Central retinal artery occlusion(CRAO)is an acute ophthalmic emergency,characterized by sudden vision loss due to retinal ischemia in areas corresponding to arterial occlusion sites.Diagnosis primarily relies on fundu...Central retinal artery occlusion(CRAO)is an acute ophthalmic emergency,characterized by sudden vision loss due to retinal ischemia in areas corresponding to arterial occlusion sites.Diagnosis primarily relies on fundus fluorescein angiography(FFA)and optical coherence tomography(OCT),which show delayed retinal artery filling time hours to days after occlusion and increased hyperreflectivity of the inner retina.展开更多
Oxygen-rich porous carbons are promising candidates for the carbon-based cathodes of zinc ion hybrid capacitors(ZIHCs).Potassium activation is a traditional and effective way to prepare oxygen-rich porous carbons.Effi...Oxygen-rich porous carbons are promising candidates for the carbon-based cathodes of zinc ion hybrid capacitors(ZIHCs).Potassium activation is a traditional and effective way to prepare oxygen-rich porous carbons.Efficient potassium activation is the key to develop high-performance oxygen-rich porous carbon cathodes.Herein,the alkali lignin,extracted from eucalyptus wood by geopolymer-assisted low-alkali pretreatment,is used to prepare oxygen-rich lignin-derived porous carbons(OLPCs)through KOH activation and K_(2)CO_(3)activation at 700-900℃.KOH activation constructs a hierarchical micro-mesoporous structure,while K_(2)CO_(3)activation constructs a microporous structure.Furthermore,K_(2)CO_(3)activation could more efficiently construct active oxygen(C=O)species than KOH activation.The OLPCs prepared by KOH/K_(2)CO_(3)activations at 800℃show the highest microporosity(78.4/87.7%)and C=O content(5.3/8.0 at.%).Due to that C=O and micropore adsorb zinc ions,the OLPCs prepared by K_(2)CO_(3)activation at 800℃with higher C=O content and microporosity deliver superior capacitive performance(256 F g^(-1)at 0.1 A g^(-1))than that by KOH activation at 800℃(224 F g^(-1)at 0.1 A g^(-1)),and excellent cycling stability.This work provides a new insight into the sustainable preparation of oxygenrich porous carbon cathodes through efficient potassium activation for ZIHCs.展开更多
Balancing CO2 emission reduction with enhanced gas recovery in carbonate reservoirs remains a key challenge in subsurface energy engineering.This study focuses on the Maokou Formation gas reservoir in the Wolonghe Gas...Balancing CO2 emission reduction with enhanced gas recovery in carbonate reservoirs remains a key challenge in subsurface energy engineering.This study focuses on the Maokou Formation gas reservoir in the Wolonghe Gas Field,Sichuan Basin,and employs a mechanistic model integrated with numerical simulations that couple CO2–water–rock geochemical interactions to systematically explore the principal engineering and chemical factors governing Carbon Capture,Utilization,and Storage–Enhanced Gas Recovery(CCUS–EGR).The analysis reveals that both the injection–production ratio and gas injection rate exhibit optimal ranges.Maximum gas output under single-parameter variation occurs at an injection–production ratio of 0.7 and an injection rate of 130,000 m3/d,while coordinated optimization of both parameters is essential to achieve the highest production enhancement.Excessively high injection–production ratios,however,may induce gas channeling and reduce the ultimate recovery factor.Chemical composition of the injected gas also strongly influences recovery.In the heterogeneous carbonate reservoir considered,a CO2–N2 mixed gas mitigates gravity segregation due to its lower density,expanding sweep efficiency and improving overall gas recovery compared to pure CO2 injection.CO2–water–rock reactions further modify reservoir properties.Near the injection well,acidic dissolution enhances porosity,whereas near the production well,a dynamic interplay of ion migration,pressure–temperature variations,and secondary mineral precipitation produces complex porosity evolution.Initial precipitation reduces porosity,while subsequent acidic dissolution partially restores it,creating a heterogeneous and time-dependent porosity profile.展开更多
The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary int...The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary intervention(PCI)significantly improved the patency of the infarct-related artery in patients with STsegment elevation myocardial infarction(STEMI),who were expected to undergo PCI within 120 min.The present study aimed to investigate the one-year clinical outcomes and the effect of the anti-r-SAK antibodies on a second r-SAK thrombolysis in OPTIMA-5 patients.The clinical outcome measured was major adverse cardiovascular events(MACE)within 360 days.Patients'anti-r-SAK antibody levels were determined on day 90(±7 days),day 180(±7 days),and day 360(±14 days)after thrombolysis,and in vitro r-SAK antibody neutralization experiments were performed to explore an optimal interval for a second r-SAK thrombolysis.Results showed that the MACE incidence was numerically lower in the r-SAK group compared with the normal saline(NS)group(14.0%vs.20.0%,hazard ratio[HR]=0.67,95%confidence interval[CI]:0.34–1.32;log-rank P=0.245).The anti-r-SAK antibody levels in the r-SAK group decreased with time,but remained significantly higher than those in the NS group on day 90(±7 days)(2.96±0.68 vs.0.22±0.53,P<0.001),day 180(±7 days)(2.19±0.74 vs.0.44±0.65,P<0.001),and day 360(±14 days)(1.73±0.97 vs.0.37±0.71,P<0.001).The in vitro anti-r-SAK antibody neutralization experiments demonstrated that the thrombolysis rate decreased exponentially as the antibody titer increased from 1.90 to 2.20(67.80%±14.19%vs.44.32%±21.54%,P<0.0001).Therefore,for STEMI patients who are expected to undergo PCI within 120 min,a single bolus of half-dose rSAK before primary PCI may reduce the one-year MACE risk.The anti-r-SAK antibody persists over one year,and a second r-SAK thrombolysis may not be indicated until at least one year after the first administration,if necessary.展开更多
Focusing on the rehabilitation training of hemiplegia patients,this paper proposes a gait-planning strategy based on a central pattern generator and an adaptive time-delay control scheme that utilizes recursive termin...Focusing on the rehabilitation training of hemiplegia patients,this paper proposes a gait-planning strategy based on a central pattern generator and an adaptive time-delay control scheme that utilizes recursive terminal sliding mode for lower limb rehabilitation exoskeleton robots.The central pattern generator network plans a reference gait trajectory for the affected leg,synchronized with the movement of the healthy leg.The proposed adaptive time-delay control scheme possesses a model-independent property due to the mechanism of time-delay estimation,with adaptive control gains that enhance the resilience against system perturbations and a recursive terminal sliding mode control component to achieve a fast convergence rate.According to the Lyapunov stability criterion,it is proved that the gait trajectory-tracking error is uniformly ultimately bounded.Experiments are conducted on a lower limb exoskeleton experimental platform,and the experimental results demonstrate the effectiveness and superiority of the proposed strategies.展开更多
Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in hu...Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.展开更多
Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML...Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.展开更多
Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 199...Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 1993.TM typically spares the foveal center,is asymptomatic,and is often detected incidentally during routine ophthalmic examinations.Through literature search,we did not identify racial or regional differences in TM.It predominantly affects children,with an estimated prevalence of 2 per 100000 in individuals under 16 ages[3].While previous reports have focused on pediatric and adult populations,this study presents four cases of TM in preterm infants.展开更多
The healing of critical-sized bone defects(CSD)remains a challenge in orthopedic medicine.In recent years,scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional(3D)printing technolog...The healing of critical-sized bone defects(CSD)remains a challenge in orthopedic medicine.In recent years,scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional(3D)printing technology have lighted up the treatment of the CSD due to the elaborate microenvironments and support they may build.Here,we established a magnesium oxide-reinforced 3D-printed biocompos-ite scaffold to investigate the effect of magnesium-enriched 3D microenvironment on CSD repairing.The composite was prepared using a biodegradable polymer matrix,polycaprolactone(PCL),and the disper-sion phase,magnesium oxide(MgO).With the appropriate surface treatment by saline coupling agent,the MgO dispersed homogeneously in the polymer matrix,leading to enhanced mechanical performance and steady release of magnesium ion(Mg^(2+))for superior cytocompatibility,higher cell viability,advanced osteogenic differentiation,and cell mineralization capabilities in comparison with the pure PCL.The in-vivo femoral implantation and critical-sized cranial bone defect studies demonstrated the importance of the 3D magnesium microenvironment,as a scaffold that released appropriate Mg^(2+) exhibited remarkably increased bone volume,enhanced angiogenesis,and almost recovered CSD after 8-week implantation.Overall,this study suggests that the magnesium-enriched 3D scaffold is a potential candidate for the treatment of CSD in a cell-free therapeutic approach.展开更多
Diffusion bonding of refractory Nb–Si-based alloy was performed with Ni/Al and Ti/Al nanolayers under the condition of 1473 K/30 MPa/60 min.The NbSS/Nb5Si3 in situ composite with the nominal composition of Nb–22 Ti...Diffusion bonding of refractory Nb–Si-based alloy was performed with Ni/Al and Ti/Al nanolayers under the condition of 1473 K/30 MPa/60 min.The NbSS/Nb5Si3 in situ composite with the nominal composition of Nb–22 Ti–16 Si–3 Cr–3 Al–2 Hf was used as the parent material.The joint microstructures were examined by using a scanning electron microscope equipped with an X-ray energy dispersive spectrometer.Shear test was conducted for the bonded joints at room temperature.Within the joint bonded with Ni/Al multilayer,element diffusion occurred between the base metal and the nanolayer,with the reaction products of AlNb2+Ni3 Al,NiAl and AlNi2 Ti phases.The average shear strength was 182 MPa.While using Ti/Al multilayer,the interface mainly consisted of TiAl,(Ti,Nb)Al and(Ti,Nb)2 Al phases,and the corresponding joints exhibited an increased strength of 228 MPa.In this case,the fracture mainly took place in the TiAl phase and presented a typical brittle characteristic.展开更多
The Advanced Space-based Solar Observatory(ASO-S) mission aims to explore the two most spectacular eruptions on the Sun: solar flares and coronal mass ejections(CMEs), and their magnetism.For the study of CMEs, the pa...The Advanced Space-based Solar Observatory(ASO-S) mission aims to explore the two most spectacular eruptions on the Sun: solar flares and coronal mass ejections(CMEs), and their magnetism.For the study of CMEs, the payload Lyman-alpha Solar Telescope(LST) has been proposed. It includes a traditional white-light coronagraph and a Lyman-alpha coronagraph which opens a new window to CME observations. Polarization measurements taken by white-light coronagraphs are crucial for deriving fundamental physical parameters of CMEs. To make such measurements, there are two options for a Stokes polarimeter which have been applied by existing white-light coronagraphs for space missions. One uses a single or triple linear polarizer, the other involves both a half-wave plate and a linear polarizer. We find that the former option is subject to less uncertainty in the derived Stokes vector propagating from detector noise.The latter option involves two plates which are prone to internal reflections and may have a reduced transmission factor. Therefore, the former option is adopted as our Stokes polarimeter scheme for LST. Based on the parameters of the intended linear polarizer(s) colorPol provided by CODIXX and the half-wave plate 2-APW-L2-012 C by Altechna, it is further shown that the imperfect maximum transmittance of the polarizer significantly increases the variance amplification of Stokes vector by at least about 50% when compared with the ideal case. The relative errors of Stokes vector caused by the imperfection of colorPol polarizer and the uncertainty due to the polarizer assembly in the telescope are estimated to be about 5%. Among the considered parameters, we find that the dominant error comes from the uncertainty in the maximum transmittance of the polarizer.展开更多
