electrode(RHE))and small Tafel slope(38.61 mV/dec).The overpotential exhibts no obvious attenuation after 10 h of constant current flow.First-principles calculation demonstrates that as-prepared 1T/2H MoS_(2) exhibit a large capacity to store protons.These protons can be subsequently transferred to Ag NPs,which significantly increases the hydrogen coverage on the surface of Ag NPs in HER process and thus change the rate-determining step of HER on Ag NPs from water dissociation to hydrogen recombination.This study provides a unique strategy to improve the catalytic activity and stability for MoS_(2)-based electrocatalyst.展开更多
Different kinds of aluminum precursors were obtained from precipitating ammonium bicarbonate, ammonium carbonate, and saturated ammonium bicarbonate, then, boehmite (AlO(OH)), ammonium alumina carbonate hydroxide (AAC...Different kinds of aluminum precursors were obtained from precipitating ammonium bicarbonate, ammonium carbonate, and saturated ammonium bicarbonate, then, boehmite (AlO(OH)), ammonium alumina carbonate hydroxide (AACH) and their mixture were obtained, and then, different kinds of alumina were obtained after calcination. Three catalysts supported on the different alumina were obtained via impregnating cobalt and ruthenium by incipient wetness. The effects of different precipitants on composition of precursors were?studied by XRD, FTIR, and TGA. The property and structure of alumina were studied by XRD and BET. The supported catalysts were studied by characterizations of XRD and H2-TPR, and the catalytic performance for Fischer-Tropsch synthesis (FTS) were evaluated at a fix-bed reactor. The relations among the composition of precursors, the property of alumina and the catalytic performance of supported catalysts were researched thoroughly.展开更多
Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regression.However,the therapeutic performance of CDK4/6i-meadiated cancer immunotherapy was impaired ...Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regression.However,the therapeutic performance of CDK4/6i-meadiated cancer immunotherapy was impaired by the immunosuppressive tumor microenvironment(ITM)due to overexpression of programmed death ligand 1(PD-L1)on the surface of cancer cell membrane.To improve the immunotherapeutic performance of CDK4/6i,we herein developed endosomal acidactivatable micelleplex for si RNA delivery and PD-L1 knockdown in the tumor cells in vitro and in vivo.We further demonstrated that the combination of PD-L1 knockdown and CDK4/6 inhibition facilitated intratumoral infiltration of cytotoxic T lymphocytes(CTLs),and elicited protective immune response and efficiently suppressed tumor growth in vivo.This study revealed the importance of molecular design of the micelleplex for highly efficient si RNA delivery,which might provide a novel insight for RNAi-based cancer immunotherapy.展开更多
This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic nanopatterns.Especially,we emphasize the structural evolution from simple columnar phases to complex 2D ti...This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic nanopatterns.Especially,we emphasize the structural evolution from simple columnar phases to complex 2D tiling morphologies in soft materials including block copolymers,liquid crystals,giant molecules,etc.Then,the state-of-the-art nanofabrication technologies for making sophisticated nanostructures with specific functions via combining both bottom-up assembly and top-down lithography-based methods are discussed,highlighting the use of directed self-assembly processes.Finally,we provide our perspective on this area.By further increasing the complexity of block molecules and the designability of lithography,low-dimensional ordered morphologies will be particularly promising for further application in nanotechnology.展开更多
Indium gallium tin oxide(IGTO)thin films have the potential for high mobility and lowtemperature processing,which makes them suitable for applications such as display backplanes and high-voltage switching devices.Howe...Indium gallium tin oxide(IGTO)thin films have the potential for high mobility and lowtemperature processing,which makes them suitable for applications such as display backplanes and high-voltage switching devices.However,very few studies have investigated the plasmaetching characteristics of IGTO and changes in its properties after etching.In this study,the etching characteristics of IGTO were investigated using Cl_(2)/Ar plasma,and changes in surface properties were analyzed.Results showed that the etch rate increased with an increase in the proportion of Cl_(2),with the highest etch rate observed at 69 nm min^(-1)in pure Cl_(2)plasma with a gas flow rate of 100 sccm.Furthermore,increased radio-frequency power caused a rise in the etch rate,while a process pressure of 15 m Torr was optimal.The primary etching mechanism for IGTO thin films under Cl_(2)plasma was a chemical reaction,and an increased work function indicated the occurrence of defects on the surface.In addition,the etching process reduced the surface roughness of Cl_(2)-containing plasma,whereas the etching process in pure Ar plasma increased surface roughness.This study contributes to a better understanding of the plasmaetching characteristics of IGTO and changes in its properties after etching,providing valuable insights for IGTO-based applications.展开更多
