Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation.Ferroptosis is involved in a range of pathological processes,such as cancer.Many studies have confirmed that fer...Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation.Ferroptosis is involved in a range of pathological processes,such as cancer.Many studies have confirmed that ferroptosis plays an essential role in inhibiting cancer cell proliferation.In addition,a series of small-molecule compounds have been developed,including erastin,RSL3,and FIN56,which can be used as ferroptosis inducers.The combination of ferroptosis inducers with anticancer drugs can produce a significant synergistic effect in cancer treatment,and patients treated with these combinations exhibit a better prognosis than patients receiving traditional therapy.Therefore,a thorough understanding of the roles of ferroptosis in cancer is of great significance for the treatment of cancer.This review mainly elaborates the molecular biological characteristics and mechanism of ferroptosis,summarizes the function of ferroptosis in cancer development and treatment,illustrates the application of ferroptosis in patient’s prognosis prediction and drug discovery,and discusses the prospects of targeting ferroptosis.展开更多
基金supported bythe National Natural Science Foundation of China(82302918)Natural Science Foundation of Zhejiang Province(LQ24H160044,LQ24H160024)+5 种基金Medical and Health Research project of Zhejiang province(2024KY758,2024KY1405)Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province(2020E10021)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(ZWB-2020-18,Nengming Lin)Zhejiang Medical Key Discipline Foundation(ZWB-2018-02-03)HangzhouMedical Key Discipline Foundation(HWF-2021-21-16)the grants from Seed Foundation of Zhejiang Provincial People’s Hospital(ZRY2022J007).
文摘Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation.Ferroptosis is involved in a range of pathological processes,such as cancer.Many studies have confirmed that ferroptosis plays an essential role in inhibiting cancer cell proliferation.In addition,a series of small-molecule compounds have been developed,including erastin,RSL3,and FIN56,which can be used as ferroptosis inducers.The combination of ferroptosis inducers with anticancer drugs can produce a significant synergistic effect in cancer treatment,and patients treated with these combinations exhibit a better prognosis than patients receiving traditional therapy.Therefore,a thorough understanding of the roles of ferroptosis in cancer is of great significance for the treatment of cancer.This review mainly elaborates the molecular biological characteristics and mechanism of ferroptosis,summarizes the function of ferroptosis in cancer development and treatment,illustrates the application of ferroptosis in patient’s prognosis prediction and drug discovery,and discusses the prospects of targeting ferroptosis.