Atmospheric pressure plasma jet(APPJ)was used to clean nitrogen-containing carbon films(C–N)fabricated by plasma-assisted chemical vapor deposition method employing the plasma surface interaction linear device at Sic...Atmospheric pressure plasma jet(APPJ)was used to clean nitrogen-containing carbon films(C–N)fabricated by plasma-assisted chemical vapor deposition method employing the plasma surface interaction linear device at Sichuan University(SCU-PSI).The properties of the contaminated films on the surface of pristine and He-plasma pre-irradiated tungsten matrix,such as morphology,crystalline structure,element composition and chemical structure were characterized by scanning electron microscopy,grazing incidence x-ray diffraction and x-ray photoelectron spectroscopy.The experimental results revealed that the removal of C–N film with a thickness of tens of microns can be realized through APPJ cleaning regardless of the morphology of the substrates.Similar removal rates of 16.82 and 13.78μm min^(-1)were obtained for C–N films deposited on a smooth pristine W surface and rough fuzz-covered W surface,respectively.This is a remarkable improvement in comparison to the traditional cleaning method.However,slight surface oxidation was found after APPJ cleaning,but the degree of oxidation was acceptable with an oxidation depth increase of only 3.15 nm.Optical emission spectroscopy analysis and mass spectrometry analysis showed that C–N contamination was mainly removed through chemical reaction with reactive oxygen species during APPJ treatment using air as the working gas.These results make APPJ cleaning a potentially effective method for the rapid removal of C–N films from the wall surfaces of fusion devices.展开更多
Traditional microtubule inhibitors fail to significantly enhance+e effect of colorectal cancer;hence,new and efficient strategies are necessary.In+is study,a supramolecular nanoreactor(DOC@TA-Fe^(3+))based on tannic a...Traditional microtubule inhibitors fail to significantly enhance+e effect of colorectal cancer;hence,new and efficient strategies are necessary.In+is study,a supramolecular nanoreactor(DOC@TA-Fe^(3+))based on tannic acid(TA),iron ion(Fe^(3+)),and docetaxel(DOC)wi+microtubule inhibition,reactive oxygen species(ROS)generation,and gluta+ione peroxidase 4(GPX4)inhibition,is prepared for ferroptosis/apoptosis treatment.After internalization by CT26 cells,+e DOC@TA-Fe^(3+)nanoreactor escapes from+e lysosomes to release payloads.+e subsequent Fe^(3+)/Fe^(2+)conversion mediated by TA reducibility can trigger+e Fenton reaction to enhance+e ROS concentration.Additionally,Fe^(3+)can consume gluta+ione to repress+e activity of GPX4 to induce ferroptosis.Meanwhile,+e released DOC controls microtubule dynamics to activate+e apoptosis pa+way.+e superior in vivo antitumor efficacy of DOC@TA-Fe^(3+)nanoreactor in terms of tumor grow+inhibition and improved survival is verified in CT26 tumor-bearing mouse model.+erefore,+e nanoreactor can act as an effective apoptosis and ferroptosis inducer for application in colorectal cancer+erapy.展开更多
Based on ab initio density functional theory calculations,we demonstrate that two carbon-doped boron nitride analog ofα-graphyne structures,B_(3) C_(2) N_(3)) and BC_(6) N monolayers,are two-dimensional direct wide b...Based on ab initio density functional theory calculations,we demonstrate that two carbon-doped boron nitride analog ofα-graphyne structures,B_(3) C_(2) N_(3)) and BC_(6) N monolayers,are two-dimensional direct wide band gap semiconductors,and there are two inequivalent valleys in the vicinities of the vertices of their hexagonal Brillouin zones.Besides,B_(3)C_(2)N_(3) and BC_(6)N monolayers exhibit relatively high carrier mobilities,and their direct band gap feature is robust against the biaxial strain.More importantly,the energetically most favorable B_(3)C_(2)N_(3) and BC_(6)N bilayers also have direct wide band gaps,and valley polarization could be achieved by optical helicity.Finally,we show that BC_(6) N monolayer might have high efficiency in photo-splitting reactions of water,and a vertical van der Waals heterostructure with a type-Ⅱenergy band alignment could be designed using B_(3)C_(2)N_(3)and BC_(6)N monolayers.All the above-mentioned characteristics make B_(3)C_(2)N_(3) and BC_(6)N monolayers,bilayers,and their heterostructures recommendable candidates for applications in valleytronic devices,metal-free photocatalysts,and photovoltaic cells.展开更多
The formation process of aromatic hydrocarbon tar during the pyrolysis process of biomass components of cel-lulose and lignin was carried out by quantum chemical calculation based on density functional theory method B...The formation process of aromatic hydrocarbon tar during the pyrolysis process of biomass components of cel-lulose and lignin was carried out by quantum chemical calculation based on density functional theory method B3LYP/6-31G++(d,p).5 Hydroxymethylfurfural was chosen as the model compound of cellulose and hemicel-lulose,and syringa ldehyde was chosen as the model compound of lignin.The calculation results show that the formation process of cellulose monocyclic aromatic hydrocarbon tar is the conversion process of benzene ring from furan ring,and the highest reaction energy barrier appears in the process of decarbonylation,which is 370.8 kJ/mol.The formation of lignin monocyclic aromatic hydrocarbon tar is mainly the process of side chains removal and the formation of phenol,The highest reaction energy barrier appears in the process of decarbonyla-tion,which is 374.9 kJ/mol.The reaction mechanism of phenanthrene formation from naphthalene was selected as the formation of cellulose and lignin polycydic aromatic hydrocarbon tar.The calculation results show that he total barrier of the pathway that naphthalene dehydrogenates to form naphthalene free radicals and then reacts with ethylene twice by addition action,finally occurs cydization reactions and isomerizes to produce phenan-threne is lowest,that is 38.6 kJ/mol.So it is proved that the evolution of tar is the process of deoxygenation and cyclization with the increase of the temperature from a theoretical point of view.展开更多
Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal a...Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal adverse impact caused by Fe2+stimulus and low bioavailability severely impedes its therapeutic effects.In recent years,it has been found that nano iron⁃based nanoparticles with high surface⁃to⁃volume ratio and low iron ion leakage can alleviate the toxic effect and improve the gastrointestinal absorbance.For further clinical development,nano materials need to meet the pharmaceutical quality demand.Carboxymethyl cellulose(CMC)is a significant pharmaceutical ingredient applied in approved drug formulations,and polyglucosorbitol carboxymethylether(PSC)has been utilized in iron⁃based nanomedicine ferumoxytol synthesis,both of which can be firmly anchored on iron oxide by carboxyl chelation.In this work,iron oxide nanoparticles(NPs)modified with CMC were designed and synthesized,and the structure composition and physicochemical properties were distinctly characterized.Oral supplement effects on rat IDA were investigated and compared with other recently reported iron supplements including NPs modified with PSC.Results show that the oral nano iron supplement achieved the recovery of hemoglobin and serum iron level in only two weeks with high safety.The nano iron oxide modified with pharmaceutical excipients provides new potential approach for oral iron supplement available in clinics.展开更多