A scheme of combing wave absorption and phase cancellation mechanisms for widening radar cross section(RCS)reduction band is proposed.An absorptive coding metasurface implementing this scheme is derived from tradition...A scheme of combing wave absorption and phase cancellation mechanisms for widening radar cross section(RCS)reduction band is proposed.An absorptive coding metasurface implementing this scheme is derived from traditional circuit analog absorber(CAA)composed of resistive ring elements which characterize dual resonances behavior.It is constructed by replacing some of the CAA elements by another kind of resistive ring elements which is singly resonant in between the original two resonant bands and has reflection phase opposite to that of the original elements at resonance.Hence the developed metasurface achieves an improved low-RCS band over which the lower and higher sub-bands are mainly contributed by wave absorption mainly while the middle sub-band is formed by joint effect of wave absorption and antiphase cancellation mechanisms.The polarization-independent wideband RCS reduction property of the metasurface is validated by full-wave simulation results of a preliminary and an advanced design examples which employ the same element configuration but different element layout schemes as partitioned distribution and random coding.The advanced design also exhibits broadband bistatic low-RCS property and keeps a stable specular RCS reduction performance with regard to incident elevation angle up to 35◦.The advanced design is fabricated and the experimental results of the sample agrees qualitatively well with their simulated counterparts.The measured figure of merit(i.e.,low-RCS bandwidth ratio versus electrical thickness)of the sample is 40.572,which is superior to or comparable with those for most of other existing metasurface with compound RCS reduction mechanism.The proposed compound metasurface technique also features simple structure,light weight,low cost and easy fabrication compared with other techniques.This makes it promising in applications such as radar stealth and electromagnetic compatibility.展开更多
This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes,which has not been depicted by the known neurodegenerative disease....This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes,which has not been depicted by the known neurodegenerative disease.We performed physical and neurological examinations with International Rating Scales to assess signs of ataxia,Parkinsonism,and cognitive function,as well as brain magnetic resonance imaging scans with seven sequences.We searched for co-segregations of abnormal repeat-expansion loci,pathogenic variants in known spinocerebellar ataxiarelated genes,and novel rare mutations via whole-genome sequencing and linkage analysis.A rare co-segregating missense mutation in the CARS gene was validated by Sanger sequencing and the aminoacylation activity of mutant CARS was measured by spectrophotometric assay.This pedigree presented novel late-onset core characteristics including cerebellar ataxia,Parkinsonism,and pyramidal signs in all nine affected members.Brain magnetic resonance imaging showed cerebellar/pons atrophy,pontine-midline linear hyperintensity,decreased rCBF in the bilateral basal ganglia and cerebellar dentate nucleus,and hypo-intensities of the cerebellar dentate nuclei,basal ganglia,mesencephalic red nuclei,and substantia nigra,all of which suggested neurodegeneration.Whole-genome sequencing identified a novel pathogenic heterozygous mutation(E795V)in the CARS gene,meanwhile,exhibited none of the known repeat-expansions or point mutations in pathogenic genes.Remarkably,this CARS mutation causes a 20%decrease in aminoacylation activity to charge tRNA^(Cys) with L-cysteine in protein synthesis compared with that of the wild type.All family members carrying a heterozygous mutation CARS(E795V)had the same clinical manifestations and neuropathological changes of Parkinsonism and spinocerebellar-ataxia.These findings identify novel pathogenesis of Parkinsonismspinocerebellar ataxia and provide insights into its genetic architecture.展开更多
In this paper, we consider the Hochschild cohomology of a class of quantum algebras ∧q^n. We construct a minimal projective bimodule resolution of ∧q^n, and calculate the k-dimensions of all the Hochschild cohomolog...In this paper, we consider the Hochschild cohomology of a class of quantum algebras ∧q^n. We construct a minimal projective bimodule resolution of ∧q^n, and calculate the k-dimensions of all the Hochschild cohomology groups of ∧q^n. Furthermore, we give the Hochschild cohomology ring structure of ∧q^n for some special cases.展开更多
文摘This paper deals with numerical computation and analysis for the initial boundary problems of two dimensional(2D)Sobolev equations with piecewise continuous argument.Firstly,a two-level high-order compact difference method(HOCDM)with computational accuracy O(τ^(2)+h_(x)^(4)+h_(y)^(4))is suggested,whereτ,h_(x),h_(y) denote the temporal and spatial stepsizes of the method,respectively.In order to improve the temporal computational accuracy of this method,the Richardson extrapolation technique is used and thus a new two-level HOCDMis derived,which is proved to be convergent of order four both in time and space.Although the new two-level HOCDM has the higher computational accuracy in time than the previous one,it will bring a larger computational cost.To overcome this deficiency,a three-level HOCDM with computational accuracy O(τ^(4)+h_(x)^(4)+h_(y)^(4))is constructed.Finally,with a series of numerical experiments,the theoretical accuracy and computational efficiency of the above methods are further verified.