New observations of auroras based on the wide-field aurora imager(WAI)onboard Fengyun-3D(FY-3D)satellite are exhibited in this paper.Validity of the WAI data is analyzed by comparing auroral boundaries derived from WA...New observations of auroras based on the wide-field aurora imager(WAI)onboard Fengyun-3D(FY-3D)satellite are exhibited in this paper.Validity of the WAI data is analyzed by comparing auroral boundaries derived from WAI observations with results obtained from data collected by the Special Sensor Ultraviolet Spectrographic Imager(SSUSI)aboard the Defense Meteorological Satellite Program(DMSP F18).Dynamic variations of the aurora with the solar wind,interplanetary magnetic field(IMF)parameters,and the SYM-H index are also investigated.The comparison of auroral boundaries indicates that the WAI data are morphologically valid and suitable to the study of auroral dynamics.Effective responses to solar wind parameters indicate that the WAI data can be useful to monitor and predict the Earth’s space weather.Since the configuration of aurora is a good indicator of the solar wind–magnetosphere–ionosphere(SW-M-I)coupling system,and can reflect the disturbance of the space environment,the WAI will provide important data to help us to study the physical processes in space.展开更多
In China, although improvements to the pesticide registration process have been made in la thirty years, no occupational exposure data are required to obtain a commercial license for pesticide product. Consequently, n...In China, although improvements to the pesticide registration process have been made in la thirty years, no occupational exposure data are required to obtain a commercial license for pesticide product. Consequently, notably little research has been conducted to establish a exposure assessment procedure in China. The present study monitored the potential derm operator exposure from knapsack electric sprayer wheat field application of imidacloprid Liaocheng City, Shandong Province and in Xinxiang City, Henan Province, China, usin whole-body dosimetry. The potential inhalation exposure was determined using a person air pump and XAD-2 sample tubes. The analytical method was developed and validate including such performance parameters as limits of detection and quantification, linear rang recovery and precision. The total potential dermal and inhalation exposures were 14.20, 16.815.39 and 20.78 mL/hr, respectively, for the four operators in Liaocheng and Xinxian corresponding to 0.02% to 0.03% of the applied volume of spray solution. In all trials, the low part（thigh, lower leg） of the body was the most contaminated, accounting for approximate76% to 88% of the total exposure. The inhalation exposure was less than 1% of the tot exposure. Such factors as the application pattern, crop type, spray equipment, operat experience and climatic conditions have been used to explain the exposure distribution ov the different parts of the body. As indicated by the calculated Margin of Exposure, the typic wheat treatment scenarios when a backpack sprayer was used are considered to be safe terms of imidacloprid exposure.展开更多
Objective： To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells （BM-MSCs） or adenovirus5- hepatocyte growth factor（Ad5-HGF） via non-infarct-related artery injection in swine myocardi...Objective： To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells （BM-MSCs） or adenovirus5- hepatocyte growth factor（Ad5-HGF） via non-infarct-related artery injection in swine myocardial infarction models. Methods：BMMSCs were obtained from swine bone marrow and expanded in vitro to a purity of 〉50%. A myocardial infarction（MI） was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs （5 × 10^6/ml） or Ad5-HGF （4 × 10^9 pfu） were transfused via the right coronary artery （non-infarcted artery） four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results： （1）The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4^th weeks. （2）In both treatment groups, capillary density was significantly higher than that of control group（P 〈 0.05）. Conclusion ：BM-MSCs or Ad5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad5-HGF.展开更多
In the present paper, we consider the problem {-△u=u^(β_(1))|■u|^(β_(2)),in Ω,u=0,on ■Ω,u>0,in Ω,(0.1) where β_(1), β_(2) > 0 and β_(1) + β_(2) < 1, and Ω is a convex domain in R~n. The existence...In the present paper, we consider the problem {-△u=u^(β_(1))|■u|^(β_(2)),in Ω,u=0,on ■Ω,u>0,in Ω,(0.1) where β_(1), β_(2) > 0 and β_(1) + β_(2) < 1, and Ω is a convex domain in R~n. The existence, uniqueness,regularity and (2-β_(2))/(1-β_(1)-β_(2))-concavity of the positive solutions of the problem(0.1) are proven.展开更多
基金Supported by National Natural Science Foundation of China(No.82070991).
文摘Central retinal artery occlusion(CRAO)is an acute ophthalmic emergency,characterized by sudden vision loss due to retinal ischemia in areas corresponding to arterial occlusion sites.Diagnosis primarily relies on fundus fluorescein angiography(FFA)and optical coherence tomography(OCT),which show delayed retinal artery filling time hours to days after occlusion and increased hyperreflectivity of the inner retina.
基金supported by the National Natural Science Foundation of China(22408061 and 22468005)Program for Introducing High-Level Talents from Guangxi University,and Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology(2023Z014).
文摘Oxygen-rich porous carbons are promising candidates for the carbon-based cathodes of zinc ion hybrid capacitors(ZIHCs).Potassium activation is a traditional and effective way to prepare oxygen-rich porous carbons.Efficient potassium activation is the key to develop high-performance oxygen-rich porous carbon cathodes.Herein,the alkali lignin,extracted from eucalyptus wood by geopolymer-assisted low-alkali pretreatment,is used to prepare oxygen-rich lignin-derived porous carbons(OLPCs)through KOH activation and K_(2)CO_(3)activation at 700-900℃.KOH activation constructs a hierarchical micro-mesoporous structure,while K_(2)CO_(3)activation constructs a microporous structure.Furthermore,K_(2)CO_(3)activation could more efficiently construct active oxygen(C=O)species than KOH activation.The OLPCs prepared by KOH/K_(2)CO_(3)activations at 800℃show the highest microporosity(78.4/87.7%)and C=O content(5.3/8.0 at.%).Due to that C=O and micropore adsorb zinc ions,the OLPCs prepared by K_(2)CO_(3)activation at 800℃with higher C=O content and microporosity deliver superior capacitive performance(256 F g^(-1)at 0.1 A g^(-1))than that by KOH activation at 800℃(224 F g^(-1)at 0.1 A g^(-1)),and excellent cycling stability.This work provides a new insight into the sustainable preparation of oxygenrich porous carbon cathodes through efficient potassium activation for ZIHCs.
基金funded by the National Science Foundation of China(52204033)the Science&Technology Department of Sichuan Province(2024NSFSC0201)Scientific research Project of Petro China Southwest Oil&Gas Field Company(No.2024D112-01-01).
文摘Balancing CO2 emission reduction with enhanced gas recovery in carbonate reservoirs remains a key challenge in subsurface energy engineering.This study focuses on the Maokou Formation gas reservoir in the Wolonghe Gas Field,Sichuan Basin,and employs a mechanistic model integrated with numerical simulations that couple CO2–water–rock geochemical interactions to systematically explore the principal engineering and chemical factors governing Carbon Capture,Utilization,and Storage–Enhanced Gas Recovery(CCUS–EGR).The analysis reveals that both the injection–production ratio and gas injection rate exhibit optimal ranges.Maximum gas output under single-parameter variation occurs at an injection–production ratio of 0.7 and an injection rate of 130,000 m3/d,while coordinated optimization of both parameters is essential to achieve the highest production enhancement.Excessively high injection–production ratios,however,may induce gas channeling and reduce the ultimate recovery factor.Chemical composition of the injected gas also strongly influences recovery.In the heterogeneous carbonate reservoir considered,a CO2–N2 mixed gas mitigates gravity segregation due to its lower density,expanding sweep efficiency and improving overall gas recovery compared to pure CO2 injection.CO2–water–rock reactions further modify reservoir properties.Near the injection well,acidic dissolution enhances porosity,whereas near the production well,a dynamic interplay of ion migration,pressure–temperature variations,and secondary mineral precipitation produces complex porosity evolution.Initial precipitation reduces porosity,while subsequent acidic dissolution partially restores it,creating a heterogeneous and time-dependent porosity profile.
基金supported by the National Natural Science Funding of China(Grant No.82170351)the Special Fund for Key R&D Plans(Social Development)of Jiangsu Province(Grant No.BE2019754)Kanion Pharmaceutical Group,Lianyungang,Jiangsu,China。
文摘The Optimal Management of Antithrombotic and Thrombolytic Agents-5(OPTIMA-5)study demonstrated that a single bolus of half the standard dose of recombinant staphylokinase(r-SAK)before primary percutaneous coronary intervention(PCI)significantly improved the patency of the infarct-related artery in patients with STsegment elevation myocardial infarction(STEMI),who were expected to undergo PCI within 120 min.The present study aimed to investigate the one-year clinical outcomes and the effect of the anti-r-SAK antibodies on a second r-SAK thrombolysis in OPTIMA-5 patients.The clinical outcome measured was major adverse cardiovascular events(MACE)within 360 days.Patients'anti-r-SAK antibody levels were determined on day 90(±7 days),day 180(±7 days),and day 360(±14 days)after thrombolysis,and in vitro r-SAK antibody neutralization experiments were performed to explore an optimal interval for a second r-SAK thrombolysis.Results showed that the MACE incidence was numerically lower in the r-SAK group compared with the normal saline(NS)group(14.0%vs.20.0%,hazard ratio[HR]=0.67,95%confidence interval[CI]:0.34–1.32;log-rank P=0.245).The anti-r-SAK antibody levels in the r-SAK group decreased with time,but remained significantly higher than those in the NS group on day 90(±7 days)(2.96±0.68 vs.0.22±0.53,P<0.001),day 180(±7 days)(2.19±0.74 vs.0.44±0.65,P<0.001),and day 360(±14 days)(1.73±0.97 vs.0.37±0.71,P<0.001).The in vitro anti-r-SAK antibody neutralization experiments demonstrated that the thrombolysis rate decreased exponentially as the antibody titer increased from 1.90 to 2.20(67.80%±14.19%vs.44.32%±21.54%,P<0.0001).Therefore,for STEMI patients who are expected to undergo PCI within 120 min,a single bolus of half-dose rSAK before primary PCI may reduce the one-year MACE risk.The anti-r-SAK antibody persists over one year,and a second r-SAK thrombolysis may not be indicated until at least one year after the first administration,if necessary.
基金supported by the National Natural Science Foundation of China(62473337,62003305)the Key Research and Development Program of Zhejiang Province(2024C03040,2022C03029)the funding of Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Province(2023R01006).
文摘Focusing on the rehabilitation training of hemiplegia patients,this paper proposes a gait-planning strategy based on a central pattern generator and an adaptive time-delay control scheme that utilizes recursive terminal sliding mode for lower limb rehabilitation exoskeleton robots.The central pattern generator network plans a reference gait trajectory for the affected leg,synchronized with the movement of the healthy leg.The proposed adaptive time-delay control scheme possesses a model-independent property due to the mechanism of time-delay estimation,with adaptive control gains that enhance the resilience against system perturbations and a recursive terminal sliding mode control component to achieve a fast convergence rate.According to the Lyapunov stability criterion,it is proved that the gait trajectory-tracking error is uniformly ultimately bounded.Experiments are conducted on a lower limb exoskeleton experimental platform,and the experimental results demonstrate the effectiveness and superiority of the proposed strategies.