基金Supported by Sichuan Provincial Science and Technology Department Application Foundation Project(No.2019YJ0673)the Meat Processing Sichuan Key Laboratory Open Fund Project(No.20-r-11)Chengdu International Science and Technology Cooperation Project(No.2019-gh02-00004-hz).
文摘A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by different feeding modes(O-noant,outdoor without antibiotics;O-ant,outdoor with antibiotics;D-noant,indoor without antibiotics;D-ant,indoor with antibiotics),respectively,to evaluate the effect on liver.The results showed that different feeding modes significantly influenced the growth,liver weight,subcutaneous fat thickness,liver fat and liver free amino acid contents.The outdoor feeding without antibiotic reflected remarkably(P﹤0.05)low liver weight and fat content with normal morphology.While,other groups showed different levels of fat metabolism disorder in the liver.Based on chicken liver healthy,the outdoor feeding without antibiotic was the optimal feeding mode for Gushi chicken.
基金supported by the National Natural Science Foundation of China(Grant number W2432035)financial support from the EPSRC SWIMS(EP/V039717/1)+3 种基金Royal Society(RGS\R1\221009 and IEC\NSFC\211201)Leverhulme Trust(RPG-2022-263)Ser Cymru programme–Enhancing Competitiveness Equipment Awards 2022-23(MA/VG/2715/22-PN66)the financial support from Kingdom of Saudi Arabia Ministry of Higher Education.
文摘Electrical energy is essential for modern society to sustain economic growths.The soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar energy.However,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban environment.To overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric energy.Current TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar panels.In this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve transparency.Figures of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV technology.Then we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic PVs.The applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and facades.Finally,current challenges and future opportunities in TPV research are pointed out.
基金supported in part by the Natural Science Foundation of Shandong Province(no.ZR2022QH373,ZR2022QH292 and ZR2023MH2474).
文摘ObjectivesThe PTPRQ gene is essential for preserving the structure and function of stereocilia in inner ear.However,research on splicing mutations within this gene is limited.This study aims to investigate novel splicing mutations in PTPRQ,clarify their molecular mechanisms,and provide new insights into the genetic factors associated with hearing loss,ultimately enhancing diagnostic accuracy.MethodClinical data and peripheral blood samples were obtained from members of a family with congenital hearing loss.Variants were identified through high-throughput sequencing and confirmed by Sanger sequencing to ensure genealogical co-segregation.The splicing effects of PTPRQ variants were evaluated using bioinformatics tools and minigene assays.ResultsWe used whole exome sequencing to identify novel double compound heterozygous splice-altering variants(c.5426+1 G>A and c.6603-3 T>G)in the PTPRQ gene with DFNB84A.We molecularly characterized these variants,and they were found to co-segregate with the disease within the family.Minigene assays and Sanger sequencing confirmed that the c.6603-3 T>G variant caused exon 43 skipping,resulting in a frameshift mutation(p.Ser2201ArgfsTer112).Further bioinformatic analysis supported these findings.ConclusionsThis study identifies a novel compound heterozygous splicing variant in the PTPRQ gene in a Chinese family with DFNB84A,expanding the known spectrum of PTPRQ mutations.These findings enhance the understanding of PTPRQ-related hearing loss and may aid in early diagnosis,prevention,and therapeutic strategies.
基金the National Natural Science Foundation of China(Grant No.52101174)the State Key Lab of Advanced Metals and Materials(No.2022-Z15).
文摘Improving the plasticity of TiAl alloys at room temperature has been a longstanding challenge for the de-velopment of next-generation aerospace engines.By adopting the nacre-like architecture design strategy,we have obtained a novel heterogeneous lamellar Ti_(2)AlC/TiAl composite with superior strength-plasticity synergy,i.e.,compressive strength of∼2065 MPa and fracture strain of∼27%.A combination of micropil-lar compression and large-scale atomistic simulation has revealed that the superior strength-plasticity synergy is attributed to the collaboration of Ti_(2)AlC reinforcement,lamellar architecture and heteroge-neous interface.More specifically,multiple deformation modes in Ti_(2)AlC,i.e.,basal-plane dislocations,atomic-scale ripples and kink bands,could be activated during the compression,thus promoting the plas-tic deformation capability of composite.Meanwhile,the lamellar architecture could not only induce sig-nificant stress redistribution and crack deflection between Ti_(2)AlC and TiAl,but also generate high-density SFs and DTs interactions in TiAl,leading to an improved strength and strain hardening ability.In addi-tion,profuse unique Ti_(2)AlC(1¯10¯3)/TiAl(111)interfaces in the composite could dramatically contribute to the strength and plasticity due to the interface-mediated dislocation nucleation and obstruction mecha-nisms.These findings offer a promising paradigm for tailoring microstructure of TiAl matrix composites with extraordinary strength and plasticity at ambient temperature.
基金supported by the National Natural Science Foundation of China(62003363,61703411)China Postdoctoral Science Foundation(271004)+1 种基金Science Foundation for Distinguished Youth of Shaanxi Province(2021JC-35)Youth Science Foundation of Shaanxi Province(2021JQ-375)。
文摘This paper investigates limited-budget consensus design and analysis problems of general high-order multiagent systems with intermittent communications and switching topologies.The main contribution of this paper is that the tradeoff design between the energy consumption and the consensus performance can be realized while achieving leaderless or leaderfollowing consensus,under constraints of limited budgets and intermittent communications.Firstly,a new intermittent limitedbudget consensus control protocol with a practical trade-off design index is proposed,where the total budget of the whole multiagent system is limited.Then,leaderless limited-budget consensus design and analysis criteria are derived,in which the matrix variables of linear matrix inequalities are determined according to the total budget and the practical trade-off design parameters.Meanwhile,an explicit formulation of the consensus function is derived to describe the consensus state trajectory of the whole system.Moreover,a new two-stage transformation strategy is utilized for leader-following cases,by which the dynamics decomposition of leaderless and leader-following cases can be converted into a unified framework,and sufficient conditions of the leader-following limited-budget consensus design and analysis are determined via those of the leaderless cases.Finally,numerical simulations are given to illustrate theoretical results.
基金The Third Affiliated Hospital of Sun Yat-Sen University,Clinical Research Program,No.YHJH201907.
文摘BACKGROUND The early diagnosis of basal ganglia and thalamus germinomas is often difficult due to the absence of elevated tumor markers,and atypical clinical symptoms and neuroimaging features.CASE SUMMARY Four male children aged 8 to 15 years were diagnosed with germinomas in the basal ganglia and thalamus by stereotactic biopsy from 2017 to 2019.All patients developed hemiplegia except patient 4 who also had cognitive decline,speech disturbance,nocturnal enuresis,polydipsia,polyuria,precocious puberty and abnormalities of thermoregulation.All four cases were alpha-fetoprotein and beta-human chorionic gonadotrophin(p-HCG)negative except patient 3 who had slightly elevated p-HCG in cerebrospinal fluid(CSF).No malignant cells were detected in the patients'CSF.Brain magnetic resonance imaging findings were diverse in these patients with the exception of the unique and common characteristics of ipsilateral hemisphere atrophy,especially in the cerebral peduncle.All patients were diagnosed with germinomas of the basal ganglia and thalamus by stereotactic brain biopsy.CONCLUSION Stereotactic brain biopsy is necessary to confirm the diagnosis of ectopic germinomas.Serial neuroimaging studies can not only differentiate disease but also determine the biopsy site.