基金supported by the National Key R&D Program of China,Nos.2017YFA0104302(to NG and XM)and 2017YFA0104304(to BW and ZZ)
文摘Mesenchymal stromal cell transplantation is an effective and promising approach for treating various systemic and diffuse diseases.However,the biological characteristics of transplanted mesenchymal stromal cells in humans remain unclear,including cell viability,distribution,migration,and fate.Conventional cell tracing methods cannot be used in the clinic.The use of superparamagnetic iron oxide nanoparticles as contrast agents allows for the observation of transplanted cells using magnetic resonance imaging.In 2016,the National Medical Products Administration of China approved a new superparamagnetic iron oxide nanoparticle,Ruicun,for use as a contrast agent in clinical trials.In the present study,an acute hemi-transection spinal cord injury model was established in beagle dogs.The injury was then treated by transplantation of Ruicun-labeled mesenchymal stromal cells.The results indicated that Ruicunlabeled mesenchymal stromal cells repaired damaged spinal cord fibers and partially restored neurological function in animals with acute spinal cord injury.T2*-weighted imaging revealed low signal areas on both sides of the injured spinal cord.The results of quantitative susceptibility mapping with ultrashort echo time sequences indicated that Ruicun-labeled mesenchymal stromal cells persisted stably within the injured spinal cord for over 4 weeks.These findings suggest that magnetic resonance imaging has the potential to effectively track the migration of Ruicun-labeled mesenchymal stromal cells and assess their ability to repair spinal cord injury.
文摘Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.
基金Supported by the National Natural Science Foundation of China(No.82070991).
文摘Dear Editor,Torpedo maculopathy(TM),first described by Roseman and Gass in 1992[1],is a rare congenital unilateral retinal pigment epithelium(RPE)abnormality.The term“torpedo maculopathy”was coined by Daily[2]in 1993.TM typically spares the foveal center,is asymptomatic,and is often detected incidentally during routine ophthalmic examinations.Through literature search,we did not identify racial or regional differences in TM.It predominantly affects children,with an estimated prevalence of 2 per 100000 in individuals under 16 ages[3].While previous reports have focused on pediatric and adult populations,this study presents four cases of TM in preterm infants.
基金The authors would like to thank Li LI and H.Z.Xie for the technical support.This work was financially supported by the National Natural Science Foundation of China(Nos.82002303 and 81702171)the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515011536,2021A1515220093,2021A1515220086,2019A1515111156,and 2022A1515011815)+7 种基金the Scientific Research Foundation of Peking University Shenzhen hospital(No.KYQD2021064)the Health and Medical Research Fund(No.19180712)the Shenzhen Double Chain Project for Innovation and Development Industry supported by the Bureau of Industry and Information Technology of Shenzhen(No.201806081018272960)the Shenzhen Science and Technology Innovation Committee Projects(Nos.JCYJ20190809182213535 and JSGG20180507183242702)the program from Shanghai Municipal Health Commission(No.201740165)the National Key R&D Program of China(No.2018YFC1105100)the Hong Kong Innovation Technology Fund(Nos.ITS/287/17 and ITS/405/18)the Hong Kong Research Grant Council General Research Fund(No.17214516).
文摘The healing of critical-sized bone defects(CSD)remains a challenge in orthopedic medicine.In recent years,scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional(3D)printing technology have lighted up the treatment of the CSD due to the elaborate microenvironments and support they may build.Here,we established a magnesium oxide-reinforced 3D-printed biocompos-ite scaffold to investigate the effect of magnesium-enriched 3D microenvironment on CSD repairing.The composite was prepared using a biodegradable polymer matrix,polycaprolactone(PCL),and the disper-sion phase,magnesium oxide(MgO).With the appropriate surface treatment by saline coupling agent,the MgO dispersed homogeneously in the polymer matrix,leading to enhanced mechanical performance and steady release of magnesium ion(Mg^(2+))for superior cytocompatibility,higher cell viability,advanced osteogenic differentiation,and cell mineralization capabilities in comparison with the pure PCL.The in-vivo femoral implantation and critical-sized cranial bone defect studies demonstrated the importance of the 3D magnesium microenvironment,as a scaffold that released appropriate Mg^(2+) exhibited remarkably increased bone volume,enhanced angiogenesis,and almost recovered CSD after 8-week implantation.Overall,this study suggests that the magnesium-enriched 3D scaffold is a potential candidate for the treatment of CSD in a cell-free therapeutic approach.
基金financially supported by the Beijing Municipal Science & Technology Commission (No. Z171100002217048)the National Natural Science Foundation of China (No. 51705489)
文摘Diffusion bonding of refractory Nb–Si-based alloy was performed with Ni/Al and Ti/Al nanolayers under the condition of 1473 K/30 MPa/60 min.The NbSS/Nb5Si3 in situ composite with the nominal composition of Nb–22 Ti–16 Si–3 Cr–3 Al–2 Hf was used as the parent material.The joint microstructures were examined by using a scanning electron microscope equipped with an X-ray energy dispersive spectrometer.Shear test was conducted for the bonded joints at room temperature.Within the joint bonded with Ni/Al multilayer,element diffusion occurred between the base metal and the nanolayer,with the reaction products of AlNb2+Ni3 Al,NiAl and AlNi2 Ti phases.The average shear strength was 182 MPa.While using Ti/Al multilayer,the interface mainly consisted of TiAl,(Ti,Nb)Al and(Ti,Nb)2 Al phases,and the corresponding joints exhibited an increased strength of 228 MPa.In this case,the fracture mainly took place in the TiAl phase and presented a typical brittle characteristic.
基金supported by NSFC (Grant Nos. 11522328, 11473070, 11427803 and U1731241)CAS Strategic Pioneer Program on Space Science (Grant Nos. XDA15010600, XDA15052200, XDA15320103 and XDA15320301)the National Key Research and Development Program of China (2018YFA0404202)
文摘The Advanced Space-based Solar Observatory(ASO-S) mission aims to explore the two most spectacular eruptions on the Sun: solar flares and coronal mass ejections(CMEs), and their magnetism.For the study of CMEs, the payload Lyman-alpha Solar Telescope(LST) has been proposed. It includes a traditional white-light coronagraph and a Lyman-alpha coronagraph which opens a new window to CME observations. Polarization measurements taken by white-light coronagraphs are crucial for deriving fundamental physical parameters of CMEs. To make such measurements, there are two options for a Stokes polarimeter which have been applied by existing white-light coronagraphs for space missions. One uses a single or triple linear polarizer, the other involves both a half-wave plate and a linear polarizer. We find that the former option is subject to less uncertainty in the derived Stokes vector propagating from detector noise.The latter option involves two plates which are prone to internal reflections and may have a reduced transmission factor. Therefore, the former option is adopted as our Stokes polarimeter scheme for LST. Based on the parameters of the intended linear polarizer(s) colorPol provided by CODIXX and the half-wave plate 2-APW-L2-012 C by Altechna, it is further shown that the imperfect maximum transmittance of the polarizer significantly increases the variance amplification of Stokes vector by at least about 50% when compared with the ideal case. The relative errors of Stokes vector caused by the imperfection of colorPol polarizer and the uncertainty due to the polarizer assembly in the telescope are estimated to be about 5%. Among the considered parameters, we find that the dominant error comes from the uncertainty in the maximum transmittance of the polarizer.