基金supported through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(2022M3H4A1A04096478)the support from the Supercomputing Center of Wuhan University。
文摘Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline HER kinetics.Here,we design ternary transition metals-based nickel telluride(Mo WNi Te)catalysts consisting of high valence non-3d Mo and W metals and oxophilic Te as a first demonstration of non-precious heterogeneous electrocatalysts following the bifunctional mechanism.The Mo WNi Te showed excellent HER catalytic performance with overpotentials of 72,125,and 182 mV to reach the current densities of 10,100,and 1000 mA cm^(-2),respectively,and the corresponding Tafel slope of 47,52,and 58 mV dec-1in alkaline media,which is much superior to commercial Pt/C.Additionally,the HER performance of Mo WNi Te is well maintained up to 3000 h at the current density of 100 mA cm^(-2).It is further demonstrated that the Mo WNi Te exhibits remarkable HER activities with an overpotential of 45 mV(31 mV)and Tafel slope of 60 mV dec-1(34 mV dec-1)at 10 mA cm^(-2)in neutral(acid)media.The superior HER performance of Mo WNi Te is attributed to the electronic structure modulation,inducing highly active low valence states by the incorporation of high valence non-3d transition metals.It is also attributed to the oxophilic effect of Te,accelerating water dissociation kinetics through a bifunctional catalytic mechanism in alkaline media.Density functional theory calculations further reveal that such synergistic effects lead to reduced free energy for an efficient water dissociation process,resulting in remarkable HER catalytic performances within universal pH environments.
基金the Shanxi Science and Technology Department bidding project(No.20191101012)the autonomous research project of SKLCC(No.2020BWZ003)for providing financial support。
文摘Lanthanum-based oxides are promising candidates for low-temperature oxidative coupling of methane(OCM).To further lower the OCM reaction temperature,the Ce doped flower-like La_(2)O_(2)CO_(3)microsphere catalysts were synthesized,achieving a significantly low reaction temperature (375℃) while maintaining high C_(2) hydrocarbon selectivity (43.0%).Doping Ce into the lattice of La_(2)O_(2)CO_(3)created more surface oxygen vacancies and bulk lattice defects,which was in favor of the transformation and migration of oxygen species at 350–400℃.The designed H_(2) temperature-programmed reduction (H_(2)-TPR) experiments provided strong evidence that the low reaction temperature of La_(x)Ce_(1-x)O_(1.5+δ)can be attributed to the transformation and migration of oxygen species,which dynamically generated surface oxygen vacancies for continuous oxygen activation to selectively convert methane.Moreover,designed temperatureprogrammed surface reaction (TPSR) clarified that two kinds of surface oxygen species in La_(x)Ce_(1-x)O_(1.5+δ)catalysts were concerned with catalytic performance,that is,the surface chemisorbed oxygen species for the activation of CH_(2)and the formation of CH_(2)·intermediates,surface La-Ce-O lattice oxygen species that caused the excessive oxidation of CH_(2)·intermediates.Finally,the factors affecting the transformation and migration of oxygen species were explored.
基金supported by the National Natural Science Foundation of China(No.52270078)the Royal Society IEC\NSFC\211201-International Exchanges 2021 Cost Share(NSFC).
文摘Molybdenum disulfide(MoS_(2))has shown significant promise as an economic hydrogen evolution reaction(HER)catalyst for hydrogen generation,but its catalytic performance is still lower than noble metalbased catalysists.Herein,a silver nanoparticles(Ag NPs)-decorated 1T/2H phase layered MoS_(2) electrocatalyst grown on titanium dioxide nanorod arrays(Ag NPs/1T(2H)MoS_(2)/TNRs)was prepared through acid-tunable ammonium ion intercalation.Taking advantage of MoS_(2) layered structure and crystal phase controllability,as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs exhibited ultrahigh HER activity.As-proposed strategy combines facile hydrogen desorption(Ag NPs)with efficient hydrogen adsorption(1T/2H MoS_(2))effectively circumventes the kinetic limitation of hydrogen desorption by 1T/2H MoS_(2).The as-prepared Ag NPs/1T(2H)MoS_(2)/TNRs electrocatalyst exhibited excellent HER activity in 0.5 mol/L H2SO4 with low overpotential(118 mV vs.reversible hydrogen electrode(RHE))and small Tafel slope(38.61 mV/dec).The overpotential exhibts no obvious attenuation after 10 h of constant current flow.First-principles calculation demonstrates that as-prepared 1T/2H MoS_(2) exhibit a large capacity to store protons.These protons can be subsequently transferred to Ag NPs,which significantly increases the hydrogen coverage on the surface of Ag NPs in HER process and thus change the rate-determining step of HER on Ag NPs from water dissociation to hydrogen recombination.This study provides a unique strategy to improve the catalytic activity and stability for MoS_(2)-based electrocatalyst.
文摘Different kinds of aluminum precursors were obtained from precipitating ammonium bicarbonate, ammonium carbonate, and saturated ammonium bicarbonate, then, boehmite (AlO(OH)), ammonium alumina carbonate hydroxide (AACH) and their mixture were obtained, and then, different kinds of alumina were obtained after calcination. Three catalysts supported on the different alumina were obtained via impregnating cobalt and ruthenium by incipient wetness. The effects of different precipitants on composition of precursors were?studied by XRD, FTIR, and TGA. The property and structure of alumina were studied by XRD and BET. The supported catalysts were studied by characterizations of XRD and H2-TPR, and the catalytic performance for Fischer-Tropsch synthesis (FTS) were evaluated at a fix-bed reactor. The relations among the composition of precursors, the property of alumina and the catalytic performance of supported catalysts were researched thoroughly.
基金financially supported by the National Natural Science Foundation of China(Nos.51873228 and 31671024)Basic Research Program of Shenzhen(No.JCYJ20180227175420974)+1 种基金Science and Technology Development Fund,Macao SAR(No.083/2017/A2)Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences。
文摘Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regression.However,the therapeutic performance of CDK4/6i-meadiated cancer immunotherapy was impaired by the immunosuppressive tumor microenvironment(ITM)due to overexpression of programmed death ligand 1(PD-L1)on the surface of cancer cell membrane.To improve the immunotherapeutic performance of CDK4/6i,we herein developed endosomal acidactivatable micelleplex for si RNA delivery and PD-L1 knockdown in the tumor cells in vitro and in vivo.We further demonstrated that the combination of PD-L1 knockdown and CDK4/6 inhibition facilitated intratumoral infiltration of cytotoxic T lymphocytes(CTLs),and elicited protective immune response and efficiently suppressed tumor growth in vivo.This study revealed the importance of molecular design of the micelleplex for highly efficient si RNA delivery,which might provide a novel insight for RNAi-based cancer immunotherapy.
基金financially supported by the National Natural Science Foundation of China (Nos. 21925102, 21991132, 92056118 and 22101010)the financial support from the National Key R&D Program of China (No. 2018YFB0703702)Beijing National Laboratory for Molecular Sciences (No. BNLMS-CXXM-202006)
文摘This review summarizes the self-assembly of block molecules forming unconventional two-dimensional(2D)periodic nanopatterns.Especially,we emphasize the structural evolution from simple columnar phases to complex 2D tiling morphologies in soft materials including block copolymers,liquid crystals,giant molecules,etc.Then,the state-of-the-art nanofabrication technologies for making sophisticated nanostructures with specific functions via combining both bottom-up assembly and top-down lithography-based methods are discussed,highlighting the use of directed self-assembly processes.Finally,we provide our perspective on this area.By further increasing the complexity of block molecules and the designability of lithography,low-dimensional ordered morphologies will be particularly promising for further application in nanotechnology.
基金supported by the Chung-Ang University Research Grants in 2021the National Research Foundation(NRF)of Korea(No.2020R1G1A1102692)。
文摘Indium gallium tin oxide(IGTO)thin films have the potential for high mobility and lowtemperature processing,which makes them suitable for applications such as display backplanes and high-voltage switching devices.However,very few studies have investigated the plasmaetching characteristics of IGTO and changes in its properties after etching.In this study,the etching characteristics of IGTO were investigated using Cl_(2)/Ar plasma,and changes in surface properties were analyzed.Results showed that the etch rate increased with an increase in the proportion of Cl_(2),with the highest etch rate observed at 69 nm min^(-1)in pure Cl_(2)plasma with a gas flow rate of 100 sccm.Furthermore,increased radio-frequency power caused a rise in the etch rate,while a process pressure of 15 m Torr was optimal.The primary etching mechanism for IGTO thin films under Cl_(2)plasma was a chemical reaction,and an increased work function indicated the occurrence of defects on the surface.In addition,the etching process reduced the surface roughness of Cl_(2)-containing plasma,whereas the etching process in pure Ar plasma increased surface roughness.This study contributes to a better understanding of the plasmaetching characteristics of IGTO and changes in its properties after etching,providing valuable insights for IGTO-based applications.