基金funded by National Key Research, Development Program of China (No. 2017YFE0301305KYWX-002)Sichuan Science and Technology Program (No. 2021YFSY0015)
文摘Atmospheric pressure plasma jet(APPJ)was used to clean nitrogen-containing carbon films(C–N)fabricated by plasma-assisted chemical vapor deposition method employing the plasma surface interaction linear device at Sichuan University(SCU-PSI).The properties of the contaminated films on the surface of pristine and He-plasma pre-irradiated tungsten matrix,such as morphology,crystalline structure,element composition and chemical structure were characterized by scanning electron microscopy,grazing incidence x-ray diffraction and x-ray photoelectron spectroscopy.The experimental results revealed that the removal of C–N film with a thickness of tens of microns can be realized through APPJ cleaning regardless of the morphology of the substrates.Similar removal rates of 16.82 and 13.78μm min^(-1)were obtained for C–N films deposited on a smooth pristine W surface and rough fuzz-covered W surface,respectively.This is a remarkable improvement in comparison to the traditional cleaning method.However,slight surface oxidation was found after APPJ cleaning,but the degree of oxidation was acceptable with an oxidation depth increase of only 3.15 nm.Optical emission spectroscopy analysis and mass spectrometry analysis showed that C–N contamination was mainly removed through chemical reaction with reactive oxygen species during APPJ treatment using air as the working gas.These results make APPJ cleaning a potentially effective method for the rapid removal of C–N films from the wall surfaces of fusion devices.
基金supported by the National Natural Science Foundation of China(Grant Nos.:31971308,81960769,and U1903211)National S&T Major Project(Grant No.:2019ZX09301-147),Luzhou Science and Technology Plan(Grant No.:2018CDLZ10)Sichuan Science and Technology Program(Grant No.:2021YFS0081).
文摘Traditional microtubule inhibitors fail to significantly enhance+e effect of colorectal cancer;hence,new and efficient strategies are necessary.In+is study,a supramolecular nanoreactor(DOC@TA-Fe^(3+))based on tannic acid(TA),iron ion(Fe^(3+)),and docetaxel(DOC)wi+microtubule inhibition,reactive oxygen species(ROS)generation,and gluta+ione peroxidase 4(GPX4)inhibition,is prepared for ferroptosis/apoptosis treatment.After internalization by CT26 cells,+e DOC@TA-Fe^(3+)nanoreactor escapes from+e lysosomes to release payloads.+e subsequent Fe^(3+)/Fe^(2+)conversion mediated by TA reducibility can trigger+e Fenton reaction to enhance+e ROS concentration.Additionally,Fe^(3+)can consume gluta+ione to repress+e activity of GPX4 to induce ferroptosis.Meanwhile,+e released DOC controls microtubule dynamics to activate+e apoptosis pa+way.+e superior in vivo antitumor efficacy of DOC@TA-Fe^(3+)nanoreactor in terms of tumor grow+inhibition and improved survival is verified in CT26 tumor-bearing mouse model.+erefore,+e nanoreactor can act as an effective apoptosis and ferroptosis inducer for application in colorectal cancer+erapy.
基金the Special Foundation for Theoretical Physics Research Program of China(Grant No.11847065)the Natural Science Foundation of Shanxi Province,China(Grant No.201901D211115).
文摘Based on ab initio density functional theory calculations,we demonstrate that two carbon-doped boron nitride analog ofα-graphyne structures,B_(3) C_(2) N_(3)) and BC_(6) N monolayers,are two-dimensional direct wide band gap semiconductors,and there are two inequivalent valleys in the vicinities of the vertices of their hexagonal Brillouin zones.Besides,B_(3)C_(2)N_(3) and BC_(6)N monolayers exhibit relatively high carrier mobilities,and their direct band gap feature is robust against the biaxial strain.More importantly,the energetically most favorable B_(3)C_(2)N_(3) and BC_(6)N bilayers also have direct wide band gaps,and valley polarization could be achieved by optical helicity.Finally,we show that BC_(6) N monolayer might have high efficiency in photo-splitting reactions of water,and a vertical van der Waals heterostructure with a type-Ⅱenergy band alignment could be designed using B_(3)C_(2)N_(3)and BC_(6)N monolayers.All the above-mentioned characteristics make B_(3)C_(2)N_(3) and BC_(6)N monolayers,bilayers,and their heterostructures recommendable candidates for applications in valleytronic devices,metal-free photocatalysts,and photovoltaic cells.
基金supported by 2021–2022 Hunan Province Enterprise Science and Technology Commissioner Program Project under the Contract No.2021GK5046the project supported by Scientific Research Fund of Hunan Provincial Education Department under the Contract No.19C0476the project supported by Scientific Research Fund of Hunan Institute of Engineering under the Contract No.XJ1902.
文摘The formation process of aromatic hydrocarbon tar during the pyrolysis process of biomass components of cel-lulose and lignin was carried out by quantum chemical calculation based on density functional theory method B3LYP/6-31G++(d,p).5 Hydroxymethylfurfural was chosen as the model compound of cellulose and hemicel-lulose,and syringa ldehyde was chosen as the model compound of lignin.The calculation results show that the formation process of cellulose monocyclic aromatic hydrocarbon tar is the conversion process of benzene ring from furan ring,and the highest reaction energy barrier appears in the process of decarbonylation,which is 370.8 kJ/mol.The formation of lignin monocyclic aromatic hydrocarbon tar is mainly the process of side chains removal and the formation of phenol,The highest reaction energy barrier appears in the process of decarbonyla-tion,which is 374.9 kJ/mol.The reaction mechanism of phenanthrene formation from naphthalene was selected as the formation of cellulose and lignin polycydic aromatic hydrocarbon tar.The calculation results show that he total barrier of the pathway that naphthalene dehydrogenates to form naphthalene free radicals and then reacts with ethylene twice by addition action,finally occurs cydization reactions and isomerizes to produce phenan-threne is lowest,that is 38.6 kJ/mol.So it is proved that the evolution of tar is the process of deoxygenation and cyclization with the increase of the temperature from a theoretical point of view.
基金National Key Research and Development Program of China(Grant No.2017YFA0104302)the National Natural Science Innovative Research Group Project(Grant No.61821002)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20190938)the Key Projects of the National Natural Science Foundation of China(Grant No.51832001).
文摘Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia(IDA)due to the convenience of large dose administration and good patient compliance.However,the gastrointestinal adverse impact caused by Fe2+stimulus and low bioavailability severely impedes its therapeutic effects.In recent years,it has been found that nano iron⁃based nanoparticles with high surface⁃to⁃volume ratio and low iron ion leakage can alleviate the toxic effect and improve the gastrointestinal absorbance.For further clinical development,nano materials need to meet the pharmaceutical quality demand.Carboxymethyl cellulose(CMC)is a significant pharmaceutical ingredient applied in approved drug formulations,and polyglucosorbitol carboxymethylether(PSC)has been utilized in iron⁃based nanomedicine ferumoxytol synthesis,both of which can be firmly anchored on iron oxide by carboxyl chelation.In this work,iron oxide nanoparticles(NPs)modified with CMC were designed and synthesized,and the structure composition and physicochemical properties were distinctly characterized.Oral supplement effects on rat IDA were investigated and compared with other recently reported iron supplements including NPs modified with PSC.Results show that the oral nano iron supplement achieved the recovery of hemoglobin and serum iron level in only two weeks with high safety.The nano iron oxide modified with pharmaceutical excipients provides new potential approach for oral iron supplement available in clinics.
基金the National Science Foundation of China(41327802,41774152 and 41674155)in part by Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017258)the Strategic Priority Program on Space Science,Chinese Academy of Sciences,Grant No.XDA15350203。
文摘New observations of auroras based on the wide-field aurora imager(WAI)onboard Fengyun-3D(FY-3D)satellite are exhibited in this paper.Validity of the WAI data is analyzed by comparing auroral boundaries derived from WAI observations with results obtained from data collected by the Special Sensor Ultraviolet Spectrographic Imager(SSUSI)aboard the Defense Meteorological Satellite Program(DMSP F18).Dynamic variations of the aurora with the solar wind,interplanetary magnetic field(IMF)parameters,and the SYM-H index are also investigated.The comparison of auroral boundaries indicates that the WAI data are morphologically valid and suitable to the study of auroral dynamics.Effective responses to solar wind parameters indicate that the WAI data can be useful to monitor and predict the Earth’s space weather.Since the configuration of aurora is a good indicator of the solar wind–magnetosphere–ionosphere(SW-M-I)coupling system,and can reflect the disturbance of the space environment,the WAI will provide important data to help us to study the physical processes in space.
基金supported by the State Key Development Program for Basic Research of China (No. 2014CB932204)the Special Fund for Agro-Scientific Research in the Public Interest of China (No. 200903054)
文摘In China, although improvements to the pesticide registration process have been made in la thirty years, no occupational exposure data are required to obtain a commercial license for pesticide product. Consequently, notably little research has been conducted to establish a exposure assessment procedure in China. The present study monitored the potential derm operator exposure from knapsack electric sprayer wheat field application of imidacloprid Liaocheng City, Shandong Province and in Xinxiang City, Henan Province, China, usin whole-body dosimetry. The potential inhalation exposure was determined using a person air pump and XAD-2 sample tubes. The analytical method was developed and validate including such performance parameters as limits of detection and quantification, linear rang recovery and precision. The total potential dermal and inhalation exposures were 14.20, 16.815.39 and 20.78 mL/hr, respectively, for the four operators in Liaocheng and Xinxian corresponding to 0.02% to 0.03% of the applied volume of spray solution. In all trials, the low part（thigh, lower leg） of the body was the most contaminated, accounting for approximate76% to 88% of the total exposure. The inhalation exposure was less than 1% of the tot exposure. Such factors as the application pattern, crop type, spray equipment, operat experience and climatic conditions have been used to explain the exposure distribution ov the different parts of the body. As indicated by the calculated Margin of Exposure, the typic wheat treatment scenarios when a backpack sprayer was used are considered to be safe terms of imidacloprid exposure.
文摘Objective： To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells （BM-MSCs） or adenovirus5- hepatocyte growth factor（Ad5-HGF） via non-infarct-related artery injection in swine myocardial infarction models. Methods：BMMSCs were obtained from swine bone marrow and expanded in vitro to a purity of 〉50%. A myocardial infarction（MI） was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs （5 × 10^6/ml） or Ad5-HGF （4 × 10^9 pfu） were transfused via the right coronary artery （non-infarcted artery） four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results： （1）The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4^th weeks. （2）In both treatment groups, capillary density was significantly higher than that of control group（P 〈 0.05）. Conclusion ：BM-MSCs or Ad5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad5-HGF.
基金The first author and the third author were supported by the National Natural Science Foundation of China (11761030)the Cultivation Project for High-Level Scientific Research Achievements of Hubei Minzu University (PY20002)The second author was supported by the China Postdoctoral Science Foundation (2021M690773)。
文摘In the present paper, we consider the problem {-△u=u^(β_(1))|■u|^(β_(2)),in Ω,u=0,on ■Ω,u>0,in Ω,(0.1) where β_(1), β_(2) > 0 and β_(1) + β_(2) < 1, and Ω is a convex domain in R~n. The existence, uniqueness,regularity and (2-β_(2))/(1-β_(1)-β_(2))-concavity of the positive solutions of the problem(0.1) are proven.