基金supported by the National Natural Science Foundation of China(Grant Nos.61871280,61372012,and 61671315).
文摘A scheme of combing wave absorption and phase cancellation mechanisms for widening radar cross section(RCS)reduction band is proposed.An absorptive coding metasurface implementing this scheme is derived from traditional circuit analog absorber(CAA)composed of resistive ring elements which characterize dual resonances behavior.It is constructed by replacing some of the CAA elements by another kind of resistive ring elements which is singly resonant in between the original two resonant bands and has reflection phase opposite to that of the original elements at resonance.Hence the developed metasurface achieves an improved low-RCS band over which the lower and higher sub-bands are mainly contributed by wave absorption mainly while the middle sub-band is formed by joint effect of wave absorption and antiphase cancellation mechanisms.The polarization-independent wideband RCS reduction property of the metasurface is validated by full-wave simulation results of a preliminary and an advanced design examples which employ the same element configuration but different element layout schemes as partitioned distribution and random coding.The advanced design also exhibits broadband bistatic low-RCS property and keeps a stable specular RCS reduction performance with regard to incident elevation angle up to 35◦.The advanced design is fabricated and the experimental results of the sample agrees qualitatively well with their simulated counterparts.The measured figure of merit(i.e.,low-RCS bandwidth ratio versus electrical thickness)of the sample is 40.572,which is superior to or comparable with those for most of other existing metasurface with compound RCS reduction mechanism.The proposed compound metasurface technique also features simple structure,light weight,low cost and easy fabrication compared with other techniques.This makes it promising in applications such as radar stealth and electromagnetic compatibility.
基金supported by the NIH-NIA Research Project (R21AG036454)the National Key R&D Program of China (2016YFC0901500)+4 种基金CAMS Innovation Fund for Medical Sciences (2016-12M-1-004)the National Key R&D Program of China (2016YFC1305900)the National Natural Science Foundation of China (3203004)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02030001)Shenzhen Municipal of Government of China (JCYJ20170412153248372 and JCYJ20180507183615145).
文摘This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes,which has not been depicted by the known neurodegenerative disease.We performed physical and neurological examinations with International Rating Scales to assess signs of ataxia,Parkinsonism,and cognitive function,as well as brain magnetic resonance imaging scans with seven sequences.We searched for co-segregations of abnormal repeat-expansion loci,pathogenic variants in known spinocerebellar ataxiarelated genes,and novel rare mutations via whole-genome sequencing and linkage analysis.A rare co-segregating missense mutation in the CARS gene was validated by Sanger sequencing and the aminoacylation activity of mutant CARS was measured by spectrophotometric assay.This pedigree presented novel late-onset core characteristics including cerebellar ataxia,Parkinsonism,and pyramidal signs in all nine affected members.Brain magnetic resonance imaging showed cerebellar/pons atrophy,pontine-midline linear hyperintensity,decreased rCBF in the bilateral basal ganglia and cerebellar dentate nucleus,and hypo-intensities of the cerebellar dentate nuclei,basal ganglia,mesencephalic red nuclei,and substantia nigra,all of which suggested neurodegeneration.Whole-genome sequencing identified a novel pathogenic heterozygous mutation(E795V)in the CARS gene,meanwhile,exhibited none of the known repeat-expansions or point mutations in pathogenic genes.Remarkably,this CARS mutation causes a 20%decrease in aminoacylation activity to charge tRNA^(Cys) with L-cysteine in protein synthesis compared with that of the wild type.All family members carrying a heterozygous mutation CARS(E795V)had the same clinical manifestations and neuropathological changes of Parkinsonism and spinocerebellar-ataxia.These findings identify novel pathogenesis of Parkinsonismspinocerebellar ataxia and provide insights into its genetic architecture.
基金supported by Beijing Natural Science Foundation(Grant No.1122006)the National Natural Science Foundation of China(Grant No.11301144)
文摘In this paper, we consider the Hochschild cohomology of a class of quantum algebras ∧q^n. We construct a minimal projective bimodule resolution of ∧q^n, and calculate the k-dimensions of all the Hochschild cohomology groups of ∧q^n. Furthermore, we give the Hochschild cohomology ring structure of ∧q^n for some special cases.
